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Viral surface geometry shapes influenza and coronavirus spike evolution through antibody pressure

JOURNAL ARTICLE published 13 December 2021 in PLOS Computational Biology

Research funded by National Institutes of Health (2U19AI057229-16)

Authors: Assaf Amitai

Editors: Becca Asquith

An enriched network motif family regulates multistep cell fate transitions with restricted reversibility

JOURNAL ARTICLE published 7 March 2019 in PLOS Computational Biology

Research funded by National Natural Science Foundation of China (11771098) | Natural Science Foundation of Shanghai (17ZR1444500)

Authors: Yujie Ye | Xin Kang | Jordan Bailey | Chunhe Li | Tian Hong

Editors: Becca Asquith

Deep inference of seabird dives from GPS-only records: Performance and generalization properties

JOURNAL ARTICLE published 11 March 2022 in PLOS Computational Biology

Research funded by Horizon 2020 (No. 817578) | Institut de Recherche pour le Dévelopement (JEAI Tabasco) | LEFE program (project IA-OAC) | Centre National d’Etudes Spatiales (SWOT-DIEGO) | Agence Nationale de la Recherche (Melody) | Agence Nationale de la Recherche (OceaniX) | Agence Nationale de la Recherche (Topineme) | LMI (DISCOH)

Authors: Amédée Roy | Sophie Lanco Bertrand | Ronan Fablet

Editors: Ephraim Hanks

Leveraging genetic interactions for adverse drug-drug interaction prediction

JOURNAL ARTICLE published 24 May 2019 in PLOS Computational Biology

Research funded by National Institute of General Medical Sciences (R01 GM124559) | National Institute of General Medical Sciences (R01 GM125639) | National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK115398) | National Science Foundation (DBI-1661380)

Authors: Sheng Qian | Siqi Liang | Haiyuan Yu

Editors: Avner Schlessinger

A Bayesian framework for the analysis of systems biology models of the brain

JOURNAL ARTICLE published 26 April 2019 in PLOS Computational Biology

Research funded by Wellcome Trust (104580/Z/14/Z) | Wellcome Trust (209409/Z/17/Z)

Authors: Joshua Russell-Buckland | Christopher P. Barnes | Ilias Tachtsidis

Editors: Jeff Beck

Active degradation of MarA controls coordination of its downstream targets

JOURNAL ARTICLE published 27 December 2018 in PLOS Computational Biology

Research funded by National Science Foundation (1347635) | National Institutes of Health (US) (R01AI102922)

Authors: Nicholas A. Rossi | Thierry Mora | Aleksandra M. Walczak | Mary J. Dunlop

Editors: Gabor Balazsi

Interspike intervals within retinal spike bursts combinatorially encode multiple stimulus features

JOURNAL ARTICLE published 6 November 2020 in PLOS Computational Biology

Research funded by Japan Society for the Promotion of Science (19300116)

Authors: Toshiyuki Ishii | Toshihiko Hosoya

Editors: Stefano Panzeri

HiCImpute: A Bayesian hierarchical model for identifying structural zeros and enhancing single cell Hi-C data

JOURNAL ARTICLE published 13 June 2022 in PLOS Computational Biology

Research funded by National Institute of General Medical Sciences (R01GM114142)

Authors: Qing Xie | Chenggong Han | Victor Jin | Shili Lin

Editors: Eli Zunder

Modeling the efficiency of filovirus entry into cells in vitro: Effects of SNP mutations in the receptor molecule

JOURNAL ARTICLE published 28 September 2020 in PLOS Computational Biology

Authors: Kwang Su Kim | Tatsunari Kondoh | Yusuke Asai | Ayato Takada | Shingo Iwami

Editors: Ruy M. Ribeiro

Modification of Gene Duplicability during the Evolution of Protein Interaction Network

JOURNAL ARTICLE published 7 April 2011 in PLoS Computational Biology

Authors: Matteo D'Antonio | Francesca D. Ciccarelli

Editors: Christos A. Ouzounis

Free energy landscape of RNA binding dynamics in start codon recognition by eukaryotic ribosomal pre-initiation complex

JOURNAL ARTICLE published 14 June 2021 in PLOS Computational Biology

Research funded by Japan Society for the Promotion of Science (KAKENHI JP18KK0388) | National Research Foundation of Korea (Japan-Korea Basic Scientific Cooperation Program) | Japan Society for the Promotion of Science (Japan-Korea Basic Scientific Cooperation Program) | National Institutes of Health (K-INBRE program Pilot Grant P20 GM103418) | National Institutes of Health (R15 grant GM125671) | National Science Foundation (Research Grant 1412250) | Japan Society for the Promotion of Science (KAKENHI JP18K19963)

Authors: Takeru Kameda | Katsura Asano | Yuichi Togashi

Editors: Eugene I. Shakhnovich

Prediction of gene regulatory enhancers across species reveals evolutionarily conserved sequence properties

JOURNAL ARTICLE published 4 October 2018 in PLOS Computational Biology

Research funded by National Institute of General Medical Sciences (R01GM115836) | National Institute of General Medical Sciences (R35GM127087)

Authors: Ling Chen | Alexandra E. Fish | John A. Capra

Editors: Jian Ma

Noise-resistant developmental reproducibility in vertebrate somite formation

JOURNAL ARTICLE published 4 February 2019 in PLOS Computational Biology

Research funded by Japan Society for the Promotion of Science (16K16147)

Authors: Honda Naoki | Ryutaro Akiyama | Dini Wahyu Kartika Sari | Shin Ishii | Yasumasa Bessho | Takaaki Matsui

Editors: Anand R. Asthagiri

Characterization and clustering of kinase isoform expression in metastatic melanoma

JOURNAL ARTICLE published 13 May 2022 in PLOS Computational Biology

Research funded by National Human Genome Research Institute (1ZIAHG200323)

Authors: David O. Holland | Valer Gotea | Kevin Fedkenheuer | Sushil K. Jaiswal | Catherine Baugher | Hua Tan | Michael Fedkenheuer | Laura Elnitski

Editors: Pau Creixell

Paired fruit flies synchronize behavior: Uncovering social interactions in Drosophila melanogaster

JOURNAL ARTICLE published 6 October 2020 in PLOS Computational Biology

Authors: Ugne Klibaite | Joshua W. Shaevitz

Editors: Jessica C. Flack

Genetic buffering and potentiation in metabolism

JOURNAL ARTICLE published 14 September 2020 in PLOS Computational Biology

Research funded by Consejo Superior de Investigaciones Científicas (FIS2016-78781-R) | Consejo Superior de Investigaciones Científicas (PRX18/00439)

Authors: Juan F. Poyatos

Editors: Shuangge Ma

Computation of condition-dependent proteome allocation reveals variability in the macro and micro nutrient requirements for growth

JOURNAL ARTICLE published 23 June 2021 in PLOS Computational Biology

Research funded by Novo Nordisk Fonden (NNF10CC1016517) | National Institute of General Medical Sciences (NIH R01 GM057089) | National Institute of General Medical Sciences (NIH 1-U01-AI124316) | Office of Science (DE-AC02-05CH11231)

Authors: Colton J. Lloyd | Jonathan Monk | Laurence Yang | Ali Ebrahim | Bernhard O. Palsson

Editors: Vassily Hatzimanikatis

Global Analysis of Small Molecule Binding to Related Protein Targets

JOURNAL ARTICLE published 12 January 2012 in PLoS Computational Biology

Authors: Felix A. Kruger | John P. Overington

Editors: Greg Tucker-Kellogg

Physicochemical and metabolic constraints for thermodynamics-based stoichiometric modelling under mesophilic growth conditions

JOURNAL ARTICLE published 25 January 2021 in PLOS Computational Biology

Research funded by Biotechnology and Biological Sciences Research Council (BB/L013940/1) | Engineering and Physical Sciences Research Council (BB/L013940/1) | University of Nottingham’s School of Life Sciences (PhD studentship)

Authors: Claudio Tomi-Andrino | Rupert Norman | Thomas Millat | Philippe Soucaille | Klaus Winzer | David A. Barrett | John King | Dong-Hyun Kim

Editors: Costas D. Maranas

Modeling the role of gap junctions between excitatory neurons in the developing visual cortex

JOURNAL ARTICLE published 6 July 2021 in PLOS Computational Biology

Research funded by National Science Foundation (DMS-1703761)

Authors: Jennifer Crodelle | David W. McLaughlin

Editors: Hugues Berry