T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity

JOURNAL ARTICLE published 21 January 2020 in Chemical Research in Toxicology

Research funded by Biotechnology and Biological Sciences Research Council (BB/R008108/1)

Authors: Sean Hammond | Paul J. Thomson | Monday O. Ogese | Dean J. Naisbitt

Pathomechanisms of Drug Hypersensitivity Targeting the Liver and Skin

BOOK CHAPTER published 2022 in Cutaneous Drug Hypersensitivity

Authors: Paul Thomson | Dean Naisbitt | Monday Ogese

In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs

JOURNAL ARTICLE published 13 April 2021 in Frontiers in Immunology

Authors: Sean Hammond | Paul Thomson | Xiaoli Meng | Dean Naisbitt

Immune dysregulation increases the incidence of delayed‐type drug hypersensitivity reactions

JOURNAL ARTICLE published April 2020 in Allergy

Authors: Dean J. Naisbitt | Anna Olsson‐Brown | Andrew Gibson | Xiaoli Meng | Monday O. Ogese | Arun Tailor | Paul Thomson

Characterization of Drug-Specific CD4⁺ T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity Reactions

JOURNAL ARTICLE published 15 May 2023 in Chemical Research in Toxicology

Research funded by Medical Research Council (G0700654,MR/R009635/1)

Authors: Kanoot Jaruthamsophon | Paul J. Thomson | Sean Hammond | Eunice Zhang | Ana Alfirevic | Chonlaphat Sukasem | Dean J. Naisbitt | Munir Pirmohamed

Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury

JOURNAL ARTICLE published 16 November 2020 in Chemical Research in Toxicology

Research funded by Medical Research Council (MR/l006758,MR/R009635/1)

Authors: Andrew Gibson | Sean Hammond | Kanoot Jaruthamsophon | Sharin Roth | Merrie Mosedale | Dean J. Naisbitt

Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System

JOURNAL ARTICLE published 20 March 2023 in Chemical Research in Toxicology

Research funded by Royal Society (IEC\NSFC\170385) | Medical Research Council (G0700654,MR/R009635/1) | Shandong First Medical University (2019LJ002,2019RC007) | National Natural Science Foundation of China (81972946,82103734) | Shandong Provincial Double Hundred Plan for Foreign Experts (WST2019004)

Authors: Serat-E Ali | Xiaoli Meng | Laila Kafu | Sean Hammond | Qing Zhao | Monday Ogese | Rowena Sison-Young | Robert Jones | Benjamin Chan | Lucia Livoti | Yonghu Sun | Lele Sun | Hong Liu | Anthony Topping | Christopher Goldring | Furen Zhang | Dean John Naisbitt

Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01

JOURNAL ARTICLE published 21 February 2022 in Chemical Research in Toxicology

Research funded by Medical Research Council (G0700654) | Biotechnology and Biological Sciences Research Council (BB/R008108/1)

Authors: Joshua Gardner | Monday Ogese | Catherine J. Betts | Munir Pirmohamed | Dean J. Naisbitt

Pathology of drug hypersensitivity reactions and mechanisms of immune tolerance

JOURNAL ARTICLE published December 2022 in Clinical & Experimental Allergy

Authors: Paul Thomson | Sean Hammond | Dean J. Naisbitt

Pathology of T-cell-mediated drug hypersensitivity reactions and impact of tolerance mechanisms on patient susceptibility

JOURNAL ARTICLE published August 2022 in Current Opinion in Allergy & Clinical Immunology

Authors: James Line | Paul Thomson | Dean J. Naisbitt

Characterization of amoxicillin and clavulanic acid specific T‐cell clones from patients with immediate drug hypersensitivity

JOURNAL ARTICLE published October 2020 in Allergy

Research funded by Institute of Health “Carlos III” (ISCIII) of the Ministry of Economy and Competitiveness (PI12/02529,PI15/01206,RD16/0006/0001,RD16/0006/0021) | Biobank platform (PT13/0010/0006,PT17/0015/0041) | Andalusian Regional Ministry of Health (PI-0699-2011,PI-0179-2014,PI-0241-2016) | Andalucía Talent Hub Fellowship Program (TAHUB/II-004) | BBSRC (BB/R008108/1) | MRC (MR/R009635/1) | Juan Rodes research (JR18/00054)

Authors: Adriana Ariza | Rubén Fernández‐Santamaría | Xiaoli Meng | María Salas | Monday O. Ogese | Arun Tailor | Gádor Bogas | María José Torres | Dean J. Naisbitt

T‐cell‐mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis

JOURNAL ARTICLE published June 2022 in Pediatric Allergy and Immunology

Research funded by Biotechnology and Biological Sciences Research Council (BB/R008108/1) | Medical Research Council Canada (G0700654)

Authors: Aida Semic‐Jusufagic | Monday O. Ogese | Christopher Edwards | Mark Wilkinson | Claire Nissenbaum | Tim Lee | Munir Pirmohamed | Dean J. Naisbitt

Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions

JOURNAL ARTICLE published 19 September 2023 in Frontiers in Toxicology

Authors: James Line | Eleanor Saville | Xiaoli Meng | Dean Naisbitt

Dapsone and Nitroso Dapsone Activation of Naı̈ve T-Cells from Healthy Donors

JOURNAL ARTICLE published 18 December 2017 in Chemical Research in Toxicology

Research funded by Medical Research Council (G0700654)

Authors: Abdulaziz Alzahrani | Monday Ogese | Xiaoli Meng | James C. Waddington | Arun Tailor | John Farrell | James L. Maggs | Catherine Betts | B. Kevin Park | Dean Naisbitt

New Approaches to Investigate Drug-Induced Hypersensitivity

JOURNAL ARTICLE published 17 January 2017 in Chemical Research in Toxicology

Research funded by Medical Research Council (MR/L006758/1) | European Research Council (115336)

Authors: Monday O. Ogese | Shaheda Ahmed | Ana Alferivic | Catherine J. Betts | Anne Dickinson | Lee Faulkner | Neil French | Andrew Gibson | Gideon M. Hirschfield | Michael Kammüller | Xiaoli Meng | Stefan F. Martin | Philippe Musette | Alan Norris | Munir Pirmohamed | B. Kevin Park | Anthony W. Purcell | Colin F. Spraggs | Jessica Whritenour | Dean J. Naisbitt

IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers

JOURNAL ARTICLE published 15 October 2012 in Chemical Research in Toxicology

Authors: Eva Kiorpelidou | Brian Foster | John Farrell | Monday O. Ogese | Lee Faulkner | Chris E. Goldring | B. Kevin Park | Dean J. Naisbitt

HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient

JOURNAL ARTICLE published 17 February 2014 in Chemical Research in Toxicology

Authors: Maike Lichtenfels | John Farrell | Monday O. Ogese | Catherine C. Bell | Sidonia Eckle | James McCluskey | B. Kevin Park | Ana Alfirevic | Dean J. Naisbitt | Munir Pirmohamed

Mechanisms leading to T-cell activation in drug hypersensitivity

JOURNAL ARTICLE published August 2018 in Current Opinion in Allergy & Clinical Immunology

Authors: Xiaoli Meng | Daniel Yerly | Dean J. Naisbitt

What’s been Hapten-ing over the last 88 years?

JOURNAL ARTICLE published September 2023 in Medicinal Chemistry Research

Authors: Paul Thomson | Sean Hammond | Xiaoli Meng | Dean J. Naisbitt

Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity

JOURNAL ARTICLE published 2015 in Toxicology Research

Research funded by Instituto Politécnico Nacional (BECA EDI / COFAA)

Authors: N. Duran-Figueroa | J. A. Badillo-Corona | D. J. Naisbitt | J. L. Castrejon-Flores