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Structure−Selectivity Investigations of D2-Like Receptor Ligands by CoMFA and CoMSIA Guiding the Discovery of D3Selective PET Radioligands

JOURNAL ARTICLE published 8 February 2007 in Journal of Medicinal Chemistry

Authors: Ismail Salama | Carsten Hocke | Wolfgang Utz | Olaf Prante | Frank Boeckler | Harald Hübner | Torsten Kuwert | Peter Gmeiner

https://doi.org/10.1021/jm0611152 Actions

2,6,8-Trisubstituted 1-Deazapurines as Adenosine Receptor Antagonists

JOURNAL ARTICLE published 1 February 2007 in Journal of Medicinal Chemistry

Authors: Lisa C. W. Chang | Jacobien K. von Frijtag Drabbe Künzel | Thea Mulder-Krieger | Joost Westerhout | Thomas Spangenberg | Johannes Brussee | Adriaan P. IJzerman

https://doi.org/10.1021/jm0607956 Actions

Design, Synthesis, Structure−Selectivity Relationship, and Effect on Human Cancer Cells of a Novel Series of Histone Deacetylase 6-Selective Inhibitors

JOURNAL ARTICLE published 1 November 2007 in Journal of Medicinal Chemistry

Authors: Yukihiro Itoh | Takayoshi Suzuki | Akiyasu Kouketsu | Nobuaki Suzuki | Satoko Maeda | Minoru Yoshida | Hidehiko Nakagawa | Naoki Miyata

https://doi.org/10.1021/jm7009217 Actions

Modeling, Chemistry, and Biology of the Benzolactam Analogues of Indolactam V (ILV). 2. Identification of the Binding Site of the Benzolactams in the CRD2 Activator-Binding Domain of PKCδ and Discovery of an ILV Analogue of Improved Isozyme Selectivity

JOURNAL ARTICLE published 1 April 1997 in Journal of Medicinal Chemistry

Authors: Alan P. Kozikowski | Shaomeng Wang | Dawei Ma | Jiangchao Yao | Shakeel Ahmad | Robert I. Glazer | Krisztina Bogi | Peter Acs | Shayan Modarres | Nancy E. Lewin | Peter M. Blumberg

https://doi.org/10.1021/jm960875h Actions

Receptor Surface Models. 1. Definition and Construction

JOURNAL ARTICLE published June 1995 in Journal of Medicinal Chemistry

Authors: Mathew Hahn

https://doi.org/10.1021/jm00012a007 Actions

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JOURNAL ARTICLE published 1 July 1960 in Journal of Medicinal Chemistry

https://doi.org/10.1021/jm50011a902 Actions

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JOURNAL ARTICLE published 1 February 1961 in Journal of Medicinal Chemistry

https://doi.org/10.1021/jm50014a908 Actions

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JOURNAL ARTICLE published 1 April 1961 in Journal of Medicinal Chemistry

https://doi.org/10.1021/jm50015a903 Actions

Discovery of Orally Bioavailable 1,3,4-Trisubstituted 2-Oxopiperazine-Based Melanocortin-4 Receptor Agonists as Potential Antiobesity Agents

JOURNAL ARTICLE published 9 October 2008 in Journal of Medicinal Chemistry

Authors: Xinrong Tian | Adrian G. Switzer | Steve A. Derose | Rajesh K. Mishra | Mark G. Solinsky | Rashid N. Mumin | Frank H. Ebetino | Lalith R. Jayasinghe | Mark E. Webster | Anny-Odile Colson | Doreen Crossdoersen | Beth B. Pinney | Julie A. Farmer | Martin E. Dowty | Cindy M. Obringer | Charles A. Cruze | Melissa L. Burklow | Paula M. Suchanek | Lily Dong | Mary Kay Dirr | Russell J. Sheldon | John A. Wos

https://doi.org/10.1021/jm800525p Actions

Narcotic antagonists. 4. Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists

JOURNAL ARTICLE published March 1975 in Journal of Medicinal Chemistry

Authors: Elliot F. Hahn | Jack Fishman | Richard D. Heilman

https://doi.org/10.1021/jm00237a008 Actions

Novel Bis(1H-indol-2-yl)methanones as Potent Inhibitors of FLT3 and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

JOURNAL ARTICLE published 1 June 2006 in Journal of Medicinal Chemistry

Authors: Siavosh Mahboobi | Andrea Uecker | Andreas Sellmer | Christophe Cénac | Heymo Höcher | Herwig Pongratz | Emerich Eichhorn | Harald Hufsky | Antje Trümpler | Marit Sicker | Florian Heidel | Thomas Fischer | Carol Stocking | Sigurd Elz | Frank-D. Böhmer | Stefan Dove

https://doi.org/10.1021/jm058033i Actions

(+)-cis-N-(para-, meta-, and ortho-substituted benzyl)-N-normetazocines: Synthesis and binding affinity at the [3H]-(+)-pentazocine-labeled (.sigma.1) site and quantitative structure-affinity relationship studies

JOURNAL ARTICLE published February 1995 in Journal of Medicinal Chemistry

Authors: S. Wayne Mascarella | Xu Bai | Wanda Williams | Bethel Sine | Wayne D. Bowen | F. Ivy Carroll

https://doi.org/10.1021/jm00003a019 Actions

Iodinated 2-Aminotetralins and 3-Amino-1-benzopyrans: Ligands for Dopamine D2 and D3 Receptors

JOURNAL ARTICLE published November 1994 in Journal of Medicinal Chemistry

Authors: Sumalee Chumpradit | Mei-Ping Kung | Janet Vessotskie | Catherine Foulon | Mu Mu | Hank F. Kung

https://doi.org/10.1021/jm00050a021 Actions

Novel Ligands Rationally Designed for Characterizing I2−Imidazoline Binding Sites Nature and Functions

JOURNAL ARTICLE published 1 August 2008 in Journal of Medicinal Chemistry

Authors: Francesco Gentili | Claudia Cardinaletti | Cristian Vesprini | Francesca Ghelfi | Aniket Farande | Mario Giannella | Alessandro Piergentili | Wilma Quaglia | Laura Mattioli | Marina Perfumi | Alan Hudson | Maria Pigini

https://doi.org/10.1021/jm800400k Actions

Stereoselective syntheses of the trans-decahydroquinoline-5-carboxylic acid epimers. Diastereomeric zwitterionic probes of .gamma.-aminobutyric acid-related biological properties in vitro and in vivo

JOURNAL ARTICLE published January 1986 in Journal of Medicinal Chemistry

Authors: Donald T. Witiak | Raymond J. Patch | S. J. Enna | Yiu K. Fung

https://doi.org/10.1021/jm00151a001 Actions

Potent angiotensin II antagonists with non-.beta.-branched amino acids in position 5

JOURNAL ARTICLE published February 1989 in Journal of Medicinal Chemistry

Authors: J. Samanen | D. Narindray | T. Cash | E. Brandeis | W. Adams | T. Yellin | D. Eggleston | C. DeBrosse | D. Regoli

https://doi.org/10.1021/jm00122a030 Actions

Rigid amino acids related to .alpha.-methyldopa

JOURNAL ARTICLE published May 1974 in Journal of Medicinal Chemistry

Authors: Joseph G. Cannon | John P. O'Donnell | John P. Rosazza | Charles R. Hoppin

https://doi.org/10.1021/jm00251a029 Actions

Probes for narcotic receptor mediated phenomena. 18. Epimeric 6.alpha.- and 6.beta.-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5.alpha.-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6.beta.-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5.alpha.-epoxymorphinan

JOURNAL ARTICLE published July 1992 in Journal of Medicinal Chemistry

Authors: Brian R. De Costa | Michael J. Iadarola | Richard B. Rothman | Karen F. Berman | Clifford George | Amy H. Newman | Artin Mahboubi | Arthur E. Jacobson | Kenner C. Rice

https://doi.org/10.1021/jm00093a016 Actions

Conformational Analysis of Ketolide, Conformations of RU 004 in Solution and Bound to Bacterial Ribosomes

JOURNAL ARTICLE published 1 August 1998 in Journal of Medicinal Chemistry

Authors: Gildas Bertho | Josyane Gharbi-Benarous | Marcel Delaforge | Catherine Lang | Annick Parent | Jean-Pierre Girault

https://doi.org/10.1021/jm970852i Actions

Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site

JOURNAL ARTICLE published September 1990 in Journal of Medicinal Chemistry

Authors: Michael S. Allen | Yun C. Tan | Mark L. Trudell | Kris Narayanan | Liesl R. Schindler | Michael J. Martin | Christopher Schultz | Timothy J. Hagen | Konrad F. Koehler

https://doi.org/10.1021/jm00171a007 Actions
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