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Investigation of the biological functions of heparan sulfate using a chemoenzymatic synthetic approach

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Research funded by National Institutes of Health (HL094463,HL144970,GM128484) | Eshelman Institute for Innovation, University of North Carolina at Chapel Hill (Glycan Innovation)

Authors: Zhangjie Wang | Katelyn Arnold | Vijay Manohar Dhurandhare | Yongmei Xu | Jian Liu

Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by National Institute of Neurological Disorders and Stroke (1R21NS112927-01) | National Institute of General Medical Sciences (R01GM134716-02) | National Science Foundation (2017248946) | Michael J. Fox Foundation for Parkinson's Research (16250)

Authors: A. Katherine Hatstat | Baiyi Quan | Morgan A. Bailey | Michael C. Fitzgerald | Michaela C. Reinhart | Dewey G. McCafferty

The multivalent G-quadruplex (G4)-ligands MultiTASQs allow for versatile click chemistry-based investigations

JOURNAL ARTICLE published 2023 in RSC Chemical Biology

Research funded by European Regional Development Fund (PO FEDER-FSE Bourgogne 2014/2020, BG0021532) | Agence Nationale de la Recherche (ANR-22-CE44-0039-01) | Conseil régional de Bourgogne-Franche-Comté (UB21018.MUB.IS)

Authors: Francesco Rota Sperti | Jérémie Mitteaux | Joanna Zell | Angélique Pipier | Ibai E. Valverde | David Monchaud

Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Research funded by Reumafonds (15-2-202) | H2020 European Research Council (ERC-CoG-865175)

Authors: Tyrza van Leeuwen | Can Araman | Linda Pieper Pournara | Arieke S. B. Kampstra | Thomas Bakkum | Mikkel H. S. Marqvorsen | Clarissa R. Nascimento | G. J. Mirjam Groenewold | Willemijn van der Wulp | Marcel G. M. Camps | George M. C. Janssen | Peter A. van Veelen | Gerard J. P. van Westen | Antonius P. A. Janssen | Bogdan I. Florea | Herman S. Overkleeft | Ferry A. Ossendorp | René E. M. Toes | Sander I. van Kasteren

Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding

JOURNAL ARTICLE published 2020 in RSC Chemical Biology

Authors: Jonathan Cramer | Xiaohua Jiang | Wojciech Schönemann | Marleen Silbermann | Pascal Zihlmann | Stefan Siegrist | Brigitte Fiege | Roman Peter Jakob | Said Rabbani | Timm Maier | Beat Ernst

Correction: Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzyme

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Authors: Christopher J. Harding | Emmajay Sutherland | Jane G. Hanna | Douglas R. Houston | Clarissa M. Czekster

A light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by National Natural Science Foundation of China (2207070006) | Natural Science Foundation of Jiangsu Province (BK20202299)

Authors: Feifei Wang | Hao Kong | Xiangfeng Meng | Xiao Tian | Changjiang Wang | Lei Xu | Xiang Zhang | Lei Wang | Ran Xie

A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by National Natural Science Foundation of China (22125702,22077107,92059109) | Natural Science Foundation of Fujian Province (2020J02001)

Authors: Zhaoxuan Yang | Jiaqi Huang | Yaying Lin | Xiangjie Luo | Haojin Lin | Hongyu Lin | Jinhao Gao

Hydrophobic cavity-directed azide-acetyllysine photochemistry for profiling non-histone interacting partners of bromodomain protein 1

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by National Institutes of Health (R01GM123234) | Cancer Institute, University of Pittsburgh (P30CA047904)

Authors: Jordan Kuwik | Shana Wagner | Babu Sudhamalla | Ronald Debiec | Kabirul Islam

Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by H2020 Marie Skłodowska-Curie Actions (675179) | Engineering and Physical Sciences Research Council (EP/K039202/1,EP/N013573/1)

Authors: Sonja Srdanović | Zsofia Hegedüs | Stuart L. Warriner | Andrew J. Wilson

Navigating complex peptide structures using macrocycle conformational maps

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Authors: Timothy J. McTiernan | Diego B. Diaz | George J. Saunders | Fiona Sprang | Andrei K. Yudin

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JOURNAL ARTICLE published 2021 in RSC Chemical Biology

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JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Non-invasive radionuclide imaging of trace metal trafficking in health and disease: “PET metallomics”

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by Engineering and Physical Sciences Research Council (EP/L015226/1,EP/S032789/1) | Wellcome Trust (WT 203148/Z/16/Z)

Authors: George Firth | Julia E. Blower | Joanna J. Bartnicka | Aishwarya Mishra | Aidan M. Michaels | Alex Rigby | Afnan Darwesh | Fahad Al-Salemee | Philip J. Blower

Back cover

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Research funded by European Commission (631871) | China Scholarship Council (20170663005)

Authors: Dominic W. P. Collis | Gokhan Yilmaz | Yichen Yuan | Alessandra Monaco | Guy Ochbaum | Yejiao Shi | Clare O’Malley | Veselina Uzunova | Richard Napier | Ronit Bitton | C. Remzi Becer | Helena S. Azevedo

Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by KU Leuven (C24/18/081) | Fonds Wetenschappelijk Onderzoek (G0A5718N) | Horizon 2020 (871037)

Authors: Evgenii M. Osipov | Ali H. Munawar | Steven Beelen | Daren Fearon | Alice Douangamath | Conor Wild | Stephen D. Weeks | Arthur Van Aerschot | Frank von Delft | Sergei V. Strelkov

Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by Shenzhen Fundamental Research Program (JCYJ20180507181642811) | Research Grants Council, University Grants Committee (CityU 11100421,CityU 11101519,CityU 11100218,N_CityU110/17) | Croucher Foundation (9509003) | City University of Hong Kong (7005503,9667222,9680261)

Authors: Hengxin Feng | Chun Kit Kwok

A prodrug strategy for the in vivo imaging of aldehyde dehydrogenase activity

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by Wellcome Trust (107610/Z/15/Z,220221/Z/20/Z)

Authors: Raul Pereira | Renée L. Flaherty | Richard S. Edwards | Hannah E. Greenwood | Adam J. Shuhendler | Timothy H. Witney

Front cover

JOURNAL ARTICLE published 2022 in RSC Chemical Biology