eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

JOURNAL ARTICLE published 5 December 2017 in eLife

Research funded by National Institutes of Health (Intramural Research Program)

Authors: Pilar Martin-Marcos | Fujun Zhou | Charm Karunasiri | Fan Zhang | Jinsheng Dong | Jagpreet Nanda | Shardul D Kulkarni | Neelam Dabas Sen | Mercedes Tamame | Michael Zeschnigk | Jon R Lorsch | Alan G Hinnebusch

Excitatory and inhibitory D-serine binding to the NMDA receptor

JOURNAL ARTICLE published 27 October 2022 in eLife

Research funded by National Institutes of Health (T32GM135131) | National Institutes of Health (NS111745) | National Institutes of Health (MH085926)

Authors: Remy A Yovanno | Tsung Han Chou | Sarah J Brantley | Hiro Furukawa | Albert Y Lau

Multisensory integration in the developing tectum is constrained by the balance of excitation and inhibition

JOURNAL ARTICLE published 24 May 2016 in eLife

Research funded by National Science Foundation (NSF IOS-1353044) | NIH Office of the Director (NEI 5T32-EY018080) | Brown University (Fox Postdoctoral Fellowship)

Authors: Daniel L Felch | Arseny S Khakhalin | Carlos D Aizenman

Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity

JOURNAL ARTICLE published 26 September 2017 in eLife

Research funded by Netherlands Organisation for Scientific Research (VIDI 864.08.001) | Netherlands Organisation for Scientific Research (Athena grant 700.58.802) | Human Frontier Science Program (RGP0014/2014) | China Scholarship Council (No. 201506880001) | Netherlands Organisation for Scientific Research (VICI 016.160.613)

Authors: Ramon A van der Valk | Jocelyne Vreede | Liang Qin | Geri F Moolenaar | Andreas Hofmann | Nora Goosen | Remus T Dame

Sexually dimorphic neuronal responses to social isolation

JOURNAL ARTICLE published 11 October 2016 in eLife

Research funded by Alberta Innovates - Health Solutions (Postdoctoral Fellowship) | Canadian Institutes of Health Research (86501)

Authors: Laura Senst | Dinara Baimoukhametova | Toni-Lee Sterley | Jaideep Singh Bains

Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver

JOURNAL ARTICLE published 16 October 2020 in eLife

Research funded by Wellcome Trust (216329/Z/19/Z) | European Society for Paediatric Research (Young Investigator Start-Up Grant)

Authors: Harriet Hunter | Dana de Gracia Hahn | Amedine Duret | Yu Ri Im | Qinrong Cheah | Jiawen Dong | Madison Fairey | Clarissa Hjalmarsson | Alice Li | Hong Kai Lim | Lorcan McKeown | Claudia-Gabriela Mitrofan | Raunak Rao | Mrudula Utukuri | Ian A Rowe | Jake P Mann

Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends

JOURNAL ARTICLE published 11 November 2020 in eLife

Research funded by H2020 European Research Council (Synergy grant 609822) | H2020 European Research Council (Consolidator grant 819219) | Nederlandse Organisatie voor Wetenschappelijk Onderzoek (ALW Open Program grant 824.15.017) | H2020 Marie Skłodowska-Curie Actions (IEF fellowship) | Nederlandse Organisatie voor Wetenschappelijk Onderzoek (STW grant OTP13391) | Fundação para a Ciência e a Tecnologia (PhD fellowship)

Authors: Andrea Serra-Marques | Maud Martin | Eugene A Katrukha | Ilya Grigoriev | Cathelijn AE Peeters | Qingyang Liu | Peter Jan Hooikaas | Yao Yao | Veronika Solianova | Ihor Smal | Lotte B Pedersen | Erik Meijering | Lukas C Kapitein | Anna Akhmanova

Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

JOURNAL ARTICLE published 4 June 2021 in eLife

Research funded by National Institutes of Health (R01CA136367) | Howard Hughes Medical Institute (Gilliam Fellowship)

Authors: Christopher Duncan-Lewis | Ella Hartenian | Valeria King | Britt A Glaunsinger

Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration

JOURNAL ARTICLE published 21 November 2023 in eLife

Research funded by Deutsche Forschungsgemeinschaft (BR 1746/11-1) | HORIZON EUROPE European Research Council (ERC AdG Zf-BrainReg) | Deutsche Forschungsgemeinschaft (EXC 168)

Authors: Laura Celotto | Fabian Rost | Anja Machate | Juliane Bläsche | Andreas Dahl | Anke Weber | Stefan Hans | Michael Brand

Resolving the prevalence of somatic transposition in Drosophila

JOURNAL ARTICLE published 25 July 2017 in eLife

Research funded by Wellcome (200846/Z/16/Z)

Authors: Christoph D Treiber | Scott Waddell

Intrinsic excitability mechanisms of neuronal ensemble formation

JOURNAL ARTICLE published 4 May 2022 in eLife

Research funded by National Institute of Mental Health (R01EY011787) | National Institute of Mental Health (R01MH115900) | Consejo Nacional de Ciencia y Tecnología (287725) | Consejo Nacional de Ciencia y Tecnología (CVU365863)

Authors: Tzitzitlini Alejandre-García | Samuel Kim | Jesús Pérez-Ortega | Rafael Yuste

Extracting grid cell characteristics from place cell inputs using non-negative principal component analysis

JOURNAL ARTICLE published 8 March 2016 in eLife

Research funded by Ollendroff center of the Department of Electrical Engineering, Technion (Research fund) | Israel Science Foundation (Personal Research Grant, 955/13) | Israel Science Foundation (New Faculty Equipment Grant, 1882/13) | Rappaport Institute (Personal Research Grant) | Allen and Jewel Prince Center for Neurodegenrative Disorders (Research Grant)

Authors: Yedidyah Dordek | Daniel Soudry | Ron Meir | Dori Derdikman

Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila

JOURNAL ARTICLE published 18 August 2022 in eLife

Research funded by National Institute on Aging (R21AG054724) | National Institute on Aging (R01AG057700)

Authors: Joyce Rigal | Ane Martin Anduaga | Elena Bitman | Emma Rivellese | Sebastian Kadener | Michael T Marr

Uncertainty alters the balance between incremental learning and episodic memory

JOURNAL ARTICLE published 2 December 2022 in eLife

Research funded by National Science Foundation (1644869) | National Science Foundation (1822619) | National Institutes of Health (MH121093) | John Templeton Foundation (60844)

Authors: Jonathan Nicholas | Nathaniel D Daw | Daphna Shohamy

ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate

JOURNAL ARTICLE published 8 June 2017 in eLife

Research funded by Memorial Sloan-Kettering Cancer Center (P30-CA008748)

Authors: Wenfu Ma | Elena Goldberg | Jonathan Goldberg

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

JOURNAL ARTICLE published 6 December 2021 in eLife

Research funded by National Institutes of Health (AI154048) | National Institutes of Health (AI118426) | National Institutes of Health (AI083359) | Welch Foundation (I-1704) | National Institutes of Health (AI158124)

Authors: Nicholas Rinkenberger | Michael E Abrams | Sumit K Matta | John W Schoggins | Neal M Alto | L David Sibley

A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

JOURNAL ARTICLE published 14 December 2020 in eLife

Research funded by National Institute of General Medical Sciences (R35GM124780) | National Institute of Diabetes and Digestive and Kidney Diseases (R01DK110358) | National Human Genome Research Institute (R01HG009299) | Glenn Foundation for Medical Research (Glenn Award) | National Human Genome Research Institute (T32HG008962) | Might family (Bertrand T Might Fellowship) | National Institute of General Medical Sciences (T32GM007464)

Authors: Dana M Talsness | Katie G Owings | Emily Coelho | Gaelle Mercenne | John M Pleinis | Raghavendran Partha | Kevin A Hope | Aamir R Zuberi | Nathan L Clark | Cathleen M Lutz | Aylin R Rodan | Clement Y Chow

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

JOURNAL ARTICLE published 15 December 2021 in eLife

Research funded by Robertson Foundation (Robertson Therapeutic Development Fund) | National Institutes of Health (P41GM109824) | National Institutes of Health (R01AI0501111) | National Institutes of Health (R01AI078788) | National Institutes of Health (U19AI125378) | National Institutes of Health (K24AI150991) | National Institutes of Health (R01GM112108)

Authors: Fred D Mast | Peter C Fridy | Natalia E Ketaren | Junjie Wang | Erica Y Jacobs | Jean Paul Olivier | Tanmoy Sanyal | Kelly R Molloy | Fabian Schmidt | Magdalena Rutkowska | Yiska Weisblum | Lucille M Rich | Elizabeth R Vanderwall | Nicholas Dambrauskas | Vladimir Vigdorovich | Sarah Keegan | Jacob B Jiler | Milana E Stein | Paul Dominic B Olinares | Louis Herlands | Theodora Hatziioannou | D Noah Sather | Jason S Debley | David Fenyö | Andrej Sali | Paul D Bieniasz | John D Aitchison | Brian T Chait | Michael P Rout

Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis

JOURNAL ARTICLE published 9 December 2019 in eLife

Research funded by National Research Foundation of Korea (2015M3C7A1030964) | National Research Foundation of Korea (2017M3C7A1047875) | National Research Foundation of Korea (2017R1A5A1015366) | National Research Foundation of Korea (2017R1A2B2009031) | Ministry of Science, ICT and Future Planning (19-BR-02-01)

Authors: Youngsik Woo | Soo Jeong Kim | Bo Kyoung Suh | Yongdo Kwak | Hyun-Jin Jung | Truong Thi My Nhung | Dong Jin Mun | Ji-Ho Hong | Su-Jin Noh | Seunghyun Kim | Ahryoung Lee | Seung Tae Baek | Minh Dang Nguyen | Youngshik Choe | Sang Ki Park

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

JOURNAL ARTICLE published 25 February 2020 in eLife

Research funded by National Institutes of Health (DA010711) | National Institutes of Health (DA012864) | National Institutes of Health (OD023048) | National Institutes of Health (GM130142) | Swiss National Science Foundation (P300PA_164712) | Swiss National Science Foundation (PCEFP3_181282) | National Institutes of Health (R21DA045884)

Authors: Miriam Stoeber | Damien Jullié | Joy Li | Soumen Chakraborty | Susruta Majumdar | Nevin A Lambert | Aashish Manglik | Mark von Zastrow