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Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

Journal Article published 14 Feb 2018 in Science Translational Medicine volume 10 issue 428 on page eaaf7444

Research funded by National Institutes of Health (award300282, 5R03MH090846) | National Center for Advancing Translational Sciences (award300284, U54MH084681) | Stiftelsen för Strategisk Forskning (award300279) | Cancerfonden (award300280) | Karolinska Institutet (award300277) | Knut och Alice Wallenbergs Stiftelse (award300281) | Oblique Therapeutics AB (award360288) | Vetenskapsrådet (award300278)

Authors: William C. Stafford, Xiaoxiao Peng, Maria Hägg Olofsson, Xiaonan Zhang, Diane K. Luci, Li Lu, Qing Cheng, Lionel Trésaugues, Thomas S. Dexheimer, Nathan P. Coussens, Martin Augsten, Hanna-Stina Martinsson Ahlzén, Owe Orwar, Arne Östman, Sharon Stone-Elander, David J. Maloney, Ajit Jadhav, Anton Simeonov, Stig Linder, Elias S. J. Arnér