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Synthesis, in Vitro Evaluation, and Radiolabeling of Fluorinated Puromycin Analogues: Potential Candidates for PET Imaging of Protein Synthesis

JOURNAL ARTICLE published 27 October 2016 in Journal of Medicinal Chemistry

Research funded by Medical Research Council (G9219778)

Authors: Helen M. Betts | Selena Milicevic Sephton | Carmen Tong | Ramla O. Awais | Philip J. Hill | Alan C. Perkins | Franklin I. Aigbirhio

https://doi.org/10.1021/acs.jmedchem.6b00968 Actions

Discovery of Novel Tricyclic Full Agonists for the G-Protein-Coupled Niacin Receptor 109A with Minimized Flushing in Rats

JOURNAL ARTICLE published 23 April 2009 in Journal of Medicinal Chemistry

Authors: Hong C. Shen | Fa-Xiang Ding | Qiaolin Deng | Larissa C. Wilsie | Mihajlo L. Krsmanovic | Andrew K. Taggart | Ester Carballo-Jane | Ning Ren | Tian-Quan Cai | Tsuei-Ju Wu | Kenneth K. Wu | Kang Cheng | Qing Chen | Michael S. Wolff | Xinchun Tong | Tom G. Holt | M. Gerard Waters | Milton L. Hammond | James R. Tata | Steven L. Colletti

https://doi.org/10.1021/jm900151e Actions

Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70

JOURNAL ARTICLE published 26 May 2016 in Journal of Medicinal Chemistry

Research funded by Cancer Research UK (C309/A11566,C309/A8274)

Authors: Matthew D. Cheeseman | Isaac M. Westwood | Olivier Barbeau | Martin Rowlands | Sarah Dobson | Alan M. Jones | Fiona Jeganathan | Rosemary Burke | Nadia Kadi | Paul Workman | Ian Collins | Rob L. M. van Montfort | Keith Jones

https://doi.org/10.1021/acs.jmedchem.5b02001 Actions

In VivoAnti-Chagas Vinylthio-, Vinylsulfinyl-, and Vinylsulfonylbenzofuroxan Derivatives

JOURNAL ARTICLE published 1 November 2007 in Journal of Medicinal Chemistry

Authors: Williams Porcal | Paola Hernández | Mariana Boiani | Gabriela Aguirre | Lucía Boiani | Agustina Chidichimo | Juan J. Cazzulo | Nuria E. Campillo | Juan A. Paez | Ana Castro | R. Luise Krauth-Siegel | Carolina Davies | Miguel Ángel Basombrío | Mercedes González | Hugo Cerecetto

https://doi.org/10.1021/jm070604e Actions

Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists

JOURNAL ARTICLE published 1 November 2007 in Journal of Medicinal Chemistry

Authors: Jianguo Ji | Michael R. Schrimpf | Kevin B. Sippy | William H. Bunnelle | Tao Li | David J. Anderson | Connie Faltynek | Carol S. Surowy | Tino Dyhring | Philip K. Ahring | Michael D. Meyer

https://doi.org/10.1021/jm070755h Actions

Activity of Sulfonium Bisphosphonates on Tumor Cell Lines

JOURNAL ARTICLE published 1 November 2007 in Journal of Medicinal Chemistry

Authors: Yonghui Zhang | Michael P. Hudock | Kilannin Krysiak | Rong Cao | Kyle Bergan | Fenglin Yin | Annette Leon | Eric Oldfield

https://doi.org/10.1021/jm700991k Actions

Synthesis, Potency, and In Vivo Profiles of Quinoline Containing Histamine H3Receptor Inverse Agonists

JOURNAL ARTICLE published 1 November 2007 in Journal of Medicinal Chemistry

Authors: Robert J. Altenbach | Huaqing Liu | Patricia N. Banfor | Kaitlin E. Browman | Gerard B. Fox | Ryan M. Fryer | Victoria A. Komater | Kathleen M. Krueger | Kennan Marsh | Thomas R. Miller | Jia Bao Pan | Liping Pan | Minghua Sun | Christine Thiffault | Jill Wetter | Chen Zhao | Deliang Zhou | Timothy A. Esbenshade | Arthur A. Hancock | Marlon D. Cowart

https://doi.org/10.1021/jm0705051 Actions

Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes

JOURNAL ARTICLE published 13 May 2021 in Journal of Medicinal Chemistry

Research funded by California Institute for Regenerative Medicine (TR4-06857)

Authors: John R. Cashman | Daniel Ryan | Wesley L. McKeithan | Karl Okolotowicz | Jorge Gomez-Galeno | Mark Johnson | Kevin J. Sampson | Robert S. Kass | Arash Pezhouman | Hrayr S. Karagueuzian | Mark Mercola

https://doi.org/10.1021/acs.jmedchem.0c01545 Actions

Design, Synthesis, and Multivariate Quantitative Structure−Activity Relationship of SalicylanilidesPotent Inhibitors of Type III Secretion inYersinia

JOURNAL ARTICLE published 1 November 2007 in Journal of Medicinal Chemistry

Authors: Markus K. Dahlgren | Anna M. Kauppi | Ing-Marie Olsson | Anna Linusson | Mikael Elofsson

https://doi.org/10.1021/jm070741b Actions

Structure−Activity Studies of Novel Cyanoguanidine ATP-Sensitive Potassium Channel Openers for the Treatment of Overactive Bladder

JOURNAL ARTICLE published 1 November 2007 in Journal of Medicinal Chemistry

Authors: Arturo Perez-Medrano | Michael E. Brune | Steven A. Buckner | Michael J. Coghlan | Thomas A. Fey | Murali Gopalakrishnan | Robert J. Gregg | Michael E. Kort | Victoria E. Scott | James P. Sullivan | Kristi L. Whiteaker | William A. Carroll

https://doi.org/10.1021/jm7010194 Actions

Bifunctional and Unusual Amino Acid β- or γ-Ester Prodrugs of Nucleoside Analogues for Improved Affinity to ATB0,+ and Enhanced Metabolic Stability: An Application to Floxuridine

JOURNAL ARTICLE published 8 October 2020 in Journal of Medicinal Chemistry

Research funded by National Natural Science Foundation of China (81360485,81560577,81860630) | Natural Science Foundation of Jiangxi Province (20181BAB205087) | Key Project of Jiangxi (20192ACB70012)

Authors: Yongbing Sun | Yu Ke | Chunshi Li | Jian Wang | Liangxing Tu | Lvjiang Hu | Yi Jin | Hao Chen | Jianping Gong | Zhiqiang Yu

https://doi.org/10.1021/acs.jmedchem.0c00149 Actions

Syntheses and Biological Activities (Topoisomerase Inhibition and Antitumor and Antimicrobial Properties) of Rebeccamycin Analogues Bearing Modified Sugar Moieties and Substituted on the Imide Nitrogen with a Methyl Group

JOURNAL ARTICLE published 1 October 1997 in Journal of Medicinal Chemistry

Authors: Fabrice Anizon | Laure Belin | Pascale Moreau | Martine Sancelme | Aline Voldoire | Michelle Prudhomme | Monique Ollier | Danièle Sevère | Jean-François Riou | Christian Bailly | Doriano Fabbro | Thomas Meyer

https://doi.org/10.1021/jm9702084 Actions

Synthesis and Antitumor Activities of Novel 6-5 Fused Ring Heterocycle Antifolates: N-[4-[.omega.-(2-Amino-4-substituted-6,7-dihydrocyclopenta[d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic Acids

JOURNAL ARTICLE published May 1994 in Journal of Medicinal Chemistry

Authors: Yoshihiko Kotake | Atsumi Iijima | Kentaro Yoshimatsu | Naoko Tamai | Yoichi Ozawa | Nozomu Koyanagi | Kyosuke Kitoh | Hiroaki Nomura

https://doi.org/10.1021/jm00037a012 Actions

Development of a Small Hybrid Molecule That Mediates Degradation of His-Tag Fused Proteins

JOURNAL ARTICLE published 25 January 2018 in Journal of Medicinal Chemistry

Research funded by Japan Society for the Promotion of Science (16H05090,16K15121,26460169)

Authors: Koyo Okitsu | Takayuki Hattori | Takashi Misawa | Takuji Shoda | Masaaki Kurihara | Mikihiko Naito | Yosuke Demizu

https://doi.org/10.1021/acs.jmedchem.7b00413 Actions

Kinase-likeness and Kinase-Privileged Fragments: Toward Virtual Polypharmacology

JOURNAL ARTICLE published 13 March 2008 in Journal of Medicinal Chemistry

Authors: Alex M. Aronov | Brian McClain | Cameron Stuver Moody | Mark A. Murcko

https://doi.org/10.1021/jm701021b Actions

Preventive Oral Treatment with Resveratrol Pro-prodrugs Drastically Reduce Colon Inflammation in Rodents

JOURNAL ARTICLE published 28 October 2010 in Journal of Medicinal Chemistry

Authors: Mar Larrosa | Joao Tomé-Carneiro | María J. Yáñez-Gascón | David Alcántara | María V. Selma | David Beltrán | María T. García-Conesa | Cristina Urbán | Ricardo Lucas | Francisco Tomás-Barberán | Juan C. Morales | Juan Carlos Espín

https://doi.org/10.1021/jm1007006 Actions

Design, Synthesis, and Biological Evaluation of Monopyrrolinone-Based HIV-1 Protease Inhibitors

JOURNAL ARTICLE published 1 May 2003 in Journal of Medicinal Chemistry

Authors: Amos B. Smith | Louis-David Cantin | Alexander Pasternak | Lisa Guise-Zawacki | Wenquin Yao | Adam K. Charnley | Joseph Barbosa | Paul A. Sprengeler | Ralph Hirschmann | Sanjeev Munshi | David B. Olsen | William A. Schleif | Lawrence C. Kuo

https://doi.org/10.1021/jm0204587 Actions

Development of Novel Aminoglycoside (NB54) with Reduced Toxicity and Enhanced Suppression of Disease-Causing Premature Stop Mutations

JOURNAL ARTICLE published 14 May 2009 in Journal of Medicinal Chemistry

Authors: Igor Nudelman | Annie Rebibo-Sabbah | Marina Cherniavsky | Valery Belakhov | Mariana Hainrichson | Fuquan Chen | Jochen Schacht | Daniel S. Pilch | Tamar Ben-Yosef | Timor Baasov

https://doi.org/10.1021/jm801640k Actions

Design, Synthesis, and Antiviral Activity of Certain 2,5,6-Trihalo-1-(.beta.-D-ribofuranosyl)benzimidazoles

JOURNAL ARTICLE published September 1995 in Journal of Medicinal Chemistry

Authors: Leroy B. Townsend | Rodrigo V. Devivar | Steven R. Turk | M. Reza Nassiri | John C. Drach

https://doi.org/10.1021/jm00020a025 Actions

Synthesis and Anticancer Activity of Brefeldin A Ester Derivatives

JOURNAL ARTICLE published 1 June 2006 in Journal of Medicinal Chemistry

Authors: Nwanne O. Anadu | V. Jo Davisson | Mark Cushman

https://doi.org/10.1021/jm0602817 Actions
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