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Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration

JOURNAL ARTICLE published 15 November 2023 in Science Translational Medicine

Authors: Zemin Ling | Janet Crane | Hao Hu | Yan Chen | Mei Wan | Shuangfei Ni | Shadpour Demehri | Bahram Mohajer | Xinsheng Peng | Xuenong Zou | Xu Cao

Liquid biopsy: Clues on prostate cancer drug resistance

JOURNAL ARTICLE published 4 November 2015 in Science Translational Medicine

Authors: Michael T. Schweizer | Emmanuel S. Antonarakis

Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation

JOURNAL ARTICLE published 4 September 2019 in Science Translational Medicine

Research funded by U.S. Department of Defense (PR-171338P1) | National Heart, Lung, and Blood Institute (R01-HL131829) | National Institute of Biomedical Imaging and Bioengineering (R01-EB020539) | National Institute of Biomedical Imaging and Bioengineering (R01-EB025985) | NIH Office of the Director / National Institute Of Dental & Craniofacial Research (DP5-OD26386)

Authors: Alvaro A. Ordonez | Mark A. Sellmyer | Gayatri Gowrishankar | Camilo A. Ruiz-Bedoya | Elizabeth W. Tucker | Christopher J. Palestro | Dima A. Hammoud | Sanjay K. Jain

CpG ODN Nanorings Induce IFNα from Plasmacytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity

JOURNAL ARTICLE published 7 May 2014 in Science Translational Medicine

Authors: Bilgi Gungor | Fuat Cem Yagci | Gizem Tincer | Banu Bayyurt | Esin Alpdundar | Soner Yildiz | Mine Ozcan | Ihsan Gursel | Mayda Gursel

Clinical trials for neurodevelopmental disorders: At a therapeutic frontier

JOURNAL ARTICLE published 13 January 2016 in Science Translational Medicine

Authors: Shafali S. Jeste | Daniel H. Geschwind

Bone morphogenetic protein 9 is a candidate prognostic biomarker and host-directed therapy target for sepsis

JOURNAL ARTICLE published 31 January 2024 in Science Translational Medicine

Authors: Haobo Bai | Qian Lu | Chunxiang Wu | Fang Xu | Jiayu Liu | Ke Wang | Hao Ding | Yibing Yin | Yi Liu | Xiaofei Lai | Ju Cao

Visualization of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness

JOURNAL ARTICLE published 16 November 2022 in Science Translational Medicine

Authors: Wadah Ibrahim | Michael J. Wilde | Rebecca L. Cordell | Matthew Richardson | Dahlia Salman | Robert C. Free | Bo Zhao | Amisha Singapuri | Beverley Hargadon | Erol A. Gaillard | Toru Suzuki | Leong L. Ng | Tim Coats | Paul Thomas | Paul S. Monks | Christopher E. Brightling | Neil J. Greening | Salman Siddiqui | Rachel Munton | John Le Quesne | Alison H. Goodall | Hitesh C. Pandya | James C. Reynolds | Martha R. J. Clokie | Nilesh J. Samani | Michael R. Barer | Jacqueline A. Shaw | On behalf of the EMBER Consortium

Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer

JOURNAL ARTICLE published 3 May 2023 in Science Translational Medicine

Authors: Mengdie Wang | Christi A. Wisniewski | Choua Xiong | Peter Chhoy | Hira Lal Goel | Ayush Kumar | Lihua Julie Zhu | Rui Li | Pamela A. St. Louis | Lindsay M. Ferreira | Hubert Pakula | Zhiwen Xu | Massimo Loda | Zhong Jiang | Michael A. Brehm | Arthur M. Mercurio

Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease

JOURNAL ARTICLE published 26 October 2016 in Science Translational Medicine

Authors: Nadine Mykicki | Alexander M. Herrmann | Nicholas Schwab | René Deenen | Tim Sparwasser | Andreas Limmer | Lydia Wachsmuth | Luisa Klotz | Karl Köhrer | Cornelius Faber | Heinz Wiendl | Thomas A. Luger | Sven G. Meuth | Karin Loser

Drug-Induced Aches and Pains

JOURNAL ARTICLE published 25 September 2013 in Science Translational Medicine

Authors: Deepak Voora

A helicase-primase drug candidate with sufficient target tissue exposure affects latent neural herpes simplex virus infections

JOURNAL ARTICLE published 16 June 2021 in Science Translational Medicine

Authors: Christian Gege | Fernando J. Bravo | Nadja Uhlig | Timo Hagmaier | Rosanne Schmachtenberg | Julia Elis | Anke Burger-Kentischer | Doris Finkelmeier | Klaus Hamprecht | Thomas Grunwald | David I. Bernstein | Gerald Kleymann

Type 2–polarized memory B cells hold allergen-specific IgE memory

JOURNAL ARTICLE published 7 February 2024 in Science Translational Medicine

Authors: Joshua F. E. Koenig | Niels Peter H. Knudsen | Allyssa Phelps | Kelly Bruton | Ilka Hoof | Gitte Lund | Danielle Della Libera | Anders Lund | Lars Harder Christensen | David R. Glass | Tina D. Walker | Allison Fang | Susan Waserman | Manel Jordana | Peter S. Andersen

Vaccines inducing immunity to Lassa virus glycoprotein and nucleoprotein protect macaques after a single shot

JOURNAL ARTICLE published 2 October 2019 in Science Translational Medicine

Research funded by Institut Pasteur (Grand Programme Fédérateur Vaccinologie) | Institut Pasteur (Bourse Roux) | Fondation pour l’Innovation en Infectiologie (Appel d’offre agents 4) | Labex ECOFECT (Proof of concept grant)

Authors: Mathieu Mateo | Stéphanie Reynard | Xavier Carnec | Alexandra Journeaux | Nicolas Baillet | Justine Schaeffer | Caroline Picard | Catherine Legras-Lachuer | Richard Allan | Emeline Perthame | Kenzo-Hugo Hillion | Natalia Pietrosemoli | Marie-Agnès Dillies | Laura Barrot | Audrey Vallve | Stéphane Barron | Lyne Fellmann | Jean-Charles Gaillard | Jean Armengaud | Caroline Carbonnelle | Hervé Raoul | Frédéric Tangy | Sylvain Baize

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model

JOURNAL ARTICLE published 20 May 2015 in Science Translational Medicine

Research funded by Wellcome Trust Intermediate Clinical Fellowship (98522) | UK Medical Research Council (G33253,G0901839)

Authors: Sander van den Driesche | Joni Macdonald | Richard A. Anderson | Zoe C. Johnston | Tarini Chetty | Lee B. Smith | Chris McKinnell | Afshan Dean | Natalie Z. Homer | Anne Jorgensen | Maria E. Camacho-Moll | Richard M. Sharpe | Rod T. Mitchell

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

JOURNAL ARTICLE published 15 August 2018 in Science Translational Medicine

Authors: Euan S. Polson | Verena B. Kuchler | Christopher Abbosh | Edith M. Ross | Ryan K. Mathew | Hester A. Beard | Bárbara da Silva | Andrew N. Holding | Stephane Ballereau | Eulashini Chuntharpursat-Bon | Jennifer Williams | Hollie B.S. Griffiths | Hao Shao | Anjana Patel | Adam J. Davies | Alastair Droop | Paul Chumas | Susan C. Short | Mihaela Lorger | Jason E. Gestwicki | Lee D. Roberts | Robin S. Bon | Simon J. Allison | Shoutian Zhu | Florian Markowetz | Heiko Wurdak

Resiliency and Vulnerability in the HER2-HER3 Tumorigenic Driver

JOURNAL ARTICLE published 27 January 2010 in Science Translational Medicine

Authors: Dhara N. Amin | Natalia Sergina | Deepika Ahuja | Martin McMahon | Jimmy A. Blair | Donghui Wang | Byron Hann | Kevin M. Koch | Kevan M. Shokat | Mark M. Moasser

Dissolving microneedle vaccination—No magic needled

JOURNAL ARTICLE published 26 September 2018 in Science Translational Medicine

Authors: Sam H. Au

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase

JOURNAL ARTICLE published 12 July 2017 in Science Translational Medicine

Research funded by National Institutes of Health (award310436,R01CA068490) | National Institutes of Health (award310437,P50CA101942)

Authors: Abhishek A. Chakraborty | Eijiro Nakamura | Jun Qi | Amanda Creech | Jacob D. Jaffe | Joshiawa Paulk | Jesse S. Novak | Kshithija Nagulapalli | Samuel K. McBrayer | Glenn S. Cowley | Javier Pineda | Jiaxi Song | Yaoyu E. Wang | Steven A. Carr | David E. Root | Sabina Signoretti | James E. Bradner | William G. Kaelin

Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity

JOURNAL ARTICLE published 9 February 2022 in Science Translational Medicine

Authors: Catherine Riou | Roanne Keeton | Thandeka Moyo-Gwete | Tandile Hermanus | Prudence Kgagudi | Richard Baguma | Ziyaad Valley-Omar | Mikhail Smith | Houriiyah Tegally | Deelan Doolabh | Arash Iranzadeh | Lynn Tyers | Hygon Mutavhatsindi | Marius B. Tincho | Ntombi Benede | Gert Marais | Lionel R. Chinhoyi | Mathilda Mennen | Sango Skelem | Elsa du Bruyn | Cari Stek | Tulio de Oliveira | Carolyn Williamson | Penny L. Moore | Robert J. Wilkinson | Ntobeko A. B. Ntusi | Wendy A. Burgers | South African cellular immunity network

The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis

JOURNAL ARTICLE published 25 October 2023 in Science Translational Medicine

Authors: Scott M. Norberg | Ke Bai | Cem Sievers | Yvette Robbins | Jay Friedman | Xinping Yang | Meg Kenyon | Elizabeth Ward | Jeffrey Schlom | James Gulley | Amy Lankford | Roshanak Semnani | Helen Sabzevari | Douglas E. Brough | Clint T. Allen