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Reactive Oxygen Species–Responsive Celastrol-Loaded Bilirubin Nanoparticles for the Treatment of Rheumatoid Arthritis

JOURNAL ARTICLE published January 2022 in The AAPS Journal

Authors: Xuan Zhao | Chengyuan Huang | Meiling Su | Yu Ran | Ying Wang | Zongning Yin

https://doi.org/10.1208/s12248-021-00636-3 Actions

Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling

JOURNAL ARTICLE published November 2017 in The AAPS Journal

Authors: Mingnan Cao | Huixia Wang | Limei Guo | Simin Yang | Chun Liu | Tin Oo Khor | Siwang Yu | Ah-Ng Kong

https://doi.org/10.1208/s12248-017-0133-1 Actions

Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile

JOURNAL ARTICLE published July 2014 in The AAPS Journal

Authors: Shuo Yang | Xianzhen Yin | Caifen Wang | Haiyan Li | You He | Tiqiao Xiao | Lixin Sun | Jiasheng Li | Peter York | Jun He | Jiwen Zhang

https://doi.org/10.1208/s12248-014-9611-x Actions

Preservation of the Immunogenicity of Dry-powder Influenza H5N1 Whole Inactivated Virus Vaccine at Elevated Storage Temperatures

JOURNAL ARTICLE published June 2010 in The AAPS Journal

Authors: Felix Geeraedts | Vinay Saluja | Wouter ter Veer | Jean-Pierre Amorij | Henderik W. Frijlink | Jan Wilschut | Wouter L. J. Hinrichs | Anke Huckriede

https://doi.org/10.1208/s12248-010-9179-z Actions

A Novel MDR1 GT1292-3TG (Cys431Leu) Genetic Variation and Its Effect on P-glycoprotein Biologic Functions

JOURNAL ARTICLE published December 2010 in The AAPS Journal

Authors: Matthew H. Crouthamel | Daniel Wu | Ziping Yang | Rodney J. Y. Ho

https://doi.org/10.1208/s12248-010-9216-y Actions

Development of an Enantioselective and Biomarker-Informed Translational Population Pharmacokinetic/Pharmacodynamic Model for Etodolac

JOURNAL ARTICLE published November 2017 in The AAPS Journal

Authors: Carolina de Miranda Silva | Adriana Rocha | Eduardo Tozatto | Lucienir Maria da Silva | Eduardo Antônio Donadi | Teresa Dalla Costa | Vera Lucia Lanchote | Stephan Schmidt | Jürgen B. Bulitta

https://doi.org/10.1208/s12248-017-0138-9 Actions

Population Pharmacokinetics of Intracellular 5-Fluorouridine 5′-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine

JOURNAL ARTICLE published January 2021 in The AAPS Journal

Authors: Julie M. Janssen | Bart A. W. Jacobs | Jeroen Roosendaal | Ellen J. B. Derissen | Serena Marchetti | Jos H. Beijnen | Alwin D. R. Huitema | Thomas P. C. Dorlo

https://doi.org/10.1208/s12248-020-00533-1 Actions

Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data

JOURNAL ARTICLE published September 2009 in The AAPS Journal

Authors: Tycho Heimbach | Suresh B. Lakshminarayana | Wenyu Hu | Handan He

https://doi.org/10.1208/s12248-009-9136-x Actions

Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state

JOURNAL ARTICLE published March 2006 in The AAPS Journal

Authors: Bei Li | Richard L. Schowen | Elizabeth M. Topp | Ronald T. Borchardt

https://doi.org/10.1208/aapsj080120 Actions

Rheological Evaluation of Silicon/Carbopol Hydrophilic Gel Systems as a Vehicle for Delivery of Water Insoluble Drugs

JOURNAL ARTICLE published March 2008 in The AAPS Journal

Authors: Giulia Bonacucina | Marco Cespi | Monica Misici-Falzi | Giovanni F. Palmieri

https://doi.org/10.1208/s12248-008-9008-9 Actions

Bayesian Quantitative Disease–Drug–Trial Models for Parkinson’s Disease to Guide Early Drug Development

JOURNAL ARTICLE published December 2011 in The AAPS Journal

Authors: Joo Yeon Lee | Jogarao V. S. Gobburu

https://doi.org/10.1208/s12248-011-9293-6 Actions

Harmonizing Biopredictive Methodologies Through the Product Quality Research Institute (PQRI) Part I: Biopredictive Dissolution of Ibuprofen and Dipyridamole Tablets

JOURNAL ARTICLE published 21 April 2023 in The AAPS Journal

Authors: Yasuhiro Tsume | Lee Ashworth | Marival Bermejo | Joan Cheng | Vincent Cicale | Jennifer Dressman | Masahiro Fushimi | Isabel Gonzalez-Alvarez | Yiwang Guo | Corinne Jankovsky | Xujin Lu | Kazuki Matsui | Sanjaykumar Patel | Natalie Sanderson | Changquan Calvin Sun | Naveen K. Thakral | Miki Yamane | Laurin Zöller

https://doi.org/10.1208/s12248-023-00793-7 Actions

Activation of G-proteins in brain by endogenous and exogenous cannabinoids

JOURNAL ARTICLE published March 2006 in The AAPS Journal

Authors: Steven R. Childers

https://doi.org/10.1208/aapsj080113 Actions

Spray-Dried Thiolated Chitosan-Coated Sodium Alginate Multilayer Microparticles for Vaginal HIV Microbicide Delivery

JOURNAL ARTICLE published May 2017 in The AAPS Journal

Authors: Jianing Meng | Vivek Agrahari | Miezan J. Ezoulin | Sudhaunshu S. Purohit | Tao Zhang | Agostino Molteni | Daniel Dim | Nathan A. Oyler | Bi-Botti C. Youan

https://doi.org/10.1208/s12248-016-0007-y Actions

Development and Validation of a Cell-Based Binding Neutralizing Antibody Assay for an Antibody–Drug Conjugate

JOURNAL ARTICLE published 28 March 2024 in The AAPS Journal

Authors: Weifeng Xu | Nazneen Bano | Olguitza Guzman-Valdes | Jessica Amberman | Elisha Bandlamudi | Pooja Khanna | Rebecca Carmean | Roy Helmy

https://doi.org/10.1208/s12248-024-00909-7 Actions

CYP3A4 Mediates Oxidative Metabolism of the Synthetic Cannabinoid AKB-48

JOURNAL ARTICLE published September 2015 in The AAPS Journal

Authors: Niels Bjerre Holm | Line Marie Nielsen | Kristian Linnet

https://doi.org/10.1208/s12248-015-9788-7 Actions

Comparison of the ELISA and ECL Assay for Vedolizumab Anti-drug Antibodies: Assessing the Impact on Pharmacokinetics and Safety Outcomes of the Phase 3 GEMINI Trials

JOURNAL ARTICLE published January 2021 in The AAPS Journal

Authors: Timothy Wyant | Lili Yang | Maria Rosario

https://doi.org/10.1208/s12248-020-00518-0 Actions

Sorafenib Decreases Tumor Exposure to an Anti-carcinoembryonic Antigen Monoclonal Antibody in a Mouse Model of Colorectal Cancer

JOURNAL ARTICLE published July 2016 in The AAPS Journal

Authors: Veena A. Thomas | Joseph P. Balthasar

https://doi.org/10.1208/s12248-016-9909-y Actions

Use of Dried Blood Spots in Drug Development: Pharmacokinetic Considerations

JOURNAL ARTICLE published September 2010 in The AAPS Journal

Authors: Malcolm Rowland | Gary T. Emmons

https://doi.org/10.1208/s12248-010-9188-y Actions

Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective

JOURNAL ARTICLE published December 2008 in The AAPS Journal

Authors: Emily O. Dumas | Gary M. Pollack

https://doi.org/10.1208/s12248-008-9056-1 Actions
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