Diminishing neuronal acidification by channelrhodopsins with low proton conduction

JOURNAL ARTICLE published 6 October 2023 in eLife

Research funded by Office of Naval Research (N00014-18-1-2859) | National Institutes of Health (1-R01-MH117042) | National Institutes of Health (1-R01-NS126043)

Authors: Rebecca Frank Hayward | F Phil Brooks | Shang Yang | Shiqiang Gao | Adam E Cohen

A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes

JOURNAL ARTICLE published 25 November 2021 in eLife

Research funded by National Institute on Deafness and Other Communication Disorders (DC017078) | National Institute of Mental Health (K08MH116135)

Authors: Blaise Robert | Eyal Y Kimchi | Yurika Watanabe | Tatenda Chakoma | Miao Jing | Yulong Li | Daniel B Polley

Skipping ahead: A circuit for representing the past, present, and future

JOURNAL ARTICLE published 14 October 2021 in eLife

Research funded by Canadian Institutes of Health Research (367017) | Canadian Institutes of Health Research (377074) | Natural Sciences and Engineering Research Council of Canada (74105) | National Institute of Mental Health (R01 MH120073 awarded to Dr. Michael Hasselmo) | National Institute of Mental Health (R01 MH060013 awarded to Dr. Michael Hasselmo)

Authors: Jennifer C Robinson | Mark P Brandon

Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker

JOURNAL ARTICLE published 9 May 2022 in eLife

Research funded by National Hemophilia Foundation (Postdoctoral fellowship grant) | Austrian Science Fund (Erwin Schrödinger Fellowship J4081-B21) | National Institutes of Health (F32HL126386) | National Institutes of Health (R01-HL148755)

Authors: Klaus Bonazza | Roxana E Iacob | Nathan E Hudson | Jing Li | Chafen Lu | John R Engen | Timothy A Springer

Oxytocin signaling in the posterior hypothalamus prevents hyperphagic obesity in mice

JOURNAL ARTICLE published 25 October 2022 in eLife

Research funded by Japan Society for the Promotion of Science (KAKENHI 19J00403) | Japan Society for the Promotion of Science (KAKENHI 19K16303) | Japan Science and Technology Agency (CREST JPMJCR2021) | Japan Society for the Promotion of Science (KAKENHI 20K20589)

Authors: Kengo Inada | Kazoku Tsujimoto | Masahide Yoshida | Katsuhiko Nishimori | Kazunari Miyamichi

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

JOURNAL ARTICLE published 1 December 2020 in eLife

Research funded by NIH (R01 AI143852)

Authors: Valerie J Morley | Clare L Kinnear | Derek G Sim | Samantha N Olson | Lindsey M Jackson | Elsa Hansen | Grace A Usher | Scott A Showalter | Manjunath P Pai | Robert J Woods | Andrew F Read

Gene expression variability in human and chimpanzee populations share common determinants

JOURNAL ARTICLE published 21 October 2020 in eLife

Research funded by National Institute of General Medical Sciences (R35GM131726)

Authors: Benjamin Jung Fair | Lauren E Blake | Abhishek Sarkar | Bryan J Pavlovic | Claudia Cuevas | Yoav Gilad

CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions

JOURNAL ARTICLE published 30 July 2021 in eLife

Research funded by National Cancer Institute (CA229560) | National Cancer Institute (CA200572) | National Cancer Institute (P50CA102701)

Authors: Veethika Pandey | Alicia Fleming-Martinez | Ligia Bastea | Heike R Doeppler | Jillian Eisenhauer | Tam Le | Brandy Edenfield | Peter Storz

The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

JOURNAL ARTICLE published 24 January 2024 in eLife

Research funded by National Institutes of Health (U01MH122849) | National Institutes of Health (R01DA053581) | National Institutes of Health (K99HG012229) | Chan Zuckerberg Initiative (CZF2019-002443) | Chan Zuckerberg Initiative (CZF2018-183446)

Authors: Lukas M Weber | Heena R Divecha | Matthew N Tran | Sang Ho Kwon | Abby Spangler | Kelsey D Montgomery | Madhavi Tippani | Rahul Bharadwaj | Joel E Kleinman | Stephanie C Page | Thomas M Hyde | Leonardo Collado-Torres | Kristen R Maynard | Keri Martinowich | Stephanie C Hicks

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

JOURNAL ARTICLE published 27 April 2016 in eLife

Research funded by U.S. Department of Defense (W81XWH-12-1-0125) | Children's Tumor Foundation (YIA) | Damon Runyon Cancer Research Foundation (DRSG-9-14) | National Institutes of Health (R01 CA180692)

Authors: Shuning He | Marc R Mansour | Mark W Zimmerman | Dong Hyuk Ki | Hillary M Layden | Koshi Akahane | Evisa Gjini | Eric D de Groh | Antonio R Perez-Atayde | Shizhen Zhu | Jonathan A Epstein | A Thomas Look

The essential role of Dnmt1 in gametogenesis in the large milkweed bug Oncopeltus fasciatus

JOURNAL ARTICLE published 12 April 2021 in eLife

Authors: Joshua T Washington | Katelyn R Cavender | Ashley U Amukamara | Elizabeth C McKinney | Robert J Schmitz | Patricia J Moore

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

JOURNAL ARTICLE published 2 June 2014 in eLife

Research funded by Flemish Goverment (Mathusalem grant) | Flemish Goverment (Mathusalem grant)

Authors: Pietro Fazzari | An Snellinx | Victor Sabanov | Tariq Ahmed | Lutgarde Serneels | Annette Gartner | S Ali M Shariati | Detlef Balschun | Bart De Strooper

Optimization of energy state transition trajectory supports the development of executive function during youth

JOURNAL ARTICLE published 27 March 2020 in eLife

Research funded by National Institute of Mental Health (R21MH106799) | National Institute of Mental Health (R01MH113550) | National Institute of Mental Health (R01MH107703) | National Institute of Mental Health (RF1MH116920) | National Institutes of Health (R01MH112847) | National Institutes of Health (R01MH107235) | National Institutes of Health (R01EB022573) | National Institutes of Health (K01MH102609) | National Institutes of Health (R01NS085211) | Army Research Laboratory (W911NF-10-2-0022) | Army Research Office (Bassett-W911NF-14-1-0679) | Army Research Office (Grafton-W911NF-16-1-0474) | Army Research Office (DCISTW911NF-17-2-0181) | National Institutes of Health (2-R01-DC-009209–11) | National Institutes of Health (1R01HD086888-01) | National Institutes of Health (R01-MH112847) | National Institutes of Health (R01-MH107235) | National Institute of Neurological Disorders and Stroke (R01 NS099348) | National Science Foundation (BCS-1441502) | National Science Foundation (BCS-1430087) | National Science Foundation (NSF PHY-1554488) | National Science Foundation (BCS-1631550)

Authors: Zaixu Cui | Jennifer Stiso | Graham L Baum | Jason Z Kim | David R Roalf | Richard F Betzel | Shi Gu | Zhixin Lu | Cedric H Xia | Xiaosong He | Rastko Ciric | Desmond J Oathes | Tyler M Moore | Russell T Shinohara | Kosha Ruparel | Christos Davatzikos | Fabio Pasqualetti | Raquel E Gur | Ruben C Gur | Danielle S Bassett | Theodore D Satterthwaite

Chromatin is an ancient innovation conserved between Archaea and Eukarya

JOURNAL ARTICLE published 13 December 2012 in eLife

Research funded by Canadian Institutes for Health Research (MOP-86705) | Canadian Cancer Society (20380) | Canadian Institutes of Health Research (MOP-86705) | Canadian Cancer Society Research Institute (20380)

Authors: Ron Ammar | Dax Torti | Kyle Tsui | Marinella Gebbia | Tanja Durbic | Gary D Bader | Guri Giaever | Corey Nislow

IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva

JOURNAL ARTICLE published 27 April 2017 in eLife

Research funded by Canadian Institutes of Health Research (MOP74667) | Natural Sciences and Engineering Research Council of Canada (312221)

Authors: Katherine M Buckley | Eric Chun Hei Ho | Taku Hibino | Catherine S Schrankel | Nicholas W Schuh | Guizhi Wang | Jonathan P Rast

Structure of bacterial phospholipid transporter MlaFEDB with substrate bound

JOURNAL ARTICLE published 25 November 2020 in eLife

Research funded by National Institutes of Health (R35GM128777) | National Institutes of Health (R00GM112982) | Damon Runyon Cancer Research Foundation (DFS-20-16) | Pew Charitable Trusts (PEW-00033055) | American Heart Association (20POST35210202) | National Institutes of Health (T32 GM088118)

Authors: Nicolas Coudray | Georgia L Isom | Mark R MacRae | Mariyah N Saiduddin | Gira Bhabha | Damian C Ekiert

Different types of theta rhythmicity are induced by social and fearful stimuli in a network associated with social memory

JOURNAL ARTICLE published 16 February 2015 in eLife

Research funded by Israel Science Foundation (ISF) (1901/08, 1350/12) | Teva Pharmaceutical Industries (Graduate student fellowship)

Authors: Alex Tendler | Shlomo Wagner

A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines

JOURNAL ARTICLE published 22 March 2022 in eLife

Authors: Sara Feola | Jacopo Chiaro | Beatriz Martins | Salvatore Russo | Manlio Fusciello | Erkko Ylösmäki | Chiara Bonini | Eliana Ruggiero | Firas Hamdan | Michaela Feodoroff | Gabriella Antignani | Tapani Viitala | Sari Pesonen | Mikaela Grönholm | Rui MM Branca | Janne Lehtiö | Vincenzo Cerullo

LPCAT1 controls phosphate homeostasis in a zinc-dependent manner

JOURNAL ARTICLE published 17 February 2018 in eLife

Research funded by ZonMw (no. 40-41009-98-11084)

Authors: Mushtak Kisko | Nadia Bouain | Alaeddine Safi | Anna Medici | Robert C Akkers | David Secco | Gilles Fouret | Gabriel Krouk | Mark GM Aarts | Wolfgang Busch | Hatem Rouached

Multivalency regulates activity in an intrinsically disordered transcription factor

JOURNAL ARTICLE published 3 August 2018 in eLife

Authors: Sarah Clark | Janette B Myers | Ashleigh King | Radovan Fiala | Jiri Novacek | Grant Pearce | Jörg Heierhorst | Steve L Reichow | Elisar J Barbar