Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests

JOURNAL ARTICLE published 14 April 2021 in Science Translational Medicine

Research funded by National Science Foundation (U54GM088558) | National Science Foundation (NIH DP5) | National Science Foundation (IIS 1837992)

Authors: Netta Barak | Roni Ben-Ami | Tal Sido | Amir Perri | Aviad Shtoyer | Mila Rivkin | Tamar Licht | Ayelet Peretz | Judith Magenheim | Irit Fogel | Ayalah Livneh | Yutti Daitch | Esther Oiknine-Djian | Gil Benedek | Yuval Dor | Dana G. Wolf | Moran Yassour | A. Klochendler | A. Eden | A. Klar | A. Geldman | A. Arbel | B. Shalom | B. L. Ochana | D. Avrahami-Tzfati | D. Neiman | D. Steinberg | D. Ben Zvi | E. Shpigel | G. Atlan | H. Klein | H. Chekroun | H. Shani | I. Hazan | I. Ansari | I. Magenheim | J. Moss | L. Peretz | L. Feigin | M. Saraby | M. Sherman | M. Bentata | M. Avital | M. Kott | M. Peyser | M. Weitz | M. Shacham | M. Grunewald | N. Sasson | N. Wallis | N. Azazmeh | N. Tzarum | O. Fridlich | R. Sher | R Condiotti | R. Refaeli | R. Zaken-Gallili | R. Helman | S. Ofek | S. Tzaban | S. Piyanzin | S. Anzi | S. Dagan | S. Lilenthal | T. Friehmann | Y. Kaufman | A. Saada | A. Dekel | A. Yeffet | A. Shaag | A. Michael-Gayego | E. Shay | E. Arbib | H. Onallah | K. Ben-Meir | L. Levinzon | L. Cohen-Daniel | L. Natan | M. Hamdan | M. Shwieki | O. Vorontsov | R. Barsuk | R. Abramovitch | R. Gutorov | S. Sirhan | S. Abdeen | Y. Yachnin | H. Golan-Berman | E. Amir | T. Fridman | E. Chabube Kripper | T. Miriam Rohrlich | G. Batshon | L. Mendelovitz | The Hebrew University-Hadassah COVID-19 Diagnosis Team

Population-level implications of the Israeli booster campaign to curtail COVID-19 resurgence

JOURNAL ARTICLE published June 2022 in Science Translational Medicine

Authors: Nir Gavish | Rami Yaari | Amit Huppert | Guy Katriel

A role for bacterial urease in gut dysbiosis and Crohn’s disease

JOURNAL ARTICLE published 15 November 2017 in Science Translational Medicine

Research funded by National Institutes of Health (award312836,UL1TR001881) | NIH Office of the Director (award309678,P30 DK050306) | NIH Office of the Director (award309679,UH3 DK083981) | NIH Office of the Director (award309680,T32 DK007066) | NIH Office of the Director (award309682,K24 DK078228) | NIH Office of the Director (award309683,R01 GM080279) | NIH Office of the Director (award309684,R01 GM103591) | Crohn’s and Colitis Foundation of America (award312837,323814) | NIH (award313156,GM097505) | NIH Office of the Director (award313155,CA127334)

Authors: Josephine Ni | Ting-Chin David Shen | Eric Z. Chen | Kyle Bittinger | Aubrey Bailey | Manuela Roggiani | Alexandra Sirota-Madi | Elliot S. Friedman | Lillian Chau | Andrew Lin | Ilana Nissim | Justin Scott | Abigail Lauder | Christian Hoffmann | Gloriany Rivas | Lindsey Albenberg | Robert N. Baldassano | Jonathan Braun | Ramnik J. Xavier | Clary B. Clish | Marc Yudkoff | Hongzhe Li | Mark Goulian | Frederic D. Bushman | James D. Lewis | Gary D. Wu

Listeria delivers tetanus toxoid protein to pancreatic tumors and induces cancer cell death in mice

JOURNAL ARTICLE published 23 March 2022 in Science Translational Medicine

Authors: Benson Chellakkan Selvanesan | Dinesh Chandra | Wilber Quispe-Tintaya | Arthee Jahangir | Ankur Patel | Kiran Meena | Rodrigo Alberto Alves Da Silva | Madeline Friedman | Lisa Gabor | Olivia Khouri | Steven K. Libutti | Ziqiang Yuan | Jenny Li | Sarah Siddiqui | Amanda Beck | Lydia Tesfa | Wade Koba | Jennifer Chuy | John C. McAuliffe | Rojin Jafari | David Entenberg | Yarong Wang | John Condeelis | Vera DesMarais | Vinod Balachandran | Xusheng Zhang | Ken Lin | Claudia Gravekamp

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

JOURNAL ARTICLE published 12 June 2019 in Science Translational Medicine

Research funded by NIH Clinical Center (P40 OD012217) | NIH Clinical Center (P30CA012197-39) | Swiss National Science Foundation (320030_162575) | NCAT (UL1TR001420)

Authors: Christina Claus | Claudia Ferrara | Wei Xu | Johannes Sam | Sabine Lang | Franziska Uhlenbrock | Rosmarie Albrecht | Sylvia Herter | Ramona Schlenker | Tamara Hüsser | Sarah Diggelmann | John Challier | Ekkehard Mössner | Ralf J. Hosse | Thomas Hofer | Peter Brünker | Catherine Joseph | Jörg Benz | Philippe Ringler | Henning Stahlberg | Matthias Lauer | Mario Perro | Stanford Chen | Christine Küttel | Preethi L. Bhavani Mohan | Valeria Nicolini | Martina Carola Birk | Amandine Ongaro | Christophe Prince | Reto Gianotti | Gregory Dugan | Christopher T. Whitlow | Kiran Kumar Solingapuram Sai | David L. Caudell | Armando G. Burgos-Rodriguez | J. Mark Cline | Michael Hettich | Maurizio Ceppi | Anna Maria Giusti | Flavio Crameri | Wouter Driessen | Peter N. Morcos | Anne Freimoser-Grundschober | Victor Levitsky | Maria Amann | Sandra Grau-Richards | Thomas von Hirschheydt | Stella Tournaviti | Michael Mølhøj | Tanja Fauti | Viola Heinzelmann-Schwarz | Volker Teichgräber | Sara Colombetti | Marina Bacac | Alfred Zippelius | Christian Klein | Pablo Umaña

Recommendations for Biomarker Identification and Qualification in Clinical Proteomics

JOURNAL ARTICLE published 25 August 2010 in Science Translational Medicine

Authors: Harald Mischak | Günter Allmaier | Rolf Apweiler | Teresa Attwood | Marc Baumann | Ariela Benigni | Samuel E. Bennett | Rainer Bischoff | Erik Bongcam-Rudloff | Giovambattista Capasso | Joshua J. Coon | Patrick D’Haese | Anna F. Dominiczak | Mohammed Dakna | Hassan Dihazi | Jochen H. Ehrich | Patricia Fernandez-Llama | Danilo Fliser | Jorgen Frokiaer | Jerome Garin | Mark Girolami | William S. Hancock | Marion Haubitz | Denis Hochstrasser | Rury R. Holman | John P. A. Ioannidis | Joachim Jankowski | Bruce A. Julian | Jon B. Klein | Walter Kolch | Theo Luider | Ziad Massy | William B. Mattes | Franck Molina | Bernard Monsarrat | Jan Novak | Karlheinz Peter | Peter Rossing | Marta Sánchez-Carbayo | Joost P. Schanstra | O. John Semmes | Goce Spasovski | Dan Theodorescu | Visith Thongboonkerd | Raymond Vanholder | Timothy D. Veenstra | Eva Weissinger | Tadashi Yamamoto | Antonia Vlahou

CpG ODN Nanorings Induce IFNα from Plasmacytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity

JOURNAL ARTICLE published 7 May 2014 in Science Translational Medicine

Authors: Bilgi Gungor | Fuat Cem Yagci | Gizem Tincer | Banu Bayyurt | Esin Alpdundar | Soner Yildiz | Mine Ozcan | Ihsan Gursel | Mayda Gursel

Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta

JOURNAL ARTICLE published 3 July 2013 in Science Translational Medicine

Authors: Elinor K. Karlsson | Jason B. Harris | Shervin Tabrizi | Atiqur Rahman | Ilya Shlyakhter | Nick Patterson | Colm O’Dushlaine | Stephen F. Schaffner | Sameer Gupta | Fahima Chowdhury | Alaullah Sheikh | Ok Sarah Shin | Crystal Ellis | Christine E. Becker | Lynda M. Stuart | Stephen B. Calderwood | Edward T. Ryan | Firdausi Qadri | Pardis C. Sabeti | Regina C. LaRocque

Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env

JOURNAL ARTICLE published 24 November 2021 in Science Translational Medicine

Authors: Amelia Escolano | Harry B. Gristick | Rajeev Gautam | Andrew T. DeLaitsch | Morgan E. Abernathy | Zhi Yang | Haoqing Wang | Magnus A.G. Hoffmann | Yoshiaki Nishimura | Zijun Wang | Nicholas Koranda | Leesa M. Kakutani | Han Gao | Priyanthi N. P. Gnanapragasam | Henna Raina | Ana Gazumyan | Melissa Cipolla | Thiago Y. Oliveira | Victor Ramos | Darrell J. Irvine | Murillo Silva | Anthony P. West | Jennifer R. Keeffe | Christopher O. Barnes | Michael S. Seaman | Michel C. Nussenzweig | Malcolm A. Martin | Pamela J. Bjorkman

Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI

JOURNAL ARTICLE published 13 May 2020 in Science Translational Medicine

Research funded by National Natural Science Foundation of China (81830020) | National Natural Science Foundation of China (81873599) | National Natural Science Foundation of China (81700604)

Authors: Xiaowen Yu | Man Xu | Xia Meng | Shumin Li | Qianqi Liu | Mi Bai | Ran You | Songming Huang | Li Yang | Yue Zhang | Zhanjun Jia | Aihua Zhang

A virus-like particle vaccine prevents equine encephalitis virus infection in nonhuman primates

JOURNAL ARTICLE published 15 May 2019 in Science Translational Medicine

Authors: Sung-Youl Ko | Wataru Akahata | Eun Sung Yang | Wing-Pui Kong | Crystal W. Burke | Shelley P. Honnold | Donald K. Nichols | Yan-Jang S. Huang | Gretchen L. Schieber | Kevin Carlton | Luis DaSilva | Vicki Traina-Dorge | Dana L. Vanlandingham | Yaroslav Tsybovsky | Tyler Stephens | Ulrich Baxa | Stephen Higgs | Chad J. Roy | Pamela J. Glass | John R. Mascola | Gary J. Nabel | Srinivas S. Rao

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism

JOURNAL ARTICLE published 19 May 2021 in Science Translational Medicine

Research funded by Wellcome Trust (WT098524MA) | Wellcome Trust (090532/Z/09/Z) | Wellcome (210774/Z18/Z) | Wellcome (204841/Z/16/Z) | Medical Research Council (MR/K02342X/1) | Medical Research Council (MR/N026101/1) | Medical Research Council (MR/R015325/1) | Medical Research Council (MR/P026494/1) | Medical Research Council (MR/T008024/1) | Medical Research Council (MR/N019075/1) | LifeArc (P2020-0008) | Medical Research Council (MR/T044853/1) | Medical Research Council (MR/R025134/1) | Medical Research Council (MR/S009434/1) | Medical Research Council (MR/S036784/1) | Medical Research Council (G0900747 91070) | National Institute for Health Research (WT098524MA) | National Institute for Health Research (MR/K02342X/1) | National Institute for Health Research (MR/R015325/1) | National Institute for Health Research (V1284) | National Institute for Health Research (NIHR-RP-2016-07-019) | Department of Health, Australian Government (608381) | Department of Health, Australian Government (UK F1701 M) | Department of Health, Australian Government (658418) | Department of Health, Australian Government (544454) | Department of Health, Australian Government (MR/P026494/1) | Department of Health, Australian Government (17UCL01) | Department of Health, Australian Government (P2020-0008) | Department of Health, Australian Government (V4720) | Department of Health, Australian Government (MR/N019075/1) | Epilepsy Research UK (F1701) | Great Ormond Street Hospital Charity (V1284) | Royal Society (UF140596) | Rosetrees Trust (M576) | Austrian Science Fund (P31255-B27) | Wellbeing of Women (RT-414) | Parkinson’s UK (J-1403) | Action Medical Research (GN2137) | Austrian Science Fund (SFB35-10) | Sparks (17UCL01) | Great Ormond Street Hospital Charity (V4720) | Action Medical Research (GN2485) | Department of Health, Australian Government (GN2137) | Department of Health, Australian Government (MRC MR/T008024/1) | Department of Health, Australian Government (72160294) | Department of Health, Australian Government (P2020-0008) | Department of Health, Australian Government (UF140596) | Department of Health, Australian Government (21552) | Department of Health, Australian Government (21593) | Department of Health, Australian Government (P31255-B27) | Department of Health, Australian Government (SFB35-10) | Department of Health, Australian Government (LSC17-026) | Department of Health, Australian Government (21077/Z/18/Z) | Department of Health, Australian Government (19507) | Department of Health, Australian Government (22946) | Department of Health, Australian Government (MR/N026101/1) | Department of Health, Australian Government (MR/R025134/1) | Department of Health, Australian Government (MR/S009434/1) | Department of Health, Australian Government (MR/S036784/1) | Department of Health, Australian Government (MR/T044853/1) | Department of Health, Australian Government (NC/L001780/1) | Department of Health, Australian Government (204841/Z/16/Z) | Department of Health, Australian Government (666918) | Department of Health, Australian Government (GN2485) | Marie Curie Fellowship (658418) | NIHR (NIHR-RP-2016-07-019) | Versus Arthritis (21552) | CONICYT Becas Chile Doctoral Fellowship Program (7216029) | Association Française contre les Myopathies (19507 and 22946) | NC3Rs (NC/L001780/1) | European Union’s Horizon 2020 (666918) | Marie Skłodowska-Curie Actions European Union’s Seventh Framework Programme FP7 (608381)

Authors: Joanne Ng | Serena Barral | Carmen De La Fuente Barrigon | Gabriele Lignani | Fatma A. Erdem | Rebecca Wallings | Riccardo Privolizzi | Giada Rossignoli | Haya Alrashidi | Sonja Heasman | Esther Meyer | Adeline Ngoh | Simon Pope | Rajvinder Karda | Dany Perocheau | Julien Baruteau | Natalie Suff | Juan Antinao Diaz | Stephanie Schorge | Jane Vowles | Lucy R. Marshall | Sally A. Cowley | Sonja Sucic | Michael Freissmuth | John R. Counsell | Richard Wade-Martins | Simon J. R. Heales | Ahad A. Rahim | Maximilien Bencze | Simon N. Waddington | Manju A. Kurian

Stronger regulation of AI in biomedicine

JOURNAL ARTICLE published 13 September 2023 in Science Translational Medicine

Authors: Artem A. Trotsyuk | Carole A. Federico | Mildred K. Cho | Russ B. Altman | David Magnus

The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis

JOURNAL ARTICLE published 25 October 2023 in Science Translational Medicine

Authors: Scott M. Norberg | Ke Bai | Cem Sievers | Yvette Robbins | Jay Friedman | Xinping Yang | Meg Kenyon | Elizabeth Ward | Jeffrey Schlom | James Gulley | Amy Lankford | Roshanak Semnani | Helen Sabzevari | Douglas E. Brough | Clint T. Allen

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

JOURNAL ARTICLE published 6 January 2016 in Science Translational Medicine

Research funded by NIH (#T32GM007171) | National Cancer Institute Small Business Innovation Research (#1U43CA165024) | National Center for Advancing Translational Science (#UL1TR001117) | Duke Comprehensive Cancer Center Support (5P30-CA-014236-38)

Authors: Melodi Javid Whitley | Diana M. Cardona | Alexander L. Lazarides | Ivan Spasojevic | Jorge M. Ferrer | Joan Cahill | Chang-Lung Lee | Matija Snuderl | Dan G. Blazer | E. Shelley Hwang | Rachel A. Greenup | Paul J. Mosca | Jeffrey K. Mito | Kyle C. Cuneo | Nicole A. Larrier | Erin K. O’Reilly | Richard F. Riedel | William C. Eward | David B. Strasfeld | Dai Fukumura | Rakesh K. Jain | W. David Lee | Linda G. Griffith | Moungi G. Bawendi | David G. Kirsch | Brian E. Brigman

Pathophysiology of Dyt1- Tor1a dystonia in mice is mediated by spinal neural circuit dysfunction

JOURNAL ARTICLE published 3 May 2023 in Science Translational Medicine

Authors: Amanda M. Pocratsky | Filipe Nascimento | M. Görkem Özyurt | Ian J. White | Roisin Sullivan | Benjamin J. O’Callaghan | Calvin C. Smith | Sunaina Surana | Marco Beato | Robert M. Brownstone

The Road We Must Take: Multidisciplinary Team Science

JOURNAL ARTICLE published 10 March 2010 in Science Translational Medicine

Authors: Mary L. Disis | John T. Slattery

Bionic Limbs: Clinical Reality and Academic Promises

JOURNAL ARTICLE published 8 October 2014 in Science Translational Medicine

Authors: Dario Farina | Oskar Aszmann

Postnatal Soluble FGFR3 Therapy Rescues Achondroplasia Symptoms and Restores Bone Growth in Mice

JOURNAL ARTICLE published 18 September 2013 in Science Translational Medicine

Authors: Stéphanie Garcia | Béatrice Dirat | Thomas Tognacci | Nathalie Rochet | Xavier Mouska | Stéphanie Bonnafous | Stéphanie Patouraux | Albert Tran | Philippe Gual | Yannick Le Marchand-Brustel | Isabelle Gennero | Elvire Gouze

Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients

JOURNAL ARTICLE published 23 July 2014 in Science Translational Medicine

Authors: Kenneth E. Sherman | Jeremie Guedj | Mohamed Tarek Shata | Jason T. Blackard | Susan D. Rouster | Mario Castro | Judith Feinberg | Richard K. Sterling | Zachary Goodman | Bruce J. Aronow | Alan S. Perelson