What Is the Greatest Regulatory Challenge in the Translation of Biomaterials to the Clinic?

JOURNAL ARTICLE published 14 November 2012 in Science Translational Medicine

Authors: Glenn D. Prestwich | Sangeeta Bhatia | Christopher K. Breuer | Shannon L. M. Dahl | Chris Mason | Richard McFarland | David J. McQuillan | Jonathan Sackner-Bernstein | Jeffrey Schox | William E. Tente | Alan Trounson

Complexities of the Uniquely Human Vagina

JOURNAL ARTICLE published 2 May 2012 in Science Translational Medicine

Authors: Steven S. Witkin | William J. Ledger

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

JOURNAL ARTICLE published 19 September 2018 in Science Translational Medicine

Research funded by MINECO (CTQ2015-68756-R)

Authors: Pedro Urquiza | Ana Laín | Arantza Sanz-Parra | Jorge Moreno | Ganeko Bernardo-Seisdedos | Pierre Dubus | Esperanza González | Virginia Gutiérrez-de-Juan | Sandra García | Hasier Eraña | Itxaso San Juan | Iratxe Macías | Fredj Ben Bdira | Paula Pluta | Gabriel Ortega | Julen Oyarzábal | Rosario González-Muñiz | Juan Rodríguez-Cuesta | Juan Anguita | Emilio Díez | Jean-Marc Blouin | Hubert de Verneuil | José M. Mato | Emmanuel Richard | Juan M. Falcón-Pérez | Joaquín Castilla | Oscar Millet

Comment on “Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast”

JOURNAL ARTICLE published 11 December 2013 in Science Translational Medicine

Authors: Jun Wang | Akash Gupta | Hong Hu | Robert T. Chatterton | Charles V. Clevenger | Seema A. Khan

Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy

JOURNAL ARTICLE published 2 June 2021 in Science Translational Medicine

Research funded by Fondazione Telethon (GGP17009) | Italian Ministry of Health (GR-2011-02351814) | Italian Ministry of Health (RF-2016-02363024) | AFM-Telethon (#21545) | Fondazione Regionale per la Ricerca Biomedica (CP2_10/2018) | European Joint Programme on Rare Diseases (19-118)

Authors: Giorgia Careccia | Marielle Saclier | Mario Tirone | Elena Ruggieri | Elisa Principi | Lizzia Raffaghello | Silvia Torchio | Deborah Recchia | Monica Canepari | Andrea Gorzanelli | Michele Ferrara | Patrizia Castellani | Anna Rubartelli | Patrizia Rovere-Querini | Maura Casalgrandi | Alessandro Preti | Isabella Lorenzetti | Claudio Bruno | Roberto Bottinelli | Silvia Brunelli | Stefano Carlo Previtali | Marco Emilio Bianchi | Graziella Messina | Emilie Vénéreau

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase

JOURNAL ARTICLE published 12 July 2017 in Science Translational Medicine

Research funded by National Institutes of Health (award310436,R01CA068490) | National Institutes of Health (award310437,P50CA101942)

Authors: Abhishek A. Chakraborty | Eijiro Nakamura | Jun Qi | Amanda Creech | Jacob D. Jaffe | Joshiawa Paulk | Jesse S. Novak | Kshithija Nagulapalli | Samuel K. McBrayer | Glenn S. Cowley | Javier Pineda | Jiaxi Song | Yaoyu E. Wang | Steven A. Carr | David E. Root | Sabina Signoretti | James E. Bradner | William G. Kaelin

Effect of population viral load on prospective HIV incidence in a hyperendemic rural African community

JOURNAL ARTICLE published 13 December 2017 in Science Translational Medicine

Authors: Frank Tanser | Alain Vandormael | Diego Cuadros | Andrew N. Phillips | Tulio de Oliveira | Andrew Tomita | Till Bärnighausen | Deenan Pillay

β-Catenin Promotes Colitis and Colon Cancer Through Imprinting of Proinflammatory Properties in T Cells

JOURNAL ARTICLE published 26 February 2014 in Science Translational Medicine

Authors: Shilpa Keerthivasan | Katayoun Aghajani | Marei Dose | Luciana Molinero | Mohammad W. Khan | Vysak Venkateswaran | Christopher Weber | Akinola Olumide Emmanuel | Tianjao Sun | David J. Bentrem | Mary Mulcahy | Ali Keshavarzian | Elena M. Ramos | Nichole Blatner | Khashayarsha Khazaie | Fotini Gounari

Agonist-antagonist myoneural interface amputation preserves proprioceptive sensorimotor neurophysiology in lower limbs

JOURNAL ARTICLE published 9 December 2020 in Science Translational Medicine

Authors: Shriya S. Srinivasan | Greta Tuckute | Jasmine Zou | Samantha Gutierrez-Arango | Hyungeun Song | Robert L. Barry | Hugh M. Herr

The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI

JOURNAL ARTICLE published November 2023 in Science Translational Medicine

Authors: Francesco Trepiccione | Anna Iervolino | Mariavittoria D’Acierno | Sabrina Siccardi | Vincenzo Costanzo | Donato Sardella | Luigi R. De La Motte | Luciano D’Apolito | Antonio Miele | Alessandra F. Perna | Giovanna Capolongo | Miriam Zacchia | Sebastian Frische | Rikke Nielsen | Leopoldo Staiano | Irene Sambri | Rossella De Cegli | Robert Unwin | Dominique Eladari | Giovambattista Capasso

Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer

JOURNAL ARTICLE published September 2021 in Science Translational Medicine

Authors: Pınar Özden Eser | Raymond M. Paranal | Jieun Son | Elena Ivanova | Yanan Kuang | Heidi M. Haikala | Ciric To | Jeffrey J. Okoro | Kshiti H. Dholakia | Jihyun Choi | Yoonji Eum | Atsuko Ogino | Pavlos Missios | Dalia Ercan | Man Xu | Michael J. Poitras | Stephen Wang | Kenneth Ngo | Michael Dills | Masahiko Yanagita | Timothy Lopez | Mika Lin | Jeanelle Tsai | Nicolas Floch | Emily S. Chambers | Jennifer Heng | Rana Anjum | Alison D. Santucci | Kesi Michael | Alwin G. Schuller | Darren Cross | Paul D. Smith | Geoffrey R. Oxnard | David A. Barbie | Lynette M. Sholl | Magda Bahcall | Sangeetha Palakurthi | Prafulla C. Gokhale | Cloud P. Paweletz | George Q. Daley | Pasi A. Jänne

Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats

JOURNAL ARTICLE published 6 December 2023 in Science Translational Medicine

Authors: Wensen Jiang | Juliane D. Glaeser | Giselle Kaneda | Julia Sheyn | Jacob T. Wechsler | Stephen Stephan | Khosrowdad Salehi | Julie L. Chan | Wafa Tawackoli | Pablo Avalos | Christopher Johnson | Chloe Castaneda | Linda E.A. Kanim | Teerachat Tanasansomboon | Joshua E. Burda | Oksana Shelest | Haneen Yameen | Tiffany G. Perry | Michael Kropf | Jason M. Cuellar | Dror Seliktar | Hyun W. Bae | Laura S. Stone | Dmitriy Sheyn

Optimizing the Delivery of Cancer Drugs That Block Angiogenesis

JOURNAL ARTICLE published 20 January 2010 in Science Translational Medicine

Authors: Yihai Cao | Robert Langer

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

JOURNAL ARTICLE published 24 January 2024 in Science Translational Medicine

Authors: Eva Lana-Elola | Rifdat Aoidi | Miriam Llorian | Dorota Gibbins | Callan Buechsenschuetz | Claudio Bussi | Helen Flynn | Tegan Gilmore | Sheona Watson-Scales | Marie Haugsten Hansen | Darryl Hayward | Ok-Ryul Song | Véronique Brault | Yann Herault | Emmanuel Deau | Laurent Meijer | Ambrosius P. Snijders | Maximiliano G. Gutierrez | Elizabeth M. C. Fisher | Victor L. J. Tybulewicz

Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy

JOURNAL ARTICLE published 22 September 2021 in Science Translational Medicine

Authors: Arwa Kohela | Sebastiaan J. van Kampen | Tara Moens | Martijn Wehrens | Bas Molenaar | Cornelis J. Boogerd | Jantine Monshouwer-Kloots | Ilaria Perini | Marie José Goumans | Anke M. Smits | J. Peter van Tintelen | Eva van Rooij

A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care

JOURNAL ARTICLE published 11 May 2022 in Science Translational Medicine

Authors: Mikael Eriksson | Stamatia Destounis | Kamila Czene | Andrew Zeiberg | Robert Day | Emily F. Conant | Kathy Schilling | Per Hall

Muse cell spheroids have therapeutic effect on corneal scarring wound in mice and tree shrews

JOURNAL ARTICLE published 23 September 2020 in Science Translational Medicine

Research funded by National Outstanding Youth Science Fund Project of National Natural Science Foundation of China (81871495) | Project funded by China Postdoctoral Science Foundation (2019M663391) | the Special Funds for Major Science and Technology Projects of Guangdong Province (2015B010125007) | Joint Fund of Basic and Applied Basic Research Fund of Guangdong Province (2019A1515110355)

Authors: Yonglong Guo | Yunxia Xue | Peiyuan Wang | Zekai Cui | Jixing Cao | Shiwei Liu | Quan Yu | Qiaolang Zeng | Deliang Zhu | Mengyuan Xie | Jun Zhang | Zhijie Li | Hongwei Liu | Jingxiang Zhong | Jiansu Chen

Response to Comment on “Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model”

JOURNAL ARTICLE published 24 October 2012 in Science Translational Medicine

Authors: Lee E. Goldstein | Ann C. McKee

Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors

JOURNAL ARTICLE published 16 November 2016 in Science Translational Medicine

Research funded by German Research Foundation (CRC1181,TRR1181)

Authors: Daniel F. Ortiz | Jonathan C. Lansing | Laura Rutitzky | Elma Kurtagic | Thomas Prod’homme | Amit Choudhury | Nathaniel Washburn | Naveen Bhatnagar | Christopher Beneduce | Kimberly Holte | Robert Prenovitz | Matthew Child | Jason Killough | Steven Tyler | Julia Brown | Stephanie Nguyen | Inessa Schwab | Maurice Hains | Robin Meccariello | Lynn Markowitz | Jing Wang | Radouane Zouaoui | Allison Simpson | Birgit Schultes | Ishan Capila | Leona Ling | Falk Nimmerjahn | Anthony M. Manning | Carlos J. Bosques

Immune checkpoint B7-H3 is a therapeutic vulnerability in prostate cancer harboring PTEN and TP53 deficiencies

JOURNAL ARTICLE published 10 May 2023 in Science Translational Medicine

Authors: Wei Shi | Yin Wang | Yuehui Zhao | Justin Jimin Kim | Haoyan Li | Chenling Meng | Feiyu Chen | Jie Zhang | Duncan H. Mak | Vivien Van | Javier Leo | Brad St. Croix | Ana Aparicio | Di Zhao