Uncertainty alters the balance between incremental learning and episodic memory

JOURNAL ARTICLE published 2 December 2022 in eLife

Research funded by National Science Foundation (1644869) | National Science Foundation (1822619) | National Institutes of Health (MH121093) | John Templeton Foundation (60844)

Authors: Jonathan Nicholas | Nathaniel D Daw | Daphna Shohamy

ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate

JOURNAL ARTICLE published 8 June 2017 in eLife

Research funded by Memorial Sloan-Kettering Cancer Center (P30-CA008748)

Authors: Wenfu Ma | Elena Goldberg | Jonathan Goldberg

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

JOURNAL ARTICLE published 6 December 2021 in eLife

Research funded by National Institutes of Health (AI154048) | National Institutes of Health (AI118426) | National Institutes of Health (AI083359) | Welch Foundation (I-1704) | National Institutes of Health (AI158124)

Authors: Nicholas Rinkenberger | Michael E Abrams | Sumit K Matta | John W Schoggins | Neal M Alto | L David Sibley

A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

JOURNAL ARTICLE published 14 December 2020 in eLife

Research funded by National Institute of General Medical Sciences (R35GM124780) | National Institute of Diabetes and Digestive and Kidney Diseases (R01DK110358) | National Human Genome Research Institute (R01HG009299) | Glenn Foundation for Medical Research (Glenn Award) | National Human Genome Research Institute (T32HG008962) | Might family (Bertrand T Might Fellowship) | National Institute of General Medical Sciences (T32GM007464)

Authors: Dana M Talsness | Katie G Owings | Emily Coelho | Gaelle Mercenne | John M Pleinis | Raghavendran Partha | Kevin A Hope | Aamir R Zuberi | Nathan L Clark | Cathleen M Lutz | Aylin R Rodan | Clement Y Chow

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

JOURNAL ARTICLE published 15 December 2021 in eLife

Research funded by Robertson Foundation (Robertson Therapeutic Development Fund) | National Institutes of Health (P41GM109824) | National Institutes of Health (R01AI0501111) | National Institutes of Health (R01AI078788) | National Institutes of Health (U19AI125378) | National Institutes of Health (K24AI150991) | National Institutes of Health (R01GM112108)

Authors: Fred D Mast | Peter C Fridy | Natalia E Ketaren | Junjie Wang | Erica Y Jacobs | Jean Paul Olivier | Tanmoy Sanyal | Kelly R Molloy | Fabian Schmidt | Magdalena Rutkowska | Yiska Weisblum | Lucille M Rich | Elizabeth R Vanderwall | Nicholas Dambrauskas | Vladimir Vigdorovich | Sarah Keegan | Jacob B Jiler | Milana E Stein | Paul Dominic B Olinares | Louis Herlands | Theodora Hatziioannou | D Noah Sather | Jason S Debley | David Fenyö | Andrej Sali | Paul D Bieniasz | John D Aitchison | Brian T Chait | Michael P Rout

Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis

JOURNAL ARTICLE published 9 December 2019 in eLife

Research funded by National Research Foundation of Korea (2015M3C7A1030964) | National Research Foundation of Korea (2017M3C7A1047875) | National Research Foundation of Korea (2017R1A5A1015366) | National Research Foundation of Korea (2017R1A2B2009031) | Ministry of Science, ICT and Future Planning (19-BR-02-01)

Authors: Youngsik Woo | Soo Jeong Kim | Bo Kyoung Suh | Yongdo Kwak | Hyun-Jin Jung | Truong Thi My Nhung | Dong Jin Mun | Ji-Ho Hong | Su-Jin Noh | Seunghyun Kim | Ahryoung Lee | Seung Tae Baek | Minh Dang Nguyen | Youngshik Choe | Sang Ki Park

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

JOURNAL ARTICLE published 25 February 2020 in eLife

Research funded by National Institutes of Health (DA010711) | National Institutes of Health (DA012864) | National Institutes of Health (OD023048) | National Institutes of Health (GM130142) | Swiss National Science Foundation (P300PA_164712) | Swiss National Science Foundation (PCEFP3_181282) | National Institutes of Health (R21DA045884)

Authors: Miriam Stoeber | Damien Jullié | Joy Li | Soumen Chakraborty | Susruta Majumdar | Nevin A Lambert | Aashish Manglik | Mark von Zastrow

IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva

JOURNAL ARTICLE published 27 April 2017 in eLife

Research funded by Canadian Institutes of Health Research (MOP74667) | Natural Sciences and Engineering Research Council of Canada (312221)

Authors: Katherine M Buckley | Eric Chun Hei Ho | Taku Hibino | Catherine S Schrankel | Nicholas W Schuh | Guizhi Wang | Jonathan P Rast

The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

JOURNAL ARTICLE published 2 August 2021 in eLife

Research funded by National Institutes of Health (R01AI157975) | National Institutes of Health (R01AI089728) | National Institutes of Health (R35GM118047)

Authors: Gang Ye | Joseph Gallant | Jian Zheng | Christopher Massey | Ke Shi | Wanbo Tai | Abby Odle | Molly Vickers | Jian Shang | Yushun Wan | Lanying Du | Hideki Aihara | Stanley Perlman | Aaron LeBeau | Fang Li

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

JOURNAL ARTICLE published 27 June 2022 in eLife

Research funded by National Health and Medical Research Council (Project grant#1053792) | National Health and Medical Research Council (Project grant#1162052) | Cancer Council Victoria (project grant#1184873) | National Health and Medical Research Council (Fellowship#1058586) | Victorian Cancer Agency (Research Fellowship (MCRF19007)

Authors: Haoran Zhu | Keefe T Chan | Xinran Huang | Carmelo Cerra | Shaun Blake | Anna S Trigos | Dovile Anderson | Darren J Creek | David P De Souza | Xi Wang | Caiyun Fu | Metta Jana | Elaine Sanij | Richard B Pearson | Jian Kang

The structure of the COPI coat determined within the cell

JOURNAL ARTICLE published 17 November 2017 in eLife

Research funded by Deutsche Forschungsgemeinschaft (SFB-1035/Project A01) | Deutsche Forschungsgemeinschaft (SFB1129 (Z2)) | Medical Research Council (MC_UP_1201/16)

Authors: Yury S Bykov | Miroslava Schaffer | Svetlana O Dodonova | Sahradha Albert | Jürgen M Plitzko | Wolfgang Baumeister | Benjamin D Engel | John AG Briggs

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

JOURNAL ARTICLE published 27 April 2016 in eLife

Research funded by U.S. Department of Defense (W81XWH-12-1-0125) | Children's Tumor Foundation (YIA) | Damon Runyon Cancer Research Foundation (DRSG-9-14) | National Institutes of Health (R01 CA180692)

Authors: Shuning He | Marc R Mansour | Mark W Zimmerman | Dong Hyuk Ki | Hillary M Layden | Koshi Akahane | Evisa Gjini | Eric D de Groh | Antonio R Perez-Atayde | Shizhen Zhu | Jonathan A Epstein | A Thomas Look

Regulation of chromatin architecture by transcription factor binding

JOURNAL ARTICLE published 19 January 2024 in eLife

Research funded by National Institute of General Medical Sciences (R35-GM122562) | National Science Foundation (2151777)

Authors: Stephanie Portillo-Ledesma | Suckwoo Chung | Jill Hoffman | Tamar Schlick

Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

JOURNAL ARTICLE published 5 June 2020 in eLife

Research funded by National Institutes of Health (R01AR069537) | National Institutes of Health (F31AR073626) | National Institutes of Health (R01AR070748)

Authors: Deepak A Kaji | Kristen L Howell | Zerina Balic | Dirk Hubmacher | Alice H Huang

HIPK4 is essential for murine spermiogenesis

JOURNAL ARTICLE published 12 March 2020 in eLife

Research funded by American Cancer Society (125153-PF-13-377-01-DMC) | National Institutes of Health (R21 HD78385)

Authors: J Aaron Crapster | Paul G Rack | Zane J Hellmann | Austen D Le | Christopher M Adams | Ryan D Leib | Joshua E Elias | John Perrino | Barry Behr | Yanfeng Li | Jennifer Lin | Hong Zeng | James K Chen

A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes

JOURNAL ARTICLE published 25 November 2021 in eLife

Research funded by National Institute on Deafness and Other Communication Disorders (DC017078) | National Institute of Mental Health (K08MH116135)

Authors: Blaise Robert | Eyal Y Kimchi | Yurika Watanabe | Tatenda Chakoma | Miao Jing | Yulong Li | Daniel B Polley

Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation

JOURNAL ARTICLE published 22 March 2022 in eLife

Authors: Mai Ahmed | Yutaka Kojima | Ichiro Masai

Binding to nucleosome poises human SIRT6 for histone H3 deacetylation

JOURNAL ARTICLE published 28 February 2024 in eLife

Research funded by French Infrastructure for Integrated Structural Biology (ANR-10-INBS-05) | GENCI (A0120713412)

Authors: Ekaterina Smirnova | Emmanuelle Bignon | Patrick Schultz | Gabor Papai | Adam Ben Shem

The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

JOURNAL ARTICLE published 24 January 2024 in eLife

Research funded by National Institutes of Health (U01MH122849) | National Institutes of Health (R01DA053581) | National Institutes of Health (K99HG012229) | Chan Zuckerberg Initiative (CZF2019-002443) | Chan Zuckerberg Initiative (CZF2018-183446)

Authors: Lukas M Weber | Heena R Divecha | Matthew N Tran | Sang Ho Kwon | Abby Spangler | Kelsey D Montgomery | Madhavi Tippani | Rahul Bharadwaj | Joel E Kleinman | Stephanie C Page | Thomas M Hyde | Leonardo Collado-Torres | Kristen R Maynard | Keri Martinowich | Stephanie C Hicks

Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation

JOURNAL ARTICLE published 20 January 2022 in eLife

Research funded by Damon Runyon Cancer Research Foundation (postdoctoral fellowship) | Damon Runyon Cancer Research Foundation (Dale Frey Scientist Award) | Howard Hughes Medical Institute (Investigator) | Welch Foundation (I-1544) | Damon Runyon Cancer Research Foundation (DRG-2249-16) | Damon Runyon Cancer Research Foundation (DFS-38-20)

Authors: Lindsay B Case | Milagros De Pasquale | Lisa Henry | Michael K Rosen