Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

JOURNAL ARTICLE published 25 October 2012 in Journal of Medicinal Chemistry

Authors: Vassilios Bavetsias | Simon Crumpler | Chongbo Sun | Sian Avery | Butrus Atrash | Amir Faisal | Andrew S. Moore | Magda Kosmopoulou | Nathan Brown | Peter W. Sheldrake | Katherine Bush | Alan Henley | Gary Box | Melanie Valenti | Alexis de Haven Brandon | Florence I. Raynaud | Paul Workman | Suzanne A. Eccles | Richard Bayliss | Spiros Linardopoulos | Julian Blagg