Biological mechanisms of aging predict age‐related disease co‐occurrence in patients

JOURNAL ARTICLE published April 2022 in Aging Cell

Research funded by Bundesministerium für Bildung und Forschung (HiGHmed 01ZZ1802U) | Dunhill Medical Trust (RPGF1806/67) | Wellcome Trust (WT 110284/Z/15/Z) | Deutsche Forschungsgemeinschaft (CRC1310,325931972) | British Heart Foundation (AA/18/6/34223)

Authors: Helen C. Fraser | Valerie Kuan | Ronja Johnen | Magdalena Zwierzyna | Aroon D. Hingorani | Andreas Beyer | Linda Partridge

Chondrocyte‐like nested cells in the aged intervertebral disc are late‐stage nucleus pulposus cells

JOURNAL ARTICLE published October 2019 in Aging Cell

Research funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR065530)

Authors: Sarthak Mohanty | Robert Pinelli | Paul Pricop | Todd J. Albert | Chitra Lekha Dahia

Reduced naïve CD 8 ⁺ T ‐cell priming efficacy in elderly adults

JOURNAL ARTICLE published February 2016 in Aging Cell

Research funded by Swiss National Science Foundation (PP0033‐110737)

Authors: Olivia Briceño | Anna Lissina | Kerstin Wanke | Georgia Afonso | Amrei Braun | Kristanto Ragon | Tiphaine Miquel | Emma Gostick | Laura Papagno | Karin Stiasny | David A. Price | Roberto Mallone | Delphine Sauce | Urs Karrer | Victor Appay

Advanced aging phenotype is revealed by epigenetic modifications in rat liver after in utero malnutrition

JOURNAL ARTICLE published October 2016 in Aging Cell

Research funded by Reproductive Scientist Development Program (NICHD K12HD00849-26) | Einstein Diabetes Research Center (DK020541) | Einstein Nathan Shock Center (P30AG038072) | Einstein's Medical Student Training Program (NIH NIGMS T32 GM007288)

Authors: Hye J. Heo | Jessica N. Tozour | Fabien Delahaye | Yongmei Zhao | Lingguang Cui | Nir Barzilai | Francine Hughes Einstein

Lnk deficiency partially mitigates hematopoietic stem cell aging

JOURNAL ARTICLE published December 2012 in Aging Cell

Authors: Alexey Bersenev | Krasimira Rozenova | Joanna Balcerek | Jing Jiang | Chao Wu | Wei Tong

Non‐enzymatic function of WRN RECQL helicase regulates removal of topoisomerase‐I‐DNA covalent complexes and triggers NF‐κB signaling in cancer

JOURNAL ARTICLE published June 2022 in Aging Cell

Authors: Pooja Gupta | Ananda Guha Majumdar | Birija Sankar Patro

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JOURNAL ARTICLE published December 2016 in Aging Cell

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JOURNAL ARTICLE published June 2017 in Aging Cell

Long‐term Tai Chi practice in older adults is associated with “younger” functional abilities

JOURNAL ARTICLE published January 2024 in Aging Cell

Research funded by Harvard Catalyst (5 KL2 RR025757‐04) | National Center for Complementary and Integrative Health (K24 AT009282,R21 AT005501‐01A1) | National Institute on Aging (1K01 AG044543‐01A1,R03‐AG025037)

Authors: Yan Ma | Brian J. Gow | Rhayun Song | Pamela M. Rist | Jeffrey M. Hausdorff | Lewis A. Lipsitz | Brad Manor | Peter M. Wayne

Caloric restriction controls stationary phase survival through Protein Kinase A (PKA) and cytosolic pH

JOURNAL ARTICLE published June 2019 in Aging Cell

Authors: Laura Dolz‐Edo | Margaretha van der Deen | Stanley Brul | Gertien Jacoba Smits

Long‐lasting pathological consequences of overexpression‐induced α‐synuclein spreading in the rat brain

JOURNAL ARTICLE published April 2018 in Aging Cell

Research funded by EU Joint Programme-Neurodegenerative Disease (01ED1612)

Authors: Raffaella Rusconi | Ayse Ulusoy | Helia Aboutalebi | Donato A. Di Monte

Chromosome‐level Asian elephant genome assembly and comparative genomics of long‐lived mammals reveal the common substitutions for cancer resistance

JOURNAL ARTICLE published September 2023 in Aging Cell

Authors: Xuanjing Li | Pengcheng Wang | Qi Pan | Gaoming Liu | Weiqiang Liu | Olatunde Omotoso | Juan Du | Zihao Li | Yang Yu | Yun Huang | Pingfen Zhu | Meng Li | Xuming Zhou

Rapamycin/metformin co‐treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice

JOURNAL ARTICLE published September 2022 in Aging Cell

Research funded by National Institute on Aging (AG022308) | National Institutes of Health (CA034196,DK090361,DK108245,DK120844,NIGM 8P30GM106391)

Authors: Peter C. Reifsnyder | Kevin Flurkey | Rosalinda Doty | Nigel A. Calcutt | Robert A. Koza | David E. Harrison

Viral uptake and pathophysiology of the lung endothelial cells in age‐associated severe SARS‐CoV‐2 infection models

JOURNAL ARTICLE published February 2024 in Aging Cell

Research funded by Japan Agency for Medical Research and Development (20fk0108537h0001,JP223fa627005)

Authors: Takuya Tsumita | Ryo Takeda | Nako Maishi | Yasuhiro Hida | Michihito Sasaki | Yasuko Orba | Akihiko Sato | Shinsuke Toba | Wataru Ito | Takahito Teshirogi | Yuya Sakurai | Tomohiro Iba | Hisamichi Naito | Hitoshi Ando | Haruhisa Watanabe | Amane Mizuno | Toshiki Nakanishi | Aya Matsuda | Ren Zixiao | Ji‐Won Lee | Tadahiro Iimura | Hirofumi Sawa | Kyoko Hida

DNA repair‐deficient premature aging models display accelerated epigenetic age

JOURNAL ARTICLE published February 2024 in Aging Cell

Authors: Kevin Perez | Alberto Parras | Sara Picó | Cheyenne Rechsteiner | Amin Haghani | Robert Brooke | Calida Mrabti | Lucas Schoenfeldt | Steve Horvath | Alejandro Ocampo

Sensitivity of the S1 neuronal calcium network to insulin and Bay‐K 8644 in vivo: Relationship to gait, motivation, and aging processes

JOURNAL ARTICLE published July 2022 in Aging Cell

Research funded by National Institute on Aging (R01 / AG033649,R01 / AG033649‐S1,T32 / AG057461)

Authors: Ruei‐Lung Lin | Hilaree N. Frazier | Katie L. Anderson | Sami L. Case | Adam O. Ghoweri | Olivier Thibault

Biomarker development for translational geroscience: Considerations for a strategic framework focusing on early clinical development

JOURNAL ARTICLE published May 2023 in Aging Cell

Authors: Jason L. Sanders

Myeloid cell‐specific mutation of Spi1 selectively reduces M2‐biased macrophage numbers in skeletal muscle, reduces age‐related muscle fibrosis and prevents sarcopenia

JOURNAL ARTICLE published October 2022 in Aging Cell

Research funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR054451) | National Institute on Aging (RO1AG041147)

Authors: Ying Wang | Steven S. Welc | Michelle Wehling‐Henricks | Ying Kong | Connor Thomas | Enca Montecino‐Rodriguez | Kenneth Dorshkind | James G. Tidball

JOURNAL ISSUE published May 2021 in Aging Cell