Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration

JOURNAL ARTICLE published 15 November 2023 in Science Translational Medicine

Authors: Zemin Ling | Janet Crane | Hao Hu | Yan Chen | Mei Wan | Shuangfei Ni | Shadpour Demehri | Bahram Mohajer | Xinsheng Peng | Xuenong Zou | Xu Cao

Liquid biopsy: Clues on prostate cancer drug resistance

JOURNAL ARTICLE published 4 November 2015 in Science Translational Medicine

Authors: Michael T. Schweizer | Emmanuel S. Antonarakis

Clinical trials for neurodevelopmental disorders: At a therapeutic frontier

JOURNAL ARTICLE published 13 January 2016 in Science Translational Medicine

Authors: Shafali S. Jeste | Daniel H. Geschwind

Bone morphogenetic protein 9 is a candidate prognostic biomarker and host-directed therapy target for sepsis

JOURNAL ARTICLE published 31 January 2024 in Science Translational Medicine

Authors: Haobo Bai | Qian Lu | Chunxiang Wu | Fang Xu | Jiayu Liu | Ke Wang | Hao Ding | Yibing Yin | Yi Liu | Xiaofei Lai | Ju Cao

Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease

JOURNAL ARTICLE published 26 October 2016 in Science Translational Medicine

Authors: Nadine Mykicki | Alexander M. Herrmann | Nicholas Schwab | René Deenen | Tim Sparwasser | Andreas Limmer | Lydia Wachsmuth | Luisa Klotz | Karl Köhrer | Cornelius Faber | Heinz Wiendl | Thomas A. Luger | Sven G. Meuth | Karin Loser

Drug-Induced Aches and Pains

JOURNAL ARTICLE published 25 September 2013 in Science Translational Medicine

Authors: Deepak Voora

CpG ODN Nanorings Induce IFNα from Plasmacytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity

JOURNAL ARTICLE published 7 May 2014 in Science Translational Medicine

Authors: Bilgi Gungor | Fuat Cem Yagci | Gizem Tincer | Banu Bayyurt | Esin Alpdundar | Soner Yildiz | Mine Ozcan | Ihsan Gursel | Mayda Gursel

Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta

JOURNAL ARTICLE published 3 July 2013 in Science Translational Medicine

Authors: Elinor K. Karlsson | Jason B. Harris | Shervin Tabrizi | Atiqur Rahman | Ilya Shlyakhter | Nick Patterson | Colm O’Dushlaine | Stephen F. Schaffner | Sameer Gupta | Fahima Chowdhury | Alaullah Sheikh | Ok Sarah Shin | Crystal Ellis | Christine E. Becker | Lynda M. Stuart | Stephen B. Calderwood | Edward T. Ryan | Firdausi Qadri | Pardis C. Sabeti | Regina C. LaRocque

Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env

JOURNAL ARTICLE published 24 November 2021 in Science Translational Medicine

Authors: Amelia Escolano | Harry B. Gristick | Rajeev Gautam | Andrew T. DeLaitsch | Morgan E. Abernathy | Zhi Yang | Haoqing Wang | Magnus A.G. Hoffmann | Yoshiaki Nishimura | Zijun Wang | Nicholas Koranda | Leesa M. Kakutani | Han Gao | Priyanthi N. P. Gnanapragasam | Henna Raina | Ana Gazumyan | Melissa Cipolla | Thiago Y. Oliveira | Victor Ramos | Darrell J. Irvine | Murillo Silva | Anthony P. West | Jennifer R. Keeffe | Christopher O. Barnes | Michael S. Seaman | Michel C. Nussenzweig | Malcolm A. Martin | Pamela J. Bjorkman

Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates

JOURNAL ARTICLE published 3 March 2021 in Science Translational Medicine

Authors: Nicole Darricarrère | Yu Qiu | Masaru Kanekiyo | Adrian Creanga | Rebecca A. Gillespie | Syed M. Moin | Jacqueline Saleh | Jose Sancho | Te-Hui Chou | Yanfeng Zhou | Ruijun Zhang | Shujia Dai | Anthony Moody | Kevin O. Saunders | Michelle C. Crank | John R. Mascola | Barney S. Graham | Chih-Jen Wei | Gary J. Nabel

Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI

JOURNAL ARTICLE published 13 May 2020 in Science Translational Medicine

Research funded by National Natural Science Foundation of China (81830020) | National Natural Science Foundation of China (81873599) | National Natural Science Foundation of China (81700604)

Authors: Xiaowen Yu | Man Xu | Xia Meng | Shumin Li | Qianqi Liu | Mi Bai | Ran You | Songming Huang | Li Yang | Yue Zhang | Zhanjun Jia | Aihua Zhang

A virus-like particle vaccine prevents equine encephalitis virus infection in nonhuman primates

JOURNAL ARTICLE published 15 May 2019 in Science Translational Medicine

Authors: Sung-Youl Ko | Wataru Akahata | Eun Sung Yang | Wing-Pui Kong | Crystal W. Burke | Shelley P. Honnold | Donald K. Nichols | Yan-Jang S. Huang | Gretchen L. Schieber | Kevin Carlton | Luis DaSilva | Vicki Traina-Dorge | Dana L. Vanlandingham | Yaroslav Tsybovsky | Tyler Stephens | Ulrich Baxa | Stephen Higgs | Chad J. Roy | Pamela J. Glass | John R. Mascola | Gary J. Nabel | Srinivas S. Rao

Long noncoding RNA SNHG12 integrates a DNA-PK–mediated DNA damage response and vascular senescence

JOURNAL ARTICLE published 19 February 2020 in Science Translational Medicine

Research funded by National Institutes of Health (HL115141) | National Institutes of Health (HL117994) | National Institutes of Health (HL134849) | National Institutes of Health (GM115605) | American Heart Association (18POST34030395) | American Heart Association (18SFRN33900144)

Authors: Stefan Haemmig | Dafeng Yang | Xinghui Sun | Debapria Das | Siavash Ghaffari | Roberto Molinaro | Lei Chen | Yihuan Deng | Dan Freeman | Norman Moullan | Yevgenia Tesmenitsky | A.K.M. Khyrul Wara | Viorel Simion | Eugenia Shvartz | James F. Lee | Tianlun Yang | Galina Sukova | Jarrod A. Marto | Peter H. Stone | Warren L. Lee | Johan Auwerx | Peter Libby | Mark W. Feinberg

Gene Therapy for Wiskott-Aldrich Syndrome—Long-Term Efficacy and Genotoxicity

JOURNAL ARTICLE published 12 March 2014 in Science Translational Medicine

Authors: Christian Jörg Braun | Kaan Boztug | Anna Paruzynski | Maximilian Witzel | Adrian Schwarzer | Michael Rothe | Ute Modlich | Rita Beier | Gudrun Göhring | Doris Steinemann | Raffaele Fronza | Claudia Regina Ball | Reinhard Haemmerle | Sonja Naundorf | Klaus Kühlcke | Martina Rose | Chris Fraser | Liesl Mathias | Rudolf Ferrari | Miguel R. Abboud | Waleed Al-Herz | Irina Kondratenko | László Maródi | Hanno Glimm | Brigitte Schlegelberger | Axel Schambach | Michael Heinrich Albert | Manfred Schmidt | Christof von Kalle | Christoph Klein

Mouse models of neurodegeneration: Know your question, know your mouse

JOURNAL ARTICLE published 22 May 2019 in Science Translational Medicine

Authors: Elizabeth M. C. Fisher | David M. Bannerman

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism

JOURNAL ARTICLE published 19 May 2021 in Science Translational Medicine

Research funded by Wellcome Trust (WT098524MA) | Wellcome Trust (090532/Z/09/Z) | Wellcome (210774/Z18/Z) | Wellcome (204841/Z/16/Z) | Medical Research Council (MR/K02342X/1) | Medical Research Council (MR/N026101/1) | Medical Research Council (MR/R015325/1) | Medical Research Council (MR/P026494/1) | Medical Research Council (MR/T008024/1) | Medical Research Council (MR/N019075/1) | LifeArc (P2020-0008) | Medical Research Council (MR/T044853/1) | Medical Research Council (MR/R025134/1) | Medical Research Council (MR/S009434/1) | Medical Research Council (MR/S036784/1) | Medical Research Council (G0900747 91070) | National Institute for Health Research (WT098524MA) | National Institute for Health Research (MR/K02342X/1) | National Institute for Health Research (MR/R015325/1) | National Institute for Health Research (V1284) | National Institute for Health Research (NIHR-RP-2016-07-019) | Department of Health, Australian Government (608381) | Department of Health, Australian Government (UK F1701 M) | Department of Health, Australian Government (658418) | Department of Health, Australian Government (544454) | Department of Health, Australian Government (MR/P026494/1) | Department of Health, Australian Government (17UCL01) | Department of Health, Australian Government (P2020-0008) | Department of Health, Australian Government (V4720) | Department of Health, Australian Government (MR/N019075/1) | Epilepsy Research UK (F1701) | Great Ormond Street Hospital Charity (V1284) | Royal Society (UF140596) | Rosetrees Trust (M576) | Austrian Science Fund (P31255-B27) | Wellbeing of Women (RT-414) | Parkinson’s UK (J-1403) | Action Medical Research (GN2137) | Austrian Science Fund (SFB35-10) | Sparks (17UCL01) | Great Ormond Street Hospital Charity (V4720) | Action Medical Research (GN2485) | Department of Health, Australian Government (GN2137) | Department of Health, Australian Government (MRC MR/T008024/1) | Department of Health, Australian Government (72160294) | Department of Health, Australian Government (P2020-0008) | Department of Health, Australian Government (UF140596) | Department of Health, Australian Government (21552) | Department of Health, Australian Government (21593) | Department of Health, Australian Government (P31255-B27) | Department of Health, Australian Government (SFB35-10) | Department of Health, Australian Government (LSC17-026) | Department of Health, Australian Government (21077/Z/18/Z) | Department of Health, Australian Government (19507) | Department of Health, Australian Government (22946) | Department of Health, Australian Government (MR/N026101/1) | Department of Health, Australian Government (MR/R025134/1) | Department of Health, Australian Government (MR/S009434/1) | Department of Health, Australian Government (MR/S036784/1) | Department of Health, Australian Government (MR/T044853/1) | Department of Health, Australian Government (NC/L001780/1) | Department of Health, Australian Government (204841/Z/16/Z) | Department of Health, Australian Government (666918) | Department of Health, Australian Government (GN2485) | Marie Curie Fellowship (658418) | NIHR (NIHR-RP-2016-07-019) | Versus Arthritis (21552) | CONICYT Becas Chile Doctoral Fellowship Program (7216029) | Association Française contre les Myopathies (19507 and 22946) | NC3Rs (NC/L001780/1) | European Union’s Horizon 2020 (666918) | Marie Skłodowska-Curie Actions European Union’s Seventh Framework Programme FP7 (608381)

Authors: Joanne Ng | Serena Barral | Carmen De La Fuente Barrigon | Gabriele Lignani | Fatma A. Erdem | Rebecca Wallings | Riccardo Privolizzi | Giada Rossignoli | Haya Alrashidi | Sonja Heasman | Esther Meyer | Adeline Ngoh | Simon Pope | Rajvinder Karda | Dany Perocheau | Julien Baruteau | Natalie Suff | Juan Antinao Diaz | Stephanie Schorge | Jane Vowles | Lucy R. Marshall | Sally A. Cowley | Sonja Sucic | Michael Freissmuth | John R. Counsell | Richard Wade-Martins | Simon J. R. Heales | Ahad A. Rahim | Maximilien Bencze | Simon N. Waddington | Manju A. Kurian

Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer’s Disease

JOURNAL ARTICLE published 5 March 2014 in Science Translational Medicine

Authors: Anne M. Fagan | Chengjie Xiong | Mateusz S. Jasielec | Randall J. Bateman | Alison M. Goate | Tammie L. S. Benzinger | Bernardino Ghetti | Ralph N. Martins | Colin L. Masters | Richard Mayeux | John M. Ringman | Martin N. Rossor | Stephen Salloway | Peter R. Schofield | Reisa A. Sperling | Daniel Marcus | Nigel J. Cairns | Virginia D. Buckles | Jack H. Ladenson | John C. Morris | David M. Holtzman | The Dominantly Inherited Alzheimer Network

Treatment of a genetic brain disease by CNS-wide microglia replacement

JOURNAL ARTICLE published 16 March 2022 in Science Translational Medicine

Authors: Yohei Shibuya | Kevin K. Kumar | Marius Marc-Daniel Mader | Yongjin Yoo | Luis Angel Ayala | Mu Zhou | Manuel Alexander Mohr | Gernot Neumayer | Ishan Kumar | Ryo Yamamoto | Paul Marcoux | Benjamin Liou | F. Chris Bennett | Hiromitsu Nakauchi | Ying Sun | Xiaoke Chen | Frank L. Heppner | Tony Wyss-Coray | Thomas C. Südhof | Marius Wernig

TLR9 Differentiates Rapidly from Slowly Progressing Forms of Idiopathic Pulmonary Fibrosis

JOURNAL ARTICLE published 10 November 2010 in Science Translational Medicine

Authors: Glenda Trujillo | Alessia Meneghin | Kevin R. Flaherty | Lynette M. Sholl | Jeffrey L. Myers | Ella A. Kazerooni | Barry H. Gross | Sameer R. Oak | Ana Lucia Coelho | Holly Evanoff | Elizabeth Day | Galen B. Toews | Amrita D. Joshi | Matthew A. Schaller | Beatrice Waters | Gabor Jarai | John Westwick | Steven L. Kunkel | Fernando J. Martinez | Cory M. Hogaboam

Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma

JOURNAL ARTICLE published 20 November 2013 in Science Translational Medicine

Authors: Andrei P. Drabovich | Apostolos Dimitromanolakis | Punit Saraon | Antoninus Soosaipillai | Ihor Batruch | Brendan Mullen | Keith Jarvi | Eleftherios P. Diamandis