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Dehydroabietylamine derived bistetrazoles from ultrasound-assisted pseudo-seven-component Ugi reactions act as efficient and selective inhibitors of cholinesterases

JOURNAL ARTICLE published April 2024 in European Journal of Medicinal Chemistry Reports

Authors: Niels V. Heise | Antonia Schmidt | Jördis-Ann Schüler | René Csuk

Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic Diseases

JOURNAL ARTICLE published 22 February 2024 in Journal of Medicinal Chemistry

Authors: Cyrille Lescop | Magdalena Birker | Christine Brotschi | Cédric Bürki | Keith Morrison | Sylvie Froidevaux | Stéphane Delahaye | Oliver Nayler | Martin H. Bolli

Discovery of Nivasorexant (ACT-539313): The First Selective Orexin-1 Receptor Antagonist (SO1RA) Investigated in Clinical Trials

JOURNAL ARTICLE published 8 February 2024 in Journal of Medicinal Chemistry

Authors: Jodi T. Williams | Martin H. Bolli | Christine Brotschi | Thierry Sifferlen | Michel A. Steiner | Alexander Treiber | John Gatfield | Christoph Boss

RNA and the RNA-binding protein FUS act in concert to prevent TDP-43 spatial segregation

JOURNAL ARTICLE published February 2024 in Journal of Biological Chemistry

Authors: Clément Demongin | Samuel Tranier | Vandana Joshi | Léa Ceschi | Bénédicte Desforges | David Pastré | Loic Hamon

Formin tails act as a switch, inhibiting or enhancing processive actin elongation

JOURNAL ARTICLE published January 2024 in Journal of Biological Chemistry

Research funded by NIGMS (R35 GM130370,T32 GM145388) | NHLBI (R01 HL14659)

Authors: Kathryn V. Bremer | Carolyn Wu | Aanand A. Patel | Kevin L. He | Alex M. Grunfeld | Guillaume F. Chanfreau | Margot E. Quinlan

Nano iron doped calcium phosphates act as pH-Sensitive and biodegradable peroxidase-like nanozymes for cancer chemodynamic therapy and MRI contrast

JOURNAL ARTICLE published January 2024 in Materials Today Chemistry

Authors: Tiago P. Ribeiro | Bárbara Salgado | Jéssica Pinto | Pedro C. Silva | João A.M. Santos | J. Agostinho Moreira | Fernando J. Monteiro | Marta S. Laranjeira

Making sense of chemical equilibrium: productive teacher–student dialogues as a balancing act between sensemaking and managing tension

JOURNAL ARTICLE published 2024 in Chemistry Education Research and Practice

Authors: Ylva Hamnell-Pamment

Balancing act: when to flex and when to stay fixed

JOURNAL ARTICLE published January 2024 in Trends in Chemistry

Authors: Rama El-khawaldeh | Jason E. Hein

Graphene’s Role in the Clean-Up Act: Progress in Industrial Wastewater Treatment

JOURNAL ARTICLE published 31 December 2023 in Asian Journal of Chemistry

Authors: Chandan Adhikari | Sramana Ghosh | Prabir Kumar Das

3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines inhibit tubulin polymerisation and act as anticancer agents

JOURNAL ARTICLE published 31 December 2024 in Journal of Enzyme Inhibition and Medicinal Chemistry

Research funded by National Natural Science Foundation of China (82303590) | Natural Science Foundation of Shandong (ZR2021QH156,ZR2020QC081) | Natural Science Foundation of Qingdao (23–2-1–141-zyyd-jch) | Medical and Health Science and Technology Development Plan Project of Shandong (202113051140)

Authors: Chao Wang | Yujing Zhang | Shanbo Yang | Lingyu Shi | Yutao Xiu | Yudong Wu | Hongfei Jiang

Polyphenolic flavonoid compounds act as the inhibitory potential of aggregation process: Implications for the prevention and therapeutics against FALS-associated D101G SOD1 mutant

JOURNAL ARTICLE published December 2023 in Computational Biology and Chemistry

Authors: Hussein maitham Qassim | Bagher Seyedalipour | Payam Baziyar | Salman Ahamady-Asbchin

Metalloborospherenes with a Stabilized Classical Fullerene-like Borospherene B40 Act as Nonlinear Optical Switches, Electron Reservoirs, Molecular Capacitors, and Molecular Reactors

JOURNAL ARTICLE published 7 December 2023 in The Journal of Physical Chemistry A

Research funded by Hebei Province Outstanding Youth Fund (JYT2020003) | National Natural Science Foundation of China (21573089,51872057) | Education Department of Jilin Province (JJKH20190117KJ)

Authors: Weihong Chen | Jiayuan Liu | Weiming Sun | Shansheng Yu | Ying Li | Zhiru Li

Semiconductor Quantum Dots Act as Photocatalysts for Carbon–Carbon Bond Formation: Selective Functionalization of Xanthene’s 9H Position

JOURNAL ARTICLE published 1 December 2023 in The Journal of Organic Chemistry

Research funded by Science and Engineering Research Board (CRG/2020/001197)

Authors: Jiteshkumar P. Deore | Mrinmoy De

4-Cyanamido-substituted benzenesulfonamides act as dual carbonic anhydrase and cathepsin inhibitors

JOURNAL ARTICLE published October 2023 in Bioorganic Chemistry

Research funded by European Regional Development Fund (1.1.1.2/VIAA/3/19/398)

Authors: Morteza Abdoli | Vesa Krasniqi | Alessandro Bonardi | Michael Gütschow | Claudiu T. Supuran | Raivis Žalubovskis

Proteolytically Stable Diaza-Peptide Foldamers Mimic Helical Hot Spots of Protein–Protein Interactions and Act as Natural Chaperones

JOURNAL ARTICLE published 14 September 2023 in Journal of Medicinal Chemistry

Authors: Chenghui Shi | Julia Kaffy | Tâp Ha-Duong | Jean-François Gallard | Alain Pruvost | Aloise Mabondzo | Lidia Ciccone | Sandrine Ongeri | Nicolo Tonali

Computing Unknown Compounds: A Balancing Act between Science and Science Fiction

JOURNAL ARTICLE published 11 September 2023 in Inorganic Chemistry

Authors: Jochen Autschbach | Stefanie Dehnen

Phenylboronic acid functionalized high-crystallinity fluorescent covalent organic framework act as a sensing platform with dual performance for rifamycin antibiotics and water and adsorbent for rifamycin antibiotics

JOURNAL ARTICLE published August 2023 in Materials Today Chemistry

Research funded by Southwest Medical University (2020LZXNYDJ25) | Natural Science Foundation of Sichuan Province (23NSFSC5092) | National Natural Science Foundation of China (21904109,22204131)

Authors: L. Wang | D. Wang | Y. Tao | J. Wang | M. Tian | Q. Liu | Y. Yang | Y. Zou | F. Ke | X. Guo | X. Li | D. Gao

Antimicrobial Resistance in Exploited Estuaries: Some Overlooked Environmental Contaminants and Microbial Niches Might Act as Drivers

JOURNAL ARTICLE published October 2023 in Environmental Toxicology and Chemistry

Authors: Lauris Evariste

Rhodium(III)–Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy

JOURNAL ARTICLE published 27 July 2023 in Journal of Medicinal Chemistry

Research funded by Natural Science Foundation of Guangxi Province (2023GXNSFDA026054,AD17129007,GUIKEZY22096015) | National Natural Science Foundation of China (22077022)

Authors: Yun-Qiong Gu | Kun Yang | Qi-Yuan Yang | Huan-Qing Li | Mei-Qi Hu | Meng-Xue Ma | Nan-Feng Chen | Yang-Han Liu | Hong Liang | Zhen-Feng Chen

Physical, chemical, and biological characterization of biodegradable chitosan dressing for biomedical applications: Could sodium bicarbonate act as a crosslinking agent?

JOURNAL ARTICLE published June 2023 in Materials Chemistry and Physics

Authors: Julia Vaz Ernesto | Ísis de Macedo Gasparini | Fúlvio Gabriel Corazza | Mônica Beatriz Mathor | Classius Ferreira da Silva | Vania Rodrigues Leite-Silva | Newton Andréo-Filho | Patricia Santos Lopes