Metadata Search Funding Data Link References Status API Help
Facet browsing currently unavailable
Page 10 of 36565 results
Sort by: relevance publication year
Showing results for ISSN matching 0022-2623

New Multifunctional Di-tert-butylphenoloctahydro(pyrido/benz)oxazine Derivatives with Antioxidant, Antihyperlipidemic, and Antidiabetic Action

JOURNAL ARTICLE published 25 April 2013 in Journal of Medicinal Chemistry

Authors: Eleni Ladopoulou | Alexios N. Matralis | Angeliki P. Kourounakis

https://doi.org/10.1021/jm400101e Actions

2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction

JOURNAL ARTICLE published 13 September 2018 in Journal of Medicinal Chemistry

Authors: Tommaso Felicetti | Rolando Cannalire | Donatella Pietrella | Gniewomir Latacz | Annamaria Lubelska | Giuseppe Manfroni | Maria Letizia Barreca | Serena Massari | Oriana Tabarrini | Katarzyna Kieć-Kononowicz | Bryan D. Schindler | Glenn W. Kaatz | Violetta Cecchetti | Stefano Sabatini

https://doi.org/10.1021/acs.jmedchem.8b00791 Actions

7-Substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials

JOURNAL ARTICLE published March 1988 in Journal of Medicinal Chemistry

Authors: John M. Domagala | Susan E. Hagen | Carl L. Heifetz | Marland P. Hutt | Thomas F. Mich | Joseph P. Sanchez | Ashok K. Trehan

https://doi.org/10.1021/jm00398a003 Actions

Synthesis and Biological Evaluation of (6- and 7-Phenyl) Coumarin Derivatives as Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1

JOURNAL ARTICLE published 13 January 2011 in Journal of Medicinal Chemistry

Authors: Štefan Starčević | Petra Brožič | Samo Turk | Jožko Cesar | Tea Lanišnik Rižner | Stanislav Gobec

https://doi.org/10.1021/jm101104z Actions

Novel Steroid Inhibitors of Glucose 6-Phosphate Dehydrogenase

JOURNAL ARTICLE published 10 May 2012 in Journal of Medicinal Chemistry

Authors: Niall M. Hamilton | Martin Dawson | Emma E. Fairweather | Nicola S. Hamilton | James R. Hitchin | Dominic I. James | Stuart D. Jones | Allan M. Jordan | Amanda J. Lyons | Helen F. Small | Graeme J. Thomson | Ian D. Waddell | Donald J. Ogilvie

https://doi.org/10.1021/jm300317k Actions

Computationally Driven Structure Optimization, Synthesis, and Biological Evaluation of Imidazole-Based Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Inhibitors

JOURNAL ARTICLE published 11 July 2019 in Journal of Medicinal Chemistry

Authors: Carmen Lammi | Jacopo Sgrignani | Anna Arnoldi | Giordano Lesma | Claudia Spatti | Alessandra Silvani | Giovanni Grazioso

https://doi.org/10.1021/acs.jmedchem.9b00402 Actions

A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor

JOURNAL ARTICLE published 12 August 2021 in Journal of Medicinal Chemistry

Research funded by Deutsche Forschungsgemeinschaft (427840891,GRK1910)

Authors: Niklas Rosier | Lukas Grätz | Hannes Schihada | Jan Möller | Ali Işbilir | Laura J. Humphrys | Martin Nagl | Ulla Seibel | Martin J. Lohse | Steffen Pockes

https://doi.org/10.1021/acs.jmedchem.1c01089 Actions

The Discovery of New 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors by Common Feature Pharmacophore Modeling and Virtual Screening

JOURNAL ARTICLE published 1 June 2006 in Journal of Medicinal Chemistry

Authors: Daniela Schuster | Evelyne M. Maurer | Christian Laggner | Lyubomir G. Nashev | Thomas Wilckens | Thierry Langer | Alex Odermatt

https://doi.org/10.1021/jm0600794 Actions

Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules

JOURNAL ARTICLE published 10 November 2016 in Journal of Medicinal Chemistry

Research funded by Norges Forskningsråd (ES546707)

Authors: Ulli Rothweiler | Wenche Stensen | Bjørn Olav Brandsdal | Johan Isaksson | Frederick Alan Leeson | Richard Alan Engh | John S. Mjøen Svendsen

https://doi.org/10.1021/acs.jmedchem.6b01086 Actions

Introduction of Scaffold Nitrogen Atoms Renders Inhibitors of the Malarial l-Lactate Transporter, PfFNT, Effective against the Gly107Ser Resistance Mutation

JOURNAL ARTICLE published 10 September 2020 in Journal of Medicinal Chemistry

Research funded by Deutsche Forschungsgemeinschaft (Be2253/8)

Authors: Philipp Walloch | Björn Henke | Susan Häuer | Bärbel Bergmann | Tobias Spielmann | Eric Beitz

https://doi.org/10.1021/acs.jmedchem.0c00852 Actions

Inhibition of Homologous Recombination in Human Cells by Targeting RAD51 Recombinase

JOURNAL ARTICLE published 12 April 2012 in Journal of Medicinal Chemistry

Authors: Fei Huang | Olga M. Mazina | Isaac J. Zentner | Simon Cocklin | Alexander V. Mazin

https://doi.org/10.1021/jm201173g Actions

Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design

JOURNAL ARTICLE published 26 December 2019 in Journal of Medicinal Chemistry

Research funded by National Institute of Diabetes and Digestive and Kidney Diseases (F31DK111171,P30DK056338,R01DK095750,R01DK114213) | National Institute of General Medical Sciences (T32GM008602) | U.S. Department of Agriculture (ARS 3092-5-001-057)

Authors: Suzanne G. Mays | Autumn R. Flynn | Jeffery L. Cornelison | C. Denise Okafor | Hongtao Wang | Guohui Wang | Xiangsheng Huang | Heather N. Donaldson | Elizabeth J. Millings | Rohini Polavarapu | David D. Moore | John W. Calvert | Nathan T. Jui | Eric A. Ortlund

https://doi.org/10.1021/acs.jmedchem.9b00753 Actions

Structure-Based Discovery of Novel Cyclophilin A Inhibitors for the Treatment of Hepatitis C Virus Infections

JOURNAL ARTICLE published 24 December 2015 in Journal of Medicinal Chemistry

Research funded by Korea Health Industry Development Institute (HI12C1640) | National Research Foundation of Korea (2011-0030072)

Authors: Suhui Yang | Jyothi K.R. | Sangbin Lim | Tae Gyu Choi | Jin-Hwan Kim | Salima Akter | Miran Jang | Hyun-Jong Ahn | Hee-Young Kim | Marc P. Windisch | Daulat B. Khadka | Chao Zhao | Yifeng Jin | Insug Kang | Joohun Ha | Byung-Chul Oh | Meehyein Kim | Sung Soo Kim | Won-Jea Cho

https://doi.org/10.1021/acs.jmedchem.5b01064 Actions

Targeted Protein Degradation Induced by HEMTACs Based on HSP90

JOURNAL ARTICLE published 12 January 2023 in Journal of Medicinal Chemistry

Research funded by National Natural Science Foundation of China (81874308,82273892) | Natural Science Foundation of Shandong Province (ZR2018ZC0233,ZR2022LSW013) | Foundation for Innovative Research Groups of State Key Laboratory of Microbial Technology (WZCX2021-03)

Authors: Zhenzhen Li | Siyue Ma | Ling Zhang | Shuxin Zhang | Zhao Ma | Lupei Du | Minyong Li

https://doi.org/10.1021/acs.jmedchem.2c01648 Actions

Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

JOURNAL ARTICLE published 1 May 2007 in Journal of Medicinal Chemistry

Authors: Andrew J. Prongay | Zhuyan Guo | Nanhua Yao | John Pichardo | Thierry Fischmann | Corey Strickland | Joseph Myers | Patricia C. Weber | Brian M. Beyer | Richard Ingram | Zhi Hong | Winifred W. Prosise | Lata Ramanathan | S. Shane Taremi | Taisa Yarosh-Tomaine | Rumin Zhang | Mary Senior | Rong-Sheng Yang | Bruce Malcolm | Ashok Arasappan | Frank Bennett | Stephane L. Bogen | Kevin Chen | Edwin Jao | Yi-Tsung Liu | Raymond G. Lovey | Anil K. Saksena | Srikanth Venkatraman | Viyyoor Girijavallabhan | F. George Njoroge | Vincent Madison

https://doi.org/10.1021/jm060173k Actions

High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes

JOURNAL ARTICLE published 12 August 2021 in Journal of Medicinal Chemistry

Research funded by Medical Research Council (MR/N002679/1,MR/P007503/1) | Global Challenges Research Fund (GCRFNG\100347) | Diamond Light Source (STU0212) | Wellcome Trust (106244/Z/14/Z) | Newton Fund (MR/P007503/1) | University of Warwick (STU0212)

Authors: Hector Newman | Alen Krajnc | Dom Bellini | Charles J. Eyermann | Grant A. Boyle | Neil G. Paterson | Katherine E. McAuley | Robert Lesniak | Mukesh Gangar | Frank von Delft | Jürgen Brem | Kelly Chibale | Christopher J. Schofield | Christopher G. Dowson

https://doi.org/10.1021/acs.jmedchem.1c00717 Actions

Design and Structural Optimization of Dual FXR/PPARδ Activators

JOURNAL ARTICLE published 13 August 2020 in Journal of Medicinal Chemistry

Authors: Simone Schierle | Sebastian Neumann | Pascal Heitel | Sabine Willems | Astrid Kaiser | Julius Pollinger | Daniel Merk

https://doi.org/10.1021/acs.jmedchem.0c00618 Actions

Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme

JOURNAL ARTICLE published 12 August 2021 in Journal of Medicinal Chemistry

Authors: Matthew M. Hamilton | Faika Mseeh | Timothy J. McAfoos | Paul G. Leonard | Naphtali J. Reyna | Angela L. Harris | Alan Xu | Michelle Han | Michael J. Soth | Barbara Czako | Jay P. Theroff | Pijus K. Mandal | Jason P. Burke | Brett Virgin-Downey | Alessia Petrocchi | Dana Pfaffinger | Norma E. Rogers | Connor A. Parker | Simon S. Yu | Yongying Jiang | Stephan Krapp | Alfred Lammens | Graham Trevitt | Martin R. Tremblay | Keith Mikule | Keith Wilcoxen | Jason B. Cross | Philip Jones | Joseph R. Marszalek | Richard T. Lewis

https://doi.org/10.1021/acs.jmedchem.1c00679 Actions

Design and Synthesis of Glycoside Inhibitors of Glioma and Melanoma Growth

JOURNAL ARTICLE published 1 January 2007 in Journal of Medicinal Chemistry

Authors: Isabel García-Álvarez | Guillermo Corrales | Ernesto Doncel-Pérez | Ana Muñoz | Manuel Nieto-Sampedro | Alfonso Fernández-Mayoralas

https://doi.org/10.1021/jm0611556 Actions

Hashish. Importance of the phenolic hydroxyl group in tetrahydrocannabinols

JOURNAL ARTICLE published February 1975 in Journal of Medicinal Chemistry

Authors: D. B. Uliss | H. C. Dalzell | G. R. Handrick | J. F. Howes | R. K. Razdan

https://doi.org/10.1021/jm00236a025 Actions
Feedback: support@crossref.org