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A Robust Kilo-Scale Synthesis of Doravirine

JOURNAL ARTICLE published 19 August 2016 in Organic Process Research & Development

Authors: Louis-Charles Campeau | Qinghao Chen | Danny Gauvreau | Mélina Girardin | Kevin Belyk | Peter Maligres | Guoyue Zhou | Chaozhan Gu | Wei Zhang | Lushi Tan | Paul D. O’Shea

https://doi.org/10.1021/acs.oprd.6b00163 Actions

Optimization of Copper(I)-Catalyzed 1,6-Conjugate Addition of a Methyl Group to 17β-Acetoxy-4,6-estradien-3-one

JOURNAL ARTICLE published 1 November 2004 in Organic Process Research & Development

Authors: Jacek Martynow | Małgorzata Krupa | Andrzej Leś | Andrzej Kutner | Wiesław Szelejewski

https://doi.org/10.1021/op040010a Actions

A Practical Method for Functionalized Peptide or Amide Bond Formation in Aqueous−Ethanol Media with EDC as Activator

JOURNAL ARTICLE published 20 March 2009 in Organic Process Research & Development

Authors: Yangwei John Pu | Radhe K. Vaid | Sathish K. Boini | Robert W. Towsley | Christopher W. Doecke | David Mitchell

https://doi.org/10.1021/op800240d Actions

Thermal Analysis of Pharmaceuticals. Edited by D. Q. M. Craig, and M.  Reading. CRC Press, Boca Raton, Florida, 2007.

JOURNAL ARTICLE published March 2008 in Organic Process Research & Development

Authors: Terry Threlfall

https://doi.org/10.1021/op800006v Actions

A New Route for the Preparation of 5-Hydroxyisophthalic Acid

JOURNAL ARTICLE published 1 September 2002 in Organic Process Research & Development

Authors: Mark Gelmont | Jakob Oren

https://doi.org/10.1021/op0100302 Actions

Kinetic Study of Addition of Some Carboxylic Acids to 1,2-Epoxy-3-phenoxypropane

JOURNAL ARTICLE published 1 November 1999 in Organic Process Research & Development

Authors: Agnieszka Bukowska | Wiktor Bukowski

https://doi.org/10.1021/op9900479 Actions

Process Development for Purification of Therapeutic Antisense Oligonucleotides by Anion-Exchange Chromatography

JOURNAL ARTICLE published 1 May 2000 in Organic Process Research & Development

Authors: Ranjit R. Deshmukh | Jamie E. Miller | Patricia De Leon | William E. Leitch | Douglas L. Cole | Yogesh S. Sanghvi

https://doi.org/10.1021/op990091o Actions

Chiral Separation of Naproxen with Immobilized Liquid Phases

JOURNAL ARTICLE published 19 February 2016 in Organic Process Research & Development

Research funded by Institute for Sustainable Process Technology (PH-00-01)

Authors: Sandra Corderí | Caecilia R. Vitasari | Michal Gramblicka | Thierry Giard | Boelo Schuur

https://doi.org/10.1021/acs.oprd.6b00020 Actions

Oligonucleotide Purification by Ion Exchange Chromatography: A Step-by-Step Guide to Process Understanding, Modeling, and Simulation

JOURNAL ARTICLE published 11 April 2024 in Organic Process Research & Development

Authors: Kilian Kobl | Lucrèce Nicoud | Edouard Nicoud | Anna Watson | John Andrews | Edward A. Wilkinson | Muhid Shahid | Christopher McKay | Benjamin I. Andrews | Batool Ahmed Omer | Olga Narducci | Edward Masson | Suzanne H. Davies | Tobias Vandermeersch

https://doi.org/10.1021/acs.oprd.4c00013 Actions

Epoxidation of Styrene to Styrene Oxide: Synergism of Heteropoly Acid and Phase-Transfer Catalyst under Ishii−Venturello Mechanism

JOURNAL ARTICLE published 1 March 2000 in Organic Process Research & Development

Authors: G. D. Yadav | A. A. Pujari

https://doi.org/10.1021/op990055p Actions

Preparation of Enantiopure 3-Aminopiperidine and 3-Aminoazepane Derivatives from Ornithine and Lysine. Consecutive Syntheses of Pharmacologically Active Analogs, Such as Besifloxacin

JOURNAL ARTICLE published 21 October 2022 in Organic Process Research & Development

Authors: Ingo Schiffers | Marcus Frings | Britta Maria Kübber | Khai-Nghi Truong | Kari Rissanen | Carsten Bolm

https://doi.org/10.1021/acs.oprd.2c00152 Actions

Evaluation of Kilogram-Scale Sonagashira, Suzuki, and Heck Coupling Routes to Oncology Candidate CP-724,714

JOURNAL ARTICLE published 1 July 2005 in Organic Process Research & Development

Authors: David H. Brown Ripin | Dennis E. Bourassa | Thomas Brandt | Michael J. Castaldi | Heather N. Frost | Joel Hawkins | Phillip J. Johnson | Stephen S. Massett | Karin Neumann | James Phillips | Jeffery W. Raggon | Peter R. Rose | Jennifer L. Rutherford | Barbara Sitter | A. Morgan Stewart | Michael G. Vetelino | Lulin Wei

https://doi.org/10.1021/op050039u Actions

Continuous-Flow Sequential Schotten–Baumann Carbamoylation and Acetate Hydrolysis in the Synthesis of Capecitabine

JOURNAL ARTICLE published 15 November 2019 in Organic Process Research & Development

Authors: Leandro S. de M. Miranda | Rodrigo O. M. A. de Souza | Raquel A. C. Leão | Paula F. Carneiro | Sergio F. Pedraza | Otavio V. de Carvalho | Stefânia P. de Souza | Rebeca V. Neves

https://doi.org/10.1021/acs.oprd.9b00206 Actions

The Impact of Solvent Quality on the Heck Reaction: Detection of Hydroperoxide in 1-Methyl-2-pyrrolidinone (NMP)

JOURNAL ARTICLE published 19 March 2021 in Organic Process Research & Development

Authors: Qiaogong Su | Hayao Matsuhashi

https://doi.org/10.1021/acs.oprd.0c00432 Actions

A Practical Telescoped Three-Step Sequence for the Preparation of (1R,2R)-2-(4-Bromobenzoyl)cyclohexanecarboxylic Acid: A Key Building Block Used in One of Our Drug Development Projects

JOURNAL ARTICLE published 18 May 2018 in Organic Process Research & Development

Authors: Staffan Karlsson | Rolf Bergman | Johan Broddefalk | Christian Löfberg | Peter R. Moore | Andrew Stark | Hans Emtenäs

https://doi.org/10.1021/acs.oprd.8b00066 Actions

Ionic Liquids on Demand in Continuous Flow

JOURNAL ARTICLE published 18 September 2009 in Organic Process Research & Development

Authors: Daniel Wilms | Johannes Klos | Andreas F. M. Kilbinger | Holger Löwe | Holger Frey

https://doi.org/10.1021/op900069a Actions

A Robust, Streamlined Approach to Bosutinib Monohydrate

JOURNAL ARTICLE published 15 March 2013 in Organic Process Research & Development

Authors: Gregory J. Withbroe | Chris Seadeek | Kevin P. Girard | Steven M. Guinness | Brian C. Vanderplas | Rajappa Vaidyanathan

https://doi.org/10.1021/op300087r Actions

Regulatory Highlights for March−August 2008

JOURNAL ARTICLE published 19 September 2008 in Organic Process Research & Development

Authors: Derek Robinson

https://doi.org/10.1021/op800187a Actions

First Scale-Up Synthesis of WAY-262398, a Novel, Dual-Acting SSRI/5HT1a Antagonist

JOURNAL ARTICLE published 16 January 2009 in Organic Process Research & Development

Authors: Antonia Nikitenko | Asaf Alimardanov | Jay Afragola | Jean Schmid | Livia Kristofova | Deborah Evrard | Nicole T. Hatzenbuhler | Vasilios Marathias | Gary Stack | Steve Lenicek | John Potoski

https://doi.org/10.1021/op8002085 Actions

Introduction and Editorial to the Phase-Transfer Catalysis Special Feature Section

JOURNAL ARTICLE published 1 July 2008 in Organic Process Research & Development

Authors: Jaan Pesti | Marc Halpern

https://doi.org/10.1021/op800116x Actions
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