Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers

JOURNAL ARTICLE published 1 January 2019 in Clinical Cancer Research

Research funded by NIH NCI (T32 CA-009666) | NIH NCI (1-R01-CA207295)

Authors: Carl M. Gay | Pan Tong | Robert J. Cardnell | Triparna Sen | Xiao Su | Jun Ma | Rasha O. Bara | Faye M. Johnson | Chris Wakefield | John V. Heymach | Jing Wang | Lauren A. Byers

Refining Immunotherapy Approvals

JOURNAL ARTICLE published 1 September 2017 in Clinical Cancer Research

Authors: Susan E. Bates

Disruption of in vivo Chronic Lymphocytic Leukemia Tumor–Microenvironment Interactions by Ibrutinib – Findings from an Investigator-Initiated Phase II Study

JOURNAL ARTICLE published 1 April 2016 in Clinical Cancer Research

Authors: Carsten U. Niemann | Sarah E.M. Herman | Irina Maric | Julio Gomez-Rodriguez | Angelique Biancotto | Betty Y. Chang | Sabrina Martyr | Maryalice Stetler-Stevenson | Constance M. Yuan | Katherine R. Calvo | Raul C. Braylan | Janet Valdez | Yuh Shan Lee | Deanna H. Wong | Jade Jones | Clare Sun | Gerald E. Marti | Mohammed Z.H. Farooqui | Adrian Wiestner

Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial)

JOURNAL ARTICLE published 15 November 2020 in Clinical Cancer Research

Research funded by Dainippon Sumitomo Pharma (NA)

Authors: Akihito Kawazoe | Yasutoshi Kuboki | Eiji Shinozaki | Hiroki Hara | Tomohiro Nishina | Yoshito Komatsu | Satoshi Yuki | Masashi Wakabayashi | Shogo Nomura | Akihiro Sato | Takeshi Kuwata | Masahito Kawazu | Hiroyuki Mano | Yosuke Togashi | Hiroyoshi Nishikawa | Takayuki Yoshino

A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors

JOURNAL ARTICLE published 15 November 2019 in Clinical Cancer Research

Research funded by Swiss National Science Foundation (31003A_166245) | NIH (P01 CA114046,P50 CA174523,U54 CA224070)

Authors: Andrea Aloia | Daniela Müllhaupt | Christophe D. Chabbert | Tanja Eberhart | Stefanie Flückiger-Mangual | Ana Vukolic | Ossia Eichhoff | Anja Irmisch | Leila T. Alexander | Ernesto Scibona | Dennie T. Frederick | Benchun Miao | Tian Tian | Chaoran Cheng | Lawrence N. Kwong | Zhi Wei | Ryan J. Sullivan | Genevieve M. Boland | Meenhard Herlyn | Keith T. Flaherty | Nicola Zamboni | Reinhard Dummer | Gao Zhang | Mitchell P. Levesque | Wilhelm Krek | Werner J. Kovacs

Camrelizumab Plus Gemcitabine, Vinorelbine, and Pegylated Liposomal Doxorubicin in Relapsed/Refractory Primary Mediastinal B-Cell Lymphoma: A Single-Arm, Open-Label, Phase II Trial

JOURNAL ARTICLE published 1 September 2020 in Clinical Cancer Research

Research funded by Science & Technology from Beijing (Z181100006318004) | National Natural Science Foundation of China (81773248) | National Natural Science Foundation of China (31991171,81830002) | National Key Research and Development Program of China (2016YFC1303501,2016YFC1303504) | National Excellent Young Scholar Science Fund (2017-YQPY-003)

Authors: Qian Mei | Wenying Zhang | Yang Liu | Qingming Yang | John E.J. Rasko | Jing Nie | Jiejie Liu | Xiang Li | Liang Dong | Meixia Chen | Yan Zhang | Lu Shi | Huitao Wu | Weidong Han

Rare, Pathogenic Germline Variants in Fanconi Anemia Genes Increase Risk for Squamous Lung Cancer

JOURNAL ARTICLE published 1 March 2019 in Clinical Cancer Research

Research funded by LUNGevity Foundation (N/A) | Icahn School of Medicine at Mount Sinai (ISMMS) (N/A)

Authors: Myvizhi Esai Selvan | Robert J. Klein | Zeynep H. Gümüş

Prospero Homeobox 1 Promotes Epithelial–Mesenchymal Transition in Colon Cancer Cells by Inhibiting E-cadherin via miR-9

JOURNAL ARTICLE published 1 December 2012 in Clinical Cancer Research

Authors: Mei-Hsuan Lu | Chao-Cheng Huang | Mei-Ren Pan | Hong-Hwa Chen | Wen-Chun Hung

Phase I, First-in-Human Study of the Probody Therapeutic CX-2029 in Adults with Advanced Solid Tumor Malignancies

JOURNAL ARTICLE published 15 August 2021 in Clinical Cancer Research

Authors: Melissa Johnson | Anthony El-Khoueiry | Navid Hafez | Nehal Lakhani | Hirva Mamdani | Jordi Rodon | Rachel E. Sanborn | Javier Garcia-Corbacho | Valentina Boni | Mark Stroh | Alison L. Hannah | Song Wang | Henry Castro | Alexander Spira

Anti–CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers—Letter

JOURNAL ARTICLE published 1 June 2019 in Clinical Cancer Research

Authors: Roberto Ferrara | Sandrine Susini | Aurelien Marabelle

Palbociclib Rechallenge for Hormone Receptor–Positive/HER-Negative Advanced Breast Cancer: Findings from the Phase II BioPER Trial

JOURNAL ARTICLE published 4 January 2023 in Clinical Cancer Research

Research funded by Pfizer Foundation (na)

Authors: Joan Albanell | José Manuel Pérez-García | Miguel Gil-Gil | Giuseppe Curigliano | Manuel Ruíz-Borrego | Laura Comerma | Joan Gibert | Meritxell Bellet | Begoña Bermejo | Lourdes Calvo | Juan de la Haba | Enrique Espinosa | Alessandro Marco Minisini | Vanesa Quiroga | Ana Santaballa Bertran | Leonardo Mina | Beatriz Bellosillo | Federico Rojo | Silvia Menéndez | Miguel Sampayo-Cordero | Crina Popa | Andrea Malfettone | Javier Cortés | Antonio Llombart-Cussac

Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML

JOURNAL ARTICLE published 15 April 2018 in Clinical Cancer Research

Authors: Andreas T. Björklund | Mattias Carlsten | Ebba Sohlberg | Lisa L. Liu | Trevor Clancy | Mohsen Karimi | Sarah Cooley | Jeffrey S. Miller | Monika Klimkowska | Marie Schaffer | Emma Watz | Kristina Wikström | Pontus Blomberg | Björn Engelbrekt Wahlin | Marzia Palma | Lotta Hansson | Per Ljungman | Eva Hellström-Lindberg | Hans-Gustaf Ljunggren | Karl-Johan Malmberg

SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity

JOURNAL ARTICLE published 15 November 2018 in Clinical Cancer Research

Research funded by Prostate Cancer UK (PG13-036) | Royal Marsden Biomedical Research Centre flagship (A34)

Authors: Gunther Boysen | Daniel N. Rodrigues | Pasquale Rescigno | George Seed | David Dolling | Ruth Riisnaes | Mateus Crespo | Zafeiris Zafeiriou | Semini Sumanasuriya | Diletta Bianchini | Joanne Hunt | Deirdre Moloney | Raquel Perez-Lopez | Nina Tunariu | Susana Miranda | Inês Figueiredo | Ana Ferreira | Rossitza Christova | Veronica Gil | Sara Aziz | Claudia Bertan | Flavia M. de Oliveira | Mark Atkin | Matthew Clarke | Jane Goodall | Adam Sharp | Theresa MacDonald | Mark A. Rubin | Wei Yuan | Christopher E. Barbieri | Suzanne Carreira | Joaquin Mateo | Johann S. de Bono

MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia

JOURNAL ARTICLE published 15 April 2013 in Clinical Cancer Research

Authors: David C. de Leeuw | Willemijn van den Ancker | Fedor Denkers | Renée X. de Menezes | Theresia M. Westers | Gert J. Ossenkoppele | Arjan A. van de Loosdrecht | Linda Smit

Significance of Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer Patients within a Randomized, Phase II Trial: TBCRC 019

JOURNAL ARTICLE published 15 June 2015 in Clinical Cancer Research

Authors: Costanza Paoletti | Yufeng Li | Maria C. Muñiz | Kelley M. Kidwell | Kimberly Aung | Dafydd G. Thomas | Martha E. Brown | Vandana G. Abramson | William J. Irvin | Nancy U. Lin | Minetta C. Liu | Rita Nanda | Julie R. Nangia | Anna M. Storniolo | Tiffany A. Traina | Christos Vaklavas | Catherine H. Van Poznak | Antonio C. Wolff | Andres Forero-Torres | Daniel F. Hayes

Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer

JOURNAL ARTICLE published 15 December 2018 in Clinical Cancer Research

Research funded by UAB-HudsonAlpha Center (R01CA200653,5I01BX002930) | UAB Comprehensive Cancer Center (P30CA013148)

Authors: Sandeep Shelar | Eun-Hee Shim | Garrett J. Brinkley | Anirban Kundu | Francesca Carobbio | Tyler Poston | Jubilee Tan | Vishwas Parekh | Daniel Benson | David K. Crossman | Phillip J. Buckhaults | Dinesh Rakheja | Richard Kirkman | Yusuke Sato | Seishi Ogawa | Shilpa Dutta | Sadanandan E. Velu | Ethan Emberley | Alison Pan | Jason Chen | Tony Huang | Devin Absher | Anja Becker | Conrad Kunick | Sunil Sudarshan

APOBEC and Cancer Viroimmunotherapy: Thinking the Unthinkable

JOURNAL ARTICLE published 15 June 2021 in Clinical Cancer Research

Research funded by NIH (P50 CA210964,R01CA108961)

Authors: Richard G. Vile | Alan Melcher | Hardev Pandha | Kevin J. Harrington | Jose S. Pulido

Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation

JOURNAL ARTICLE published 1 March 2009 in Clinical Cancer Research

Authors: Xianping Shi | Yanli Jin | Chao Cheng | Hui Zhang | Waiyi Zou | Qin Zheng | Zhongzheng Lu | Qi Chen | Yingrong Lai | Jingxuan Pan

Inflammation Mediates the Development of Aggressive Breast Cancer Following Radiotherapy

JOURNAL ARTICLE published 15 March 2021 in Clinical Cancer Research

Research funded by NASA (NNX09AM52G,NNX13AF06G) | NIH (R01CA190980)

Authors: Lin Ma | Alba Gonzalez-Junca | Yufei Zheng | Haoxu Ouyang | Irineu Illa-Bochaca | Kathleen C. Horst | Gregor Krings | Yinghao Wang | Ignacio Fernandez-Garcia | William Chou | Mary Helen Barcellos-Hoff

ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer

JOURNAL ARTICLE published 1 February 2019 in Clinical Cancer Research

Research funded by NIH (CA082088) | NIH (CA008748) | NIH (R21CA218976) | NCI (1K08CA219504)

Authors: Qiang Li | Alexis W. Damish | Zoë Frazier | David Liu | Elizaveta Reznichenko | Atanas Kamburov | Andrew Bell | Huiyong Zhao | Emmet J. Jordan | S. Paul Gao | Jennifer Ma | Philip H. Abbosh | Joaquim Bellmunt | Elizabeth R. Plimack | Jean-Bernard Lazaro | David B. Solit | Dean Bajorin | Jonathan E. Rosenberg | Alan D. D'Andrea | Nadeem Riaz | Eliezer M. Van Allen | Gopa Iyer | Kent W. Mouw