A live vaccine rapidly protects against cholera in an infant rabbit model

JOURNAL ARTICLE published 13 June 2018 in Science Translational Medicine

Research funded by National Institute of Allergy and Infectious Diseases (NIH R37-AI-042347) | National Institute of Allergy and Infectious Diseases (F31 AI-120665)

Authors: Troy P. Hubbard | Gabriel Billings | Tobias Dörr | Brandon Sit | Alyson R. Warr | Carole J. Kuehl | Minsik Kim | Fernanda Delgado | John J. Mekalanos | Joseph A. Lewnard | Matthew K. Waldor

A dye-assisted paper-based point-of-care assay for fast and reliable blood grouping

JOURNAL ARTICLE published 15 March 2017 in Science Translational Medicine

Research funded by National Natural Science Foundation of China (81572079,81371899) | Science Fund for Distinguished Young Scholars of Chongqing, China (CSTC2014JCYJJQ10007) | China Academy of Engineering Physics (WSS-2014-09) | Third Military Medical University (2015XZH11) | Southwest Hospital (SWH2016ZDCX1017)

Authors: Hong Zhang | Xiaopei Qiu | Yurui Zou | Yanyao Ye | Chao Qi | Lingyun Zou | Xiang Yang | Ke Yang | Yuanfeng Zhu | Yongjun Yang | Yang Zhou | Yang Luo

Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits

JOURNAL ARTICLE published 12 January 2022 in Science Translational Medicine

Authors: Yang Liu | Godwin Dzidotor | Thinh T. Le | Tra Vinikoor | Kristin Morgan | Eli J. Curry | Ritopa Das | Aneesah McClinton | Ellen Eisenberg | Lorraine N. Apuzzo | Khanh T. M. Tran | Pooja Prasad | Tyler J. Flanagan | Seok-Woo Lee | Ho-Man Kan | Meysam T. Chorsi | Kevin W. H. Lo | Cato T. Laurencin | Thanh D. Nguyen

TLR9 Differentiates Rapidly from Slowly Progressing Forms of Idiopathic Pulmonary Fibrosis

JOURNAL ARTICLE published 10 November 2010 in Science Translational Medicine

Authors: Glenda Trujillo | Alessia Meneghin | Kevin R. Flaherty | Lynette M. Sholl | Jeffrey L. Myers | Ella A. Kazerooni | Barry H. Gross | Sameer R. Oak | Ana Lucia Coelho | Holly Evanoff | Elizabeth Day | Galen B. Toews | Amrita D. Joshi | Matthew A. Schaller | Beatrice Waters | Gabor Jarai | John Westwick | Steven L. Kunkel | Fernando J. Martinez | Cory M. Hogaboam

An anti–TNF–glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases

JOURNAL ARTICLE published 20 March 2024 in Science Translational Medicine

Authors: Michael J. McPherson | Adrian D. Hobson | Axel Hernandez | Christopher C. Marvin | Wendy Waegell | Christian Goess | Jason Z. Oh | Dan Shi | Martin E. Hayes | Lu Wang | Lu Wang | Diana Schmidt | Zhi Wang | Victoria Pitney | Kimberley McCarthy | Ying Jia | Ce Wang | Bit Na Kang | Shaughn Bryant | Suzanne Mathieu | Melanie Ruzek | Julie Parmentier | Ronilda R. D’Cunha | Yinuo Pang | Lucy Phillips | Nathan J. Brown | Jianwen Xu | Candace Graff | Yu Tian | Kenton L. Longenecker | Wei Qiu | Haizhong Zhu | Wei Liu | Pingping Zheng | Yingtao Bi | Robert Stoffel

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

JOURNAL ARTICLE published 21 June 2017 in Science Translational Medicine

Research funded by Swiss National Science Foundation (award297457,406340-128129) | Swiss National Science Foundation (award297458,31003A-163476) | Ministry of Economy and Competitiveness, Spain (award297459,CB16/11/00483) | Ministry of Economy and Competitiveness, Spain (award297460,RYC-2010-05797) | Ministry of Economy and Competitiveness, Spain (award297461,PI15/01909) | Hope Funds for Cancer Research (award297463,Grillo-Marxuach Family Fellow) | The Netherlands Organization for Scientific Research (award297464,VIDI grant no 91714363) | The Netherlands Heart Foundation (award297465,Dekker 2014T105) | European Union (award297462,HEALTH-2013-602904)

Authors: Rudi Micheletti | Isabelle Plaisance | Brian J. Abraham | Alexandre Sarre | Ching-Chia Ting | Michael Alexanian | Daniel Maric | Damien Maison | Mohamed Nemir | Richard A. Young | Blanche Schroen | Arantxa González | Samir Ounzain | Thierry Pedrazzini

The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis

JOURNAL ARTICLE published 4 May 2022 in Science Translational Medicine

Authors: Marion Flipo | Rosangela Frita | Marilyne Bourotte | María S. Martínez-Martínez | Markus Boesche | Gary W. Boyle | Geo Derimanov | Gerard Drewes | Pablo Gamallo | Sonja Ghidelli-Disse | Stephanie Gresham | Elena Jiménez | Jaime de Mercado | Esther Pérez-Herrán | Esther Porras-De Francisco | Joaquín Rullas | Patricia Casado | Florence Leroux | Catherine Piveteau | Mehdi Kiass | Vanessa Mathys | Karine Soetaert | Véronique Megalizzi | Abdalkarim Tanina | René Wintjens | Rudy Antoine | Priscille Brodin | Vincent Delorme | Martin Moune | Kamel Djaout | Stéphanie Slupek | Christian Kemmer | Marc Gitzinger | Lluis Ballell | Alfonso Mendoza-Losana | Sergio Lociuro | Benoit Deprez | David Barros-Aguirre | Modesto J. Remuiñán | Nicolas Willand | Alain R. Baulard

An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo

JOURNAL ARTICLE published 22 June 2022 in Science Translational Medicine

Authors: Nariko Ikemura | Shunta Taminishi | Tohru Inaba | Takao Arimori | Daisuke Motooka | Kazutaka Katoh | Yuhei Kirita | Yusuke Higuchi | Songling Li | Tatsuya Suzuki | Yumi Itoh | Yuki Ozaki | Shota Nakamura | Satoaki Matoba | Daron M. Standley | Toru Okamoto | Junichi Takagi | Atsushi Hoshino

Immune-mediated pathology in Duchenne muscular dystrophy

JOURNAL ARTICLE published 5 August 2015 in Science Translational Medicine

Authors: Amy S. Rosenberg | Montserrat Puig | Kanneboyina Nagaraju | Eric P. Hoffman | S. Armando Villalta | V. Ashutosh Rao | Lalage M. Wakefield | Janet Woodcock

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

JOURNAL ARTICLE published 27 April 2011 in Science Translational Medicine

Authors: Ruili Huang | Noel Southall | Yuhong Wang | Adam Yasgar | Paul Shinn | Ajit Jadhav | Dac-Trung Nguyen | Christopher P. Austin

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

JOURNAL ARTICLE published 9 August 2017 in Science Translational Medicine

Research funded by Juvenile Diabetes Research Foundation International (award310708,1-SRA-2014-236-M-R) | Diabetes UK (award310712,11/0004166) | Diabetes Vaccine Development Centre (award310710) | NIHR Biomedical Research Centre (award310709,IS-BRC-1215-20006)

Authors: Mohammad Alhadj Ali | Yuk-Fun Liu | Sefina Arif | Danijela Tatovic | Hina Shariff | Vivienne B. Gibson | Norkhairin Yusuf | Roman Baptista | Martin Eichmann | Nedyalko Petrov | Susanne Heck | Jennie H. M. Yang | Timothy I. M. Tree | Irma Pujol-Autonell | Lorraine Yeo | Lucas Baumard | Rachel Stenson | Alex Howell | Alison Clark | Zoe Boult | Jake Powrie | Laura Adams | Florence S. Wong | Stephen Luzio | Gareth Dunseath | Kate Green | Alison O’Keefe | Graham Bayly | Natasha Thorogood | Robert Andrews | Nicola Leech | Frank Joseph | Sunil Nair | Susan Seal | HoYee Cheung | Craig Beam | Robert Hills | Mark Peakman | Colin M. Dayan

The A4 Study: Stopping AD Before Symptoms Begin?

JOURNAL ARTICLE published 19 March 2014 in Science Translational Medicine

Authors: Reisa A. Sperling | Dorene M. Rentz | Keith A. Johnson | Jason Karlawish | Michael Donohue | David P. Salmon | Paul Aisen

Novel targets for mitochondrial medicine

JOURNAL ARTICLE published 17 February 2016 in Science Translational Medicine

Research funded by NIH (HL114760,HL088634,HL110349,HL118989,HL126209,HL129510) | American Heart Association (10SDG3450009)

Authors: Wang Wang | Georgios Karamanlidis | Rong Tian

Pharmacogenomic landscape of head and neck squamous cell carcinoma informs precision oncology therapy

JOURNAL ARTICLE published 7 September 2022 in Science Translational Medicine

Authors: Ziyue Gu | Yanli Yao | Guizhu Yang | Guopei Zhu | Zhen Tian | Rui Wang | Qi Wu | Yujue Wang | Yaping Wu | Lan Chen | Chong Wang | Jiamin Gao | Xindan Kang | Jie Zhang | Lizhen Wang | Shengzhong Duan | Zhongming Zhao | Zhiyuan Zhang | Shuyang Sun

Formyl peptide receptor 1 signaling potentiates inflammatory brain injury

JOURNAL ARTICLE published 4 August 2021 in Science Translational Medicine

Research funded by National Natural Science Foundation of China (91642205) | National Natural Science Foundation of China (81830038) | National Natural Science Foundation of China (91949208) | National Natural Science Foundation of China (82071327) | National Key Research and Development Program of China Stem Cell and Translational Research (2018YFC1312200) | National Science Foundation of China (91642205, 81830038, 91949208, 81701176) | The National Key Research and Development Program of China (2018YFC1312200)

Authors: Zhiguo Li | Yulin Li | Jinrui Han | Zilong Zhu | Minshu Li | Qiang Liu | Yongjun Wang | Fu-Dong Shi

Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration

JOURNAL ARTICLE published 15 November 2023 in Science Translational Medicine

Authors: Zemin Ling | Janet Crane | Hao Hu | Yan Chen | Mei Wan | Shuangfei Ni | Shadpour Demehri | Bahram Mohajer | Xinsheng Peng | Xuenong Zou | Xu Cao

The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England

JOURNAL ARTICLE published 6 July 2022 in Science Translational Medicine

Authors: Robert S. Paton | Christopher E. Overton | Thomas Ward

Neutralization of NET-associated human ARG1 enhances cancer immunotherapy

JOURNAL ARTICLE published 15 March 2023 in Science Translational Medicine

Authors: Stefania Canè | Roza Maria Barouni | Marina Fabbi | John Cuozzo | Giulio Fracasso | Annalisa Adamo | Stefano Ugel | Rosalinda Trovato | Francesco De Sanctis | Mauro Giacca | Rita Lawlor | Aldo Scarpa | Borislav Rusev | Gabriella Lionetto | Salvatore Paiella | Roberto Salvia | Claudio Bassi | Susanna Mandruzzato | Silvano Ferrini | Vincenzo Bronte

Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress

JOURNAL ARTICLE published 9 May 2018 in Science Translational Medicine

Research funded by Swiss National Science Foundation (31003A_169204)

Authors: Kristin Seltmann | Michael Meyer | Jitka Sulcova | Tobias Kockmann | Ulrike Wehkamp | Stephan Weidinger | Ulrich auf dem Keller | Sabine Werner

Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting

JOURNAL ARTICLE published 15 June 2022 in Science Translational Medicine

Authors: Mithila Sawant | Kiran Mahajan | Arun Renganathan | Cody Weimholt | Jingqin Luo | Vandna Kukshal | Joseph M. Jez | Myung Sik Jeon | Bo Zhang | Tiandao Li | Bin Fang | Yunting Luo | Nicholas J. Lawrence | Harshani R. Lawrence | Felix Y. Feng | Nupam P. Mahajan