Recurrent network model for learning goal-directed sequences through reverse replay

JOURNAL ARTICLE published 3 July 2018 in eLife

Research funded by Ministry of Education, Culture, Sports, Science, and Technology (15H04265) | Core Research for Evolutional Science and Technology (JPMJCR13W1) | Ministry of Education, Culture, Sports, Science, and Technology (16H01289) | Ministry of Education, Culture, Sports, Science, and Technology (17H06036)

Authors: Tatsuya Haga | Tomoki Fukai

Cis-regulatory evolution integrated the Bric-à-brac transcription factors into a novel fruit fly gene regulatory network

JOURNAL ARTICLE published 3 January 2018 in eLife

Research funded by National Science Foundation (IOS-1555906) | National Institutes of Health (5R01GM114093-02)

Authors: Maxwell J Roeske | Eric M Camino | Sumant Grover | Mark Rebeiz | Thomas Michael Williams

The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor

JOURNAL ARTICLE published 17 November 2017 in eLife

Research funded by National Institutes of Health (AI 18785) | National Institutes of Health (AI 092108) | National Institutes of Health (AI 103736) | National Institutes of Health (DK099317)

Authors: Philippa Marrack | Sai Harsha Krovi | Daniel Silberman | Janice White | Eleanor Kushnir | Maki Nakayama | James Crooks | Thomas Danhorn | Sonia Leach | Randy Anselment | James Scott-Browne | Laurent Gapin | John Kappler

A new genus of horse from Pleistocene North America

JOURNAL ARTICLE published 28 November 2017 in eLife

Research funded by National Science Foundation (PLR-1417036) | National Science Foundation (PLR-09090456) | Danish Council for Independent Research Natural Sciences (4002-00152B) | European Research Council (ERC-CoG-2015-681605) | Gordon and Betty Moore Foundation (GBMF3804) | Norges Forskningsråd (250963)

Authors: Peter D Heintzman | Grant D Zazula | Ross DE MacPhee | Eric Scott | James A Cahill | Brianna K McHorse | Joshua D Kapp | Mathias Stiller | Matthew J Wooller | Ludovic Orlando | John Southon | Duane G Froese | Beth Shapiro

Dyslexics’ faster decay of implicit memory for sounds and words is manifested in their shorter neural adaptation

JOURNAL ARTICLE published 24 January 2017 in eLife

Research funded by Israel Science Foundation (616/11) | German-Israeli Foundation for Scientific Research and Development (I-1303-105.4/2015) | Israel Science Foundation (2425/15)

Authors: Sagi Jaffe-Dax | Or Frenkel | Merav Ahissar

Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila

JOURNAL ARTICLE published 2 February 2018 in eLife

Research funded by Fundação para a Ciência e a Tecnologia (PTDC/BIA-BCM/118684/2010) | Fundação para a Ciência e a Tecnologia (SFRH/BPD/79325/2011) | Human Frontier Science Program (RGP0022/2012) | Fundação Bial (283/14) | Fundação Bial (279/16) | European Commission (FLiACT ITN)

Authors: Kathrin Steck | Samuel J Walker | Pavel M Itskov | Célia Baltazar | José-Maria Moreira | Carlos Ribeiro

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

JOURNAL ARTICLE published 7 February 2018 in eLife

Research funded by Horizon 2020 Framework Programme (HEALTH-F4-2007-201413) | National Institutes of Health (U01-DK105535) | Wellcome Trust (099673/Z/12/Z) | National Institutes of Health (R01-DK098032) | Wellcome Trust (106130) | National Institutes of Health (R01-MH090941) | Wellcome Trust (095101/Z/10/Z) | Wellcome Trust (200837/Z/16/Z) | Wellcome Trust (090532) | Wellcome Trust (098381) | National Institutes of Health (U01-DK085545) | Wellcome Trust (090367)

Authors: Matthias Thurner | Martijn van de Bunt | Jason M Torres | Anubha Mahajan | Vibe Nylander | Amanda J Bennett | Kyle J Gaulton | Amy Barrett | Carla Burrows | Christopher G Bell | Robert Lowe | Stephan Beck | Vardhman K Rakyan | Anna L Gloyn | Mark I McCarthy

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

JOURNAL ARTICLE published 31 March 2016 in eLife

Research funded by National Institute of General Medical Sciences (F32GM112308) | Wellcome Trust (095951) | Gordon and Betty Moore Foundation (GBMF775) | National Institutes of Health (CA164803)

Authors: Ruzbeh Mosadeghi | Kurt M Reichermeier | Martin Winkler | Anne Schreiber | Justin M Reitsma | Yaru Zhang | Florian Stengel | Junyue Cao | Minsoo Kim | Michael J Sweredoski | Sonja Hess | Alexander Leitner | Ruedi Aebersold | Matthias Peter | Raymond J Deshaies | Radoslav I Enchev

Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket

JOURNAL ARTICLE published 10 February 2017 in eLife

Research funded by National Eye Institute (EY06837) | National Eye Institute (EY001157) | National Natural Science Foundation of China (31471053) | Antonio Champalimaud Foundation, Portugal (Antonio Champalimaud Vision Award) | Howard Hughes Medical Institute (International Student Research Fellowships)

Authors: Wendy Wing Sze Yue | Rikard Frederiksen | Xiaozhi Ren | Dong-Gen Luo | Takahiro Yamashita | Yoshinori Shichida | M Carter Cornwall | King-Wai Yau

GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

JOURNAL ARTICLE published 13 November 2020 in eLife

Research funded by National Institute of Neurological Disorders and Stroke (NS094637)

Authors: Markus Terrey | Scott I Adamson | Alana L Gibson | Tianda Deng | Ryuta Ishimura | Jeffrey H Chuang | Susan L Ackerman

Functional visualization of NK cell-mediated killing of metastatic single tumor cells

JOURNAL ARTICLE published 3 February 2022 in eLife

Research funded by Japan Society for the Promotion of Science (18K15317) | Japan Society for the Promotion of Science (15H05949) | Japan Society for the Promotion of Science (19H00993) | Japan Agency for Medical Research and Development (19gm5010003h0003) | Core Research for Evolutional Science and Technology (JPMJCR1654)

Authors: Hiroshi Ichise | Shoko Tsukamoto | Tsuyoshi Hirashima | Yoshinobu Konishi | Choji Oki | Shinya Tsukiji | Satoshi Iwano | Atsushi Miyawaki | Kenta Sumiyama | Kenta Terai | Michiyuki Matsuda

Efficient sampling and noisy decisions

JOURNAL ARTICLE published 15 September 2020 in eLife

Research funded by European Commission (grant agreement No. 758604) | ERC (ENTRAINER)

Authors: Joseph A Heng | Michael Woodford | Rafael Polania

Alternative polyadenylation mediates genetic regulation of gene expression

JOURNAL ARTICLE published 25 June 2020 in eLife

Research funded by National Institutes of Health (T32 GM09197) | National Institutes of Health (F31HL149259) | National Institutes of Health (R01GM130738) | National Institutes of Health (K12 HL119995)

Authors: Briana E Mittleman | Sebastian Pott | Shane Warland | Tony Zeng | Zepeng Mu | Mayher Kaur | Yoav Gilad | Yang Li

Multimeric single-domain antibody complexes protect against bunyavirus infections

JOURNAL ARTICLE published 21 April 2020 in eLife

Research funded by Innovative Medicines Initiative (ZAPI (grant agreement no. 115760)) | Ministerio de Ciencia Tecnología y Telecomunicaciones (Student Fellowship (PEM-066-2015-II)) | Universidad de Costa Rica (Student Fellowship (OAICE-CAB-05-56-2016))

Authors: Paul J Wichgers Schreur | Sandra van de Water | Michiel Harmsen | Erick Bermúdez-Méndez | Dubravka Drabek | Frank Grosveld | Kerstin Wernike | Martin Beer | Andrea Aebischer | Olalekan Daramola | Sara Rodriguez Conde | Karen Brennan | Dorota Kozub | Maiken Søndergaard Kristiansen | Kieran K Mistry | Ziyan Deng | Jan Hellert | Pablo Guardado-Calvo | Félix A Rey | Lucien van Keulen | Jeroen Kortekaas

Testosterone pulses paired with a location induce a place preference to the nest of a monogamous mouse under field conditions

JOURNAL ARTICLE published 30 March 2022 in eLife

Research funded by National Science Foundation (1355163) | Sigma Xi (Spring 2018)

Authors: Radmila Petric | Matina Kalcounis-Rueppell | Catherine A Marler

NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase

JOURNAL ARTICLE published 12 May 2021 in eLife

Research funded by National Institute of General Medical Sciences (R01-GM101056) | National Science Foundation (NSF1457055) | NIA (R01AG051659) | Canadian Institutes of Health Research (PJT-153199)

Authors: Khursheed A Wani | Debanjan Goswamy | Stefan Taubert | Ramesh Ratnappan | Arjumand Ghazi | Javier E Irazoqui

The layered costs and benefits of translational redundancy

JOURNAL ARTICLE published 2 March 2023 in eLife

Research funded by Department of Atomic Energy, Government of India (Project 695 Identification No. RTI 4006) | CSIR-UGC (June/2018/430) | Deutsche Forschungsgemeinschaft (AOBJ:679030)

Authors: Parth K Raval | Wing Yui Ngan | Jenna Gallie | Deepa Agashe

The axonal actin-spectrin lattice acts as a tension buffering shock absorber

JOURNAL ARTICLE published 8 April 2020 in eLife

Research funded by Department of Biotechnology, Ministry of Science and Technology (BT/PR13244/GBD/27/245/2009) | Science and Engineering Research Board (EMR/2016/003730)

Authors: Sushil Dubey | Nishita Bhembre | Shivani Bodas | Sukh Veer | Aurnab Ghose | Andrew Callan-Jones | Pramod Pullarkat

Modulation of pulsatile GnRH dynamics across the ovarian cycle via changes in the network excitability and basal activity of the arcuate kisspeptin network

JOURNAL ARTICLE published 17 November 2021 in eLife

Research funded by Engineering and Physical Sciences Research Council (EP/N014391/1) | Biotechnology and Biological Sciences Research Council (BB/S000550/1) | Biotechnology and Biological Sciences Research Council (BB/S001255/1)

Authors: Margaritis Voliotis | Xiao Feng Li | Ross Alexander De Burgh | Geffen Lass | Deyana Ivanova | Caitlin McIntyre | Kevin O'Byrne | Krasimira Tsaneva-Atanasova

Different brain systems support learning from received and avoided pain during human pain-avoidance learning

JOURNAL ARTICLE published 22 June 2022 in eLife

Research funded by Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Veni)

Authors: Marieke Jepma | Mathieu Roy | Kiran Ramlakhan | Monique van Velzen | Albert Dahan