The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor

JOURNAL ARTICLE published 17 November 2017 in eLife

Research funded by National Institutes of Health (AI 18785) | National Institutes of Health (AI 092108) | National Institutes of Health (AI 103736) | National Institutes of Health (DK099317)

Authors: Philippa Marrack | Sai Harsha Krovi | Daniel Silberman | Janice White | Eleanor Kushnir | Maki Nakayama | James Crooks | Thomas Danhorn | Sonia Leach | Randy Anselment | James Scott-Browne | Laurent Gapin | John Kappler

A new genus of horse from Pleistocene North America

JOURNAL ARTICLE published 28 November 2017 in eLife

Research funded by National Science Foundation (PLR-1417036) | National Science Foundation (PLR-09090456) | Danish Council for Independent Research Natural Sciences (4002-00152B) | European Research Council (ERC-CoG-2015-681605) | Gordon and Betty Moore Foundation (GBMF3804) | Norges Forskningsråd (250963)

Authors: Peter D Heintzman | Grant D Zazula | Ross DE MacPhee | Eric Scott | James A Cahill | Brianna K McHorse | Joshua D Kapp | Mathias Stiller | Matthew J Wooller | Ludovic Orlando | John Southon | Duane G Froese | Beth Shapiro

Dyslexics’ faster decay of implicit memory for sounds and words is manifested in their shorter neural adaptation

JOURNAL ARTICLE published 24 January 2017 in eLife

Research funded by Israel Science Foundation (616/11) | German-Israeli Foundation for Scientific Research and Development (I-1303-105.4/2015) | Israel Science Foundation (2425/15)

Authors: Sagi Jaffe-Dax | Or Frenkel | Merav Ahissar

Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila

JOURNAL ARTICLE published 2 February 2018 in eLife

Research funded by Fundação para a Ciência e a Tecnologia (PTDC/BIA-BCM/118684/2010) | Fundação para a Ciência e a Tecnologia (SFRH/BPD/79325/2011) | Human Frontier Science Program (RGP0022/2012) | Fundação Bial (283/14) | Fundação Bial (279/16) | European Commission (FLiACT ITN)

Authors: Kathrin Steck | Samuel J Walker | Pavel M Itskov | Célia Baltazar | José-Maria Moreira | Carlos Ribeiro

Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

JOURNAL ARTICLE published 27 March 2018 in eLife

Research funded by Wellcome (WT098051) | Medical Research Council (G1100339) | Royal Society (01239/Z/13/Z)

Authors: Adam J Reid | Arthur M Talman | Hayley M Bennett | Ana R Gomes | Mandy J Sanders | Christopher J R Illingworth | Oliver Billker | Matthew Berriman | Mara KN Lawniczak

Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

JOURNAL ARTICLE published 3 April 2018 in eLife

Research funded by National Eye Institute (EY024694) | Research to Prevent Blindness (Unrestricted grant to Duke University) | National Eye Institute (EY026344) | National Eye Institute (EY024567) | National Eye Institute (EY5722 to Duke University)

Authors: Thomas A Ray | Suva Roy | Christopher Kozlowski | Jingjing Wang | Jon Cafaro | Samuel W Hulbert | Christopher V Wright | Greg D Field | Jeremy N Kay

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

JOURNAL ARTICLE published 7 February 2018 in eLife

Research funded by Horizon 2020 Framework Programme (HEALTH-F4-2007-201413) | National Institutes of Health (U01-DK105535) | Wellcome Trust (099673/Z/12/Z) | National Institutes of Health (R01-DK098032) | Wellcome Trust (106130) | National Institutes of Health (R01-MH090941) | Wellcome Trust (095101/Z/10/Z) | Wellcome Trust (200837/Z/16/Z) | Wellcome Trust (090532) | Wellcome Trust (098381) | National Institutes of Health (U01-DK085545) | Wellcome Trust (090367)

Authors: Matthias Thurner | Martijn van de Bunt | Jason M Torres | Anubha Mahajan | Vibe Nylander | Amanda J Bennett | Kyle J Gaulton | Amy Barrett | Carla Burrows | Christopher G Bell | Robert Lowe | Stephan Beck | Vardhman K Rakyan | Anna L Gloyn | Mark I McCarthy

Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure

JOURNAL ARTICLE published 25 July 2018 in eLife

Research funded by National Institutes of Health (2U19AI089674) | Bill and Melinda Gates Foundation (OPP1110495)

Authors: Isabel Rodriguez-Barraquer | Emmanuel Arinaitwe | Prasanna Jagannathan | Moses R Kamya | Phillip J Rosenthal | John Rek | Grant Dorsey | Joaniter Nankabirwa | Sarah G Staedke | Maxwell Kilama | Chris Drakeley | Isaac Ssewanyana | David L Smith | Bryan Greenhouse

A gonad-expressed opsin mediates light-induced spawning in the jellyfish Clytia

JOURNAL ARTICLE published 5 January 2018 in eLife

Research funded by European Commission (FP7-PEOPLE-2012-ITN 317172 (NEPTUNE)) | Agence Nationale de la Recherche (ANR- 13-BSV2-0008-01 ("OOCAMP"))

Authors: Gonzalo Quiroga Artigas | Pascal Lapébie | Lucas Leclère | Noriyo Takeda | Ryusaku Deguchi | Gáspár Jékely | Tsuyoshi Momose | Evelyn Houliston

Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality

JOURNAL ARTICLE published 9 March 2020 in eLife

Research funded by National Institute of Neurological Disorders and Stroke (5R37NS081242) | National Institute of Mental Health (5R01MH083686) | National Institutes of Health (F32NS070514-01A1)

Authors: Amina A Kinkhabwala | Yi Gu | Dmitriy Aronov | David W Tank

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

JOURNAL ARTICLE published 31 March 2016 in eLife

Research funded by National Institute of General Medical Sciences (F32GM112308) | Wellcome Trust (095951) | Gordon and Betty Moore Foundation (GBMF775) | National Institutes of Health (CA164803)

Authors: Ruzbeh Mosadeghi | Kurt M Reichermeier | Martin Winkler | Anne Schreiber | Justin M Reitsma | Yaru Zhang | Florian Stengel | Junyue Cao | Minsoo Kim | Michael J Sweredoski | Sonja Hess | Alexander Leitner | Ruedi Aebersold | Matthias Peter | Raymond J Deshaies | Radoslav I Enchev

Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments

JOURNAL ARTICLE published 16 August 2016 in eLife

Research funded by Wellcome Trust (098375/Z/12/Z) | Biotechnology and Biological Sciences Research Council (BB/N005570/1) | Royal Society (RG130585)

Authors: Didi He | Sam Hughes | Sally Vanden-Hehir | Atanas Georgiev | Kirsten Altenbach | Emma Tarrant | C Logan Mackay | Kevin J Waldron | David J Clarke | Jon Marles-Wright

GLO-Roots: an imaging platform enabling multidimensional characterization of soil-grown root systems

JOURNAL ARTICLE published 19 August 2015 in eLife

Research funded by National Science Foundation (MCB-115795) | U.S. Department of Energy (DE-SC0008769) | National Science Foundation (MCB-0519898) | National Science Foundation (IOS-0820854) | National Institutes of Health (GM48707) | Consejo Nacional de Ciencia y Tecnología (National Council of Science and Technology, Mexico) (CB-2014-01-238101) | U.S. Department of Energy (DE-AI02-07ER64452)

Authors: Rubén Rellán-Álvarez | Guillaume Lobet | Heike Lindner | Pierre-Luc Pradier | Jose Sebastian | Muh-Ching Yee | Yu Geng | Charlotte Trontin | Therese LaRue | Amanda Schrager-Lavelle | Cara H Haney | Rita Nieu | Julin Maloof | John P Vogel | José R Dinneny

Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia

JOURNAL ARTICLE published 16 July 2015 in eLife

Research funded by National Institutes of Health (NIH) (DA010154) | National Science Foundation (NSF) (predoctoral fellowship) | National Institutes of Health (NIH) (DA010711) | National Institutes of Health (NIH) (DA012864)

Authors: Alison Leaf | Mark Von Zastrow

Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons

JOURNAL ARTICLE published 3 December 2015 in eLife

Research funded by Canadian Institutes of Health Research (MOP-97756) | Canadian Institutes of Health Research (MOP-77556) | Ministry of Science and Technology, Taiwan (104-2311-B-038 -004)

Authors: Sebastian Poliak | Daniel Morales | Louis-Philippe Croteau | Dayana Krawchuk | Elena Palmesino | Susan Morton | Jean-François Cloutier | Frederic Charron | Matthew B Dalva | Susan L Ackerman | Tzu-Jen Kao | Artur Kania

Pupil diameter encodes the idiosyncratic, cognitive complexity of belief updating

JOURNAL ARTICLE published 18 May 2020 in eLife

Research funded by National Science Foundation (NSF-NCS 1533623) | National Institute of Biomedical Imaging and Bioengineering (R01 EB026945) | National Institute of Mental Health (F32 MH117924)

Authors: Alexandre LS Filipowicz | Christopher M Glaze | Joseph W Kable | Joshua I Gold

Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket

JOURNAL ARTICLE published 10 February 2017 in eLife

Research funded by National Eye Institute (EY06837) | National Eye Institute (EY001157) | National Natural Science Foundation of China (31471053) | Antonio Champalimaud Foundation, Portugal (Antonio Champalimaud Vision Award) | Howard Hughes Medical Institute (International Student Research Fellowships)

Authors: Wendy Wing Sze Yue | Rikard Frederiksen | Xiaozhi Ren | Dong-Gen Luo | Takahiro Yamashita | Yoshinori Shichida | M Carter Cornwall | King-Wai Yau

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress

JOURNAL ARTICLE published 5 January 2018 in eLife

Research funded by Cancer Research UK (C33269/A20752) | Cancer Research UK (C33269/A23215)

Authors: Megan C Kopp | Piotr R Nowak | Natacha Larburu | Christopher J Adams | Maruf MU Ali

Acetylcholine acts on songbird premotor circuitry to invigorate vocal output

JOURNAL ARTICLE published 19 May 2020 in eLife

Authors: Paul I Jaffe | Michael S Brainard

GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

JOURNAL ARTICLE published 13 November 2020 in eLife

Research funded by National Institute of Neurological Disorders and Stroke (NS094637)

Authors: Markus Terrey | Scott I Adamson | Alana L Gibson | Tianda Deng | Ryuta Ishimura | Jeffrey H Chuang | Susan L Ackerman