Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy
Authors: Judith Wienke | Lindy L. Visser | Waleed M. Kholosy | Kaylee M. Keller | Marta Barisa | Evon Poon | Sophie Munnings-Tomes | Courtney Himsworth | Elizabeth Calton | Ana Rodriguez | Ronald Bernardi | Femke van den Ham | Sander R. van Hooff | Yvette A.H. Matser | Michelle L. Tas | Karin P.S. Langenberg | Philip Lijnzaad | Anne L. Borst | Elisa Zappa | Francisca J. Bergsma | Josephine G.M. Strijker | Bronte M. Verhoeven | Shenglin Mei | Amira Kramdi | Restuadi Restuadi | Alvaro Sanchez-Bernabeu | Annelisa M. Cornel | Frank C.P. Holstege | Juliet C. Gray | Godelieve A.M. Tytgat | Marijn A. Scheijde-Vermeulen | Marc H.W.A. Wijnen | Miranda P. Dierselhuis | Karin Straathof | Sam Behjati | Wei Wu | Albert J.R. Heck | Jan Koster | Stefan Nierkens | Isabelle Janoueix-Lerosey | Ronald R. de Krijger | Ninib Baryawno | Louis Chesler | John Anderson | Hubert N. Caron | Thanasis Margaritis | Max M. van Noesel | Jan J. Molenaar
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The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells
Authors: Darren F. Seals | Eduardo F. Azucena | Ian Pass | Lia Tesfay | Rebecca Gordon | Melissa Woodrow | James H. Resau | Sara A. Courtneidge
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A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization
Authors: Clare Pacini | Emma Duncan | Emanuel Gonçalves | James Gilbert | Shriram Bhosle | Stuart Horswell | Emre Karakoc | Howard Lightfoot | Ed Curry | Francesc Muyas | Monsif Bouaboula | Chandra Sekhar Pedamallu | Isidro Cortes-Ciriano | Fiona M. Behan | Lykourgos-Panagiotis Zalmas | Andrew Barthorpe | Hayley Francies | Steve Rowley | Jack Pollard | Pedro Beltrao | Leopold Parts | Francesco Iorio | Mathew J. Garnett
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Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5
Authors: Charles W.M Roberts | Monique M Leroux | Mark D Fleming | Stuart H Orkin
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ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
Authors: Elisa Bergaggio | Wei-Tien Tai | Andrea Aroldi | Carmen Mecca | Elisa Landoni | Manuel Nüesch | Ines Mota | Jasna Metovic | Luca Molinaro | Leyuan Ma | Diego Alvarado | Chiara Ambrogio | Claudia Voena | Rafael B. Blasco | Tongqing Li | Daryl Klein | Darrell J. Irvine | Mauro Papotti | Barbara Savoldo | Gianpietro Dotti | Roberto Chiarle
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Growth Factor Receptors Define Cancer Hierarchies
Authors: Monica Venere | Justin D. Lathia | Jeremy N. Rich
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Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma
Authors: Tracy-Ann Read | Marie P. Fogarty | Shirley L. Markant | Roger E. McLendon | Zhengzheng Wei | David W. Ellison | Phillip G. Febbo | Robert J. Wechsler-Reya
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Tony Pawson (1952–2013)
Authors: Joseph Schlessinger
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Mammary Ductal Environment Is Necessary for Faithful Maintenance of Estrogen Signaling in ER + Breast Cancer
Authors: Svasti Haricharan | Jonathan Lei | Matthew Ellis
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Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse
Authors: Liguo Zhang | Xuelian He | Xuezhao Liu | Feng Zhang | L. Frank Huang | Andrew S. Potter | Lingli Xu | Wenhao Zhou | Tao Zheng | Zaili Luo | Kalen P. Berry | Allison Pribnow | Stephanie M. Smith | Christine Fuller | Blaise V. Jones | Maryam Fouladi | Rachid Drissi | Zeng-Jie Yang | W. Clay Gustafson | Marc Remke | Scott L. Pomeroy | Emily J. Girard | James M. Olson | A. Sorana Morrissy | Maria C. Vladoiu | Jiao Zhang | Weidong Tian | Mei Xin | Michael D. Taylor | S. Steven Potter | Martine F. Roussel | William A. Weiss | Q. Richard Lu
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Antiapoptotic BCL-2 is required for maintenance of a model leukemia
Authors: Anthony Letai | Mia D. Sorcinelli | Caroline Beard | Stanley J. Korsmeyer
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Englerin A Stimulates PKCθ to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality
Authors: Carole Sourbier | Bradley T. Scroggins | Ranjala Ratnayake | Thomas L. Prince | Sunmin Lee | Min-Jung Lee | Peter Literati Nagy | Young H. Lee | Jane B. Trepel | John A. Beutler | W. Marston Linehan | Len Neckers
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Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression
Authors: Chi-Chiu Lau | Tingting Sun | Arthur K.K. Ching | Mian He | Jing-Woei Li | Alissa M. Wong | Ngai Na Co | Anthony W.H. Chan | Pik-Shan Li | Raymond W.M. Lung | Joanna H.M. Tong | Paul B.S. Lai | Henry L.Y. Chan | Ka-Fai To | Ting-Fung Chan | Nathalie Wong
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Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity
Authors: Xiaojie Yu | H.T. Claude Chan | Hayden Fisher | Christine A. Penfold | Jinny Kim | Tatyana Inzhelevskaya | C. Ian Mockridge | Ruth R. French | Patrick J. Duriez | Leon R. Douglas | Vikki English | J. Sjef Verbeek | Ann L. White | Ivo Tews | Martin J. Glennie | Mark S. Cragg
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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
Authors: Hye-Min Jeon | Jeong-Yub Kim | Hee Jin Cho | Won Jun Lee | Dayna Nguyen | Sung Soo Kim | Young Taek Oh | Hee-Jin Kim | Chan-Woong Jung | Gonzalo Pinero | Tanvi Joshi | Dolores Hambardzumyan | Takuya Sakaguchi | Christopher G. Hubert | Thomas M. McIntyre | Howard A. Fine | Candece L. Gladson | Bingcheng Wang | Benjamin W. Purow | Jong Bae Park | Myung Jin Park | Do-Hyun Nam | Jeongwu Lee
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Cancer therapeutics in yeast
Authors: Mary-Ann Bjornsti
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Serial assessment of measurable residual disease in medulloblastoma liquid biopsies
Authors: Anthony P.Y. Liu | Kyle S. Smith | Rahul Kumar | Leena Paul | Laure Bihannic | Tong Lin | Kendra K. Maass | Kristian W. Pajtler | Murali Chintagumpala | Jack M. Su | Eric Bouffet | Michael J. Fisher | Sridharan Gururangan | Richard Cohn | Tim Hassall | Jordan R. Hansford | Paul Klimo | Frederick A. Boop | Clinton F. Stewart | Julie H. Harreld | Thomas E. Merchant | Ruth G. Tatevossian | Geoffrey Neale | Matthew Lear | Jeffery M. Klco | Brent A. Orr | David W. Ellison | Richard J. Gilbertson | Arzu Onar-Thomas | Amar Gajjar | Giles W. Robinson | Paul A. Northcott
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The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance
Authors: Sunil K. Joshi | Tamilla Nechiporuk | Daniel Bottomly | Paul D. Piehowski | Julie A. Reisz | Janét Pittsenbarger | Andy Kaempf | Sara J.C. Gosline | Yi-Ting Wang | Joshua R. Hansen | Marina A. Gritsenko | Chelsea Hutchinson | Karl K. Weitz | Jamie Moon | Francesca Cendali | Thomas L. Fillmore | Chia-Feng Tsai | Athena A. Schepmoes | Tujin Shi | Osama A. Arshad | Jason E. McDermott | Ozgun Babur | Kevin Watanabe-Smith | Emek Demir | Angelo D'Alessandro | Tao Liu | Cristina E. Tognon | Jeffrey W. Tyner | Shannon K. McWeeney | Karin D. Rodland | Brian J. Druker | Elie Traer
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Single-chromosome Gains Commonly Function as Tumor Suppressors
Authors: Jason M. Sheltzer | Julie H. Ko | John M. Replogle | Nicole C. Habibe Burgos | Erica S. Chung | Colleen M. Meehl | Nicole M. Sayles | Verena Passerini | Zuzana Storchova | Angelika Amon
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Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia
Authors: Ngai Cheung | Tsz Kan Fung | Bernd B. Zeisig | Katie Holmes | Jayant K. Rane | Kerri A. Mowen | Michael G. Finn | Boris Lenhard | Li Chong Chan | Chi Wai Eric So
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