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Showing results for ISSN matching 0022-2623

Application of the λ-Dynamics Method To Evaluate the Relative Binding Free Energies of Inhibitors to HCV Protease

JOURNAL ARTICLE published 1 December 2003 in Journal of Medicinal Chemistry

Authors: Zhuyan Guo | James Durkin | Thierry Fischmann | Richard Ingram | Andrew Prongay | Rumin Zhang | Vincent Madison

https://doi.org/10.1021/jm030040o Actions

1-[(ω-Aminoalkyl)amino]-4-[N-(ω-aminoalkyl)carbamoyl]-9-oxo-9,10-dihydro- acridines as Intercalating Cytotoxic Agents:  Synthesis, DNA Binding, and Biological Evaluation

JOURNAL ARTICLE published 1 November 1997 in Journal of Medicinal Chemistry

Authors: Ippolito Antonini | Paolo Polucci | Terence C. Jenkins | Lloyd R. Kelland | Ernesto Menta | Nicoletta Pescalli | Barbara Stefanska | Jan Mazerski | Sante Martelli

https://doi.org/10.1021/jm970114u Actions

Fluorine-Substituted Cyclofenil Derivatives as Estrogen Receptor Ligands:  Synthesis and Structure−Affinity Relationship Study of Potential Positron Emission Tomography Agents for Imaging Estrogen Receptors in Breast Cancer

JOURNAL ARTICLE published 1 April 2006 in Journal of Medicinal Chemistry

Authors: Jai Woong Seo | John S. Comninos | Dae Yoon Chi | Dong Wook Kim | Kathryn E. Carlson | John A. Katzenellenbogen

https://doi.org/10.1021/jm0512037 Actions

Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α

JOURNAL ARTICLE published 1 March 2007 in Journal of Medicinal Chemistry

Authors: Katherine L. Lee | Megan A. Foley | Lihren Chen | Mark L. Behnke | Frank E. Lovering | Steven J. Kirincich | Weiheng Wang | Jaechul Shim | Steve Tam | Marina W. H. Shen | SooPeang Khor | Xin Xu | Debra G. Goodwin | Manjunath K. Ramarao | Cheryl Nickerson-Nutter | Frances Donahue | M. Sherry Ku | James D. Clark | John C. McKew

https://doi.org/10.1021/jm061131z Actions

Synthesis and Antiviral Activity of Novel 5-(1-Cyanamido-2-haloethyl) and 5-(1-Hydroxy(or methoxy)-2-azidoethyl) Analogues of Uracil Nucleosides

JOURNAL ARTICLE published 1 October 2001 in Journal of Medicinal Chemistry

Authors: Rakesh Kumar | Dinesh Rai | Sanjay K. Sharma | Holly A. Saffran | Ryan Blush | D. Lorne J. Tyrrell

https://doi.org/10.1021/jm010226s Actions

Synthesis and Biological Evaluation of Selective Aromatase Expression Regulators in Breast Cancer Cells

JOURNAL ARTICLE published 1 April 2007 in Journal of Medicinal Chemistry

Authors: Bin Su | Serena Landini | Danyetta D. Davis | Robert W. Brueggemeier

https://doi.org/10.1021/jm061133j Actions

Preparation of Asymmetric Urea Derivatives that Target Prostate-Specific Membrane Antigen for SPECT Imaging

JOURNAL ARTICLE published 24 October 2013 in Journal of Medicinal Chemistry

Authors: Naoya Harada | Hiroyuki Kimura | Masahiro Ono | Hideo Saji

https://doi.org/10.1021/jm400895s Actions

Targeting Metalloenzymes by Boron-Containing Metal-Binding Pharmacophores

JOURNAL ARTICLE published 23 December 2021 in Journal of Medicinal Chemistry

Research funded by National Natural Science Foundation of China (81874291,82073698,82122065) | Higher Education Discipline Innovation Project (B18035) | West China Hospital of Sichuan University (ZYJC18024) | Sichuan Science and Technology Program (22GJHZ0253)

Authors: You-Cai Xiao | Jun-Lin Yu | Qing-Qing Dai | Gen Li | Guo-Bo Li

https://doi.org/10.1021/acs.jmedchem.1c01691 Actions

Characterization and Solubilization of Pyrrole–Imidazole Polyamide Aggregates

JOURNAL ARTICLE published 14 June 2012 in Journal of Medicinal Chemistry

Authors: Amanda E. Hargrove | Jevgenij A. Raskatov | Jordan L. Meier | David C. Montgomery | Peter B. Dervan

https://doi.org/10.1021/jm300380a Actions

Discovery of Biarylaminoquinazolines as Novel Tubulin Polymerization Inhibitors

JOURNAL ARTICLE published 12 June 2014 in Journal of Medicinal Chemistry

Authors: Giovanni Marzaro | Antonio Coluccia | Alessandro Ferrarese | Paola Brun | Ignazio Castagliuolo | Maria Teresa Conconi | Giuseppe La Regina | Ruoli Bai | Romano Silvestri | Ernest Hamel | Adriana Chilin

https://doi.org/10.1021/jm500034j Actions

Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogs

JOURNAL ARTICLE published April 1991 in Journal of Medicinal Chemistry

Authors: Gregory S. Bisacchi | Abbe Braitman | Christopher W. Cianci | Junius M. Clark | A. Kirk Field | Moira E. Hagen | Deborah R. Hockstein | Mary F. Malley | Toomas Mitt

https://doi.org/10.1021/jm00108a026 Actions

Discovery of Novel PPAR Ligands by a Virtual Screening Approach Based on Pharmacophore Modeling, 3D Shape, and Electrostatic Similarity Screening

JOURNAL ARTICLE published 23 October 2008 in Journal of Medicinal Chemistry

Authors: Patrick Markt | Rasmus K. Petersen | Esben N. Flindt | Karsten Kristiansen | Johannes Kirchmair | Gudrun Spitzer | Simona Distinto | Daniela Schuster | Gerhard Wolber | Christian Laggner | Thierry Langer

https://doi.org/10.1021/jm800128k Actions

Emerging Therapies for the Prevention or Treatment of Postmenopausal Osteoporosis

JOURNAL ARTICLE published 1 January 1999 in Journal of Medicinal Chemistry

Authors: Masahiko Sato | Timothy A. Grese | Jeffrey A. Dodge | Henry U. Bryant | Charles H. Turner

https://doi.org/10.1021/jm980344o Actions

Synthesis, Molecular Modeling Studies, and Pharmacological Activity of Selective A1Receptor Antagonists

JOURNAL ARTICLE published 1 October 2002 in Journal of Medicinal Chemistry

Authors: Francesco Bondavalli | Maurizio Botta | Olga Bruno | Andrea Ciacci | Federico Corelli | Paola Fossa | Antonio Lucacchini | Fabrizio Manetti | Claudia Martini | Giulia Menozzi | Luisa Mosti | Angelo Ranise | Silvia Schenone | Andrea Tafi | Maria Letizia Trincavelli

https://doi.org/10.1021/jm0209580 Actions

Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

JOURNAL ARTICLE published 25 April 2013 in Journal of Medicinal Chemistry

Authors: Kevin W. Hunt | Adam W. Cook | Ryan J. Watts | Christopher T. Clark | Guy Vigers | Darin Smith | Andrew T. Metcalf | Indrani W. Gunawardana | Michael Burkard | April A. Cox | Mary K. Geck Do | Darrin Dutcher | Allen A. Thomas | Sumeet Rana | Nicholas C. Kallan | Robert K. DeLisle | James P. Rizzi | Kelly Regal | Douglas Sammond | Robert Groneberg | Michael Siu | Hans Purkey | Joseph P. Lyssikatos | Allison Marlow | Xingrong Liu | Tony P. Tang

https://doi.org/10.1021/jm4002154 Actions

Synthesis of Cytotoxic 6E-Hydroximino-4-ene Steroids:  Structure/Activity Studies

JOURNAL ARTICLE published 1 August 2001 in Journal of Medicinal Chemistry

Authors: Noé Deive | Jaime Rodríguez | Carlos Jiménez

https://doi.org/10.1021/jm010867n Actions

Design, Synthesis, and Inhibitory Activity of Potent, Photoswitchable Mast Cell Activation Inhibitors

JOURNAL ARTICLE published 13 June 2013 in Journal of Medicinal Chemistry

Authors: Willem A. Velema | Marco van der Toorn | Wiktor Szymanski | Ben L. Feringa

https://doi.org/10.1021/jm400115k Actions

Piperidino Groups in Antitussive Activity

JOURNAL ARTICLE published March 1963 in Journal of Medicinal Chemistry

Authors: Yoshitoshi Kasé | Tomokazu Yuizono | Mieko Muto

https://doi.org/10.1021/jm00338a007 Actions

Design and SAR of Novel Potassium Channel Openers Targeted for Urge Urinary Incontinence. 2. Selective and Potent Benzylamino Cyclobutenediones

JOURNAL ARTICLE published 1 March 2000 in Journal of Medicinal Chemistry

Authors: Adam M. Gilbert | Madelene M. Antane | Thomas M. Argentieri | John A. Butera | Gerardo D. Francisco | Chris Freeden | Eric G. Gundersen | Russell F. Graceffa | David Herbst | Bradford H. Hirth | Joseph R. Lennox | Geraldine McFarlane | N. Wesley Norton | Dominick Quagliato | Jeffrey H. Sheldon | Dawn Warga | Alexandra Wojdan | Morgan Woods

https://doi.org/10.1021/jm9905108 Actions

Modeling Cyclooxygenase Inhibition. Implication of Active Site Hydration on the Selectivity of Ketoprofen Analogues

JOURNAL ARTICLE published 1 June 2000 in Journal of Medicinal Chemistry

Authors: Albert Palomer | Juan J. Pérez | Susana Navea | Oriol Llorens | Jaume Pascual | Lluïsa García | David Mauleón

https://doi.org/10.1021/jm9906217 Actions
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