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The Discovery of New 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors by Common Feature Pharmacophore Modeling and Virtual Screening JOURNAL ARTICLE published 1 June 2006 in Journal of Medicinal Chemistry |
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Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules JOURNAL ARTICLE published 10 November 2016 in Journal of Medicinal Chemistry Research funded by Norges Forskningsråd (ES546707) |
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Inhibition of Homologous Recombination in Human Cells by Targeting RAD51 Recombinase JOURNAL ARTICLE published 12 April 2012 in Journal of Medicinal Chemistry |
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Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design JOURNAL ARTICLE published 26 December 2019 in Journal of Medicinal Chemistry Research funded by National Institute of Diabetes and Digestive and Kidney Diseases (F31DK111171,P30DK056338,R01DK095750,R01DK114213) | National Institute of General Medical Sciences (T32GM008602) | U.S. Department of Agriculture (ARS 3092-5-001-057) |
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Structure-Based Discovery of Novel Cyclophilin A Inhibitors for the Treatment of Hepatitis C Virus Infections JOURNAL ARTICLE published 24 December 2015 in Journal of Medicinal Chemistry Research funded by Korea Health Industry Development Institute (HI12C1640) | National Research Foundation of Korea (2011-0030072) |
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Targeted Protein Degradation Induced by HEMTACs Based on HSP90 JOURNAL ARTICLE published 12 January 2023 in Journal of Medicinal Chemistry Research funded by National Natural Science Foundation of China (81874308,82273892) | Natural Science Foundation of Shandong Province (ZR2018ZC0233,ZR2022LSW013) | Foundation for Innovative Research Groups of State Key Laboratory of Microbial Technology (WZCX2021-03) |
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Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization JOURNAL ARTICLE published 1 May 2007 in Journal of Medicinal Chemistry |
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High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes JOURNAL ARTICLE published 12 August 2021 in Journal of Medicinal Chemistry Research funded by Medical Research Council (MR/N002679/1,MR/P007503/1) | Global Challenges Research Fund (GCRFNG\100347) | Diamond Light Source (STU0212) | Wellcome Trust (106244/Z/14/Z) | Newton Fund (MR/P007503/1) | University of Warwick (STU0212) |
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Design and Structural Optimization of Dual FXR/PPARδ Activators JOURNAL ARTICLE published 13 August 2020 in Journal of Medicinal Chemistry |
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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme JOURNAL ARTICLE published 12 August 2021 in Journal of Medicinal Chemistry |
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Design and Synthesis of Glycoside Inhibitors of Glioma and Melanoma Growth JOURNAL ARTICLE published 1 January 2007 in Journal of Medicinal Chemistry |
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Hashish. Importance of the phenolic hydroxyl group in tetrahydrocannabinols JOURNAL ARTICLE published February 1975 in Journal of Medicinal Chemistry |
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Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay JOURNAL ARTICLE published 12 September 2019 in Journal of Medicinal Chemistry Research funded by Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-06747) | Quebec Network for Research on Protein Function, Structure, and Engineering (PROTEO) (FT109664) | Canadian Foundation for Innovation (35334) |
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Akt-Dependent Anabolic Activity of Natural and Synthetic Brassinosteroids in Rat Skeletal Muscle Cells JOURNAL ARTICLE published 23 June 2011 in Journal of Medicinal Chemistry |
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Design and Synthesis of Potent C2-Symmetric Diol-Based HIV-1 Protease Inhibitors: Effects of Fluoro Substitution JOURNAL ARTICLE published 1 September 2001 in Journal of Medicinal Chemistry |
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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease JOURNAL ARTICLE published 26 March 2020 in Journal of Medicinal Chemistry |
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An Effort To Understand the Molecular Basis of Hypertension through the Study of Conformational Analysis of Losartan and Sarmesin Using a Combination of Nuclear Magnetic Resonance Spectroscopy and Theoretical Calculations JOURNAL ARTICLE published 1 May 1999 in Journal of Medicinal Chemistry |
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Discovery of the First Low Nanomolar Liver Receptor Homolog-1 (LRH-1) Agonist JOURNAL ARTICLE published 26 December 2019 in Journal of Medicinal Chemistry |
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Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Cav3.1 Low Voltage-Gated Ca2+ Channel JOURNAL ARTICLE published 27 February 2020 in Journal of Medicinal Chemistry Research funded by Natural Science Foundation of Yunnan Province (2016FB138,2019FA003) | State Key Laboratory of Phytochemistry and Plant Resources in West China (P2018-KF05,P2019-ZZ05) | Southeast Asia Biodiversity Research Institute, CAS (2017CASSEABRIQG003) | NSFC-Joint Foundation of Yunnan Province (U1902213) | Second Tibetan Plateau Scientific Expedition and Research (2019QZKK0502) |
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.alpha.-Ethynyl and .alpha.-vinyl analogs of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase JOURNAL ARTICLE published January 1981 in Journal of Medicinal Chemistry |