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Showing results for ISSN matching 0022-2623

Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors

JOURNAL ARTICLE published 26 November 2009 in Journal of Medicinal Chemistry

Authors: Coco N. Kapanda | Giulio G. Muccioli | Geoffray Labar | Jacques H. Poupaert | Didier M. Lambert

https://doi.org/10.1021/jm901323s Actions

Flavonoid Derivatives as Adenosine Receptor Antagonists:  A Comparison of the Hypothetical Receptor Binding Site Based on a Comparative Molecular Field Analysis Model

JOURNAL ARTICLE published 1 January 1998 in Journal of Medicinal Chemistry

Authors: Stefano Moro | A. Michiel van Rhee | Lawrence H. Sanders | Kenneth A. Jacobson

https://doi.org/10.1021/jm970446z Actions

New Bis(2-aminoimidazoline) and Bisguanidine DNA Minor Groove Binders with Potent in Vivo Antitrypanosomal and Antiplasmodial Activity

JOURNAL ARTICLE published 1 February 2008 in Journal of Medicinal Chemistry

Authors: Fernando Rodríguez | Isabel Rozas | Marcel Kaiser | Reto Brun | Binh Nguyen | W. David Wilson | Rory Nelson García | Christophe Dardonville

https://doi.org/10.1021/jm7013088 Actions

Synthesis, Molecular Pharmacology, and Structure–Activity Relationships of 3-(Indanoyl)indoles as Selective Cannabinoid Type 2 Receptor Antagonists

JOURNAL ARTICLE published 13 May 2021 in Journal of Medicinal Chemistry

Research funded by National Institute on Drug Abuse (R01 DA039143) | National Institute of General Medical Sciences (P20 GM130456)

Authors: Harvey F. Fulo | Amal Shoeib | Christian V. Cabanlong | Alexander H. Williams | Chang-Guo Zhan | Paul L. Prather | Gregory B. Dudley

https://doi.org/10.1021/acs.jmedchem.1c00442 Actions

Portage transport of sulfanilamide and sulfanilic acid

JOURNAL ARTICLE published March 1989 in Journal of Medicinal Chemistry

Authors: Se Young Hwang | David A. Berges | John J. Taggart | Charles Gilvarg

https://doi.org/10.1021/jm00123a034 Actions

Structure−Activity Relationship Study on Anti-HIV 6-Desfluoroquinolones

JOURNAL ARTICLE published 11 September 2008 in Journal of Medicinal Chemistry

Authors: Oriana Tabarrini | Serena Massari | Dirk Daelemans | Miguel Stevens | Giuseppe Manfroni | Stefano Sabatini | Jan Balzarini | Violetta Cecchetti | Christophe Pannecouque | Arnaldo Fravolini

https://doi.org/10.1021/jm701585h Actions

Synthesis and Biological Activity of 2,22-Dimethylene Analogues of 19-Norcalcitriol and Related Compounds

JOURNAL ARTICLE published 9 July 2020 in Journal of Medicinal Chemistry

Authors: Izabela K. Sibilska-Kaminski | Rafal R. Sicinski | Lori A. Plum | Hector F. DeLuca

https://doi.org/10.1021/acs.jmedchem.0c00580 Actions

Chemistry and Pharmacological Characterization of Novel Nitrogen Analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(Azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-Nicotinic Acetylcholine Receptor-Selective Partial Agonists

JOURNAL ARTICLE published 14 October 2010 in Journal of Medicinal Chemistry

Authors: Jianhua Liu | J. Brek Eaton | Barbara Caldarone | Ronald J. Lukas | Alan P. Kozikowski

https://doi.org/10.1021/jm100765u Actions

Design, Synthesis, and in Vitro and in Vivo Evaluation of High Affinity and Specificity Near-Infrared Fluorescent Bombesin Antagonists for Tumor Imaging

JOURNAL ARTICLE published 13 September 2018 in Journal of Medicinal Chemistry

Research funded by U.S. Department of Veterans Affairs (1I01BX003392) | Medical Research and Materiel Command (W91ZSQ8335N612) | U.S. Department of Defense (W81XWH0920176)

Authors: Hang Xu | Rajendra P. Bandari | Li Lee | Ran Li | Ping Yu | Charles J. Smith | Lixin Ma

https://doi.org/10.1021/acs.jmedchem.8b00614 Actions

Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1

JOURNAL ARTICLE published 28 October 2021 in Journal of Medicinal Chemistry

Authors: Daniel Zaienne | Sabine Willems | Simone Schierle | Jan Heering | Daniel Merk

https://doi.org/10.1021/acs.jmedchem.1c01077 Actions

Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

JOURNAL ARTICLE published 22 June 2017 in Journal of Medicinal Chemistry

Authors: Gisele A. Nishiguchi | Alice Rico | Huw Tanner | Robert J. Aversa | Benjamin R. Taft | Sharadha Subramanian | Lina Setti | Matthew T. Burger | Lifeng Wan | Victoriano Tamez | Aaron Smith | Yan Lou | Paul A. Barsanti | Brent A. Appleton | Mulugeta Mamo | Laura Tandeske | Ina Dix | John E. Tellew | Shenlin Huang | Lesley A. Mathews Griner | Vesselina G. Cooke | Anne Van Abbema | Hanne Merritt | Sylvia Ma | Kalyani Gampa | Fei Feng | Jing Yuan | Yingyun Wang | Jacob R. Haling | Sepideh Vaziri | Mohammad Hekmat-Nejad | Johanna M. Jansen | Valery Polyakov | Richard Zang | Vijay Sethuraman | Payman Amiri | Mallika Singh | Emma Lees | Wenlin Shao | Darrin D. Stuart | Michael P. Dillon | Savithri Ramurthy

https://doi.org/10.1021/acs.jmedchem.6b01862 Actions

Structure-Based Design, Synthesis, and Biological Evaluation of Conformationally Restricted Novel 2-Alkylthio-6-[1-(2,6-difluorophenyl)alkyl]- 3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase

JOURNAL ARTICLE published 1 August 2001 in Journal of Medicinal Chemistry

Authors: Antonello Mai | Gianluca Sbardella | Marino Artico | Rino Ragno | Silvio Massa | Ettore Novellino | Giovanni Greco | Antonio Lavecchia | Chiara Musiu | Massimiliano La Colla | Chiara Murgioni | Paolo La Colla | Roberta Loddo

https://doi.org/10.1021/jm010853h Actions

Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction

JOURNAL ARTICLE published 26 August 2021 in Journal of Medicinal Chemistry

Research funded by National Cancer Institute (P30-CA76292) | Florida Breast Cancer Foundation (19012901) | Susan G. Komen (CCR16380693)

Authors: Zhen Wang | Min Zhang | Victor Quereda | Sylvia M. Frydman | Qianqian Ming | Vincent C. Luca | Derek R. Duckett | Haitao Ji

https://doi.org/10.1021/acs.jmedchem.1c00742 Actions

Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate

JOURNAL ARTICLE published 12 December 2019 in Journal of Medicinal Chemistry

Authors: Vidya Ramdas | Rashmi Talwar | Moloy Banerjee | Advait Arun Joshi | Amit Kumar Das | Deepak Sahebrao Walke | Prashant Borhade | Usha Dhayagude | Rajesh Loriya | Ganesh Gote | Apparao Bommakanti | Aruna Sivaram | Gautam Agarwal | Arnab Goswami | Prashant Nigade | Maneesh Mehta | Vinod Patil | Dipak Modi | Hemant Kumar | Sadanand Mallurwar | Amruta Dash | Falguni Modi | Sandip Kuldharan | Pratima Srivastava | Minakshi Singh | Lakshmi Narasimham | Jayasagar Gundu | Sharad Sharma | Rajender Kumar Kamboj | Venkata P. Palle

https://doi.org/10.1021/acs.jmedchem.9b01562 Actions

Tackling Antimicrobial Resistance with Small Molecules Targeting LsrK: Challenges and Opportunities

JOURNAL ARTICLE published 24 December 2020 in Journal of Medicinal Chemistry

Authors: Pasquale Linciano | Valeria Cavalloro | Emanuela Martino | Johannes Kirchmair | Roberta Listro | Daniela Rossi | Simona Collina

https://doi.org/10.1021/acs.jmedchem.0c01282 Actions

Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases

JOURNAL ARTICLE published 24 September 2015 in Journal of Medicinal Chemistry

Research funded by Australian Research Council (DP110100071,FT10100185)

Authors: Gregory M. Rankin | Daniela Vullo | Claudiu T. Supuran | Sally-Ann Poulsen

https://doi.org/10.1021/acs.jmedchem.5b01228 Actions

Exploration of the Amine Terminus in a Novel Series of 1,2,4-Triazolo-3-yl-azabicyclo[3.1.0]hexanes as Selective Dopamine D3 Receptor Antagonists

JOURNAL ARTICLE published 14 October 2010 in Journal of Medicinal Chemistry

Authors: Fabrizio Micheli | Luca Arista | Barbara Bertani | Simone Braggio | Anna Maria Capelli | Susanna Cremonesi | Romano Di-Fabio | Giacomo Gelardi | Gabriella Gentile | Carla Marchioro | Alessandra Pasquarello | Stefano Provera | Giovanna Tedesco | Luca Tarsi | Silvia Terreni | Angela Worby | Christian Heidbreder

https://doi.org/10.1021/jm100832d Actions

Structure−Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H4 Receptor Ligands

JOURNAL ARTICLE published 23 October 2008 in Journal of Medicinal Chemistry

Authors: Robert J. Altenbach | Ronald M. Adair | Brian M. Bettencourt | Lawrence A. Black | Shannon R. Fix-Stenzel | Sujatha M. Gopalakrishnan | Gin C. Hsieh | Huaqing Liu | Kennan C. Marsh | Michael J. McPherson | Ivan Milicic | Thomas R. Miller | Timothy A. Vortherms | Usha Warrior | Jill M. Wetter | Neil Wishart | David G. Witte | Prisca Honore | Timothy A. Esbenshade | Arthur A. Hancock | Jorge D. Brioni | Marlon D. Cowart

https://doi.org/10.1021/jm8005959 Actions

Quick Assembly of 1,4-Diphenyltriazoles as Probes Targeting β-Amyloid Aggregates in Alzheimer's Disease

JOURNAL ARTICLE published 1 July 2007 in Journal of Medicinal Chemistry

Authors: Wenchao Qu | Mei-Ping Kung | Catherine Hou | Shunichi Oya | Hank F. Kung

https://doi.org/10.1021/jm070467l Actions

Molecular Determinants of MAO Selectivity in a Series of Indolylmethylamine Derivatives:  Biological Activities, 3D-QSAR/CoMFA Analysis, and Computational Simulation of Ligand Recognition

JOURNAL ARTICLE published 1 May 2000 in Journal of Medicinal Chemistry

Authors: Jose A. Morón | Mercedes Campillo | Virgili Perez | Mercedes Unzeta | Leonardo Pardo

https://doi.org/10.1021/jm991164x Actions
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