Lessons from the Fersht laboratory could be vital for the future of the pharmaceutical industry

JOURNAL ARTICLE published 1 January 2011 in Protein Engineering Design and Selection

Authors: W. H. J. Ward

Exploring the unique pharmacology of a novel opioid receptor, ZFOR1, using molecular modeling and the `message–address' concept

JOURNAL ARTICLE published December 2001 in Protein Engineering, Design and Selection

Authors: Iain J. McFadyen | Thomas G. Metzger | M.Germana Paterlini | David M. Ferguson

A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2

JOURNAL ARTICLE published 1 January 2007 in Protein Engineering, Design and Selection

Authors: Ajay Singh | K. Jordan Walker | Puran S. Sijwali | Anthony L. Lau | Philip J. Rosenthal

A simple method for assessing the mutational effect on the protein-DNA interaction: application to amino acid substitutions

JOURNAL ARTICLE published 1994 in "Protein Engineering, Design and Selection"

Authors: Yifei Wang | Akinori Sarai

Concluding comment:–Fersht

JOURNAL ARTICLE published 1987 in "Protein Engineering, Design and Selection"

Authors: Alan R. Fersht

A yeast selection system for the detection of proteasomal activation

JOURNAL ARTICLE published 1 November 2018 in Protein Engineering, Design and Selection

Research funded by National Science Foundation (CBET-1805317,CBET-1615562) | Welch Foundation (C-1824)

Authors: Wenting Zhao | Bhagyashree Bachhav | Claire McWhite | Laura Segatori

Locating the unpaired cysteine of tissue-type plasminogen activator

JOURNAL ARTICLE published 1996 in "Protein Engineering, Design and Selection"

Authors: Louis c. Sehl | Hung V. Nguyen | Lea T. Berleau | Patricia Arcila | William F. Bennett | Bruce A. Keyt

Novel reagents for human prolactin research: large-scale preparation and characterization of prolactin receptor extracellular domain, non-pegylated and pegylated prolactin and prolactin receptor antagonist

JOURNAL ARTICLE published 1 January 2018 in Protein Engineering, Design and Selection

Authors: Ewa Ocłoń | Gili Solomon | Zvi Hayouka | Tomer Meir Salame | Vincent Goffin | Arieh Gertler

Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase

JOURNAL ARTICLE published 1996 in "Protein Engineering, Design and Selection"

Authors: Janet S. Finer-Moore | Eric B. Fauman | Richard J. Morse | Daniel V. Santi | Robert M. Stroud

Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting

JOURNAL ARTICLE published July 2017 in Protein Engineering, Design and Selection

Authors: Richard Obexer | Moritz Pott | Cathleen Zeymer | Andrew D. Griffiths | Donald Hilvert

Effects of pore mutations and permeant ion concentration on the spontaneous gating activity of OmpC porin

JOURNAL ARTICLE published July 2000 in Protein Engineering, Design and Selection

Authors: Nazhen Liu | Hrissi Samartzidou | Keun Woo Lee | James M. Briggs | Anne H. Delcour

Influence of mutations of Val226 on the catalytic rate of haloalkane dehalogenase

JOURNAL ARTICLE published 1 January 1997 in Protein Engineering Design and Selection

Authors: J. P. Schanstra | A. Ridder | J. Kingma | D. B. Janssen

Understanding the role of phosphorylation in the binding mechanism of a PDZ domain

JOURNAL ARTICLE published 19 October 2016 in Protein Engineering Design and Selection

Research funded by Sapienza University of Rome (C26A155S48)

Authors: Angelo Toto | Annalisa Mattei | Per Jemth | Stefano Gianni

Investigations on the thermostability and function of truncated Thermus aquaticus DNA polymerase fragments

JOURNAL ARTICLE published 1 November 1997 in Protein Engineering Design and Selection

Authors: B. Villbrandt | G. Sagner | D. Schomburg

His-tags as Zn(II) binding motifs in a protein-based fluorescent sensor

JOURNAL ARTICLE published 13 May 2008 in Protein Engineering Design and Selection

Authors: T. H. Evers | M. A.M. Appelhof | E.W. Meijer | M. Merkx

Protein engineering of alcohol dehydrogenases; effects of amino acid changes at positions 93 and 48 of yeast ADH1

JOURNAL ARTICLE published 1990 in "Protein Engineering, Design and Selection"

Authors: E.H. Creaser | C. Murali | K.A. Britt

OUP accepted manuscript

JOURNAL ARTICLE published 2016 in Protein Engineering, Design & Selection

Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities

JOURNAL ARTICLE published 14 April 2008 in Protein Engineering Design and Selection

Authors: T.E. Reeves | M.E. Wales | J.K. Grimsley | P. Li | D.M. Cerasoli | J.R. Wild

Metal-bound claMP Tag inhibits proteolytic cleavage

JOURNAL ARTICLE published 1 June 2017 in Protein Engineering, Design and Selection

Research funded by National Institutes of Health (COBRE P20 RR017708) | National Institutes of Health Collaborative Administrative Supplement (DE022054-03) | National Institutes of Health Chemical Biology Training (T32GM008545)

Authors: Michaela L. McNiff | Jennifer S. Chadwick

Modular mutagenesis of a TEM-barrel enzyme: the crystal structure of a chimeric E.coli TIM having the eighth βα-unit replaced by the equivalent unit of chicken TIM

JOURNAL ARTICLE published 1994 in "Protein Engineering, Design and Selection"

Authors: Radha Kishan | Ph. Johan Zeelen | Martin E.M. Noble | Torben V. Borchert | Véronique Mainfroid | Karine Goraj | Joseph A. Martial | Rik K. Wierenga