An Integrated Pharmacokinetic Study of an Acanthopanax senticosus Extract Preparation by Combination of Virtual Screening, Systems Pharmacology, and Multi-Component Pharmacokinetics in Rats

JOURNAL ARTICLE published 14 August 2020 in Frontiers in Pharmacology

Authors: Peiying Shi | Yunjiao Xie | Rongfang Xie | Zuan Lin | Hong Yao | Shuang Wu

Role of Phospholipases A2 in Vascular Relaxation and Sympatholytic Effects of Five Australian Brown Snake, Pseudonaja spp., Venoms in Rat Isolated Tissues

JOURNAL ARTICLE published 21 October 2021 in Frontiers in Pharmacology

Authors: Nhi Thuc Vuong | Timothy N. W. Jackson | Christine E. Wright

Aquaporins with anion/monocarboxylate permeability: mechanisms, relevance for pathogen–host interactions

JOURNAL ARTICLE published 1 September 2014 in Frontiers in Pharmacology

Authors: Janis Rambow | Binghua Wu | Deike Rönfeldt | Eric Beitz

Small Molecule Palmatine Targeting Musashi-2 in Colorectal Cancer

JOURNAL ARTICLE published 27 January 2022 in Frontiers in Pharmacology

Research funded by National Natural Science Foundation of China (81703757 81874210 81874319) | Science and Technology Commission of Shanghai Municipality (18401933500) | Shanghai Municipal Education Commission (2019-01-07-00-10-E00072 2021-01-07-00-10-E00116)

Authors: Xue Zhang | Kaiyan Su | Yifan Liu | Darong Zhu | Yuting Pan | Xisong Ke | Yi Qu

Characterizing CD38 Expression and Enzymatic Activity in the Brain of Spontaneously Hypertensive Stroke-Prone Rats

JOURNAL ARTICLE published 31 May 2022 in Frontiers in Pharmacology

Authors: Yousef Hannawi | Mohamed G. Ewees | Jordan T. Moore | Jay L. Zweier

A Glycoengineered Interferon-β Mutein (R27T) Generates Prolonged Signaling by an Altered Receptor-Binding Kinetics

JOURNAL ARTICLE published 24 January 2019 in Frontiers in Pharmacology

Authors: Saehyung Lee | Woo Sung Son | Ho Bin Yang | Nirmal Rajasekaran | Sung-Su Kim | Sungyoul Hong | Joon-Seok Choi | Jun Young Choi | Kyoung Song | Young Kee Shin

Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?

JOURNAL ARTICLE published 9 December 2020 in Frontiers in Pharmacology

Authors: Claudio Viegas | Carlos A. Manssour Fraga | Maria Emilia Sousa | Andrea Tarozzi

Influence of Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study

JOURNAL ARTICLE published 9 June 2020 in Frontiers in Pharmacology

Authors: Narmeen Mallah | Maruxa Zapata-Cachafeiro | Carmelo Aguirre | Eguzkiñe Ibarra-García | Itziar Palacios–Zabalza | Fernando Macías-García | J. Enrique Domínguez-Muñoz | María Piñeiro-Lamas | Luisa Ibáñez | Xavier Vidal | Lourdes Vendrell | Luis Martin-Arias | María Sáinz-Gil | Verónica Velasco-González | Adolfo Figueiras

Roles and inhibitors of FAK in cancer: current advances and future directions

JOURNAL ARTICLE published 12 February 2024 in Frontiers in Pharmacology

Authors: Hui-Hui Hu | Sai-Qi Wang | Hai-Li Shang | Hui-Fang Lv | Bei-Bei Chen | She-Gan Gao | Xiao-Bing Chen

Neuroprotection afforded by targeting G protein-coupled receptors in heteromers and by heteromer-selective drugs

JOURNAL ARTICLE published 13 July 2023 in Frontiers in Pharmacology

Research funded by Ministerio de Ciencia e Innovación (PID 2020-113430RB-I00)

Authors: Rafael Franco | Gemma Navarro

Leniolisib: a novel treatment for activated phosphoinositide-3 kinase delta syndrome

JOURNAL ARTICLE published 12 February 2024 in Frontiers in Pharmacology

Authors: Surya K. De

Study on the Chemical Constituents and Anti-Migraine Activity of Supercritical CO2 Extracts of Zanthoxylum schinifolium

JOURNAL ARTICLE published 30 November 2021 in Frontiers in Pharmacology

Authors: Ruifang Yuan | Yunzhen Shi | Jinming Zhang | Qi Hu | Xichuan Wei | Chuanhong Luo | Yi Wu | Jinhui Yang | Ming Yang | Fang Wang | Chuan Zheng | Dingkun Zhang

Blood Immune Cell Composition Associated with Obesity and Drug Repositioning Revealed by Epigenetic and Transcriptomic Conjoint Analysis

JOURNAL ARTICLE published 12 October 2021 in Frontiers in Pharmacology

Research funded by Natural Science Foundation of Hunan Province (2020JJ5856)

Authors: Jia-Chen Liu | Sheng-Hua Liu | Guang Fu | Xiao-Rui Qiu | Run-Dong Jiang | Sheng-Yuan Huang | Li-Yong Zhu | Wei-Zheng Li

A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels

JOURNAL ARTICLE published 18 March 2022 in Frontiers in Pharmacology

Research funded by Fondo Nacional de Desarrollo Científico y Tecnológico (1191133 1170662) | Generalitat de Catalunya (2017-SGR-1414 2017-SGR-1328) | Ministerio de Economía, Industria y Competitividad, Gobierno de España (SEV-2015-0493 TIN2015-65316-P BES-2016-078046) | Departamento de Investigaciones Científicas y Tecnológicas, Universidad de Santiago de Chile (5392102RP-ACDicyt) | Comisión Nacional de Investigación Científica y Tecnológica (FONDEQUIP-EQM160063)

Authors: Alejandro Valdés-Jiménez | Daniel Jiménez-González | Aytug K. Kiper | Susanne Rinné | Niels Decher | Wendy González | Miguel Reyes-Parada | Gabriel Núñez-Vivanco

Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

JOURNAL ARTICLE published 2 December 2019 in Frontiers in Pharmacology

Authors: Sabrina Reinehr | Sara C. Gomes | Caroline J. Gassel | M. Ali Asaad | Gesa Stute | Marc Schargus | H. Burkhard Dick | Stephanie C. Joachim

Medication use in Italian nursing homes: preliminary results from the national monitoring system

JOURNAL ARTICLE published 17 May 2023 in Frontiers in Pharmacology

Authors: S. Zito | E. Poluzzi | A. Pierantozzi | G. Onder | R. Da Cas | I. Ippoliti | C. Lunghi | A. Cangini | F. Trotta

Bufadienolides originated from toad source and their anti-inflammatory activity

JOURNAL ARTICLE published 19 October 2022 in Frontiers in Pharmacology

Authors: Denglang Zou | Qiqi Wang | Tao Chen | Duocheng Sang | Tingqin Yang | Yuhan Wang | Mengze Gao | Fangfang He | Yulin Li | Liangliang He | Duojie Longzhu

The Molecular Determinants of Small-Molecule Ligand Binding at P2X Receptors

JOURNAL ARTICLE published 2 February 2018 in Frontiers in Pharmacology

Authors: Gaia Pasqualetto | Andrea Brancale | Mark T. Young

Mitochondrial homeostasis: a potential target for delaying renal aging

JOURNAL ARTICLE published 15 June 2023 in Frontiers in Pharmacology

Authors: Ming Yang | Chongbin Liu | Na Jiang | Yan Liu | Shilu Luo | Chenrui Li | Hao Zhao | Yachun Han | Wei Chen | Li Li | Li Xiao | Lin Sun

Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells

JOURNAL ARTICLE published 19 November 2021 in Frontiers in Pharmacology

Authors: Oghenemega Okoloko | Elizabeth R. Vanderwall | Lucille M. Rich | Maria P. White | Stephen R. Reeves | Whitney E. Harrington | Kaitlyn A. Barrow | Jason S. Debley