Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase

JOURNAL ARTICLE published 10 February 2016 in Science Translational Medicine

Research funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 048632)

Authors: Rachael Jarrett | Mariolina Salio | Antonia Lloyd-Lavery | Sumithra Subramaniam | Elvire Bourgeois | Charles Archer | Ka Lun Cheung | Clare Hardman | David Chandler | Maryam Salimi | Danuta Gutowska-Owsiak | Jorge Bernardino de la Serna | Padraic G. Fallon | Helen Jolin | Andrew Mckenzie | Andrzej Dziembowski | Ewa Izabela Podobas | Wojciech Bal | David Johnson | D. Branch Moody | Vincenzo Cerundolo | Graham Ogg

Swiss public health measures associated with reduced SARS-CoV-2 transmission using genome data

JOURNAL ARTICLE published 25 January 2023 in Science Translational Medicine

Authors: Sarah A. Nadeau | Timothy G. Vaughan | Christiane Beckmann | Ivan Topolsky | Chaoran Chen | Emma Hodcroft | Tobias Schär | Ina Nissen | Natascha Santacroce | Elodie Burcklen | Pedro Ferreira | Kim Philipp Jablonski | Susana Posada-Céspedes | Vincenzo Capece | Sophie Seidel | Noemi Santamaria de Souza | Julia M. Martinez-Gomez | Phil Cheng | Philipp P. Bosshard | Mitchell P. Levesque | Verena Kufner | Stefan Schmutz | Maryam Zaheri | Michael Huber | Alexandra Trkola | Samuel Cordey | Florian Laubscher | Ana Rita Gonçalves | Sébastien Aeby | Trestan Pillonel | Damien Jacot | Claire Bertelli | Gilbert Greub | Karoline Leuzinger | Madlen Stange | Alfredo Mari | Tim Roloff | Helena Seth-Smith | Hans H. Hirsch | Adrian Egli | Maurice Redondo | Olivier Kobel | Christoph Noppen | Louis du Plessis | Niko Beerenwinkel | Richard A. Neher | Christian Beisel | Tanja Stadler

A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care

JOURNAL ARTICLE published 11 May 2022 in Science Translational Medicine

Authors: Mikael Eriksson | Stamatia Destounis | Kamila Czene | Andrew Zeiberg | Robert Day | Emily F. Conant | Kathy Schilling | Per Hall

Muse cell spheroids have therapeutic effect on corneal scarring wound in mice and tree shrews

JOURNAL ARTICLE published 23 September 2020 in Science Translational Medicine

Research funded by National Outstanding Youth Science Fund Project of National Natural Science Foundation of China (81871495) | Project funded by China Postdoctoral Science Foundation (2019M663391) | the Special Funds for Major Science and Technology Projects of Guangdong Province (2015B010125007) | Joint Fund of Basic and Applied Basic Research Fund of Guangdong Province (2019A1515110355)

Authors: Yonglong Guo | Yunxia Xue | Peiyuan Wang | Zekai Cui | Jixing Cao | Shiwei Liu | Quan Yu | Qiaolang Zeng | Deliang Zhu | Mengyuan Xie | Jun Zhang | Zhijie Li | Hongwei Liu | Jingxiang Zhong | Jiansu Chen

Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors

JOURNAL ARTICLE published 16 November 2016 in Science Translational Medicine

Research funded by German Research Foundation (CRC1181,TRR1181)

Authors: Daniel F. Ortiz | Jonathan C. Lansing | Laura Rutitzky | Elma Kurtagic | Thomas Prod’homme | Amit Choudhury | Nathaniel Washburn | Naveen Bhatnagar | Christopher Beneduce | Kimberly Holte | Robert Prenovitz | Matthew Child | Jason Killough | Steven Tyler | Julia Brown | Stephanie Nguyen | Inessa Schwab | Maurice Hains | Robin Meccariello | Lynn Markowitz | Jing Wang | Radouane Zouaoui | Allison Simpson | Birgit Schultes | Ishan Capila | Leona Ling | Falk Nimmerjahn | Anthony M. Manning | Carlos J. Bosques

Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma

JOURNAL ARTICLE published 24 October 2018 in Science Translational Medicine

Research funded by National Cancer Institute (4K08CA138912-05) | National Cancer Institute (P30CA016672) | University of Texas MD Anderson Cancer Center (Knowledge Gap Funding)

Authors: Liran Zhou | Hongmei Husted | Todd Moore | Mason Lu | Defeng Deng | Yan Liu | Vijaya Ramachandran | Thiruvengadam Arumugam | Christof Niehrs | Huamin Wang | Paul Chiao | Jianhua Ling | Michael A. Curran | Anirban Maitra | Mien-Chie Hung | Jeffrey E. Lee | Craig D. Logsdon | Rosa F. Hwang

A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors

JOURNAL ARTICLE published 10 May 2023 in Science Translational Medicine

Authors: Ignacio Melero | Tamara Tanos | Mariana Bustamante | Miguel F. Sanmamed | Emiliano Calvo | Irene Moreno | Victor Moreno | Tatiana Hernandez | Maria Martinez Garcia | Alejo Rodriguez-Vida | Josep Tabernero | Analia Azaro | Mariano Ponz-Sarvisé | Iben Spanggaard | Kristoffer Rohrberg | Ernesto Guarin | Eveline Nüesch | Iakov I. Davydov | Chiahuey Ooi | José Duarte | Evelyne Chesne | Christine McIntyre | Maurizio Ceppi | Marta Cañamero | Oliver Krieter

GDNF rescues the fate of neural progenitor grafts by attenuating Notch signals in the injured spinal cord in rodents

JOURNAL ARTICLE published 8 January 2020 in Science Translational Medicine

Authors: Mohamad Khazaei | Christopher S. Ahuja | Hiroaki Nakashima | Narihito Nagoshi | Lijun Li | Jian Wang | Jonathon Chio | Anna Badner | David Seligman | Ayaka Ichise | Shinsuke Shibata | Michael G. Fehlings

Analysis of recurrently protected genomic regions in cell-free DNA found in urine

JOURNAL ARTICLE published 17 February 2021 in Science Translational Medicine

Research funded by National Cancer Institute (U01CA243078) | National Cancer Institute (R01CA223481) | Science Foundation Arizona (BSP-0542-13)

Authors: Havell Markus | Jun Zhao | Tania Contente-Cuomo | Michelle D. Stephens | Elizabeth Raupach | Ahuva Odenheimer-Bergman | Sydney Connor | Bradon R. McDonald | Bethine Moore | Elizabeth Hutchins | Marissa McGilvrey | Michelina C. de la Maza | Kendall Van Keuren-Jensen | Patrick Pirrotte | Ajay Goel | Carlos Becerra | Daniel D. Von Hoff | Scott A. Celinski | Pooja Hingorani | Muhammed Murtaza

Restoring the natural tropism of AAV2 vectors for human liver

JOURNAL ARTICLE published 9 September 2020 in Science Translational Medicine

Research funded by National Science Foundation (DMS 1563234) | National Science Foundation (DMS 1563234) | Australian Research Council (DP150101253) | National Health and Medical Research Council (APP1156431) | National Health and Medical Research Council (APP1161583) | National Health and Medical Research Council (APP1108311) | National Health and Medical Research Council (APP1161583) | National Health and Medical Research Council (APP1156431) | Department of Science and Higher Education of Ministry of National Defense, Republic of Poland (k/10/8047/DNiSW/T – WIHE/3) | National Science Centre, Republic of Poland (UMO-2017/25/B/NZ1/02790)

Authors: Marti Cabanes-Creus | Claus V. Hallwirth | Adrian Westhaus | Boaz H. Ng | Sophia H.Y. Liao | Erhua Zhu | Renina Gale Navarro | Grober Baltazar | Matthieu Drouyer | Suzanne Scott | Grant J. Logan | Giorgia Santilli | Antonette Bennett | Samantha L. Ginn | Geoff McCaughan | Adrian J. Thrasher | Mavis Agbandje-McKenna | Ian E. Alexander | Leszek Lisowski

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors

JOURNAL ARTICLE published 10 July 2019 in Science Translational Medicine

Research funded by National Institutes of Health (NS080979) | National Institutes of Health (NS038631) | NINDS (P30NS061800)

Authors: Brian E. Jones | Kenneth R. Tovar | April Goehring | Farzad Jalali-Yazdi | Nana J. Okada | Eric Gouaux | Gary L. Westbrook

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma

JOURNAL ARTICLE published 10 May 2017 in Science Translational Medicine

Research funded by National Cancer Institute (award301791,R01 CA181683-01A1)

Authors: Salomon Manier | Daisy Huynh | Yu J. Shen | Jia Zhou | Timur Yusufzai | Karma Z. Salem | Richard Y. Ebright | Jiantao Shi | Jihye Park | Siobhan V. Glavey | William G. Devine | Chia-Jen Liu | Xavier Leleu | Bruno Quesnel | Catherine Roche-Lestienne | John K. Snyder | Lauren E. Brown | Nathanael Gray | James Bradner | Luke Whitesell | John A. Porco | Irene M. Ghobrial

Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell–dependent regression of glioblastoma

JOURNAL ARTICLE published 24 May 2023 in Science Translational Medicine

Authors: Thomas Look | Emanuele Puca | Marcel Bühler | Daniel Kirschenbaum | Roberto De Luca | Riccardo Stucchi | Domenico Ravazza | Cesare Di Nitto | Patrick Roth | Yonatan Katzenelenbogen | Assaf Weiner | Lukas Rindlisbacher | Burkhard Becher | Ido Amit | Michael Weller | Dario Neri | Teresa Hemmerle | Tobias Weiss

Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function

JOURNAL ARTICLE published 8 May 2024 in Science Translational Medicine

Authors: Benjamin P. Hurrell | Yoshihiro Sakano | Stephen Shen | Doumet Georges Helou | Meng Li | Pedram Shafiei-Jahani | Mohammad Hossein Kazemi | Kei Sakano | Xin Li | Christine Quach | Richard Barbers | Omid Akbari

Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABA _B Receptors with Arbaclofen

JOURNAL ARTICLE published 19 September 2012 in Science Translational Medicine

Authors: Christina Henderson | Lasani Wijetunge | Mika Nakamoto Kinoshita | Matthew Shumway | Rebecca S. Hammond | Friso R. Postma | Christopher Brynczka | Roger Rush | Alexia Thomas | Richard Paylor | Stephen T. Warren | Peter W. Vanderklish | Peter C. Kind | Randall L. Carpenter | Mark F. Bear | Aileen M. Healy

Clinical trials for neurodevelopmental disorders: At a therapeutic frontier

JOURNAL ARTICLE published 13 January 2016 in Science Translational Medicine

Authors: Shafali S. Jeste | Daniel H. Geschwind

Dissolving microneedle vaccination—No magic needled

JOURNAL ARTICLE published 26 September 2018 in Science Translational Medicine

Authors: Sam H. Au

Liquid biopsy: Clues on prostate cancer drug resistance

JOURNAL ARTICLE published 4 November 2015 in Science Translational Medicine

Authors: Michael T. Schweizer | Emmanuel S. Antonarakis

Keratinocytes: From passive targets to active mediators of systemic autoimmunity

JOURNAL ARTICLE published 27 April 2022 in Science Translational Medicine

Authors: Antonios Psarras | Edward M. Vital

Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer

JOURNAL ARTICLE published 15 November 2023 in Science Translational Medicine

Authors: Zibo Meng | Aaron Rodriguez Ehrenfried | Chin Leng Tan | Laura K. Steffens | Hannes Kehm | Stefan Zens | Claudia Lauenstein | Alina Paul | Marius Schwab | Jonas D. Förster | Mogjiborahman Salek | Angelika B. Riemer | Heshui Wu | Christoph Eckert | Carl-Stephan Leonhardt | Oliver Strobel | Michael Volkmar | Isabel Poschke | Rienk Offringa