Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis

JOURNAL ARTICLE published 21 February 2023 in eLife

Research funded by Japan Society for the Promotion of Science (JP19H03449) | Japan Society for the Promotion of Science (JP20K06535) | Japan Society for the Promotion of Science (JP20K15742)

Authors: Kunli Zhao | Kohichi Matsunaga | Kouichi Mizuno | Hao Wang | Katsuhide Okunishi | Tetsuro Izumi

Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

JOURNAL ARTICLE published 8 December 2016 in eLife

Research funded by National Institutes of Health (CA79765) | National Institutes of Health (AI082039) | National Institutes of Health (T32 CA085183) | National Institutes of Health (5T32 CA108456) | National Institutes of Health (CA203348) | National Institutes of Health (GM021248) | National Institutes of Health (CA115880) | National Institutes of Health (CA140622) | National Institutes of Health (CA172105) | National Cancer Institute (Cancer Center Support Grant 5P30 CA016056) | National Institutes of Health (1R50CA211108)

Authors: Amy W Ku | Jason B Muhitch | Colin A Powers | Michael Diehl | Minhyung Kim | Daniel T Fisher | Anand P Sharda | Virginia K Clements | Kieran O'Loughlin | Hans Minderman | Michelle N Messmer | Jing Ma | Joseph J Skitzki | Douglas A Steeber | Bruce Walcheck | Suzanne Ostrand-Rosenberg | Scott I Abrams | Sharon S Evans

Multimeric single-domain antibody complexes protect against bunyavirus infections

JOURNAL ARTICLE published 21 April 2020 in eLife

Research funded by Innovative Medicines Initiative (ZAPI (grant agreement no. 115760)) | Ministerio de Ciencia Tecnología y Telecomunicaciones (Student Fellowship (PEM-066-2015-II)) | Universidad de Costa Rica (Student Fellowship (OAICE-CAB-05-56-2016))

Authors: Paul J Wichgers Schreur | Sandra van de Water | Michiel Harmsen | Erick Bermúdez-Méndez | Dubravka Drabek | Frank Grosveld | Kerstin Wernike | Martin Beer | Andrea Aebischer | Olalekan Daramola | Sara Rodriguez Conde | Karen Brennan | Dorota Kozub | Maiken Søndergaard Kristiansen | Kieran K Mistry | Ziyan Deng | Jan Hellert | Pablo Guardado-Calvo | Félix A Rey | Lucien van Keulen | Jeroen Kortekaas

Manganese is a physiologically relevant TORC1 activator in yeast and mammals

JOURNAL ARTICLE published 29 July 2022 in eLife

Research funded by Universidad de Sevilla (2020/00001326) | Junta de Andalucía (P20-RT-01220) | European Molecular Biology Organization (STF-8685) | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030_166474/184671) | Ministerio de Ciencia, Innovación y Universidades (PGC2018-096244-B-I00) | Ministerio de Ciencia, Innovación y Universidades (FPU19/04914)

Authors: Raffaele Nicastro | Hélène Gaillard | Laura Zarzuela | Marie-Pierre Péli-Gulli | Elisabet Fernández-García | Mercedes Tomé | Néstor García-Rodríguez | Raúl V Durán | Claudio De Virgilio | Ralf Erik Wellinger

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

JOURNAL ARTICLE published 29 March 2022 in eLife

Research funded by Wellcome Trust (224982/Z/22/Z) | Cancer Research UK (C18281/A29019) | Hellenic Republic's Operational Programme "Competitiveness, Entrepreneurship & Innovation" (OΠΣ 5047228) | NIHR Senior Investigator (NIHR202411) | Medical Research Council (MC_UU_00011/5 and MC_UU_00011/1) | Alzheimer's Society (AS-PG-19b-010) | National Institutes of Health (U01 AG-18-018)

Authors: Fernanda Morales Berstein | Daniel L McCartney | Ake T Lu | Konstantinos K Tsilidis | Emmanouil Bouras | Philip Haycock | Kimberley Burrows | Amanda I Phipps | Daniel D Buchanan | Iona Cheng | Richard M Martin | George Davey Smith | Caroline L Relton | Steve Horvath | Riccardo E Marioni | Tom G Richardson | Rebecca C Richmond | the PRACTICAL consortium

PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

JOURNAL ARTICLE published 15 June 2020 in eLife

Research funded by National Health and Medical Research Council (App #1120477) | National Health and Medical Research Council (App #1156727) | Australian Research Council (DP120100920) | Australian Research Council (DP170104582) | University of Melbourne (- McKenzie Research Fellowship) | Fondation pour la Recherche Médicale (Fellowship ARF20160936221)

Authors: Clément Menuet | Angela A Connelly | Jaspreet K Bassi | Mariana R Melo | Sheng Le | Jessica Kamar | Natasha N Kumar | Stuart J McDougall | Simon McMullan | Andrew M Allen

Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia

JOURNAL ARTICLE published 16 July 2015 in eLife

Research funded by National Institutes of Health (NIH) (DA010154) | National Science Foundation (NSF) (predoctoral fellowship) | National Institutes of Health (NIH) (DA010711) | National Institutes of Health (NIH) (DA012864)

Authors: Alison Leaf | Mark Von Zastrow

Transient acidosis while retrieving a fear-related memory enhances its lability

JOURNAL ARTICLE published 26 June 2017 in eLife

Authors: Jianyang Du | Margaret P Price | Rebecca J Taugher | Daniel Grigsby | Jamison J Ash | Austin C Stark | Md Zubayer Hossain Saad | Kritika Singh | Juthika Mandal | John A Wemmie | Michael J Welsh

Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles

JOURNAL ARTICLE published 16 August 2019 in eLife

Research funded by University College London (Excellence Research Fellowship) | Russian Foundation for Basic Research (18-04-00324) | Russian Science Foundation (18-14-00123) | Saint Petersburg State University (1.42.1099.2016) | Saint Petersburg State University (1.42.723.2017)

Authors: Jan Janouškovec | Gita G Paskerova | Tatiana S Miroliubova | Kirill V Mikhailov | Thomas Birley | Vladimir V Aleoshin | Timur G Simdyanov

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

JOURNAL ARTICLE published 11 January 2021 in eLife

Research funded by Stand Up To Cancer Canada, Genome Canada, CIHR, OICR, AACR (SU2C-AACR-DT-19-15) | CIHR (TGH-158221) | CIHR (MFE 338954)

Authors: Paul Guilhamon | Charles Chesnelong | Michelle M Kushida | Ana Nikolic | Divya Singhal | Graham MacLeod | Seyed Ali Madani Tonekaboni | Florence MG Cavalli | Christopher Arlidge | Nishani Rajakulendran | Naghmeh Rastegar | Xiaoguang Hao | Rozina Hassam | Laura J Smith | Heather Whetstone | Fiona J Coutinho | Bettina Nadorp | Katrina I Ellestad | H Artee Luchman | Jennifer Ai-wen Chan | Molly S Shoichet | Michael D Taylor | Benjamin Haibe-Kains | Samuel Weiss | Stephane Angers | Marco Gallo | Peter B Dirks | Mathieu Lupien

Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons

JOURNAL ARTICLE published 3 December 2015 in eLife

Research funded by Canadian Institutes of Health Research (MOP-97756) | Canadian Institutes of Health Research (MOP-77556) | Ministry of Science and Technology, Taiwan (104-2311-B-038 -004)

Authors: Sebastian Poliak | Daniel Morales | Louis-Philippe Croteau | Dayana Krawchuk | Elena Palmesino | Susan Morton | Jean-François Cloutier | Frederic Charron | Matthew B Dalva | Susan L Ackerman | Tzu-Jen Kao | Artur Kania

Immunoproteasome functions explained by divergence in cleavage specificity and regulation

JOURNAL ARTICLE published 28 November 2017 in eLife

Research funded by National Institutes of Health (F32CA168150) | University of California, San Francisco (Program for Breakthrough Biomedical Research) | University of California, San Francisco (Enabling Technologies Advisory Committee) | National Institutes of Health (R21CA186077) | National Institutes of Health (R21AI133393) | National Institutes of Health (P41CA196276)

Authors: Michael B Winter | Florencia La Greca | Shirin Arastu-Kapur | Francesco Caiazza | Peter Cimermancic | Tonia J Buchholz | Janet L Anderl | Matthew Ravalin | Markus F Bohn | Andrej Sali | Anthony J O'Donoghue | Charles S Craik

IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25+Foxp3- T cells

JOURNAL ARTICLE published 21 December 2021 in eLife

Research funded by Czech Science Foundation (13-12885S) | Institutional Research Concept RVO (61388971) | Czech Science Foundation (18-12973S) | Ministry of Health of the Czech Republic (NV19-03-00179)

Authors: Jakub Tomala | Petra Weberova | Barbora Tomalova | Zuzana Jiraskova Zakostelska | Ladislav Sivak | Jirina Kovarova | Marek Kovar

Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling

JOURNAL ARTICLE published 13 March 2020 in eLife

Research funded by National Institutes of Health (HL070123) | American Heart Association (17SDG33400141) | National Science Foundation (OIA-1655740)

Authors: Hua Shen | Peiheng Gan | Kristy Wang | Ali Darehzereshki | Kai Wang | S Ram Kumar | Ching-Ling Lien | Michaela Patterson | Ge Tao | Henry M Sucov

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

JOURNAL ARTICLE published 24 June 2020 in eLife

Research funded by Deutsche Forschungsgemeinschaft (SPP 1926) | Deutsche Forschungsgemeinschaft (SPP 1726) | Deutsche Forschungsgemeinschaft (TRR83/SFB) | Deutsche Forschungsgemeinschaft (Germany's Excellence Strategy - EXC2151 - 390873048) | Deutsche Forschungsgemeinschaft (FOR2743) | Deutsche Forschungsgemeinschaft (Emmy Noether) | Boehringer Ingelheim Fonds (PhD fellowship) | Samarbeidsorganet Helse Midt-Norge (grant) | Deutsche Forschungsgemeinschaft (SFB894/TP-A22)

Authors: Jan N Hansen | Fabian Kaiser | Christina Klausen | Birthe Stüven | Raymond Chong | Wolfgang Bönigk | David U Mick | Andreas Möglich | Nathalie Jurisch-Yaksi | Florian I Schmidt | Dagmar Wachten

Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations

JOURNAL ARTICLE published 6 December 2022 in eLife

Research funded by National Science Foundation (1715591) | Gordon and Betty Moore Foundation (1901709) | National Institutes of Health (1R21CA207832-01)

Authors: I Can Kazan | Prerna Sharma | Mohammad Imtiazur Rahman | Andrey Bobkov | Raimund Fromme | Giovanna Ghirlanda | S Banu Ozkan

Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysis

JOURNAL ARTICLE published 12 May 2017 in eLife

Research funded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (2012_149278) | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (20020_163042/1) | Agence Nationale de la Recherche (ANR-14-ACHN-0016)

Authors: Duccio Malinverni | Alfredo Jost Lopez | Paolo De Los Rios | Gerhard Hummer | Alessandro Barducci

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

JOURNAL ARTICLE published 31 May 2019 in eLife

Research funded by National Institutes of Health (GM111126) | National Institutes of Health (DP2 OD021007)

Authors: Sandra Elizabeth Torres | Ciara M Gallagher | Lars Plate | Meghna Gupta | Christina R Liem | Xiaoyan Guo | Ruilin Tian | Robert M Stroud | Martin Kampmann | Jonathan S Weissman | Peter Walter

ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells

JOURNAL ARTICLE published 25 June 2021 in eLife

Research funded by Melanoma Research Alliance (688232) | American Cancer Society (RSG-20-019-01 - CCG)

Authors: Maria F Ullo | Jeremy S Logue

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

JOURNAL ARTICLE published 11 March 2019 in eLife

Research funded by National Institute of General Medical Sciences (U01GM98256-01) | National Institute of General Medical Sciences (R01GM083960) | National Institute of General Medical Sciences (P41GM109824) | National Institute of General Medical Sciences (R01GM112108) | University of Texas at Dallas (Start-up funds) | National Institute of General Medical Sciences (R01GM069909) | Welch Foundation (I-1532) | Leukemia and Lymphoma Society (Scholar Award) | University of Texas Southwestern Medical Center (Endowed Scholars Program)

Authors: Abhilash Padavannil | Prithwijit Sarkar | Seung Joong Kim | Tolga Cagatay | Jenny Jiou | Chad A Brautigam | Diana R Tomchick | Andrej Sali | Sheena D'Arcy | Yuh Min Chook