A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα

JOURNAL ARTICLE published 2024 in Chemical Science

Research funded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (200021_204602,310030_189065,CRSII5_186230) | H2020 European Research Council (ExploDProteins,866345) | Krebsliga Schweiz (KFS-5442-08-2021)

Authors: Werner Theodor Jauslin | Matthias Schild | Thorsten Schaefer | Chiara Borsari | Clara Orbegozo | Lukas Bissegger | Saule Zhanybekova | Danilo Ritz | Alexander Schmidt | Matthias Wymann | Dennis Gillingham

Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation

JOURNAL ARTICLE published 2019 in Chemical Science

Research funded by Imperial College London (Junior Research Fellowship) | Cancer Research UK (C309/A11566) | Leverhulme Trust (RPG-2015-345) | Biotechnology and Biological Sciences Research Council (BB/M021149/1,BB/G00954X/1)

Authors: James A. H. Gilburt | Paul Girvan | Julian Blagg | Liming Ying | Charlotte A. Dodson

Quantification of photoinduced bending of dynamic molecular crystals: from macroscopic strain to kinetic constants and activation energies

JOURNAL ARTICLE published 2018 in Chemical Science

Research funded by Russian Academy of Sciences (0301-2016-0014,0301-2016-0020)

Authors: Stanislav Chizhik | Anatoly Sidelnikov | Boris Zakharov | Panče Naumov | Elena Boldyreva

Thermochemical functionalisation of graphenes with minimal framework damage

JOURNAL ARTICLE published 2017 in Chem. Sci.

Research funded by National Institute of Environmental Health Sciences (U19ES019536) | Engineering and Physical Sciences Research Council (EP/G007314/1,EP/M506679/1) | European Commission (FP7 604093)

Authors: Sheng Hu | Zachary P. L. Laker | Hannah S. Leese | Noelia Rubio | Martina De Marco | Heather Au | Mark S. Skilbeck | Neil R. Wilson | Milo S. P. Shaffer

Harnessing α-l-fucosidase for in vivo cellular senescence imaging

JOURNAL ARTICLE published 2021 in Chemical Science

Research funded by National Research Foundation of Korea (2018R1A3B1052702,2019R1A6A1A10073079,2020H1D3A1A02080172,2020R1A6A3A01100551,2020R1A6A3A01100558,2019M3E5D1A01068998) | Welch Foundation (F-0018) | Department of Biotechnology, Ministry of Science and Technology, India (BT/RLF/Re-entry/59/2018)

Authors: Seyoung Koo | Miae Won | Hao Li | Won Young Kim | Mingle Li | Chenxu Yan | Amit Sharma | Zhiqian Guo | Wei-Hong Zhu | Jonathan L. Sessler | Jin Yong Lee | Jong Seung Kim

The effect of iron binding on uranyl(v) stability

JOURNAL ARTICLE published 2018 in Chemical Science

Research funded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CR23I2_16645)

Authors: Radmila Faizova | Sarah White | Rosario Scopelliti | Marinella Mazzanti

Synthesis and characterization of carbene derivatives of Th@C_3v(8)-C₈₂ and U@C_2v(9)-C₈₂: exceptional chemical properties induced by strong actinide–carbon cage interaction

JOURNAL ARTICLE published 2021 in Chemical Science

Research funded by Natural Science Foundation of Hebei Province (B2019202210) | Natural Science Foundation of Jiangsu Province (BK20200041) | National Natural Science Foundation of China (51302178,91961109)

Authors: Xinye Liu | Bo Li | Wei Yang | Yang-Rong Yao | Le Yang | Jiaxin Zhuang | Xiaomeng Li | Peng Jin | Ning Chen

Self-assembly of nucleic acid molecular aggregates catalyzed by a triple-helix probe for miRNA detection and single cell imaging

JOURNAL ARTICLE published 2016 in Chemical Science

Research funded by National Science Foundation of China (21535002,21227008,21405071,21275086) | Linyi University (LYDX2015BS013)

Authors: Zhen Zhang | Yuanyuan Wang | Ningbo Zhang | Shusheng Zhang

Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopy

JOURNAL ARTICLE published 2017 in Chemical Science

Research funded by European Research Council (Advanced Investigator Grant 294440) | Biotechnology and Biological Sciences Research Council (BB/N021614/1) | Cancer Research UK (C10195/A18075,C157/A12753,C157/A15703)

Authors: William J. Tipping | Martin Lee | Alan Serrels | Valerie G. Brunton | Alison N. Hulme

(C₅H_6.16N₂Cl_0.84)(IO₂Cl₂): a birefringent crystal featuring unprecedented (IO₂Cl₂)⁻ anions and π-conjugated organic cations

JOURNAL ARTICLE published 2023 in Chemical Science

Research funded by National Natural Science Foundation of China (21921001,21975256,22031009,22375201)

Authors: Qian-Qian Chen | Chun-Li Hu | Ming-Zhi Zhang | Jiang-Gao Mao

A NIR dye with high-performance n-type semiconducting properties

JOURNAL ARTICLE published 2016 in Chemical Science

Research funded by National Natural Science Foundation of China (21174004,21222403,51473003)

Authors: Jiajun Xie | Ke Shi | Kang Cai | Di Zhang | Jie-Yu Wang | Jian Pei | Dahui Zhao

Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers

JOURNAL ARTICLE published 2017 in Chemical Science

Research funded by Wellcome Trust (015615/Z/14/Z) | National Institutes of Health (GM078114) | Biotechnology and Biological Sciences Research Council (BB/E012558/1,BB/I015361/1) | European Research Council (322408)

Authors: Lydia M. Young | Ling-Hsien Tu | Daniel P. Raleigh | Alison E. Ashcroft | Sheena E. Radford

Streamlining the interface between electronics and neural systems for bidirectional electrochemical communication

JOURNAL ARTICLE published 2023 in Chemical Science

Research funded by National Research Foundation of Korea (2021R1A5A1030054,2022R1A2C3004327)

Authors: Wonkyung Cho | Sun-heui Yoon | Taek Dong Chung

Anatomy and formation mechanisms of early amyloid-β oligomers with lateral branching: graph network analysis on large-scale simulations

JOURNAL ARTICLE published 2022 in Chemical Science

Research funded by Shenzhen Fundamental Research Program (GXWD20201231165807007-20200827170132001) | National Natural Science Foundation of China (21977011)

Authors: Miao Yuan | Xuan Tang | Wei Han

Alkali-metal-mediated zincation (AMMZn) meets N-heterocyclic carbene (NHC) chemistry: Zn–H exchange reactions and structural authentication of a dinuclear Au(i) complex with a NHC anion

JOURNAL ARTICLE published 2013 in Chemical Science

Authors: David R. Armstrong | Sharon E. Baillie | Victoria L. Blair | Nicolas G. Chabloz | Josefina Diez | Joaquin Garcia-Alvarez | Alan R. Kennedy | Stuart D. Robertson | Eva Hevia

Machine learning and molecular descriptors enable rational solvent selection in asymmetric catalysis

JOURNAL ARTICLE published 2019 in Chemical Science

Authors: Yehia Amar | Artur M. Schweidtmann | Paul Deutsch | Liwei Cao | Alexei Lapkin

Modulating proton diffusion and conductivity in metal–organic frameworks by incorporation of accessible free carboxylic acid groups

JOURNAL ARTICLE published 2019 in Chemical Science

Research funded by H2020 European Research Council (AdG 742041) | Engineering and Physical Sciences Research Council (EP/I011870,EP/P001386)

Authors: Peter Rought | Christopher Marsh | Simona Pili | Ian P. Silverwood | Victoria García Sakai | Ming Li | Martyn S. Brown | Stephen P. Argent | Inigo Vitorica-Yrezabal | George Whitehead | Mark R. Warren | Sihai Yang | Martin Schröder

Water sensitivity of heteroepitaxial Cu-MOF films: dissolution and re-crystallization of 3D-oriented MOF superstructures

JOURNAL ARTICLE published 2023 in Chemical Science

Research funded by Vetenskapsrådet (2022-02939) | H2020 European Research Council (771834) | Svenska Forskningsrådet Formas (2020-00831)

Authors: Lea A. Brandner | Mercedes Linares-Moreau | Guojun Zhou | Heinz Amenitsch | Simone Dal Zilio | Zhehao Huang | Christian Doonan | Paolo Falcaro

Plasmon-induced light concentration enhanced imaging visibility as observed by a composite-field microscopy imaging system

JOURNAL ARTICLE published 2016 in Chem. Sci.

Research funded by National Natural Science Foundation of China (No. 21535006)

Authors: Peng Fei Gao | Ming Xuan Gao | Hong Yan Zou | Rong Sheng Li | Jun Zhou | Jun Ma | Qiang Wang | Feng Liu | Na Li | Yuan Fang Li | Cheng Zhi Huang

Calculation of absolute molecular entropies and heat capacities made simple

JOURNAL ARTICLE published 2021 in Chemical Science

Research funded by Deutsche Forschungsgemeinschaft (Gottfried Wilhelm Leibniz-Prize)

Authors: Philipp Pracht | Stefan Grimme