The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding

JOURNAL ARTICLE published 26 November 2018 in eLife

Research funded by Knut och Alice Wallenbergs Stiftelse (2012.0282) | Vetenskapsrådet (621-2014-3713) | Cancerfonden (15 0888) | National Institutes of Health (Intramural) | National Institutes of Health (R35GM122543)

Authors: Renuka Kudva | Pengfei Tian | Fátima Pardo-Avila | Marta Carroni | Robert B Best | Harris D Bernstein | Gunnar von Heijne

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

JOURNAL ARTICLE published 17 November 2020 in eLife

Research funded by FP7 People: Marie-Curie Actions (International Reintegration Grant PIRG07-GA-2010-268397) | European Research Council (ERC-2018-AdG 834860 EYELETS)

Authors: Yan Xiong | M Julia Scerbo | Anett Seelig | Francesco Volta | Nils O'Brien | Andrea Dicker | Daniela Padula | Heiko Lickert | Jantje Mareike Gerdes | Per-Olof Berggren

Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

JOURNAL ARTICLE published 4 March 2021 in eLife

Research funded by ATIP-AVENIR (RSE11005JSA) | Idex PSL (ANR-10-IDEX-0001-02 PSL*) | Agence Nationale de la Recherche (ANR 9139SAMA90010901) | Agence Nationale de la Recherche (ANR-15-CE37-0001-01 CeMod) | Fondation pour la Recherche Médicale (DEQ20150331748) | Fondation pour la Recherche Médicale (DEQ20140329514) | H2020 European Research Council (SynID 724601) | Labex Memolife (ANR-10-LABX-54 MEMO LIFE) | Labex (ANR-11-IDEX-0004-02)

Authors: Inés González-Calvo | Keerthana Iyer | Mélanie Carquin | Anouar Khayachi | Fernando A Giuliani | Séverine M Sigoillot | Jean Vincent | Martial Séveno | Maxime Veleanu | Sylvana Tahraoui | Mélanie Albert | Oana Vigy | Célia Bosso-Lefèvre | Yann Nadjar | Andréa Dumoulin | Antoine Triller | Jean-Louis Bessereau | Laure Rondi-Reig | Philippe Isope | Fekrije Selimi

Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli

JOURNAL ARTICLE published 27 June 2017 in eLife

Research funded by Natural Sciences and Engineering Research Council of Canada (PGSD2-471587-2015)

Authors: Srinivas Gorur-Shandilya | Mahmut Demir | Junjiajia Long | Damon A Clark | Thierry Emonet

Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models

JOURNAL ARTICLE published 20 April 2017 in eLife

Authors: Hui Qin Wang | Ensar Halilovic | Xiaoyan Li | Jinsheng Liang | Yichen Cao | Daniel P Rakiec | David A Ruddy | Sebastien Jeay | Jens U Wuerthner | Noelito Timple | Shailaja Kasibhatla | Nanxin Li | Juliet A Williams | William R Sellers | Alan Huang | Fang Li

Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

JOURNAL ARTICLE published 26 February 2024 in eLife

Research funded by National Institutes of Health (DP2NS087943-01) | National Institutes of Health (R01NS112534) | National Institutes of Health (R01AG045036)

Authors: E Nicholas Petersen | Mahmud Arif Pavel | Samuel S Hansen | Manasa Gudheti | Hao Wang | Zixuan Yuan | Keith R Murphy | William Ja | Heather A Ferris | Erik Jorgensen | Scott B Hansen

HID-1 is required for homotypic fusion of immature secretory granules during maturation

JOURNAL ARTICLE published 18 October 2016 in eLife

Research funded by Ministry of Science and Technology of the People's Republic of China (2016YFA0500200) | Ministry of Science and Technology of the People's Republic of China (2013CB910103) | National Natural Science Foundation of China (31130065) | National Natural Science Foundation of China (31127901) | National Natural Science Foundation of China (31127002) | National Natural Science Foundation of China (31400658) | National Natural Science Foundation of China (31300700)

Authors: Wen Du | Maoge Zhou | Wei Zhao | Dongwan Cheng | Lifen Wang | Jingze Lu | Eli Song | Wei Feng | Yanhong Xue | Pingyong Xu | Tao Xu

Auditory synapses to song premotor neurons are gated off during vocalization in zebra finches

JOURNAL ARTICLE published 18 February 2014 in eLife

Research funded by National Institutes of Health (R01 DC02524) | National Institutes of Health (R21 NS079929) | National Institutes of Health (R01 GM78031) | National Science Foundation Integrative Organismal Systems (0821914) | National Institutes of Health (R01 DC02524) | National Institutes of Health (R21 NS079929) | National Institutes of Health (R01 GM78031) | National Science Foundation (0821914)

Authors: Kosuke Hamaguchi | Katherine A Tschida | Inho Yoon | Bruce R Donald | Richard Mooney

Dpp dependent Hematopoietic stem cells give rise to Hh dependent blood progenitors in larval lymph gland of Drosophila

JOURNAL ARTICLE published 26 October 2016 in eLife

Research funded by Wellcome Trust DBT Alliance (500124/Z09/Z)

Authors: Nidhi Sharma Dey | Parvathy Ramesh | Mayank Chugh | Sudip Mandal | Lolitika Mandal

Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1

JOURNAL ARTICLE published 31 December 2015 in eLife

Research funded by National Institute of Mental Health (5R01MH080379-09, 5R37MH038256-32 and 2R01MH070957-11A1) | National Institute of Neurological Disorders and Stroke (NS002994-13) | National Natural Science Foundation of China (31371061) | Ministry of Science and Technology of the People's Republic of China (2014CB942804) | National Natural Science Foundation of China (31571060)

Authors: Nengyin Sheng | Yun S Shi | Richa Madan Lomash | Katherine W Roche | Roger A Nicoll

Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission

JOURNAL ARTICLE published 1 November 2018 in eLife

Research funded by National Institutes of Health (NS073981) | National Institutes of Health (NS101596) | National Institutes of Health (NS096029)

Authors: Heun Soh | Suhyeorn Park | Kali Ryan | Kristen Springer | Atul Maheshwari | Anastasios V Tzingounis

Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network

JOURNAL ARTICLE published 23 August 2016 in eLife

Research funded by National Institute of General Medical Sciences (5T32GM008396) | University of Missouri (Research Board) | National Institutes of Health (MH087755) | National Science Foundation (CNS-1429294) | National Institutes of Health (MH46742)

Authors: Brian J Lane | Pranit Samarth | Joseph L Ransdell | Satish S Nair | David J Schulz

Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations

JOURNAL ARTICLE published 1 October 2021 in eLife

Research funded by National Institutes of Health (GM007598) | Howard Hughes Medical Institute (Hanna H. Gray Postdoctoral Fellowship) | National Science Foundation (PHY-1914916) | National Institutes of Health (GM104239) | Harvard University (FAS Division of Science Research Computing Group Cannon cluster)

Authors: Christopher W Bakerlee | Angela M Phillips | Alex N Nguyen Ba | Michael M Desai

Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

JOURNAL ARTICLE published 23 December 2022 in eLife

Research funded by Deutsche Forschungsgemeinschaft (CRC 889 Project A02) | Deutsche Forschungsgemeinschaft (CRC 889 Project A07) | Deutsche Forschungsgemeinschaft (CRC 1286 Project A04) | Deutsche Forschungsgemeinschaft (CRC 1286 Project B05) | Deutsche Forschungsgemeinschaft (CRC 1286 Project Z04) | Leibniz Program (Leibniz Prize) | Niedersächsisches Ministerium für Wissenschaft und Kultur (Niedersächsisches Vorab) | European Commission (Erasmus Mundus Neurasmus Scholarship) | Fondation Pour l'Audition (FPA RD-2020-10) | Multiscale Bioimaging (MBExC) is a Cluster of Excellence of the University of Göttingen, Germany (EXC 2067/1- 390729940) | Max Planck Institute for Multidisciplinary Sciences (Erwin Neher Fellowship) | Deutsche Forschungsgemeinschaft (CRC 889 Project B09)

Authors: Rituparna Chakrabarti | Lina María Jaime Tobón | Loujin Slitin | Magdalena Redondo Canales | Gerhard Hoch | Marina Slashcheva | Elisabeth Fritsch | Kai Bodensiek | Özge Demet Özçete | Mehmet Gültas | Susann Michanski | Felipe Opazo | Jakob Neef | Tina Pangrsic | Tobias Moser | Carolin Wichmann

Reconstruction of natural images from responses of primate retinal ganglion cells

JOURNAL ARTICLE published 4 November 2020 in eLife

Research funded by National Science Foundation (NSF IGERT 0801700) | National Science Foundation (GRFP DGE-114747) | National Eye Institute (F31EY027166) | Pew Charitable Trusts (Fellowship in Biomedical Sciences) | John Chen (Donation) | National Institutes of Health (R01EY017992) | National Institutes of Health (R01-EY029247) | National Eye Institute (R01-EY029247) | National Institutes of Health (CRCNS Grant IIS-1430348) | National Science Foundation (CRCNS Grant IIS-1430348)

Authors: Nora Brackbill | Colleen Rhoades | Alexandra Kling | Nishal P Shah | Alexander Sher | Alan M Litke | EJ Chichilnisky

R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton

JOURNAL ARTICLE published 2 November 2022 in eLife

Research funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR064724) | National Institute of Dental and Craniofacial Research (R01DE029615)

Authors: Kenichi Nagano | Kei Yamana | Hiroaki Saito | Riku Kiviranta | Ana Clara Pedroni | Dhairya Raval | Christof Niehrs | Francesca Gori | Roland Baron

Histological E-data Registration in rodent Brain Spaces

JOURNAL ARTICLE published 13 January 2023 in eLife

Research funded by Norges Forskningsråd (300709) | Norges Forskningsråd (223262) | Norges Forskningsråd (197467)

Authors: Jingyi Guo Fuglstad | Pearl Saldanha | Jacopo Paglia | Jonathan R Whitlock

Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

JOURNAL ARTICLE published 3 October 2018 in eLife

Research funded by National Institutes of Health (CA136367) | National Institutes of Health (GM114141)

Authors: Sarah Gilbertson | Joel D Federspiel | Ella Hartenian | Ileana M Cristea | Britt Glaunsinger

Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

JOURNAL ARTICLE published 30 September 2019 in eLife

Research funded by Fondation ARC pour la Recherche sur le Cancer (PJA20141201621) | Fondation ARC pour la Recherche sur le Cancer (Fin de thèse) | Canceropôle PACA (Starting Package Single Cell) | Aix-Marseille Université (Bio trail) | Ligue Contre le Cancer (Comprendre les principes fondamentaux régissant la hiérarchie cellulaire dans les tumeurs neurales)

Authors: Sara Genovese | Raphaël Clément | Cassandra Gaultier | Florence Besse | Karine Narbonne-Reveau | Fabrice Daian | Sophie Foppolo | Nuno Miguel Luis | Cédric Maurange

Regulation of Eag1 gating by its intracellular domains

JOURNAL ARTICLE published 6 September 2019 in eLife

Research funded by Damon Runyon Cancer Research Foundation (DRG-2212-15) | National Institutes of Health (GM43949)

Authors: Jonathan R Whicher | Roderick MacKinnon