GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

JOURNAL ARTICLE published 4 March 2020 in Science Translational Medicine

Research funded by NIH Office of the Director (DK115762) | NIH Office of the Director (DA037897) | NIH Office of the Director (DA037897) | NIH Office of the Director (DA045792) | Novo Nordisk (IISP)

Authors: Samantha M. Fortin | Rachele K. Lipsky | Rinzin Lhamo | Jack Chen | Eun Kim | Tito Borner | Heath D. Schmidt | Matthew R. Hayes

Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity

JOURNAL ARTICLE published 9 March 2022 in Science Translational Medicine

Authors: Saborni Chakraborty | Joseph C. Gonzalez | Benjamin L. Sievers | Vamsee Mallajosyula | Srijoni Chakraborty | Megha Dubey | Usama Ashraf | Bowie Yik-Ling Cheng | Nimish Kathale | Kim Quyen Thi Tran | Courtney Scallan | Aanika Sinnott | Arianna Cassidy | Steven T. Chen | Terri Gelbart | Fei Gao | Yarden Golan | Xuhuai Ji | Seunghee Kim-Schulze | Mary Prahl | Stephanie L. Gaw | Sacha Gnjatic | Thomas U. Marron | Miriam Merad | Prabhu S. Arunachalam | Scott D. Boyd | Mark M. Davis | Marisa Holubar | Chaitan Khosla | Holden T. Maecker | Yvonne Maldonado | Elizabeth D. Mellins | Kari C. Nadeau | Bali Pulendran | Upinder Singh | Aruna Subramanian | Paul J. Utz | Robert Sherwood | Sheng Zhang | Prasanna Jagannathan | Gene S. Tan | Taia T. Wang

TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure

JOURNAL ARTICLE published 2 November 2022 in Science Translational Medicine

Authors: Maria Areli Lorenzana-Carrillo | Keshav Gopal | Nikole J. Byrne | Saymon Tejay | Bruno Saleme | Subhash K. Das | Yongneng Zhang | Alois Haromy | Farah Eaton | Michelle Mendiola Pla | Dawn E. Bowles | Jason R. B. Dyck | John R. Ussher | Evangelos D. Michelakis | Gopinath Sutendra

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies

JOURNAL ARTICLE published 2 March 2016 in Science Translational Medicine

Research funded by Medical Research Council (MR/K023489/1) | NHS Blood and Transplant (RG59534,RG/09/12/28096)

Authors: Ernest Turro | Daniel Greene | Anouck Wijgaerts | Chantal Thys | Claire Lentaigne | Tadbir K. Bariana | Sarah K. Westbury | Anne M. Kelly | Dominik Selleslag | Jonathan C. Stephens | Sofia Papadia | Ilenia Simeoni | Christopher J. Penkett | Sofie Ashford | Antony Attwood | Steve Austin | Tamam Bakchoul | Peter Collins | Sri V. V. Deevi | Rémi Favier | Myrto Kostadima | Michele P. Lambert | Mary Mathias | Carolyn M. Millar | Kathelijne Peerlinck | David J. Perry | Sol Schulman | Deborah Whitehorn | Christine Wittevrongel | Marc De Maeyer | Augusto Rendon | Keith Gomez | Wendy N. Erber | Andrew D. Mumford | Paquita Nurden | Kathleen Stirrups | John R. Bradley | F. Lucy Raymond | Michael A. Laffan | Chris Van Geet | Sylvia Richardson | Kathleen Freson | Willem H. Ouwehand | BRIDGE-BPD Consortium

Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

JOURNAL ARTICLE published 12 June 2019 in Science Translational Medicine

Research funded by National Institute on Alcohol Abuse and Alcoholism (R21AA025841) | National Institute on Alcohol Abuse and Alcoholism (R21AA025841) | National Institute on Alcohol Abuse and Alcoholism (R01 AA027036) | National Heart, Lung, and Blood Institute (R01HL122068) | National Heart, Lung, and Blood Institute (R01HL122068) | National Heart, Lung, and Blood Institute (1T32HL134637-01) | National Heart, Lung, and Blood Institute (P01HL108793) | National Institute of Allergy and Infectious Diseases (R01AI052201) | National Institute of Diabetes and Digestive and Kidney Diseases (R01DK085252) | National Institute of Diabetes and Digestive and Kidney Diseases (R01DK085252) | National Institute of Diabetes and Digestive and Kidney Diseases (R01DK107288) | American Liver Foundation (ALF Irwin M. Arias, MD Postdoctoral Research Fellowship) | National Heart, Lung, and Blood Institute (1T32HL134637-01) | American Association for the Study of Liver Diseases (AASLD The Leonard B. Seeff Award for Outstanding Research by Young Investigator) | American Liver Foundation (ALF Congressman John Joseph Moakley Postdoctoral Research Fellowship) | Cedars-Sinai Medical Center (Winnick Research award) | National Research Foundation of Korea (2014R1A6A3A01054056) | Colleges and universities in Shanghai (A-U151902) | National Natural Science Foundation of China (81673788) | American Association for the Study of Liver Diseases (AASLD The Leonard B. Seeff Award for Outstanding Research by Young Investigator) | National Research Foundation of Korea (2017R1A5A2015541) | National Research Foundation of Korea (2017R1C1B2004423) | National Health and Medical Research Council of Australia (NHMRC Senior Research Fellowship, ID: 1107914)

Authors: Yoon Mee Yang | Mazen Noureddin | Cheng Liu | Koichiro Ohashi | So Yeon Kim | Divya Ramnath | Elizabeth E. Powell | Matthew J. Sweet | Yoon Seok Roh | I-Fang Hsin | Nan Deng | Zhenqiu Liu | Jiurong Liang | Edward Mena | Daniel Shouhed | Robert F. Schwabe | Dianhua Jiang | Shelly C. Lu | Paul W. Noble | Ekihiro Seki

Evolution of inflammation and immunity in a dengue virus 1 human infection model

JOURNAL ARTICLE published 26 October 2022 in Science Translational Medicine

Authors: Adam T. Waickman | Joseph Q. Lu | HengSheng Fang | Mitchell J. Waldran | Chad Gebo | Jeffrey R. Currier | Lisa Ware | Liesbeth Van Wesenbeeck | Nathalie Verpoorten | Oliver Lenz | Lotke Tambuyzer | Guillermo Herrera-Taracena | Marnix Van Loock | Timothy P. Endy | Stephen J. Thomas

Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema

JOURNAL ARTICLE published 9 July 2014 in Science Translational Medicine

Authors: Maria Quaranta | Bettina Knapp | Natalie Garzorz | Martina Mattii | Venu Pullabhatla | Davide Pennino | Christian Andres | Claudia Traidl-Hoffmann | Andrea Cavani | Fabian J. Theis | Johannes Ring | Carsten B. Schmidt-Weber | Stefanie Eyerich | Kilian Eyerich

The broad socioeconomic benefits of vaccination

JOURNAL ARTICLE published 16 May 2018 in Science Translational Medicine

Authors: David E. Bloom | Victoria Y. Fan | J. P. Sevilla

Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress

JOURNAL ARTICLE published 9 May 2018 in Science Translational Medicine

Research funded by Swiss National Science Foundation (31003A_169204)

Authors: Kristin Seltmann | Michael Meyer | Jitka Sulcova | Tobias Kockmann | Ulrike Wehkamp | Stephan Weidinger | Ulrich auf dem Keller | Sabine Werner

Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera

JOURNAL ARTICLE published 14 October 2015 in Science Translational Medicine

Authors: Joan O. Ngwuta | Man Chen | Kayvon Modjarrad | M. Gordon Joyce | Masaru Kanekiyo | Azad Kumar | Hadi M. Yassine | Syed M. Moin | April M. Killikelly | Gwo-Yu Chuang | Aliaksandr Druz | Ivelin S. Georgiev | Emily J. Rundlet | Mallika Sastry | Guillaume B. E. Stewart-Jones | Yongping Yang | Baoshan Zhang | Martha C. Nason | Cristina Capella | Mark E. Peeples | Julie E. Ledgerwood | Jason S. McLellan | Peter D. Kwong | Barney S. Graham

An RNA interference screen identifies druggable regulators of MeCP2 stability

JOURNAL ARTICLE published 23 August 2017 in Science Translational Medicine

Research funded by National Institutes of Health (award333651,5R01NS057819) | U.S. Department of Veterans Affairs (award333000,I01 RX002133) | U.S. Department of Veterans Affairs (award333001,I01 BX001108) | NINDS (award332999,R01 NS098516)

Authors: Laura M. Lombardi | Manar Zaghlula | Yehezkel Sztainberg | Steven A. Baker | Tiemo J. Klisch | Amy A. Tang | Eric J. Huang | Huda Y. Zoghbi

Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer

JOURNAL ARTICLE published 17 October 2012 in Science Translational Medicine

Authors: Hermioni Zouridis | Niantao Deng | Tatiana Ivanova | Yansong Zhu | Bernice Wong | Dan Huang | Yong Hui Wu | Yingting Wu | Iain Beehuat Tan | Natalia Liem | Veena Gopalakrishnan | Qin Luo | Jeanie Wu | Minghui Lee | Wei Peng Yong | Liang Kee Goh | Bin Tean Teh | Steve Rozen | Patrick Tan

Drug-Induced Aches and Pains

JOURNAL ARTICLE published 25 September 2013 in Science Translational Medicine

Authors: Deepak Voora

T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway

JOURNAL ARTICLE published 7 May 2014 in Science Translational Medicine

Authors: Aline Bozec | Mario M. Zaiss | Rosebeth Kagwiria | Reinhard Voll | Manfred Rauh | Zhu Chen | Sandra Mueller-Schmucker | Richard A. Kroczek | Lucie Heinzerling | Muriel Moser | Andrew L. Mellor | Jean-Pierre David | Georg Schett

Analysis of recurrently protected genomic regions in cell-free DNA found in urine

JOURNAL ARTICLE published 17 February 2021 in Science Translational Medicine

Research funded by National Cancer Institute (U01CA243078) | National Cancer Institute (R01CA223481) | Science Foundation Arizona (BSP-0542-13)

Authors: Havell Markus | Jun Zhao | Tania Contente-Cuomo | Michelle D. Stephens | Elizabeth Raupach | Ahuva Odenheimer-Bergman | Sydney Connor | Bradon R. McDonald | Bethine Moore | Elizabeth Hutchins | Marissa McGilvrey | Michelina C. de la Maza | Kendall Van Keuren-Jensen | Patrick Pirrotte | Ajay Goel | Carlos Becerra | Daniel D. Von Hoff | Scott A. Celinski | Pooja Hingorani | Muhammed Murtaza

Peripheral Blood Mononuclear Cell Gene Expression Profiles Predict Poor Outcome in Idiopathic Pulmonary Fibrosis

JOURNAL ARTICLE published 2 October 2013 in Science Translational Medicine

Authors: Jose D. Herazo-Maya | Imre Noth | Steven R. Duncan | SungHwan Kim | Shwu-Fan Ma | George C. Tseng | Eleanor Feingold | Brenda M. Juan-Guardela | Thomas J. Richards | Yves Lussier | Yong Huang | Rekha Vij | Kathleen O. Lindell | Jianmin Xue | Kevin F. Gibson | Steven D. Shapiro | Joe G. N. Garcia | Naftali Kaminski

A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles

JOURNAL ARTICLE published 18 November 2020 in Science Translational Medicine

Research funded by National Institute of Allergy and Infectious Diseases (R01 AI101018) | National Institute of Diabetes and Digestive and Kidney Diseases (DP1 DK113598) | National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK110174) | National Center for Complementary and Alternative Medicine (U41 AT008718) | Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-03962)

Authors: Jan Claesen | Jennifer B. Spagnolo | Stephany Flores Ramos | Kenji L. Kurita | Allyson L. Byrd | Alexander A. Aksenov | Alexey V. Melnik | Weng R. Wong | Shuo Wang | Ryan D. Hernandez | Mohamed S. Donia | Pieter C. Dorrestein | Heidi H. Kong | Julia A. Segre | Roger G. Linington | Michael A. Fischbach | Katherine P. Lemon

A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors

JOURNAL ARTICLE published 10 May 2023 in Science Translational Medicine

Authors: Ignacio Melero | Tamara Tanos | Mariana Bustamante | Miguel F. Sanmamed | Emiliano Calvo | Irene Moreno | Victor Moreno | Tatiana Hernandez | Maria Martinez Garcia | Alejo Rodriguez-Vida | Josep Tabernero | Analia Azaro | Mariano Ponz-Sarvisé | Iben Spanggaard | Kristoffer Rohrberg | Ernesto Guarin | Eveline Nüesch | Iakov I. Davydov | Chiahuey Ooi | José Duarte | Evelyne Chesne | Christine McIntyre | Maurizio Ceppi | Marta Cañamero | Oliver Krieter

Serum Amyloid P Inhibits Fibrosis Through FcγR-Dependent Monocyte-Macrophage Regulation in Vivo

JOURNAL ARTICLE published 4 November 2009 in Science Translational Medicine

Authors: Ana P. Castaño | Shuei-Liong Lin | Teresa Surowy | Brian T. Nowlin | Swathi A. Turlapati | Tejas Patel | Ajay Singh | Shawn Li | Mark L. Lupher | Jeremy S. Duffield

Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats

JOURNAL ARTICLE published 20 December 2017 in Science Translational Medicine

Research funded by Top Institute Pharma (award292928)

Authors: Danai Riga | Ioannis Kramvis | Maija K. Koskinen | Pieter van Bokhoven | Johanneke E. van der Harst | Tim S. Heistek | A. Jaap Timmerman | Pim van Nierop | Roel C. van der Schors | Anton W. Pieneman | Anouk de Weger | Yvar van Mourik | Anton N. M. Schoffelmeer | Huib D. Mansvelder | Rhiannon M. Meredith | Witte J. G. Hoogendijk | August B. Smit | Sabine Spijker