HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase

JOURNAL ARTICLE published 12 July 2017 in Science Translational Medicine

Research funded by National Institutes of Health (award310436,R01CA068490) | National Institutes of Health (award310437,P50CA101942)

Authors: Abhishek A. Chakraborty | Eijiro Nakamura | Jun Qi | Amanda Creech | Jacob D. Jaffe | Joshiawa Paulk | Jesse S. Novak | Kshithija Nagulapalli | Samuel K. McBrayer | Glenn S. Cowley | Javier Pineda | Jiaxi Song | Yaoyu E. Wang | Steven A. Carr | David E. Root | Sabina Signoretti | James E. Bradner | William G. Kaelin

Agonist-antagonist myoneural interface amputation preserves proprioceptive sensorimotor neurophysiology in lower limbs

JOURNAL ARTICLE published 9 December 2020 in Science Translational Medicine

Authors: Shriya S. Srinivasan | Greta Tuckute | Jasmine Zou | Samantha Gutierrez-Arango | Hyungeun Song | Robert L. Barry | Hugh M. Herr

The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI

JOURNAL ARTICLE published November 2023 in Science Translational Medicine

Authors: Francesco Trepiccione | Anna Iervolino | Mariavittoria D’Acierno | Sabrina Siccardi | Vincenzo Costanzo | Donato Sardella | Luigi R. De La Motte | Luciano D’Apolito | Antonio Miele | Alessandra F. Perna | Giovanna Capolongo | Miriam Zacchia | Sebastian Frische | Rikke Nielsen | Leopoldo Staiano | Irene Sambri | Rossella De Cegli | Robert Unwin | Dominique Eladari | Giovambattista Capasso

Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer

JOURNAL ARTICLE published September 2021 in Science Translational Medicine

Authors: Pınar Özden Eser | Raymond M. Paranal | Jieun Son | Elena Ivanova | Yanan Kuang | Heidi M. Haikala | Ciric To | Jeffrey J. Okoro | Kshiti H. Dholakia | Jihyun Choi | Yoonji Eum | Atsuko Ogino | Pavlos Missios | Dalia Ercan | Man Xu | Michael J. Poitras | Stephen Wang | Kenneth Ngo | Michael Dills | Masahiko Yanagita | Timothy Lopez | Mika Lin | Jeanelle Tsai | Nicolas Floch | Emily S. Chambers | Jennifer Heng | Rana Anjum | Alison D. Santucci | Kesi Michael | Alwin G. Schuller | Darren Cross | Paul D. Smith | Geoffrey R. Oxnard | David A. Barbie | Lynette M. Sholl | Magda Bahcall | Sangeetha Palakurthi | Prafulla C. Gokhale | Cloud P. Paweletz | George Q. Daley | Pasi A. Jänne

Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats

JOURNAL ARTICLE published 6 December 2023 in Science Translational Medicine

Authors: Wensen Jiang | Juliane D. Glaeser | Giselle Kaneda | Julia Sheyn | Jacob T. Wechsler | Stephen Stephan | Khosrowdad Salehi | Julie L. Chan | Wafa Tawackoli | Pablo Avalos | Christopher Johnson | Chloe Castaneda | Linda E.A. Kanim | Teerachat Tanasansomboon | Joshua E. Burda | Oksana Shelest | Haneen Yameen | Tiffany G. Perry | Michael Kropf | Jason M. Cuellar | Dror Seliktar | Hyun W. Bae | Laura S. Stone | Dmitriy Sheyn

Optimizing the Delivery of Cancer Drugs That Block Angiogenesis

JOURNAL ARTICLE published 20 January 2010 in Science Translational Medicine

Authors: Yihai Cao | Robert Langer

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

JOURNAL ARTICLE published 24 January 2024 in Science Translational Medicine

Authors: Eva Lana-Elola | Rifdat Aoidi | Miriam Llorian | Dorota Gibbins | Callan Buechsenschuetz | Claudio Bussi | Helen Flynn | Tegan Gilmore | Sheona Watson-Scales | Marie Haugsten Hansen | Darryl Hayward | Ok-Ryul Song | Véronique Brault | Yann Herault | Emmanuel Deau | Laurent Meijer | Ambrosius P. Snijders | Maximiliano G. Gutierrez | Elizabeth M. C. Fisher | Victor L. J. Tybulewicz

Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy

JOURNAL ARTICLE published 22 September 2021 in Science Translational Medicine

Authors: Arwa Kohela | Sebastiaan J. van Kampen | Tara Moens | Martijn Wehrens | Bas Molenaar | Cornelis J. Boogerd | Jantine Monshouwer-Kloots | Ilaria Perini | Marie José Goumans | Anke M. Smits | J. Peter van Tintelen | Eva van Rooij

A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care

JOURNAL ARTICLE published 11 May 2022 in Science Translational Medicine

Authors: Mikael Eriksson | Stamatia Destounis | Kamila Czene | Andrew Zeiberg | Robert Day | Emily F. Conant | Kathy Schilling | Per Hall

Muse cell spheroids have therapeutic effect on corneal scarring wound in mice and tree shrews

JOURNAL ARTICLE published 23 September 2020 in Science Translational Medicine

Research funded by National Outstanding Youth Science Fund Project of National Natural Science Foundation of China (81871495) | Project funded by China Postdoctoral Science Foundation (2019M663391) | the Special Funds for Major Science and Technology Projects of Guangdong Province (2015B010125007) | Joint Fund of Basic and Applied Basic Research Fund of Guangdong Province (2019A1515110355)

Authors: Yonglong Guo | Yunxia Xue | Peiyuan Wang | Zekai Cui | Jixing Cao | Shiwei Liu | Quan Yu | Qiaolang Zeng | Deliang Zhu | Mengyuan Xie | Jun Zhang | Zhijie Li | Hongwei Liu | Jingxiang Zhong | Jiansu Chen

Response to Comment on “Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model”

JOURNAL ARTICLE published 24 October 2012 in Science Translational Medicine

Authors: Lee E. Goldstein | Ann C. McKee

Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors

JOURNAL ARTICLE published 16 November 2016 in Science Translational Medicine

Research funded by German Research Foundation (CRC1181,TRR1181)

Authors: Daniel F. Ortiz | Jonathan C. Lansing | Laura Rutitzky | Elma Kurtagic | Thomas Prod’homme | Amit Choudhury | Nathaniel Washburn | Naveen Bhatnagar | Christopher Beneduce | Kimberly Holte | Robert Prenovitz | Matthew Child | Jason Killough | Steven Tyler | Julia Brown | Stephanie Nguyen | Inessa Schwab | Maurice Hains | Robin Meccariello | Lynn Markowitz | Jing Wang | Radouane Zouaoui | Allison Simpson | Birgit Schultes | Ishan Capila | Leona Ling | Falk Nimmerjahn | Anthony M. Manning | Carlos J. Bosques

Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma

JOURNAL ARTICLE published 24 October 2018 in Science Translational Medicine

Research funded by National Cancer Institute (4K08CA138912-05) | National Cancer Institute (P30CA016672) | University of Texas MD Anderson Cancer Center (Knowledge Gap Funding)

Authors: Liran Zhou | Hongmei Husted | Todd Moore | Mason Lu | Defeng Deng | Yan Liu | Vijaya Ramachandran | Thiruvengadam Arumugam | Christof Niehrs | Huamin Wang | Paul Chiao | Jianhua Ling | Michael A. Curran | Anirban Maitra | Mien-Chie Hung | Jeffrey E. Lee | Craig D. Logsdon | Rosa F. Hwang

Aging as a driver of leukemogenesis

JOURNAL ARTICLE published 23 September 2015 in Science Translational Medicine

Research funded by Wellcome Trust Clinician Scientist Fellowship (WT098051) | Wellcome Trust Senior Fellowship in Clinical Science (WT095663MA)

Authors: Thomas McKerrell | George S. Vassiliou

Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis

JOURNAL ARTICLE published 30 November 2016 in Science Translational Medicine

Research funded by Deutsche Forschungsgemeinschaft (SFB 1123,SFB 914)

Authors: Tobias Petzold | Manuela Thienel | Ildiko Konrad | Irene Schubert | Ron Regenauer | Boj Hoppe | Michael Lorenz | Annekathrin Eckart | Sue Chandraratne | Carsten Lennerz | Christof Kolb | Daniel Braun | Janina Jamasbi | Richard Brandl | Siegmund Braun | Wolfgang Siess | Christian Schulz | Steffen Massberg

Digital Genomic Quantification of Tumor-Infiltrating Lymphocytes

JOURNAL ARTICLE published 4 December 2013 in Science Translational Medicine

Authors: Harlan S. Robins | Nolan G. Ericson | Jamie Guenthoer | Kathy C. O’Briant | Muneesh Tewari | Charles W. Drescher | Jason H. Bielas

Structure-based drug design identifies polythiophenes as antiprion compounds

JOURNAL ARTICLE published 5 August 2015 in Science Translational Medicine

Research funded by European Union Seventh Framework Program (Bio-NMR 261863) | Agence Nationale de la Recherche (ANR-11-BSV-8021-01,ANR-12-BS08-0013-01) | Swiss National Science Foundation (200020_146757,315230_149897)

Authors: Uli S. Herrmann | Anne K. Schütz | Hamid Shirani | Danzhi Huang | Dino Saban | Mario Nuvolone | Bei Li | Boris Ballmer | Andreas K. O. Åslund | Jeffrey J. Mason | Elisabeth Rushing | Herbert Budka | Sofie Nyström | Per Hammarström | Anja Böckmann | Amedeo Caflisch | Beat H. Meier | K. Peter R. Nilsson | Simone Hornemann | Adriano Aguzzi

RNAi Therapies: Drugging the Undruggable

JOURNAL ARTICLE published 11 June 2014 in Science Translational Medicine

Authors: Sherry Y. Wu | Gabriel Lopez-Berestein | George A. Calin | Anil K. Sood

Applying What We Know to Accelerate Cancer Prevention

JOURNAL ARTICLE published 28 March 2012 in Science Translational Medicine

Authors: Graham A. Colditz | Kathleen Y. Wolin | Sarah Gehlert

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

JOURNAL ARTICLE published 23 November 2016 in Science Translational Medicine

Research funded by National Cancer Institute (K08 CA181475) | Damon Runyon Cancer Research Foundation (DRG-2195-14) | NIH (P30 CA008748)

Authors: Jill Bayliss | Piali Mukherjee | Chao Lu | Siddhant U. Jain | Chan Chung | Daniel Martinez | Benjamin Sabari | Ashley S. Margol | Pooja Panwalkar | Abhijit Parolia | Melike Pekmezci | Richard C. McEachin | Marcin Cieslik | Benita Tamrazi | Benjamin A. Garcia | Gaspare La Rocca | Mariarita Santi | Peter W. Lewis | Cynthia Hawkins | Ari Melnick | C. David Allis | Craig B. Thompson | Arul M. Chinnaiyan | Alexander R. Judkins | Sriram Venneti