Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting

JOURNAL ARTICLE published 15 June 2022 in Science Translational Medicine

Authors: Mithila Sawant | Kiran Mahajan | Arun Renganathan | Cody Weimholt | Jingqin Luo | Vandna Kukshal | Joseph M. Jez | Myung Sik Jeon | Bo Zhang | Tiandao Li | Bin Fang | Yunting Luo | Nicholas J. Lawrence | Harshani R. Lawrence | Felix Y. Feng | Nupam P. Mahajan

Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration

JOURNAL ARTICLE published 15 November 2023 in Science Translational Medicine

Authors: Zemin Ling | Janet Crane | Hao Hu | Yan Chen | Mei Wan | Shuangfei Ni | Shadpour Demehri | Bahram Mohajer | Xinsheng Peng | Xuenong Zou | Xu Cao

Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress

JOURNAL ARTICLE published 9 May 2018 in Science Translational Medicine

Research funded by Swiss National Science Foundation (31003A_169204)

Authors: Kristin Seltmann | Michael Meyer | Jitka Sulcova | Tobias Kockmann | Ulrike Wehkamp | Stephan Weidinger | Ulrich auf dem Keller | Sabine Werner

The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England

JOURNAL ARTICLE published 6 July 2022 in Science Translational Medicine

Authors: Robert S. Paton | Christopher E. Overton | Thomas Ward

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy

JOURNAL ARTICLE published 20 March 2019 in Science Translational Medicine

Research funded by Fundacion BBVA (#67_2015) | H2020 European Research Council (CoG Grant #617473) | Worldwide Cancer Research (WCR/AICR Grant #13-1182) | Ministerio de Economía y Competitividad (IJCI-2014-22403) | Instituto de Salud Carlos III (FIS Grant #PI13/01705)

Authors: Marie-Eve Beaulieu | Toni Jauset | Daniel Massó-Vallés | Sandra Martínez-Martín | Peter Rahl | Loïka Maltais | Mariano F. Zacarias-Fluck | Sílvia Casacuberta-Serra | Erika Serrano del Pozo | Christopher Fiore | Laia Foradada | Virginia Castillo Cano | Meritxell Sánchez-Hervás | Matthew Guenther | Eduardo Romero Sanz | Marta Oteo | Cynthia Tremblay | Génesis Martín | Danny Letourneau | Martin Montagne | Miguel Ángel Morcillo Alonso | Jonathan R. Whitfield | Pierre Lavigne | Laura Soucek

An anti–TNF–glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases

JOURNAL ARTICLE published 20 March 2024 in Science Translational Medicine

Authors: Michael J. McPherson | Adrian D. Hobson | Axel Hernandez | Christopher C. Marvin | Wendy Waegell | Christian Goess | Jason Z. Oh | Dan Shi | Martin E. Hayes | Lu Wang | Lu Wang | Diana Schmidt | Zhi Wang | Victoria Pitney | Kimberley McCarthy | Ying Jia | Ce Wang | Bit Na Kang | Shaughn Bryant | Suzanne Mathieu | Melanie Ruzek | Julie Parmentier | Ronilda R. D’Cunha | Yinuo Pang | Lucy Phillips | Nathan J. Brown | Jianwen Xu | Candace Graff | Yu Tian | Kenton L. Longenecker | Wei Qiu | Haizhong Zhu | Wei Liu | Pingping Zheng | Yingtao Bi | Robert Stoffel

Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2

JOURNAL ARTICLE published 22 February 2023 in Science Translational Medicine

Authors: Priya Bhardwaj | Neil M. Iyengar | Heba Zahid | Katharine M. Carter | Dong Jun Byun | Man Ho Choi | Qi Sun | Oleksandr Savenkov | Charalambia Louka | Catherine Liu | Phoebe Piloco | Monica Acosta | Rohan Bareja | Olivier Elemento | Miguel Foronda | Lukas E. Dow | Sofya Oshchepkova | Dilip D. Giri | Michael Pollak | Xi Kathy Zhou | Benjamin D. Hopkins | Ashley M. Laughney | Melissa K. Frey | Lora Hedrick Ellenson | Monica Morrow | Jason A. Spector | Lewis C. Cantley | Kristy A. Brown

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

JOURNAL ARTICLE published 9 March 2016 in Science Translational Medicine

Authors: Sang Ho Lee | Hao Wang | Marc Labroli | Sandra Koseoglu | Paul Zuck | Todd Mayhood | Charles Gill | Paul Mann | Xinwei Sher | Sookhee Ha | Shu-Wei Yang | Mihir Mandal | Christine Yang | Lianzhu Liang | Zheng Tan | Paul Tawa | Yan Hou | Reshma Kuvelkar | Kristine DeVito | Xiujuan Wen | Jing Xiao | Michelle Batchlett | Carl J. Balibar | Jenny Liu | Jianying Xiao | Nicholas Murgolo | Charles G. Garlisi | Payal R. Sheth | Amy Flattery | Jing Su | Christopher Tan | Terry Roemer

Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles

JOURNAL ARTICLE published 10 June 2020 in Science Translational Medicine

Research funded by European Commission (n°115300 and n°777394) | Bundesministerium für Bildung und Forschung (01EK1611C) | Comitato Telethon Fondazione Onlus (GGP16131)

Authors: Anne-Kathrin Lutz | Stefanie Pfaender | Berra Incearap | Valentin Ioannidis | Ilaria Ottonelli | Karl J. Föhr | Judith Cammerer | Marvin Zoller | Julia Higelin | Federica Giona | Maximilian Stetter | Nicole Stoecker | Najwa Ouali Alami | Michael Schön | Michael Orth | Stefan Liebau | Gotthold Barbi | Andreas M. Grabrucker | Richard Delorme | Michael Fauler | Benjamin Mayer | Sarah Jesse | Francesco Roselli | Albert C. Ludolph | Thomas Bourgeron | Chiara Verpelli | Maria Demestre | Tobias M. Boeckers

Sustained fetal hemoglobin induction in vivo is achieved by BCL11A interference and coexpressed truncated erythropoietin receptor

JOURNAL ARTICLE published 28 April 2021 in Science Translational Medicine

Authors: Naoya Uchida | Francesca Ferrara | Claire M. Drysdale | Morgan Yapundich | Jackson Gamer | Tina Nassehi | Julia DiNicola | Yoshitaka Shibata | Matthew Wielgosz | Yoon-Sang Kim | Matthew Bauler | Robert E. Throm | Juan J. Haro-Mora | Selami Demirci | Aylin C. Bonifacino | Allen E. Krouse | N. Seth Linde | Robert E. Donahue | Byoung Ryu | John F. Tisdale

Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice

JOURNAL ARTICLE published 9 September 2020 in Science Translational Medicine

Research funded by Agence Nationale de la Recherche (MAD-GUT)

Authors: Antoine P. Fournier | Sara Martinez de Lizarrondo | Adrien Rateau | Axel Gerard-Brisou | Maximilian J. Waldner | Markus F. Neurath | Denis Vivien | Fabian Docagne | Maxime Gauberti

⁶⁸ Ga-DOTA-GGNle-CycMSH _hex targets the melanocortin-1 receptor for melanoma imaging

JOURNAL ARTICLE published 7 November 2018 in Science Translational Medicine

Research funded by National Institutes of Health (R01CA225837) | University of Colorado Denver (Start-up fund)

Authors: Jianquan Yang | Jingli Xu | Rene Gonzalez | Thomas Lindner | Clemens Kratochwil | Yubin Miao

Rapamycin and Alzheimer’s disease: Time for a clinical trial?

JOURNAL ARTICLE published 23 January 2019 in Science Translational Medicine

Research funded by National Institute on Aging (P30AG013280) | National Institute on Aging (P30AG013319)

Authors: Matt Kaeberlein | Veronica Galvan

Postnatal Soluble FGFR3 Therapy Rescues Achondroplasia Symptoms and Restores Bone Growth in Mice

JOURNAL ARTICLE published 18 September 2013 in Science Translational Medicine

Authors: Stéphanie Garcia | Béatrice Dirat | Thomas Tognacci | Nathalie Rochet | Xavier Mouska | Stéphanie Bonnafous | Stéphanie Patouraux | Albert Tran | Philippe Gual | Yannick Le Marchand-Brustel | Isabelle Gennero | Elvire Gouze

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia

JOURNAL ARTICLE published 17 May 2023 in Science Translational Medicine

Authors: Ernest Moles | Christopher B. Howard | Pie Huda | Mawar Karsa | Hannah McCalmont | Kathleen Kimpton | Alastair Duly | Yongjuan Chen | Yizhou Huang | Melinda L. Tursky | David Ma | Sonia Bustamante | Russell Pickford | Patrick Connerty | Sofia Omari | Christopher J. Jolly | Swapna Joshi | Sylvie Shen | John E. Pimanda | Alla Dolnikov | Laurence C. Cheung | Rishi S. Kotecha | Murray D. Norris | Michelle Haber | Charles E. de Bock | Klaartje Somers | Richard B. Lock | Kristofer J. Thurecht | Maria Kavallaris

Modular immune-homeostatic microparticles promote immune tolerance in mouse autoimmune models

JOURNAL ARTICLE published 10 March 2021 in Science Translational Medicine

Research funded by National Natural Science Foundation of China (81601606) | National Natural Science Foundation of China (31670995) | National Key Research and Development Program of China (Nos.2016YFC1101400) | Young Elite Scientist Sponsorship Program by CAST (2017QNRC001) | Fundamental Research Funds for the Central Universities, open fund of the State Key Laboratory of Military Stomatology (2017KA02) | Knowledge Innovation Program of Shenzhen (JCYJ20170816100941258)

Authors: Xin Chen | Xiaoshan Yang | Pingyun Yuan | Ronghua Jin | Lili Bao | Xinyu Qiu | Siying Liu | Tao Liu | John Justin Gooding | WanJun Chen | Guozhen Liu | Yongkang Bai | Shiyu Liu | Yan Jin

Regulatory T cells engineered with TCR signaling–responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter

JOURNAL ARTICLE published 11 November 2020 in Science Translational Medicine

Research funded by National Institutes of Health (AI134842) | National Institutes of Health (T32 DK007527) | American Diabetes Association (1-17-IBS-206) | American Heart Association (13FTF17000018) | Qatar Foundation (NPRP8-1744-3-357X)

Authors: Siawosh K. Eskandari | Ina Sulkaj | Mariane B. Melo | Na Li | Hazim Allos | Juliano B. Alhaddad | Branislav Kollar | Thiago J. Borges | Arach S. Eskandari | Max A. Zinter | Songjie Cai | Jean Pierre Assaker | John Y. Choi | Basmah S. Al Dulaijan | Amr Mansouri | Yousef Haik | Bakhos A. Tannous | Willem J. van Son | Henri G. D. Leuvenink | Bohdan Pomahac | Leonardo V. Riella | Li Tang | Marc A. J. Seelen | Darrell J. Irvine | Jamil R. Azzi

Evolution of inflammation and immunity in a dengue virus 1 human infection model

JOURNAL ARTICLE published 26 October 2022 in Science Translational Medicine

Authors: Adam T. Waickman | Joseph Q. Lu | HengSheng Fang | Mitchell J. Waldran | Chad Gebo | Jeffrey R. Currier | Lisa Ware | Liesbeth Van Wesenbeeck | Nathalie Verpoorten | Oliver Lenz | Lotke Tambuyzer | Guillermo Herrera-Taracena | Marnix Van Loock | Timothy P. Endy | Stephen J. Thomas

Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer

JOURNAL ARTICLE published 14 December 2022 in Science Translational Medicine

Authors: Kentaro Tanaka | Kenji Chamoto | Sho Saeki | Ryusuke Hatae | Yuki Ikematsu | Kazuko Sakai | Nobuhisa Ando | Kazuhiro Sonomura | Shinsuke Kojima | Masanori Taketsuna | Young Hak Kim | Hironori Yoshida | Hiroaki Ozasa | Yuichi Sakamori | Tomoko Hirano | Fumihiko Matsuda | Toyohiro Hirai | Kazuto Nishio | Takuro Sakagami | Masanori Fukushima | Yoichi Nakanishi | Tasuku Honjo | Isamu Okamoto

Interfering with HIV therapy

JOURNAL ARTICLE published 4 January 2017 in Science Translational Medicine

Authors: Amanda W. Lund