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Human Serum Albumin and HER2-Binding Affibody Fusion Proteins for Targeted Delivery of Fatty Acid-Modified Molecules and Therapy

JOURNAL ARTICLE published 3 October 2016 in Molecular Pharmaceutics

Authors: Daoyuan Dong | Guanjun Xia | Zhijun Li | Zhiyu Li

Micelle System Based on Molecular Economy Principle for Overcoming Multidrug Resistance and Inhibiting Metastasis

JOURNAL ARTICLE published 5 March 2018 in Molecular Pharmaceutics

Research funded by Ministry of Education of the People's Republic of China (2015ZDTD048) | National Natural Science Foundation of China (81673374,81373360) | Wuhan Municipality (2017060201010146)

Authors: Yan Qi | Xianya Qin | Conglian Yang | Tingting Wu | Qi Qiao | Qingle Song | Zhiping Zhang

H2O2 Self-Supplying and GSH-Depleting Nanocatalyst for Copper Metabolism-Based Synergistic Chemodynamic Therapy and Chemotherapy

JOURNAL ARTICLE published 6 March 2023 in Molecular Pharmaceutics

Research funded by Ministry of Science and Technology of the People's Republic of China (2019YFA0705803) | Youth Innovation Promotion Association of the Chinese Academy of Sciences (2020190) | National Natural Science Foundation of China (51803174) | Southwest Petroleum University (2022SCXWYXWFC002)

Authors: Zhaomin Tang | Shuting Jiang | Wanlan Tang | Qian He | Huangzhao Wei | Chengyu Jin | Shuai Wang | Hui Zhang

Cordycepin Augments the Chemosensitivity of Human Glioma Cells to Temozolomide by Activating AMPK and Inhibiting the AKT Signaling Pathway

JOURNAL ARTICLE published 5 November 2018 in Molecular Pharmaceutics

Research funded by National Youth Foundation of China (21401072) | National Natural Science Foundation of China (81772684)

Authors: Yiming Bi | Han Li | Dazhuang Yi | Yuxue Sun | Yang Bai | Sheng Zhong | Yang Song | Gang Zhao | Yong Chen

Porphyrin-Loaded TyroSpheres for the Intracellular Delivery of Drugs and Photoinduced Oxidant Species

JOURNAL ARTICLE published 3 August 2020 in Molecular Pharmaceutics

Research funded by Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (303831/2019-7) | Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (2013/07937-8,2013/16532-1)

Authors: Tayana Mazin Tsubone | Zheng Zhang | Ritu Goyal | Carolina Santacruz | Waleska Kerllen Martins | Joachim Kohn | Mauricio S. Baptista

Intrinsic Dynamics of DNA–Polymer Complexes: A Mechanism for DNA Release

JOURNAL ARTICLE published 4 September 2012 in Molecular Pharmaceutics

Authors: Lisa E. Prevette | Evgenia N. Nikolova | Hashim M. Al-Hashimi | Mark M. Banaszak Holl

Developing an Anticancer Copper(II) Multitarget Pro-Drug Based on the His146 Residue in the IB Subdomain of Modified Human Serum Albumin

JOURNAL ARTICLE published 4 June 2018 in Molecular Pharmaceutics

Research funded by Ministry of Education of the People's Republic of China (CMEMR2017-A03,IRT-16R15) | Natural Science Foundation of Guangxi Province (AD17129007,2017GXNSFEA198002) | National Natural Science Foundation of China (21431001,31460232)

Authors: Jun Wang | Yi Gou | Zhenlei Zhang | Ping Yu | Jinxu Qi | Qipin Qin | Hongbin Sun | Xiaoyang Wu | Hong Liang | Feng Yang

Physiologically Based Biopharmaceutics Modeling (PBBM): Best Practices for Drug Product Quality, Regulatory and Industry Perspectives: 2023 Workshop Summary Report

JOURNAL ARTICLE published 10 April 2024 in Molecular Pharmaceutics

Research funded by U.S. Food and Drug Administration (5U01FD005946)

Authors: Claire Mackie | Sumit Arora | Paul Seo | Rebecca Moody | Bhagwant Rege | Xavier Pepin | Tycho Heimbach | Christer Tannergren | Amitava Mitra | Sandra Suarez-Sharp | Luiza Novaes Borges | Shinichi Kijima | Evangelos Kotzagiorgis | Maria Malamatari | Shereeni Veerasingham | James E. Polli | Gregory Rullo

Evaluation of Cellular Uptake and Gene Transfer Efficiency of Pegylated Poly-l-lysine Compacted DNA:  Implications for Cancer Gene Therapy

JOURNAL ARTICLE published 1 December 2006 in Molecular Pharmaceutics

Authors: M. Walsh | M. Tangney | M. J. O'Neill | J. O. Larkin | D. M. Soden | S. L. McKenna | R. Darcy | G. C. O'Sullivan | C. M. O'Driscoll

Photodisruption of the Structurally Conserved Cys-Cys-Trp Triads Leads to Reduction-Resistant Scrambled Intrachain Disulfides in an IgG1 Monoclonal Antibody

JOURNAL ARTICLE published 2 April 2018 in Molecular Pharmaceutics

Authors: Aaron T. Wecksler | Jian Yin | Paula Lee Tao | Bruce Kabakoff | Alavattam Sreedhara | Galahad Deperalta

Relevance of Biophysical Interactions of Nanoparticles with a Model Membrane in Predicting Cellular Uptake: Study with TAT Peptide-Conjugated Nanoparticles

JOURNAL ARTICLE published 5 October 2009 in Molecular Pharmaceutics

Authors: Chiranjeevi Peetla | Kavitha S. Rao | Vinod Labhasetwar

Live Cells versus Fixated Cells: Kinetic Measurements of Biomolecular Interactions with the LigandTracer Method and Surface Plasmon Resonance Microscopy

JOURNAL ARTICLE published 3 April 2023 in Molecular Pharmaceutics

Research funded by National Natural Science Foundation of China (21802051,21906065)

Authors: Tianbao Dong | Chaowei Han | Xin Liu | Zhichao Wang | Yanhui Wang | Qing Kang | Pengcheng Wang | Feimeng Zhou

Investigation on the Interaction of Dabrafenib with Human Serum Albumin Using Combined Experiment and Molecular Dynamics Simulation: Exploring the Binding Mechanism, Esterase-like Activity, and Antioxidant Activity

JOURNAL ARTICLE published 3 December 2018 in Molecular Pharmaceutics

Research funded by Ministry of Education of the People's Republic of China (2018SCU12043) | National Natural Science Foundation of China (21808020) | Sichuan Province (2018JY0188,2018JY0151)

Authors: Zili Suo | Xinnuo Xiong | Qiaomei Sun | Ludan Zhao | Peixiao Tang | Quan Hou | Yongkui Zhang | Di Wu | Hui Li

Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination

JOURNAL ARTICLE published 5 November 2018 in Molecular Pharmaceutics

Authors: Eugene C. Chen | Fabio Broccatelli | Emile Plise | Buyun Chen | Liling Liu | Jonathan Cheong | Shu Zhang | Jamie Jorski | Katherine Gaffney | Kayla K. Umemoto | Laurent Salphati

Long-Acting Nanohybrid Hydrogel Induces Persistent Immunogenic Chemotherapy for Suppressing Postoperative Tumor Recurrence and Metastasis

JOURNAL ARTICLE published 4 December 2023 in Molecular Pharmaceutics

Research funded by Jiangsu Provincial Key Research and Development Program (BE2022724) | National Key Research and Development Program of China (2022YFA1206000) | Science and Technology Program of Suzhou (SYS2020083) | National Natural Science Foundation of China (31500811,81703512,52125304,51873143)

Authors: Yaoqi Li | Jie Zhu | Yifan Yang | Yitian Chen | Lishan Liu | Jing Tao | Huabing Chen | Yibin Deng

AVN-211, Novel and Highly Selective 5-HT6 Receptor Small Molecule Antagonist, for the Treatment of Alzheimer’s Disease

JOURNAL ARTICLE published 7 March 2016 in Molecular Pharmaceutics

Authors: Alexandre V. Ivachtchenko | Yan Lavrovsky | Yan A. Ivanenkov

Chalcone Based Homodimeric PET Agent, 11C-(Chal)2DEA-Me, for Beta Amyloid Imaging: Synthesis and Bioevaluation

JOURNAL ARTICLE published 2 April 2018 in Molecular Pharmaceutics

Research funded by Defence Research and Development Organisation (TD-16-17/INM-321)

Authors: Kanchan Chauhan | Anjani K. Tiwari | Nidhi Chadha | Ankur Kaul | Ajai Kumar Singh | Anupama Datta

Investigation of Poor Solubility of a Salt-Cocrystal Hydrate: A Case Study of the Common-Ion Effect in Betrixaban, an Anticoagulant Drug

JOURNAL ARTICLE published 1 March 2021 in Molecular Pharmaceutics

Authors: Ramesh Devarapalli | Anjaneyaraju Indukuri | Manjunath Bollineni | Amit Mondal | C. Malla Reddy | Ramanaiah Chennuru

Importance of Gastric Secretion and the Rapid Gastric Emptying of Ingested Water along the Lesser Curvature (“Magenstraße”) in Predicting the In Vivo Performance of Liquid Oral Dosage Forms in the Fed State Using a Modeling and Simulation

JOURNAL ARTICLE published 7 February 2022 in Molecular Pharmaceutics

Authors: Tsuyoshi Kiyota | Atsushi Kambayashi | Toshihide Takagi | Shinji Yamashita

In Vitro Predictive Dissolution Test Should Be Developed and Recommended as a Bioequivalence Standard for the Immediate-Release Solid Oral Dosage Forms of the Highly Variable Mycophenolate Mofetil

JOURNAL ARTICLE published 4 July 2022 in Molecular Pharmaceutics

Authors: Kai Wang | Yangbing Li | Bing Chen | Hao Chen | David E. Smith | Duxin Sun | Meihua R. Feng | Gordon L. Amidon