Prediction models for hormone receptor status in female breast cancer do not extend to males: further evidence of sex-based disparity in breast cancer

JOURNAL ARTICLE published 8 November 2023 in npj Breast Cancer

Research funded by Scottish Funding Council (Saltire Emerging Researcher European Exchange Award) | Deutsche Krebshilfe (70113864) | Bundesministerium für Gesundheit (DEEP LIVERα,ZMVI1-2520DAT111)

Authors: Subarnarekha Chatterji | Jan Moritz Niehues | Marko van Treeck | Chiara Maria Lavinia Loeffler | Oliver Lester Saldanha | Gregory Patrick Veldhuizen | Didem Cifci | Zunamys Itzell Carrero | Rasha Abu-Eid | Valerie Speirs | Jakob Nikolas Kather

A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis

JOURNAL ARTICLE published 30 April 2018 in npj Breast Cancer

Authors: Emily Powell | Jiansu Shao | Hector M. Picon | Christopher Bristow | Zhongqi Ge | Michael Peoples | Frederick Robinson | Sabrina L. Jeter-Jones | Christopher Schlosberg | Caitlin L. Grzeskowiak | Fei Yang | Yun Wu | Ignacio Wistuba | Stacy L. Moulder | William F. Symmans | Kenneth L. Scott | John R. Edwards | Han Liang | Timothy P. Heffernan | Helen Piwnica-Worms

Inflammatory breast cancer: a model for investigating cluster-based dissemination

JOURNAL ARTICLE published 6 June 2017 in npj Breast Cancer

Authors: Mohit Kumar Jolly | Marcelo Boareto | Bisrat G. Debeb | Nicola Aceto | Mary C. Farach-Carson | Wendy A. Woodward | Herbert Levine

Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast

JOURNAL ARTICLE published 7 September 2020 in npj Breast Cancer

Research funded by U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (1ZIACP010126,1ZIACP010126-23,1ZIACP010126,1ZIACP010126,1ZIACP010126,1ZIACP010126,1ZIACP010126,1ZIACP010126,1ZIACP010126,1ZIACP010126,1ZIACP010126,1ZIACP010126,1ZIACP010126) | U.S. Department of Health & Human Services | NIH | National Cancer Institute (U01 CA196383,U01 CA196383,U01 CA196383)

Authors: Clara Bodelon | Hannah Oh | Andriy Derkach | Joshua N. Sampson | Brian L. Sprague | Pamela Vacek | Donald L. Weaver | Shaoqi Fan | Maya Palakal | Daphne Papathomas | Jackie Xiang | Deesha A. Patel | Laura Linville | Susan E. Clare | Daniel W. Visscher | Carolyn Mies | Stephen M. Hewitt | Louise A. Brinton | Anna Maria V. Storniolo | Chunyan He | Stephen J. Chanock | Montserrat Garcia-Closas | Gretchen L. Gierach | Jonine D. Figueroa

Immunotherapy for early triple negative breast cancer: research agenda for the next decade

JOURNAL ARTICLE published 18 February 2022 in npj Breast Cancer

Authors: Paolo Tarantino | Chiara Corti | Peter Schmid | Javier Cortes | Elizabeth A. Mittendorf | Hope Rugo | Sara M. Tolaney | Giampaolo Bianchini | Fabrice Andrè | Giuseppe Curigliano

Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families

JOURNAL ARTICLE published 25 August 2021 in npj Breast Cancer

Research funded by Cancer Research Society (OG-24377)

Authors: Thibaut S. Matis | Nadia Zayed | Bouchra Labraki | Manon de Ladurantaye | Théophane A. Matis | José Camacho Valenzuela | Nancy Hamel | Adrienne Atayan | Barbara Rivera | Yuval Tabach | Patricia N. Tonin | Alexandre Orthwein | Anne-Marie Mes-Masson | Zaki El Haffaf | William D. Foulkes | Paz Polak

Efficacy of platinum-based chemotherapy in metastatic breast cancer and HRD biomarkers: utility of exome sequencing

JOURNAL ARTICLE published 4 March 2022 in npj Breast Cancer

Authors: Loïck Galland | Elise Ballot | Hugo Mananet | Romain Boidot | Julie Lecuelle | Juliette Albuisson | Laurent Arnould | Isabelle Desmoulins | Didier Mayeur | Courèche Kaderbhai | Silvia Ilie | Audrey Hennequin | Anthony Bergeron | Valentin Derangère | François Ghiringhelli | Caroline Truntzer | Sylvain Ladoire

Cyclin E1 and Rb modulation as common events at time of resistance to palbociclib in hormone receptor-positive breast cancer

JOURNAL ARTICLE published 28 November 2018 in npj Breast Cancer

Authors: Cristina Guarducci | Martina Bonechi | Matteo Benelli | Chiara Biagioni | Giulia Boccalini | Dario Romagnoli | Roberto Verardo | Rachel Schiff | C. Kent Osborne | Carmine De Angelis | Angelo Di Leo | Luca Malorni | Ilenia Migliaccio

The human intermediate prolactin receptor is a mammary proto-oncogene

JOURNAL ARTICLE published 26 March 2021 in npj Breast Cancer

Research funded by U.S. Department of Health & Human Services | NIH | National Cancer Institute (CA173305) | U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (UL1TR002649) | Susan G. Komen (CCR19608826)

Authors: Jacqueline M. Grible | Patricija Zot | Amy L. Olex | Shannon E. Hedrick | J. Chuck Harrell | Alicia E. Woock | Michael O. Idowu | Charles V. Clevenger

ERα/PR crosstalk is altered in the context of the ERα Y537S mutation and contributes to endocrine therapy-resistant tumor proliferation

JOURNAL ARTICLE published 30 November 2023 in npj Breast Cancer

Research funded by U.S. Department of Health & Human Services | NIH | National Cancer Institute (5F31CA257634-02)

Authors: Rosemary J. Huggins | Geoffrey L. Greene

Multi-center study on predicting breast cancer lymph node status from core needle biopsy specimens using multi-modal and multi-instance deep learning

JOURNAL ARTICLE published 13 July 2023 in npj Breast Cancer

Authors: Yan Ding | Fan Yang | Mengxue Han | Chunhui Li | Yanan Wang | Xin Xu | Min Zhao | Meng Zhao | Meng Yue | Huiyan Deng | Huichai Yang | Jianhua Yao | Yueping Liu

Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer

JOURNAL ARTICLE published 16 April 2021 in npj Breast Cancer

Authors: Lillian M. Smyth | Gerald Batist | Funda Meric-Bernstam | Peter Kabos | Iben Spanggaard | Ana Lluch | Komal Jhaveri | Andrea Varga | Andrea Wong | Alison M. Schram | Helen Ambrose | T. Hedley Carr | Elza C. de Bruin | Carolina Salinas-Souza | Andrew Foxley | Joana Hauser | Justin P. O. Lindemann | Rhiannon Maudsley | Robert McEwen | Michele Moschetta | Myria Nikolaou | Gaia Schiavon | Pedram Razavi | Udai Banerji | José Baselga | David M. Hyman | Sarat Chandarlapaty

Spatial interplay of tissue hypoxia and T-cell regulation in ductal carcinoma in situ

JOURNAL ARTICLE published 15 September 2022 in npj Breast Cancer

Authors: Faranak Sobhani | Sathya Muralidhar | Azam Hamidinekoo | Allison H. Hall | Lorraine M. King | Jeffrey R. Marks | Carlo Maley | Hugo M. Horlings | E. Shelley Hwang | Yinyin Yuan

TNF is a key cytokine mediating neutrophil cytotoxic activity in breast cancer patients

JOURNAL ARTICLE published 20 April 2016 in npj Breast Cancer

Authors: Elizabeth Comen | Paulina Wojnarowicz | Venkatraman E Seshan | Riddhi Shah | Courtney Coker | Larry Norton | Robert Benezra

HER2-low-positive breast cancer: evolution from primary tumor to residual disease after neoadjuvant treatment

JOURNAL ARTICLE published 20 May 2022 in npj Breast Cancer

Research funded by Università degli Studi di Padova (BIRD 2019,BIRD 2020,BIRD 2020,BIRD-2019,BIRD 2019,BIRD 2020,DOR-2194859/21) | Associazione Italiana per la Ricerca sul Cancro (5 per mille ID. 22759 program,5 per mille ID. 22759 program)

Authors: Federica Miglietta | Gaia Griguolo | Michele Bottosso | Tommaso Giarratano | Marcello Lo Mele | Matteo Fassan | Matilde Cacciatore | Elisa Genovesi | Debora De Bartolo | Grazia Vernaci | Ottavia Amato | Francesca Porra | PierFranco Conte | Valentina Guarneri | Maria Vittoria Dieci

Incidence of brain metastases in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy with trastuzumab and pertuzumab

JOURNAL ARTICLE published 22 March 2022 in npj Breast Cancer

Authors: Emanuela Ferraro | Jasmeet Singh | Sujata Patil | Pedram Razavi | Shanu Modi | Sarat Chandarlapaty | Andrea V. Barrio | Rachna Malani | Ingo K. Mellinghoff | Adrienne Boire | Hannah Y. Wen | Edi Brogi | Andrew D. Seidman | Larry Norton | Mark E. Robson | Chau T. Dang

Extended adjuvant endocrine therapy in a longitudinal cohort of young breast cancer survivors

JOURNAL ARTICLE published 25 April 2023 in npj Breast Cancer

Authors: Tal Sella | Yue Zheng | Shoshana M. Rosenberg | Kathryn J. Ruddy | Shari I. Gelber | Rulla M. Tamimi | Jeffrey M. Peppercorn | Lidia Schapira | Virginia F. Borges | Steven E. Come | Lisa A. Carey | Eric P. Winer | Ann H. Partridge

Prognostic characteristics in hormone receptor-positive advanced breast cancer and characterization of abemaciclib efficacy

JOURNAL ARTICLE published 18 December 2018 in npj Breast Cancer

Authors: Angelo Di Leo | Joyce O’Shaughnessy | George W. Sledge | Miguel Martin | Yong Lin | Martin Frenzel | Molly C. Hardebeck | Ian C. Smith | Antonio Llombart-Cussac | Matthew P. Goetz | Stephen Johnston

TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression

JOURNAL ARTICLE published 2 March 2023 in npj Breast Cancer

Research funded by Cancer Research UK (C10847/A27781) | Breast Cancer Now (2017NovPR988)

Authors: Shayin V. Gibson | Elena Tomas Bort | Lucía Rodríguez-Fernández | Michael D. Allen | Jennifer J. Gomm | Iain Goulding | Ulrich auf dem Keller | Andrea Agnoletto | Cathrin Brisken | Barrie Peck | Angus J. Cameron | John F. Marshall | J. Louise Jones | Edward P. Carter | Richard P. Grose

The deubiquitinating enzyme USP4 regulates BRCA1 stability and function

JOURNAL ARTICLE published 11 May 2024 in npj Breast Cancer

Research funded by National Natural Science Foundation of China (82172924,81972477,81772953) | National Science Foundation of China | Major Research Plan (2017YFA0503900)

Authors: Xueyuan Guo | Yanfang Ma | Ting Zhang | Runyu Liu | Fen Chang | Xingyue Yan | Tianyun Yu | Pengfei Wu | Qin Li | Luzheng Xu | Junyi Duan | Li Li | Yanrong Su | Genze Shao