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2242P Engineering immune-cell targeting nanoparticles for precise delivery of loaded-cargo and enhanced immunotherapy efficacy

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Research funded by National Research Foundation of Korea (2023-00208913)

Authors: N.K. Lee | W. Park | S. KIM | C.G. Park

430P Real-world patient characteristics and treatment patterns in HR+/HER2+ metastatic breast cancer patients in 5 European countries

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: C. Criscitiello | K. Lewis | A. Lambert | G. Thomason | E. Broughton

632P Predictive value of C-reactive protein (CRP) in microsatellite-stable (MSS) metastatic colorectal cancer (mCRC) patients given first-line alternating short-course oxaliplatin-based chemotherapy (FLOX) and nivolumab

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: S. Meltzer | J.P. Berg | H.M. Hamre | C. Kersten | E. Hofsli | M.G. Guren | H. Sorbye | K. Flatmark | A.H. Ree

105P A phase II study of SHR-1316 plus IBI310 in patients with advanced intrahepatic cholangiocarcinoma after failure of first-line therapy

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: J. Fan | J. Zhou | G. SHI | X. Huang | X. Guo | J. Lu | F. Liang | Y. Chen | D. Wu | Y. Ji | Y. Hou | X. Meng | Z. Tang | X. Huang | Q. Ye | S. Qiu | Q. Gao | Y. Shi | H. Sun | H. Li

1369P BrigAlec study: Focus on alectinib efficacy after brigatinib exposure in BrigALK2 study (GFPC 02-2019)

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: R. Descourt | F. Guisier | M. Pérol | J. Cadranel | M. Duruisseaux | H. Doubre | S. Culine | C. Lamour | D. Moro-Sibilot | B. Mennecier | N. Martin | O. Bylicki | C. Chouaid | L. Greillier

1024MO Interpretable AI-identified spatial tumor microenvironment (TME) neighborhoods associate with severe immune-related adverse events (irAE) and progressive disease (PD) in patients with melanoma treated with anti-PD-1-based therapy

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: D. Jimenez-Sanchez | E.M. Will | J. Lai | G. Warrier | E.J. Lipson | J.S. Deutsch | A.S. Szalay | J. Taube

1824P Treatment patterns among novel hormonal therapy-experienced patients with metastatic castration-resistant prostate cancer

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: V. Narayan | M. Patel | S. Teitsson | L. Rosenblatt | X. Yin | K.A. Betts | I. Pivneva | S. Gao | M. Sundar

2350P Single-cell RNA-seq dissecting the initiating liver metastasis cells in various cancers

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: S-Y. Zheng | X. Guan

1183MO Molecular characterization of rectal neuroendocrine tumors (NETs) with unfavorable prognosis by multiomics analysis: A multicenter retrospective cohort study (GARNET)

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: T. Shibuki | N. Mizuno | N. Kobayashi | H. Hirano | T. Tsuchikawa | S. Matsumoto | H. Okuyama | E. Sasaki | K. Shinjo | R. Yamaguchi | T. Kawata | W. Hosoda

1673P Trajectories of immune-related serum proteins and quality of life in patients with pancreatic and other periampullary cancer: The champ study

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: S. Olsson Hau | M. Svensson | A. Petersson | J. Eberhard | K. Jirström

784P HPV integration promotes HPV carcinogenesis via remodeling chromatin interactions between universal stripe factors and super-enhancer in HPV-related carcinoma

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Research funded by National Key Research and Development Program of China (21YFC2701201) | National Natural Science Foundation of China (82072895,82141106,82203453)

Authors: C. Cao | Z. Zhu | P. Wu

13P Disrupting the immunosuppressive tumor microenvironment using genetically engineered macrophages for triple-negative breast cancer therapy

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: S. Traxel | C. Beerli | F. Schmidt | V. Dinh-Van | R.F. Speck | S. Bredl

102P Potentially prognostic factors of overall survival in advanced biliary tract cancer in the randomised phase III TOPAZ-1 study

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: A.R. He | M. Bouattour | V.G. Gupta | L. Evesque | D.B. Zhen | J.O. Park | A. Sookprasert | A. Salvatierra | G.M. Vaccaro | S.C. Oh | S.A. Ostoich | T. Satoh | M. Żotkiewicz | N. Rokutanda | H. Kim | D-Y. Oh

2121P Association between nutritional status and adverse events in gastrointestinal cancer patients undergoing outpatient chemotherapy in Japan

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Research funded by Japan Society for the Promotion of Science (JP 16K07140)

Authors: N. Sato | F. Motoi | H. Imai | H. Shirota | C. Ishioka | M. Unno

1360P Updated patient-reported outcomes from the CROWN study: Analyses in first-line ALK+ patients with (w) and without (w/o) baseline brain metastases (BMs) and w or w/o central nervous system adverse events (CNS AEs)

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: G. Liu | Q. Zhou | B.J. Solomon | H. Le | A. Reisman | D. Thomaidou | F. Toffalorio | J. Mazieres

581P The effect of exercise intervention on defecation related symptoms of colorectal cancer patients a randomized controlled trial

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Research funded by Ministry of Health and Welfare (2021-22-0009,HA16C0012020020)

Authors: J. Jeon | D-H. Park | Y.J. LEE | T.H. Lee | E. Kim | C. Oh | R. Park | J.W. Kang | S. Jun | K. Chiho | S. Yeon

83P Impact of VHL-associated tumor treatment on mental health: An international patient survey

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: O. Iliopoulos | C. Atkinson | C. Cooper | G. Taylor-Stokes | J. Mann | M. Sundaram

1523P Phase II dose optimization results from MOUNTAINEER-02: A study of tucatinib, trastuzumab, ramucirumab, and paclitaxel for HER2+ gastroesophageal cancer (GEC)

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: M. Tehfe | J. Lee | S.Y. Rha | Y. Nakamura | J. Tabernero | K. Shitara | D-Y. Oh | J. Eads | J. Marshall | Z.A. Wainberg | K-W. Lee | Y-K. Kang | C-Y. Liao | S.Y. Oh | K-H. Yeh | D. Richards | M.M. Ubowski | K. Zhao | S. Bhaumik | J.H. Strickler

30P Prostaglandin signaling in tumour stroma interaction in colorectal cancer and its impact on the secretome and functional relevance

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: M. Macia-Guardado | M. Ertl | V. Lutz | E. Ebner | E. Koncina | S. Stang | M. Hengstschläger | E. Letellier | J. Schüler | H. Dolznig

720TiP Phase I, open-label, first-in-human (FIH) study of JZP815 in advanced or metastatic solid tumors harboring mitogen-activated protein kinase (MAPK) alterations

JOURNAL ARTICLE published October 2023 in Annals of Oncology

Authors: A-R. Naqash | J.S. Wang | C.A. Perez | J.T. Henry | B. Bashir | A. Panneerselvam | S. Markova | R.S. Cheung | D.R. Spigel