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Dissolution Mechanisms of Amorphous Solid Dispersions: Application of Ternary Phase Diagrams To Explain Release Behavior

JOURNAL ARTICLE published 1 April 2024 in Molecular Pharmaceutics

Authors: Alexandru Deac | Christian Luebbert | Qingqing Qi | Reagan M. Courtney | Anura S. Indulkar | Yi Gao | Geoff G. Z. Zhang | Gabriele Sadowski | Lynne S. Taylor

Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia

JOURNAL ARTICLE published 1 February 2021 in Molecular Pharmaceutics

Research funded by Comisi?n Nacional de Investigaci?n Cient?fica y Tecnol?gica (15130011,21120192,ACT192144) | Fondo Nacional de Desarrollo Cient?fico y Tecnol?gico (1181689)

Authors: Johanna Catalan-Figueroa | Mauricio A. García | Pilar Contreras | Constanza B. Boisset | Pablo M. Gonzalez | Jenny L. Fiedler | Mariela F. Pérez | Javier O. Morales

Conjugation of cRGD Peptide to Chlorophyll a Based Photosensitizer (HPPH) Alters Its Pharmacokinetics with Enhanced Tumor-Imaging and Photosensitizing (PDT) Efficacy

JOURNAL ARTICLE published 1 August 2011 in Molecular Pharmaceutics

Authors: Avinash Srivatsan | Manivannan Ethirajan | Suresh K. Pandey | Shipra Dubey | Xiang Zheng | Ting-Hsiu Liu | Masayuki Shibata | Joseph Missert | Janet Morgan | Ravindra K. Pandey

Investigating Key Molecular Descriptors Affecting Particle Size: A Predictive Exemplary Approach for Self-Emulsifying System

JOURNAL ARTICLE published 1 May 2023 in Molecular Pharmaceutics

Authors: Snehal Daware | Vishvesh Raje | Akanksha Patel | Ketan Patel

Oral Gene Delivery with cyclo-(d-Trp-Tyr) Peptide Nanotubes

JOURNAL ARTICLE published 7 May 2012 in Molecular Pharmaceutics

Authors: Wei-Hsien Hsieh | Shwu-Fen Chang | Hui-Min Chen | Jeng-Hsien Chen | Jiahorng Liaw

Toward Understanding the Binding Synergy of Trastuzumab and Pertuzumab to Human Epidermal Growth Factor Receptor 2

JOURNAL ARTICLE published 6 December 2021 in Molecular Pharmaceutics

Authors: Rohit Sharma | Manoj Kumbhakar | Archana Mukherjee

Fluorescent Self-Reporting Lipid Nanoparticles for Nitric Oxide/Gene Co-Delivery and Combination Therapy

JOURNAL ARTICLE published 6 February 2023 in Molecular Pharmaceutics

Research funded by National Natural Science Foundation of China (21977077)

Authors: Hui-Zhen Yang | Yu Guo | Lin Pu | Xiao-Qi Yu | Ji Zhang

Mapping of Translocator Protein (18 kDa) in Peripheral Sterile Inflammatory Disease and Cancer through PET Imaging

JOURNAL ARTICLE published 5 April 2021 in Molecular Pharmaceutics

Research funded by University Grants Commission (F.4-2/2006 (BSR)/CH/17-18/0261)

Authors: Anupriya Adhikari | Priya Singh | Kamalesh S Mahar | Manish Adhikari | Bhawana Adhikari | Ming-Rong Zhang | Anjani Kumar Tiwari

An In Vitro Model for Cocrystal Dissolution with Simultaneous Surface and Bulk Precipitation

JOURNAL ARTICLE published 6 November 2023 in Molecular Pharmaceutics

Research funded by Research Grants Council, University Grants Committee (16308122)

Authors: Nethrue Pramuditha Mendis | Richard Lakerveld

A Silk-Based Platform to Stabilize Phenylalanine Ammonia-lyase for Orally Administered Enzyme Replacement Therapy

JOURNAL ARTICLE published 5 December 2022 in Molecular Pharmaceutics

Research funded by National Institute of Child Health and Human Development (DP2HD091798) | Office of Naval Research (N00014-19-1-2399)

Authors: Luciana d’Amone | Vikas D. Trivedi | Nikhil U. Nair | Fiorenzo G. Omenetto

Influence of the Valine Zipper Region on the Structure and Aggregation of the Basic Leucine Zipper (bZIP) Domain of Activating Transcription Factor 5 (ATF5)

JOURNAL ARTICLE published 5 November 2012 in Molecular Pharmaceutics

Authors: Natalie A. Ciaccio | T. Steele Reynolds | C. Russell Middaugh | Jennifer S. Laurence

Phagocytic Uptake of Polymeric Particles by Immune Cells under Flow Conditions

JOURNAL ARTICLE published 6 December 2021 in Molecular Pharmaceutics

Research funded by The Wellcome Trust DBT India Alliance (IA/I/19/1/504265)

Authors: Megha Srinivas | Preeti Sharma | Siddharth Jhunjhunwala

Exploiting Transport Activity of P-Glycoprotein at the Blood–Brain Barrier for the Development of Peripheral Cannabinoid Type 1 Receptor Antagonists

JOURNAL ARTICLE published 7 May 2012 in Molecular Pharmaceutics

Authors: Hanneke G. M. Wittgen | Rick Greupink | Jeroen J. M. W. van den Heuvel | Petra H. H. van den Broek | Heike Dinter-Heidorn | Jan B. Koenderink | Frans G. M. Russel

Synthesis and Evaluation of [11C]MCC950 for Imaging NLRP3-Mediated Inflammation in Atherosclerosis

JOURNAL ARTICLE published 6 March 2023 in Molecular Pharmaceutics

Research funded by Canada Foundation for Innovation (JELF 36848,JELF 39358) | Institute of Circulatory and Respiratory Health (PJT 148968) | Natural Sciences and Engineering Research Council of Canada (RGPIN-2017-06167) | Ministry of Research and Innovation (ER17-13-119)

Authors: Uzair S. Ismailani | Ariel Buchler | Nicole MacMullin | Faduma Abdirahman | Myriam Adi | Benjamin H. Rotstein

Bacillus-Shape Design of Polymer Based Drug Delivery Systems with Janus-Faced Function for Synergistic Targeted Drug Delivery and More Effective Cancer Therapy

JOURNAL ARTICLE published 6 April 2015 in Molecular Pharmaceutics

Research funded by National Natural Science Foundation of China (81000660) | Natural Science Foundation of Fujian Province (2013J01384)

Authors: Fei Cui | Jinyan Lin | Yang Li | Yanxiu Li | Hongjie Wu | Fei Yu | Mengmeng Jia | Xiangrui Yang | Shichao Wu | Liya Xie | Shefang Ye | Fanghong Luo | Zhenqing Hou

A Pseudopolyrotaxane for Glucose-Responsive Insulin Release: The Effect of Binding Ability and Spatial Arrangement of Phenylboronic Acid Group

JOURNAL ARTICLE published 7 November 2016 in Molecular Pharmaceutics

Research funded by Japan Society for the Promotion of Science (25860027)

Authors: Tomohiro Seki | Keigo Abe | Yuya Egawa | Ryotaro Miki | Kazuhiko Juni | Toshinobu Seki

Versatile Reticular Polyethylenimine Derivative-Mediated Targeted Drug and Gene Codelivery for Tumor Therapy

JOURNAL ARTICLE published 6 October 2014 in Molecular Pharmaceutics

Research funded by Ministry of Education of the People's Republic of China (20110096120003,20113234120008,SDD2012-03) | China Pharmaceutical University (SKLNMKF201215,SKLNMKF201305) | National Natural Science Foundation of China (81102398,81273469,J1030830) | Graduate Cultivation Innovative Project of Jiangsu Province (CXLX13_30) | Fundamental Research Funds for the Central Universities (JKVD2013011) | Natural Science Foundation of Jiangsu Province (BK2011624)

Authors: Xuefang Ding | Wei Wang | Yazhe Wang | Xiuli Bao | Yu Wang | Cheng Wang | Jian Chen | Fangrong Zhang | Jianping Zhou

Synergistic Combination of Small Molecule Inhibitor and RNA Interference against Antiapoptotic Bcl-2 Protein in Head and Neck Cancer Cells

JOURNAL ARTICLE published 1 July 2013 in Molecular Pharmaceutics

Authors: Yen-Ling Lin | Yasemin Yuksel Durmaz | Jacques E. Nör | Mohamed E. H. ElSayed

Size and Surface Charge of Engineered Poly(amidoamine) Dendrimers Modulate Tumor Accumulation and Penetration: A Model Study Using Multicellular Tumor Spheroids

JOURNAL ARTICLE published 5 July 2016 in Molecular Pharmaceutics

Research funded by National Cancer Institute (R01-CA182528) | National Center for Research Resources (C06RR15482) | Division of Materials Research (1409161)

Authors: Jason Bugno | Hao-Jui Hsu | Ryan M. Pearson | Hyeran Noh | Seungpyo Hong

Oral Delivery of Puerarin Nanocrystals To Improve Brain Accumulation and Anti-Parkinsonian Efficacy

JOURNAL ARTICLE published 1 April 2019 in Molecular Pharmaceutics

Research funded by National Natural Science Foundation of China (81673627) | Natural Science Foundation of Guangdong Province (2018A030310623) | Guangzhou Science Technology and Innovation Commission (201805010005)

Authors: Sha Xiong | Wei Liu | Dongli Li | Xiaojia Chen | Fang Liu | Dongsheng Yuan | Huafeng Pan | Qi Wang | Shuhuan Fang | Tongkai Chen