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What Is the Greatest Regulatory Challenge in the Translation of Biomaterials to the Clinic?

JOURNAL ARTICLE published 14 November 2012 in Science Translational Medicine

Authors: Glenn D. Prestwich | Sangeeta Bhatia | Christopher K. Breuer | Shannon L. M. Dahl | Chris Mason | Richard McFarland | David J. McQuillan | Jonathan Sackner-Bernstein | Jeffrey Schox | William E. Tente | Alan Trounson

Complexities of the Uniquely Human Vagina

JOURNAL ARTICLE published 2 May 2012 in Science Translational Medicine

Authors: Steven S. Witkin | William J. Ledger

Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning

JOURNAL ARTICLE published 7 December 2016 in Science Translational Medicine

Research funded by NIH (F32 HL132418,R01 HL111706,R01 GM113816,R21 ES027390,R01 HL058091,R01 HL098032,R01 HL125886,P01 HL103455,T32 HL110849,T32 HL007563)

Authors: Ivan Azarov | Ling Wang | Jason J. Rose | Qinzi Xu | Xueyin N. Huang | Andrea Belanger | Ying Wang | Lanping Guo | Chen Liu | Kamil B. Ucer | Charles F. McTiernan | Christopher P. O’Donnell | Sruti Shiva | Jesús Tejero | Daniel B. Kim-Shapiro | Mark T. Gladwin

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

JOURNAL ARTICLE published 19 September 2018 in Science Translational Medicine

Research funded by MINECO (CTQ2015-68756-R)

Authors: Pedro Urquiza | Ana Laín | Arantza Sanz-Parra | Jorge Moreno | Ganeko Bernardo-Seisdedos | Pierre Dubus | Esperanza González | Virginia Gutiérrez-de-Juan | Sandra García | Hasier Eraña | Itxaso San Juan | Iratxe Macías | Fredj Ben Bdira | Paula Pluta | Gabriel Ortega | Julen Oyarzábal | Rosario González-Muñiz | Juan Rodríguez-Cuesta | Juan Anguita | Emilio Díez | Jean-Marc Blouin | Hubert de Verneuil | José M. Mato | Emmanuel Richard | Juan M. Falcón-Pérez | Joaquín Castilla | Oscar Millet

Comment on “Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast”

JOURNAL ARTICLE published 11 December 2013 in Science Translational Medicine

Authors: Jun Wang | Akash Gupta | Hong Hu | Robert T. Chatterton | Charles V. Clevenger | Seema A. Khan

Donor Myocardial Infarction Impairs the Therapeutic Potential of Bone Marrow Cells by an Interleukin-1–Mediated Inflammatory Response

JOURNAL ARTICLE published 14 September 2011 in Science Translational Medicine

Authors: Xiaoyin Wang | Junya Takagawa | Viola C. Lam | Daniel J. Haddad | Diana L. Tobler | Pamela Y. Mok | Yan Zhang | Brian T. Clifford | Kranthi Pinnamaneni | Shereen A. Saini | Robert Su | Maya J. Bartel | Richard E. Sievers | Larry Carbone | Scott Kogan | Yerem Yeghiazarians | Michelle L. Hermiston | Matthew L. Springer

Helminth infections drive heterogeneity in human type 2 and regulatory cells

JOURNAL ARTICLE published January 2020 in Science Translational Medicine

Research funded by Royal Netherlands Academy of Arts and Sciences (Ref 57-SPIN3-JRP)

Authors: Karin de Ruiter | Simon P. Jochems | Dicky L. Tahapary | Koen A. Stam | Marion König | Vincent van Unen | Sandra Laban | Thomas Höllt | Moustapha Mbow | Boudewijn P. F. Lelieveldt | Frits Koning | Erliyani Sartono | Johannes W. A. Smit | Taniawati Supali | Maria Yazdanbakhsh

Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy

JOURNAL ARTICLE published 24 February 2021 in Science Translational Medicine

Research funded by National Natural Science Foundation of China (81773098) | National Natural Science Foundation of China (8201101247) | Pearl River S and T Nova Program of Guangzhou (201806010036) | Fundamental Research Funds for the Central Universities (19ykpy151) | National Key Research and Development Program of China Stem Cell and Translational Research (2017YFC1308800) | Natural Science Foundation of Guangdong Province (2019A1515010229) | Key Program of Guangzhou Scientific Research Plan (201804020010) | Guangdong Provincial Science and technology plan (2017A020215199) | Guangdong Special Young Talent Plan of Scientific and Technological Innovation (2019TQ05Y510) | Guangdong International Joint Research Program (2020A0505100027)

Authors: Weisi Lu | Yunling Xie | Binjie Huang | Tenghui Ma | Huaiming Wang | Boxiong Deng | Shaomin Zou | Wencong Wang | Qin Tang | Ziqing Yang | Xuri Li | Lei Wang | Lekun Fang

Neutralization of NET-associated human ARG1 enhances cancer immunotherapy

JOURNAL ARTICLE published 15 March 2023 in Science Translational Medicine

Authors: Stefania Canè | Roza Maria Barouni | Marina Fabbi | John Cuozzo | Giulio Fracasso | Annalisa Adamo | Stefano Ugel | Rosalinda Trovato | Francesco De Sanctis | Mauro Giacca | Rita Lawlor | Aldo Scarpa | Borislav Rusev | Gabriella Lionetto | Salvatore Paiella | Roberto Salvia | Claudio Bassi | Susanna Mandruzzato | Silvano Ferrini | Vincenzo Bronte

Distinct neural mechanisms for the prosocial and rewarding properties of MDMA

JOURNAL ARTICLE published 11 December 2019 in Science Translational Medicine

Research funded by National Institute of Mental Health (MH110610) | National Institute of Mental Health (MH115668) | National Institute of Mental Health (MG105839) | National Institute on Drug Abuse (DA042012)

Authors: Boris D. Heifets | Juliana S. Salgado | Madison D. Taylor | Paul Hoerbelt | Daniel F. Cardozo Pinto | Elizabeth E. Steinberg | Jessica J. Walsh | Ji Y. Sze | Robert C. Malenka

Targeting pancreatic islet PTP1B improves islet graft revascularization and transplant outcomes

JOURNAL ARTICLE published 19 June 2019 in Science Translational Medicine

Research funded by Generalitat de Catalunya (2014 SGR 659) | Instituto de Salud Carlos III (FIS PI16/0074) | Academy of Medical and Health Science of Catalonia and the Balearic Islands (Recerca Basica 2014)

Authors: Hugo Figueiredo | Ana Lucia C. Figueroa | Ainhoa Garcia | Rebeca Fernandez-Ruiz | Christophe Broca | Anne Wojtusciszyn | Rita Malpique | Rosa Gasa | Ramon Gomis

Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease

JOURNAL ARTICLE published 26 January 2011 in Science Translational Medicine

Authors: Erin Gatza | Daniel R. Wahl | Anthony W. Opipari | Thomas B. Sundberg | Pavan Reddy | Chen Liu | Gary D. Glick | James L. M. Ferrara

Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia

JOURNAL ARTICLE published 3 June 2015 in Science Translational Medicine

Research funded by National Health and Medical Research Council of Australia (APP1042446,546087,634304)

Authors: Vasyl Holobotovskyy | Yee Seng Chong | Jennifer Burchell | Bo He | Michael Phillips | Leo Leader | Timothy V. Murphy | Shaun L. Sandow | Douglas J. McKitrick | Adrian K. Charles | Marianne Tare | Leonard F. Arnolda | Ruth Ganss

Magnetic resonance image features identify glioblastoma phenotypic subtypes with distinct molecular pathway activities

JOURNAL ARTICLE published 2 September 2015 in Science Translational Medicine

Research funded by NIH (R01EB020527) | National Cancer Institute (R01CA160251)

Authors: Haruka Itakura | Achal S. Achrol | Lex A. Mitchell | Joshua J. Loya | Tiffany Liu | Erick M. Westbroek | Abdullah H. Feroze | Scott Rodriguez | Sebastian Echegaray | Tej D. Azad | Kristen W. Yeom | Sandy Napel | Daniel L. Rubin | Steven D. Chang | Griffith R. Harsh | Olivier Gevaert

Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy

JOURNAL ARTICLE published 2 June 2021 in Science Translational Medicine

Research funded by Fondazione Telethon (GGP17009) | Italian Ministry of Health (GR-2011-02351814) | Italian Ministry of Health (RF-2016-02363024) | AFM-Telethon (#21545) | Fondazione Regionale per la Ricerca Biomedica (CP2_10/2018) | European Joint Programme on Rare Diseases (19-118)

Authors: Giorgia Careccia | Marielle Saclier | Mario Tirone | Elena Ruggieri | Elisa Principi | Lizzia Raffaghello | Silvia Torchio | Deborah Recchia | Monica Canepari | Andrea Gorzanelli | Michele Ferrara | Patrizia Castellani | Anna Rubartelli | Patrizia Rovere-Querini | Maura Casalgrandi | Alessandro Preti | Isabella Lorenzetti | Claudio Bruno | Roberto Bottinelli | Silvia Brunelli | Stefano Carlo Previtali | Marco Emilio Bianchi | Graziella Messina | Emilie Vénéreau

Anti–CTLA-4 therapy broadens the melanoma-reactive CD8 + T cell response

JOURNAL ARTICLE published 17 September 2014 in Science Translational Medicine

Authors: Pia Kvistborg | Daisy Philips | Sander Kelderman | Lois Hageman | Christian Ottensmeier | Deborah Joseph-Pietras | Marij J. P. Welters | Sjoerd van der Burg | Ellen Kapiteijn | Olivier Michielin | Emanuela Romano | Carsten Linnemann | Daniel Speiser | Christian Blank | John B. Haanen | Ton N. Schumacher

The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis

JOURNAL ARTICLE published 25 October 2023 in Science Translational Medicine

Authors: Scott M. Norberg | Ke Bai | Cem Sievers | Yvette Robbins | Jay Friedman | Xinping Yang | Meg Kenyon | Elizabeth Ward | Jeffrey Schlom | James Gulley | Amy Lankford | Roshanak Semnani | Helen Sabzevari | Douglas E. Brough | Clint T. Allen

Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity

JOURNAL ARTICLE published 9 February 2022 in Science Translational Medicine

Authors: Catherine Riou | Roanne Keeton | Thandeka Moyo-Gwete | Tandile Hermanus | Prudence Kgagudi | Richard Baguma | Ziyaad Valley-Omar | Mikhail Smith | Houriiyah Tegally | Deelan Doolabh | Arash Iranzadeh | Lynn Tyers | Hygon Mutavhatsindi | Marius B. Tincho | Ntombi Benede | Gert Marais | Lionel R. Chinhoyi | Mathilda Mennen | Sango Skelem | Elsa du Bruyn | Cari Stek | Tulio de Oliveira | Carolyn Williamson | Penny L. Moore | Robert J. Wilkinson | Ntobeko A. B. Ntusi | Wendy A. Burgers | South African cellular immunity network

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase

JOURNAL ARTICLE published 12 July 2017 in Science Translational Medicine

Research funded by National Institutes of Health (award310436,R01CA068490) | National Institutes of Health (award310437,P50CA101942)

Authors: Abhishek A. Chakraborty | Eijiro Nakamura | Jun Qi | Amanda Creech | Jacob D. Jaffe | Joshiawa Paulk | Jesse S. Novak | Kshithija Nagulapalli | Samuel K. McBrayer | Glenn S. Cowley | Javier Pineda | Jiaxi Song | Yaoyu E. Wang | Steven A. Carr | David E. Root | Sabina Signoretti | James E. Bradner | William G. Kaelin

Aging as a driver of leukemogenesis

JOURNAL ARTICLE published 23 September 2015 in Science Translational Medicine

Research funded by Wellcome Trust Clinician Scientist Fellowship (WT098051) | Wellcome Trust Senior Fellowship in Clinical Science (WT095663MA)

Authors: Thomas McKerrell | George S. Vassiliou