Glucagon‐like peptide‐1 receptor agonists to expand the healthy lifespan: Current and future potentials

JOURNAL ARTICLE published May 2023 in Aging Cell

Authors: Frederik Flindt Kreiner | Bernt Johan von Scholten | Peter Kurtzhals | Stephen Charles Langford Gough

Reduced endosomal microautophagy activity in aging associates with enhanced exocyst‐mediated protein secretion

JOURNAL ARTICLE published October 2022 in Aging Cell

Research funded by American Federation for Aging Research (Sagol Network GerOmics Award) | National Cancer Institute (CA244780) | National Institute of Diabetes and Digestive and Kidney Diseases (DK098408) | National Institute of Neurological Disorders and Stroke (NS095435,NS100717) | National Institute on Aging (AG021904,AG031782,AG054108,AG062359) | NIH Office of the Director (1S10OD030286)

Authors: Gregory J. Krause | Antonio Diaz | Maryam Jafari | Rabia R. Khawaja | Esperanza Agullo‐Pascual | Olaya Santiago‐Fernández | Alicia L. Richards | Kuei‐Ho Chen | Phillip Dmitriev | Yan Sun | Stephanie K. See | Kotb Abdelmohsen | Krystyna Mazan‐Mamczarz | Nevan J. Krogan | Myriam Gorospe | Danielle L. Swaney | Simone Sidoli | Jose Javier Bravo‐Cordero | Martin Kampmann | Ana Maria Cuervo

A rationally designed fluorescence probe achieves highly specific and long‐term detection of senescence in vitro and in vivo

JOURNAL ARTICLE published August 2023 in Aging Cell

Research funded by National Natural Science Foundation of China (22277131,82171558)

Authors: Li Hu | Chanjuan Dong | Zhe Wang | Shengyuan He | Yiwen Yang | Meiting Zi | Huiqin Li | Yanghuan Zhang | Chuanjie Chen | Runzi Zheng | Shuting Jia | Jing Liu | Xuan Zhang | Yonghan He

Type I IFN stimulates lymph node stromal cells from adult and old mice during a West Nile virus infection

JOURNAL ARTICLE published April 2023 in Aging Cell

Research funded by National Institute of Allergy and Infectious Diseases (R01AI150672)

Authors: Allison K. Bennett | Michelle Richner | Madeline D. Mun | Justin M. Richner

Genetic context drives age‐related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits

JOURNAL ARTICLE published February 2024 in Aging Cell

Research funded by National Institute on Aging (AG055104,AG062409,AG079877)

Authors: Sarah E. Heuer | Emily W. Nickerson | Gareth R. Howell | Erik B. Bloss

Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice

JOURNAL ARTICLE published April 2023 in Aging Cell

Authors: Xiuli Dan | Beimeng Yang | Ross A. McDevitt | Samuel Gray | Xixia Chu | Quia Claybourne | David M. Figueroa | Yongqing Zhang | Deborah L. Croteau | Vilhelm A. Bohr

Characterization of age‐associated exhausted CD8⁺ T cells defined by increased expression of Tim‐3 and PD‐1

JOURNAL ARTICLE published April 2016 in Aging Cell

Authors: Kyoo‐A Lee | Kwang‐Soo Shin | Ga‐Young Kim | You Chan Song | Eun‐Ah Bae | Il‐Kyu Kim | Choong‐Hyun Koh | Chang‐Yuil Kang

Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain

JOURNAL ARTICLE published July 2023 in Aging Cell

Research funded by American Heart Association (AHA834339,CDA941290) | Center for Strategic Scientific Initiatives, National Cancer Institute (P30 CA225520,R01CA255840) | National Institute of General Medical Sciences (P30 GM110766‐01) | National Institute of Neurological Disorders and Stroke (R01NS100782) | National Institute on Aging (K01AG073613,K01AG073614,P30AG050911,R01AG055395,R01AG068295,R01AG070915,R03AG070479,RF1AG072295)

Authors: Chetan Ahire | Adam Nyul‐Toth | Jordan DelFavero | Rafal Gulej | Janet A. Faakye | Stefano Tarantini | Tamas Kiss | Anna Kuan‐Celarier | Priya Balasubramanian | Anna Ungvari | Amber Tarantini | Raghavendra Nagaraja | Feng Yan | Qinggong Tang | Peter Mukli | Tamas Csipo | Andriy Yabluchanskiy | Judith Campisi | Zoltan Ungvari | Anna Csiszar

Extracellular adenosine signaling reverses the age‐driven decline in the ability of neutrophils to kill Streptococcus pneumoniae

JOURNAL ARTICLE published October 2020 in Aging Cell

Research funded by National Institute of Aging (R00AG051784)

Authors: Manmeet Bhalla | Shaunna R. Simmons | Alexsandra Abamonte | Sydney E. Herring | Sara E. Roggensack | Elsa N. Bou Ghanem

Transcriptomics age acceleration in prolonged treated HIV infection

JOURNAL ARTICLE published October 2023 in Aging Cell

Authors: Flora Mikaeloff | Marco Gelpi | Alejandra Escos | Andreas D. Knudsen | Julie Høgh | Thomas Benfield | João Pedro de Magalhães | Susanne D. Nielsen | Ujjwal Neogi

Oculopharyngeal muscular dystrophy mutations link the RNA‐binding protein HNRNPQ to autophagosome biogenesis

JOURNAL ARTICLE published October 2023 in Aging Cell

Authors: Hasan Ishtayeh | Margarita Galves | Tania T. Barnatan | Yevgeny Berdichevsky | Fatima Amer‐Sarsour | Metsada Pasmanik‐Chor | Itzhak Braverman | Sergiu C. Blumen | Avraham Ashkenazi

Heterochromatic silencing of immune‐related genes in glia is required for BBB integrity and normal lifespan in drosophila

JOURNAL ARTICLE published October 2023 in Aging Cell

Research funded by National Natural Science Foundation of China (31970697,32270812) | Science and Technology Commission of Shanghai Municipality (201409003300,2019SHZDZX02,20490712600)

Authors: Shunpan Shu | Mingsheng Jiang | Xue Deng | Wenkai Yue | Xu Cao | Kai Zhang | Zeqing Wang | Hao He | Jihong Cui | Qiangqiang Wang | Kun Qu | Yanshan Fang

A model of canine leukocyte telomere dynamics

JOURNAL ARTICLE published December 2011 in Aging Cell

Authors: Athanase Benetos | Masayuki Kimura | Carlos Labat | Gerald M. Buchoff | Shell Huber | Laura Labat | Xiaobin Lu | Abraham Aviv

Nitrones as therapeutics in age‐related diseases

JOURNAL ARTICLE published February 2006 in Aging Cell

Authors: Robert A. Floyd

coq7/clk‐1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q

JOURNAL ARTICLE published October 2004 in Aging Cell

Authors: Daisuke Nakai | Takahiko Shimizu | Hidetoshi Nojiri | Satoshi Uchiyama | Hideo Koike | Mayumi Takahashi | Katsuiku Hirokawa | Takuji Shirasawa

Amyloid β‐peptide 31–35‐induced neuronal apoptosis is mediated by caspase‐dependent pathways via cAMP‐dependent protein kinase A activation

JOURNAL ARTICLE published February 2008 in Aging Cell

Authors: Li Zhao | Zhong‐Ming Qian | Ce Zhang | Ho Yung Wing | Fang Du | Ke Ya

Alzheimer’s disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR‐edited human neuronal cells

JOURNAL ARTICLE published June 2022 in Aging Cell

Research funded by National Institute on Aging (P30AG013846,R01AG048927,R01AG054672,R01AG066429,R01AG067763,RF1AG054199,RF1AG057519,U01AG032984,U01AG058654,U01AG062602,U19AG068753)

Authors: Yang You | Samuel W. Hersh | Roshanak Aslebagh | Scott A. Shaffer | Seiko Ikezu | Jesse Mez | Kathryn L. Lunetta | Mark W. Logue | Lindsay A. Farrer | Tsuneya Ikezu

Oestradiol or genistein rescues neurons from amyloid beta‐induced cell death by inhibiting activation of p38

JOURNAL ARTICLE published February 2008 in Aging Cell

Authors: Soraya L. Vallés | Consuelo Borrás | Juan Gambini | Jessica Furriol | Angel Ortega | Juan Sastre | Federico V. Pallardó | Jose Viña

Gene expression changes in long‐term culture of T‐cell clones: genomic effects of chronic antigenic stress in aging and immunosenescence

JOURNAL ARTICLE published April 2007 in Aging Cell

Authors: Dawn J. Mazzatti | Andrew White | Rosalyn J. Forsey | Jonathan R. Powell | Graham Pawelec

Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging

JOURNAL ARTICLE published December 2021 in Aging Cell

Research funded by National Institutes of Health (R01AG056397)

Authors: Manisha Dixit | Silvana Duran‐Ortiz | Godze Yildirim | Sher Bahadur Poudel | Leeann D. Louis | Andrzej Bartke | Mitchell B. Schaffler | John J. Kopchick | Shoshana Yakar