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Open science takes on Parkinson’s disease

JOURNAL ARTICLE published 25 February 2021 in eLife

Authors: Ekemini AU Riley | Randy Schekman

Cycles, sources, and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks

JOURNAL ARTICLE published 5 February 2021 in eLife

Research funded by Wellcome Trust/DBT India Alliance (IA/I/14/2/501523) | Science and Engineering Research Board (CRG/2019/004772) | Science and Engineering Research Board (PDF/2016/000416)

Authors: Ritu Gupta | Sunil Laxman

CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism

JOURNAL ARTICLE published 12 February 2024 in eLife

Research funded by National Institutes of Health (R21NS125767) | National Institutes of Health (R01NS113611) | Wu Tsai Neurosciences Institute (Interdisciplinary Scholar Award) | Stanford Bio-X (Bowes Fellowship)

Authors: Mengyuan Xu | Torben Neelands | Alexander S Powers | Yan Liu | Steven D Miller | Grigore D Pintilie | J Du Bois | Ron O Dror | Wah Chiu | Merritt Maduke

Hippocampome.org 2.0 is a knowledge base enabling data-driven spiking neural network simulations of rodent hippocampal circuits

JOURNAL ARTICLE published 12 February 2024 in eLife

Research funded by National Institutes of Health (R01NS39600) | National Institutes of Health (RF1MH128693) | National Institutes of Health (U01MH114829)

Authors: Diek W Wheeler | Jeffrey D Kopsick | Nate Sutton | Carolina Tecuatl | Alexander O Komendantov | Kasturi Nadella | Giorgio A Ascoli

Fundamental differences

JOURNAL ARTICLE published 1 February 2018 in eLife

Authors: Peter W Gunning | Edna C Hardeman

How new genes are born

JOURNAL ARTICLE published 19 February 2020 in eLife

Authors: Urminder Singh | Eve Syrkin Wurtele

Mega-scale movie-fields in the mouse visuo-hippocampal network

JOURNAL ARTICLE published 1 November 2023 in eLife

Research funded by National Institutes of Health (1U01MH115746)

Authors: Chinmay Purandare | Mayank Mehta

Efficient estimation for large-scale linkage disequilibrium patterns of the human genome

JOURNAL ARTICLE published 27 December 2023 in eLife

Research funded by National Natural Science Foundation of China (31771392) | China National Tobacco Corporation (110202101032(JY-09))

Authors: Xin Huang | Tian-Neng Zhu | Ying-Chao Liu | Guo-An Qi | Jian-Nan Zhang | Guo-Bo Chen

Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

JOURNAL ARTICLE published 29 January 2024 in eLife

Research funded by National Natural Science Foundation of China (82372255) | Advanced Customer Cultivation Project of the Wuhan National Biosafety Laboratory, the Chinese Academy of Sciences (2022ACCP-MS04) | National Major Science and Technology Projects of China (2018ZX09711003-005-005) | National Major Science and Technology Projects of China (2022YFC2600704)

Authors: Lin Zhu | Jing Jin | Tingting Wang | Yong Hu | Hainan Liu | Ting Gao | Qincai Dong | Yanwen Jin | Ping Li | Zijing Liu | Yi Huang | Xuan Liu | Cheng Cao

Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer’s disease, restores synapse integrity and memory in a disease mouse model

JOURNAL ARTICLE published 29 January 2024 in eLife

Research funded by Alzheimer's Society (AS-PG-17-006) | Medical Research Council (MR/S012125/1) | Medical Research Council (MR/M024083/1) | Alzheimer's Research UK (ARUK-PG2018A-002) | Medical Research Council (MR/X010589/1)

Authors: Nuria Martin Flores | Marina Podpolny | Faye McLeod | Isaac Workman | Karen Crawford | Dobril Ivanov | Ganna Leonenko | Valentina Escott-Price | Patricia C Salinas

Setting the right tone

JOURNAL ARTICLE published 10 February 2020 in eLife

Authors: Tanita Casci | Elizabeth Adams

A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities

JOURNAL ARTICLE published 2 February 2024 in eLife

Research funded by National Science Foundation (2047289)

Authors: Marina Chan | Yuqi Kang | Shannon Osborne | Michael Zager | Taranjit S Gujral

Reading the epigenetic code for exchanging DNA

JOURNAL ARTICLE published 16 September 2020 in eLife

Authors: Mathilde Biot | Bernard de Massy

Overburdened ferroptotic stress impairs tooth morphogenesis

JOURNAL ARTICLE published 22 November 2023 in eLife

Research funded by National Natural Science Foundation of China (U21A20368) | National Natural Science Foundation of China (82101000) | National Natural Science Foundation of China (82201045) | China Association for Science and Technology (2022QNRC001)

Authors: Haisheng Wang | Xiaofeng Wang | Liuyan Huang | Chenglin Wang | Fanyuan Yu | Ling Ye

A generative model of electrophysiological brain responses to stimulation

JOURNAL ARTICLE published 17 January 2024 in eLife

Research funded by Novo Nordisk Fonden (NNF19OC-0054895) | Horizon 2020 Framework Programme (ERC-StG-2019-850404) | Wellcome Trust (215573/Z/19/Z) | Wellcome Trust (106183/Z/14/Z)

Authors: Diego Vidaurre

Plant quality declines as CO2 levels rise

JOURNAL ARTICLE published 28 May 2014 in eLife

Authors: Hans-Joachim Weigel

Variation in the basal immune state and implications for disease

JOURNAL ARTICLE published 26 January 2024 in eLife

Research funded by National Institute of Allergy and Infectious Diseases (HHSN272201400006C) | National Institute of Allergy and Infectious Diseases (75N93021C00016) | National Institute of Allergy and Infectious Diseases (75N93019C00052) | National Institute of Allergy and Infectious Diseases (U01AI150747) | National Institute of Allergy and Infectious Diseases (R01AI154470) | National Institute of Allergy and Infectious Diseases (U01AI144616) | National Institute of Allergy and Infectious Diseases (R01AI107625)

Authors: Aisha Souquette | Paul G Thomas

Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making

JOURNAL ARTICLE published 1 December 2023 in eLife

Research funded by HORIZON EUROPE European Research Council (ERC STG 715605)

Authors: Stijn A Nuiten | Jan Willem de Gee | Jasper B Zantvoord | Johannes J Fahrenfort | Simon van Gaal

Does disease start in the mouth, the gut or both?

JOURNAL ARTICLE published 19 March 2019 in eLife

Authors: Andrei Prodan | Evgeni Levin | Max Nieuwdorp

Judging the difficulty of perceptual decisions

JOURNAL ARTICLE published 17 November 2023 in eLife

Research funded by National Institutes of Health (R01NS117699) | National Institutes of Health (R01NS113113) | Air Force Office of Scientific Research (FA9550-22-1-0337)

Authors: Anne Löffler | Ariel Zylberberg | Michael N Shadlen | Daniel M Wolpert