Pharmacokinetics and Tolerability of the Novel Non-immunosuppressive Fingolimod Derivative, OSU-2S, in Dogs and Comparisons with Data in Mice and Rats

JOURNAL ARTICLE published July 2020 in The AAPS Journal

Authors: Zhiliang Xie | Min Chen | Swagata Goswami | Rajes Mani | Dasheng Wang | Samuel K. Kulp | Chris C. Coss | Larry J. Schaaf | Fengyu Cui | John C. Byrd | Ryan N. Jennings | Karsten K. Schober | Carrie Freed | Stephanie Lewis | Raphael Malbrue | Natarajan Muthusamy | Chad Bennett | William C. Kisseberth | Mitch A. Phelps

Correction: Harmonizing Biopredictive Methodologies Through the Product Quality Research Institute (PQRI) Part I: Biopredictive Dissolution of Ibuprofen and Dipyridamole Tablets

JOURNAL ARTICLE published 8 June 2023 in The AAPS Journal

Authors: Yasuhiro Tsume | Lee Ashworth | Marival Bermejo | Joan Cheng | Vincent Cicale | Jennifer Dressman | Masahiro Fushimi | Isabel Gonzalez-Alvarez | Yiwang Guo | Corinne Jankovsky | Xujin Lu | Kazuki Matsui | Sanjaykumar Patel | Natalie Sanderson | Changquan Calvin Sun | Naveen K. Thakral | Miki Yamane | Laurin Zöller

A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models

JOURNAL ARTICLE published 28 June 2023 in The AAPS Journal

Authors: Michael J. White | Letitia Cheatham | Shenghua Wen | Graeme Scarfe | Justin Cidado | Corinne Reimer | Niresh Hariparsad | Rhys D. O. Jones | Lisa Drew | Dermot F. McGinnity | Christina Vasalou

A Novel MDR1 GT1292-3TG (Cys431Leu) Genetic Variation and Its Effect on P-glycoprotein Biologic Functions

JOURNAL ARTICLE published December 2010 in The AAPS Journal

Authors: Matthew H. Crouthamel | Daniel Wu | Ziping Yang | Rodney J. Y. Ho

Development of an Enantioselective and Biomarker-Informed Translational Population Pharmacokinetic/Pharmacodynamic Model for Etodolac

JOURNAL ARTICLE published November 2017 in The AAPS Journal

Authors: Carolina de Miranda Silva | Adriana Rocha | Eduardo Tozatto | Lucienir Maria da Silva | Eduardo Antônio Donadi | Teresa Dalla Costa | Vera Lucia Lanchote | Stephan Schmidt | Jürgen B. Bulitta

Molecular Imaging of Membrane Transporters’ Activity in Cancer: a Picture is Worth a Thousand Tubes

JOURNAL ARTICLE published July 2015 in The AAPS Journal

Authors: Aniv Mann | Inessa Semenenko | Michal Meir | Sara Eyal

The influence of market exclusivity on drug availability and medical innovations

JOURNAL ARTICLE published September 2007 in The AAPS Journal

Authors: Gregory J. Glover

Nanomedicine Drug Development: A Scientific Symposium Entitled “Charting a Roadmap to Commercialization”

JOURNAL ARTICLE published July 2014 in The AAPS Journal

Authors: Gregory Finch | Henry Havel | Mostafa Analoui | Randall W. Barton | Anil R. Diwan | Meliessa Hennessy | Vijayapal Reddy | Nakissa Sadrieh | Lawrence Tamarkin | Marc Wolfgang | Benjamin Yerxa | Banu Zolnik | Man Liu

Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics

JOURNAL ARTICLE published September 2018 in The AAPS Journal

Authors: Helga Kristin Olafsdottir | Jacob Leander | Joachim Almquist | Mats Jirstrand

Simplification of Complex Physiologically Based Pharmacokinetic Models of Monoclonal Antibodies

JOURNAL ARTICLE published July 2014 in The AAPS Journal

Authors: Mohamed Elmeliegy | Philip Lowe | Wojciech Krzyzanski

The AAPS Journal Theme Issue: Rising Stars in Drug Delivery and Novel Carriers

JOURNAL ARTICLE published May 2022 in The AAPS Journal

Authors: Aliasger K. Salem | Juliane Nguyen | Kristy M. Ainslie

Is Incurred Sample Reanalysis (ISR) Applicable in Biomarker Assays?

JOURNAL ARTICLE published May 2022 in The AAPS Journal

Authors: Amanda Hays | Lakshmi Amaravadi | Carmen Fernandez-Metzler | Lindsay King | Joel Mathews | Yan Ni | Karen Quadrini | Chunyan Tinder | Faye Vazvaei | Jianing Zeng

A Three-Treatment Two-Stage Design for Selection of a Candidate Formulation and Subsequent Demonstration of Bioequivalence

JOURNAL ARTICLE published September 2020 in The AAPS Journal

Authors: Anders Fuglsang

Balancing Antibacterial Efficacy and Reduction in Renal Function to Optimise Initial Gentamicin Dosing in Paediatric Oncology Patients

JOURNAL ARTICLE published January 2018 in The AAPS Journal

Authors: Carolina Consuelo Llanos-Paez | Christine Staatz | Stefanie Hennig

Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data

JOURNAL ARTICLE published January 2016 in The AAPS Journal

Authors: Thierry Wendling | Nikolaos Tsamandouras | Swati Dumitras | Etienne Pigeolet | Kayode Ogungbenro | Leon Aarons

Is It Time to Use Modeling of Cellular Transporter Homeostasis to Inform Drug-Drug Interaction Studies: Theoretical Considerations

JOURNAL ARTICLE published September 2021 in The AAPS Journal

Authors: Roberto A. Abbiati | M. Guillaume Wientjes | Jessie L.-S. Au

Physiologically Based Pharmacokinetic Modeling to Characterize the Effect of Molecular Charge on Whole-Body Disposition of Monoclonal Antibodies

JOURNAL ARTICLE published 28 April 2023 in The AAPS Journal

Authors: Shufang Liu | Dhaval K. Shah

Advantageous Solubility-Permeability Interplay When Using Amorphous Solid Dispersion (ASD) Formulation for the BCS Class IV P-gp Substrate Rifaximin: Simultaneous Increase of Both the Solubility and the Permeability

JOURNAL ARTICLE published May 2017 in The AAPS Journal

Authors: Avital Beig | Noa Fine-Shamir | David Lindley | Jonathan M Miller | Arik Dahan

Structure-Based Virtual Screening for Drug Discovery: a Problem-Centric Review

JOURNAL ARTICLE published March 2012 in The AAPS Journal

Authors: Tiejun Cheng | Qingliang Li | Zhigang Zhou | Yanli Wang | Stephen H. Bryant

Simultaneous population optimal design for pharmacokinetic-pharmacodynamic experiments

JOURNAL ARTICLE published December 2005 in The AAPS Journal

Authors: Andrew Hooker | Paolo Vicini