Open science takes on Parkinson’s disease

JOURNAL ARTICLE published 25 February 2021 in eLife

Authors: Ekemini AU Riley | Randy Schekman

CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism

JOURNAL ARTICLE published 12 February 2024 in eLife

Research funded by National Institutes of Health (R21NS125767) | National Institutes of Health (R01NS113611) | Wu Tsai Neurosciences Institute (Interdisciplinary Scholar Award) | Stanford Bio-X (Bowes Fellowship)

Authors: Mengyuan Xu | Torben Neelands | Alexander S Powers | Yan Liu | Steven D Miller | Grigore D Pintilie | J Du Bois | Ron O Dror | Wah Chiu | Merritt Maduke

Hippocampome.org 2.0 is a knowledge base enabling data-driven spiking neural network simulations of rodent hippocampal circuits

JOURNAL ARTICLE published 12 February 2024 in eLife

Research funded by National Institutes of Health (R01NS39600) | National Institutes of Health (RF1MH128693) | National Institutes of Health (U01MH114829)

Authors: Diek W Wheeler | Jeffrey D Kopsick | Nate Sutton | Carolina Tecuatl | Alexander O Komendantov | Kasturi Nadella | Giorgio A Ascoli

Fundamental differences

JOURNAL ARTICLE published 1 February 2018 in eLife

Authors: Peter W Gunning | Edna C Hardeman

How new genes are born

JOURNAL ARTICLE published 19 February 2020 in eLife

Authors: Urminder Singh | Eve Syrkin Wurtele

Mega-scale movie-fields in the mouse visuo-hippocampal network

JOURNAL ARTICLE published 1 November 2023 in eLife

Research funded by National Institutes of Health (1U01MH115746)

Authors: Chinmay Purandare | Mayank Mehta

Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

JOURNAL ARTICLE published 29 January 2024 in eLife

Research funded by National Natural Science Foundation of China (82372255) | Advanced Customer Cultivation Project of the Wuhan National Biosafety Laboratory, the Chinese Academy of Sciences (2022ACCP-MS04) | National Major Science and Technology Projects of China (2018ZX09711003-005-005) | National Major Science and Technology Projects of China (2022YFC2600704)

Authors: Lin Zhu | Jing Jin | Tingting Wang | Yong Hu | Hainan Liu | Ting Gao | Qincai Dong | Yanwen Jin | Ping Li | Zijing Liu | Yi Huang | Xuan Liu | Cheng Cao

Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer’s disease, restores synapse integrity and memory in a disease mouse model

JOURNAL ARTICLE published 29 January 2024 in eLife

Research funded by Alzheimer's Society (AS-PG-17-006) | Medical Research Council (MR/S012125/1) | Medical Research Council (MR/M024083/1) | Alzheimer's Research UK (ARUK-PG2018A-002) | Medical Research Council (MR/X010589/1)

Authors: Nuria Martin Flores | Marina Podpolny | Faye McLeod | Isaac Workman | Karen Crawford | Dobril Ivanov | Ganna Leonenko | Valentina Escott-Price | Patricia C Salinas

Setting the right tone

JOURNAL ARTICLE published 10 February 2020 in eLife

Authors: Tanita Casci | Elizabeth Adams

A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities

JOURNAL ARTICLE published 2 February 2024 in eLife

Research funded by National Science Foundation (2047289)

Authors: Marina Chan | Yuqi Kang | Shannon Osborne | Michael Zager | Taranjit S Gujral

Reading the epigenetic code for exchanging DNA

JOURNAL ARTICLE published 16 September 2020 in eLife

Authors: Mathilde Biot | Bernard de Massy

Overburdened ferroptotic stress impairs tooth morphogenesis

JOURNAL ARTICLE published 22 November 2023 in eLife

Research funded by National Natural Science Foundation of China (U21A20368) | National Natural Science Foundation of China (82101000) | National Natural Science Foundation of China (82201045) | China Association for Science and Technology (2022QNRC001)

Authors: Haisheng Wang | Xiaofeng Wang | Liuyan Huang | Chenglin Wang | Fanyuan Yu | Ling Ye

Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays

JOURNAL ARTICLE published 11 December 2023 in eLife

Research funded by Office of Research Infrastructure Programs, National Institutes of Health (U54 OD030165) | Office of Research Infrastructure Programs, National Institutes of Health (R24 OD022005) | Office of Research Infrastructure Programs, National Institutes of Health (R24 OD031447) | Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50 HD103555) | National Center for Advancing Translational Sciences (UL1 TR002369) | National Institute of General Medical Sciences (R35 GM142486) | U.S. Department of Veterans Affairs (CDA2 grant 5IK2BX004523) | Office of Strategic Coordination (U01 HG007690)

Authors: Xueyang Pan | Albert N Alvarez | Mengqi Ma | Shenzhao Lu | Michael W Crawford | Lauren C Briere | Oguz Kanca | Shinya Yamamoto | David A Sweetser | Jenny L Wilson | Ruth J Napier | Jonathan N Pruneda | Hugo J Bellen

Digging for biosynthetic dark matter

JOURNAL ARTICLE published 13 February 2015 in eLife

Authors: Jia Jia Zhang | Bradley S Moore

Putting early sensory neurons to sleep

JOURNAL ARTICLE published 10 November 2023 in eLife

Authors: Julia Fadjukov | Gregory Schwartz

Correction: Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

JOURNAL ARTICLE published 22 March 2023 in eLife

Authors: Merrick D Pierson Smela | Christian C Kramme | Patrick RJ Fortuna | Jessica L Adams | Alina Rui Su | Edward Dong | Mutsumi Kobayashi | Garyk Brixi | Venkata Srikar Kavirayuni | Emma Tysinger | Richie E Kohman | Toshi Shioda | Pranam Chatterjee | George M Church

Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

JOURNAL ARTICLE published 27 February 2024 in eLife

Research funded by Texas A and M University (Ray B. Nesbitt Endowed Chair) | Tufts University (Karol Family Professorship)

Authors: Yufang Ding | Karin Yanagi | Fang Yang | Evelyn Callaway | Clint Cheng | Martha E Hensel | Rani Menon | Robert C Alaniz | Kyongbum Lee | Arul Jayaraman

Small deviations in kinematics and body form dictate muscle performances in the finely tuned avian downstroke

JOURNAL ARTICLE published 26 February 2024 in eLife

Research funded by National Science Foundation (Graduate Research Fellowship Program DGE-114747) | Air Force Office of Scientific Research (FA9550-16-1-0182) | National Science Foundation (CAREER Award 1552419) | Stanford University (Stanford Graduate Fellowship) | National Science Foundation (IOS-1838688) | National Science Foundation (EFRI 1935216)

Authors: Marc E Deetjen | Diana D Chin | Ashley M Heers | Bret W Tobalske | David Lentink

Pentagone internalises glypicans to fine-tune multiple signalling pathways

JOURNAL ARTICLE published 8 June 2016 in eLife

Research funded by Deutsche Forschungsgemeinschaft (PY72/1-1) | Excellence Initiative of the German Federal and State Governments (EXC294)

Authors: Mark Norman | Robin Vuilleumier | Alexander Springhorn | Jennifer Gawlik | George Pyrowolakis

A generative model of electrophysiological brain responses to stimulation

JOURNAL ARTICLE published 17 January 2024 in eLife

Research funded by Novo Nordisk Fonden (NNF19OC-0054895) | Horizon 2020 Framework Programme (ERC-StG-2019-850404) | Wellcome Trust (215573/Z/19/Z) | Wellcome Trust (106183/Z/14/Z)

Authors: Diego Vidaurre