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Showing results for ISSN matching 0022-2623

4-Benzyloxy-γ-Sultone Derivatives: Discovery of a Novel Family of Non-Nucleoside Inhibitors of Human Cytomegalovirus and Varicella Zoster Virus

JOURNAL ARTICLE published 14 May 2009 in Journal of Medicinal Chemistry

Authors: Sonia De Castro | Carlos García-Aparicio | Graciela Andrei | Robert Snoeck | Jan Balzarini | María-José Camarasa | Sonsoles Velázquez

https://doi.org/10.1021/jm900444d Actions

Rapid Identification of Ligand-Binding Sites by Using an Assignment-Free NMR Approach

JOURNAL ARTICLE published 27 November 2013 in Journal of Medicinal Chemistry

Authors: Yuya Kodama | Koh Takeuchi | Nobuhisa Shimba | Kohki Ishikawa | Ei-ichiro Suzuki | Ichio Shimada | Hideo Takahashi

https://doi.org/10.1021/jm4014357 Actions

17-Substituted 3β-Hydroxy-4-pregnen-20-ones

JOURNAL ARTICLE published May 1964 in Journal of Medicinal Chemistry

Authors: David J. Marshall | Peter F. Morand | Clara Revesz | R. Gaudry

https://doi.org/10.1021/jm00333a025 Actions

Further Studies on Lead Compounds Containing the Opioid Pharmacophore Dmt-Tic

JOURNAL ARTICLE published 1 August 2008 in Journal of Medicinal Chemistry

Authors: Gianfranco Balboni | Stella Fiorini | Anna Baldisserotto | Claudio Trapella | Yusuke Sasaki | Akihiro Ambo | Ewa D. Marczak | Lawrence H. Lazarus | Severo Salvadori

https://doi.org/10.1021/jm800587e Actions

Structure−Activity Relationships of [2‘,5‘-Bis-O-(tert-butyldimethylsilyl)-β-d-ribofuranosyl]- 3‘-spiro-5‘ ‘-(4‘ ‘-amino-1‘ ‘,2‘ ‘-oxathiole-2‘ ‘,2‘ ‘-dioxide)thymine Derivatives as Inhibitors of HIV-1 Reverse Transcriptase Dimerization

JOURNAL ARTICLE published 1 August 2006 in Journal of Medicinal Chemistry

Authors: Nicolas Sluis-Cremer | Noureddine Hamamouch | Ana San Félix | Sonsoles Velázquez | Jan Balzarini | María-José Camarasa

https://doi.org/10.1021/jm0604575 Actions

Performance of Dark Chemical Matter in High Throughput Screening

JOURNAL ARTICLE published 10 November 2016 in Journal of Medicinal Chemistry

Authors: Ingo Muegge | Prasenjit Mukherjee

https://doi.org/10.1021/acs.jmedchem.6b01038 Actions

Correction to “Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069”

JOURNAL ARTICLE published 12 January 2023 in Journal of Medicinal Chemistry

Authors: Douglas L. Orsi | Elisabeth Pook | Nico Bräuer | Anders Friberg | Philip Lienau | Christopher T. Lemke | Timo Stellfeld | Ulf Brüggemeier | Vera Pütter | Hanna Meyer | Maria Baco | Stephanie Tang | Andrew D. Cherniack | Lindsay Westlake | Samantha A. Bender | Mustafa Kocak | Craig A. Strathdee | Matthew Meyerson | Knut Eis | Jonathan T. Goldstein

https://doi.org/10.1021/acs.jmedchem.2c02002 Actions

De Novo Discovery of Serotonin N-Acetyltransferase Inhibitors

JOURNAL ARTICLE published 1 November 2007 in Journal of Medicinal Chemistry

Authors: Lawrence M. Szewczuk | S. Adrian Saldanha | Surajit Ganguly | Erin M. Bowers | Margarita Javoroncov | Balasubramanyam Karanam | Jeffrey C. Culhane | Marc A. Holbert | David C. Klein | Ruben Abagyan | Philip A. Cole

https://doi.org/10.1021/jm0706463 Actions

A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins

JOURNAL ARTICLE published 25 November 2020 in Journal of Medicinal Chemistry

Research funded by National Cancer Institute (U54CA231649) | Welch Foundation (I-1422,I-2040) | Damon Runyon Cancer Research Foundation (102-19) | Cancer Prevention and Research Institute of Texas (RP190141,RR140084)

Authors: Juan Manuel Povedano | Rameshu Rallabandi | Xin Bai | Xuecheng Ye | Joel Liou | Hong Chen | Jiwoong Kim | Yang Xie | Bruce Posner | Luke Rice | Jef K. De Brabander | David G. McFadden

https://doi.org/10.1021/acs.jmedchem.0c01482 Actions

Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors

JOURNAL ARTICLE published 22 November 2017 in Journal of Medicinal Chemistry

Research funded by Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (2016/10149-0)

Authors: Predrag Kalaba | Nilima Y. Aher | Marija Ilić | Vladimir Dragačević | Marcus Wieder | Andras G. Miklosi | Martin Zehl | Judith Wackerlig | Alexander Roller | Tetyana Beryozkina | Bojana Radoman | Sivaprakasam R. Saroja | Wolfgang Lindner | Eduardo Perez Gonzalez | Vasiliy Bakulev | Johann Jakob Leban | Harald H. Sitte | Ernst Urban | Thierry Langer | Gert Lubec

https://doi.org/10.1021/acs.jmedchem.7b01313 Actions

Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists

JOURNAL ARTICLE published 24 August 2017 in Journal of Medicinal Chemistry

Authors: Sarah Line Skovbakke | André Holdfeldt | Christina Nielsen | Anna Mette Hansen | Iris Perez-Gassol | Claes Dahlgren | Huamei Forsman | Henrik Franzyk

https://doi.org/10.1021/acs.jmedchem.7b00489 Actions

Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12

JOURNAL ARTICLE published 27 August 2009 in Journal of Medicinal Chemistry

Authors: Frédéric Thuaud | Yohann Bernard | Gülen Türkeri | Ronan Dirr | Geneviève Aubert | Thierry Cresteil | Aurélie Baguet | Catherine Tomasetto | Yuri Svitkin | Nahum Sonenberg | Canan G. Nebigil | Laurent Désaubry

https://doi.org/10.1021/jm900365v Actions

Potent, Brain-Penetrant, Hydroisoindoline-Based Human Neurokinin-1 Receptor Antagonists

JOURNAL ARTICLE published 14 May 2009 in Journal of Medicinal Chemistry

Authors: Jinlong Jiang | Jaime L. Bunda | Geoge A. Doss | Gary G. Chicchi | Marc M. Kurtz | Kwei-Lan C. Tsao | Xinchun Tong | Song Zheng | Alana Upthagrove | Koppara Samuel | Richard Tschirret-Guth | Sanjeev Kumar | Alan Wheeldon | Emma J. Carlson | Richard Hargreaves | Donald Burns | Terence Hamill | Christine Ryan | Stephen M. Krause | WaiSi Eng | Robert J. DeVita | Sander G. Mills

https://doi.org/10.1021/jm8016514 Actions

On the Applicability of GPCR Homology Models to Computer-Aided Drug Discovery: A Comparison between In Silico and Crystal Structures of the β2-Adrenergic Receptor

JOURNAL ARTICLE published 1 May 2008 in Journal of Medicinal Chemistry

Authors: Stefano Costanzi

https://doi.org/10.1021/jm800044k Actions

Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women

JOURNAL ARTICLE published 22 October 2020 in Journal of Medicinal Chemistry

Authors: Olaf Panknin | Andrea Wagenfeld | Wilhelm Bone | Eckhard Bender | Katrin Nowak-Reppel | Amaury E. Fernández-Montalván | Reinhard Nubbemeyer | Stefan Bäurle | Sven Ring | Norbert Schmees | Olaf Prien | Martina Schäfer | Christian Friedrich | Thomas M. Zollner | Andreas Steinmeyer | Thomas Mueller | Gernot Langer

https://doi.org/10.1021/acs.jmedchem.0c01076 Actions

Cytotoxicity and antitumor activity of bis(platinum) complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1,2-diaminocyclohexane complexes

JOURNAL ARTICLE published August 1990 in Journal of Medicinal Chemistry

Authors: Nicholas Farrell | Yun Qu | Miles P. Hacker

https://doi.org/10.1021/jm00170a021 Actions

Design, Synthesis, and In Vitro Testing of α-Methylacyl-CoA Racemase Inhibitors

JOURNAL ARTICLE published 1 May 2007 in Journal of Medicinal Chemistry

Authors: Andrew J. Carnell | Ian Hale | Simone Denis | Ronald J. A. Wanders | William B. Isaacs | Brice A. Wilson | Sacha Ferdinandusse

https://doi.org/10.1021/jm0702377 Actions

New Substituted 1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl Derivatives with α2-Adrenoceptor Antagonist Activity

JOURNAL ARTICLE published 1 October 2000 in Journal of Medicinal Chemistry

Authors: Patrice Mayer | Pascale Brunel | Céline Chaplain | Christel Piedecoq | Francis Calmel | Philippe Schambel | Philippe Chopin | Thierry Wurch | Petrus J. Pauwels | Marc Marien | Jean-Louis Vidaluc | Thierry Imbert

https://doi.org/10.1021/jm991121g Actions

N-3-Substituted Imidazoquinazolinones:  Potent and Selective PDE5 Inhibitors as Potential Agents for Treatment of Erectile Dysfunction

JOURNAL ARTICLE published 6 April 2000 in Journal of Medicinal Chemistry

Authors: David P. Rotella | Zhong Sun | Yeheng Zhu | John Krupinski | Ronald Pongrac | Laurie Seliger | Diane Normandin | John E. Macor

https://doi.org/10.1021/jm000081+ Actions

DNA Binding Ligands Targeting Drug-Resistant Bacteria:  Structure, Activity, and Pharmacology

JOURNAL ARTICLE published 1 August 2003 in Journal of Medicinal Chemistry

Authors: Jacob A. Kaizerman | Matthew I. Gross | Yigong Ge | Sarah White | Wenhao Hu | Jian-Xin Duan | Eldon E. Baird | Kirk W. Johnson | Richard D. Tanaka | Heinz E. Moser | Roland W. Bürli

https://doi.org/10.1021/jm030097a Actions
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