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Treating Parkinson’s disease by astrocyte reprogramming: Progress and challenges

JOURNAL ARTICLE published 25 June 2021 in Science Advances

Research funded by National Institutes of Health (NIH-NINDS R01NS106907) | U.S. Department of Defense (W81XWH-17-1-0447) | U.S. Department of Defense (W81XWH1910548) | National Institutes of Health National Institute of Neurological Disorders and Stroke (NIH-NINDS R01NS106907-01)

Authors: Zhuang-Yao D. Wei | Ashok K. Shetty

Pathogen effector AvrSr35 triggers Sr35 resistosome assembly via a direct recognition mechanism

JOURNAL ARTICLE published 9 September 2022 in Science Advances

Authors: Yan-Bo Zhao | Meng-Xi Liu | Tao-Tao Chen | Xiaomin Ma | Ze-Kai Li | Zichao Zheng | Si-Ru Zheng | Lifei Chen | You-Zhi Li | Li-Rui Tang | Qi Chen | Peiyi Wang | Songying Ouyang

The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing

JOURNAL ARTICLE published 4 November 2016 in Science Advances

Authors: Aizhuo Liu | Dexin Sui | Dianqing Wu | Jian Hu

Nematicity with a twist: Rotational symmetry breaking in a moiré superlattice

JOURNAL ARTICLE published 7 August 2020 in Science Advances

Research funded by U.S. Department of Energy (DE-SC0020045)

Authors: Rafael M. Fernandes | Jörn W. F. Venderbos

Tailoring emergent spin phenomena in Dirac material heterostructures

JOURNAL ARTICLE published 7 September 2018 in Science Advances

Research funded by Swedish Research Council Formas (2015-06813, 2016-03658) | Horizon 2020 (GrapheneCore2 contract number 785219) | European Regional Development Fund (Project No. FIS2015-67767-P MINECO/FEDER) | MINECO (Grant No. SEV2013-0295)

Authors: Dmitrii Khokhriakov | Aron W. Cummings | Kenan Song | Marc Vila | Bogdan Karpiak | André Dankert | Stephan Roche | Saroj P. Dash

Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras -driven lung cancer

JOURNAL ARTICLE published 30 September 2022 in Science Advances

Authors: Marie Pariollaud | Lara H. Ibrahim | Emanuel Irizarry | Rebecca M. Mello | Alanna B. Chan | Brian J. Altman | Reuben J. Shaw | Michael J. Bollong | R. Luke Wiseman | Katja A. Lamia

Viscoelastic properties of vimentin originate from nonequilibrium conformational changes

JOURNAL ARTICLE published June 2018 in Science Advances

Research funded by H2020 European Research Council (724932) | H2020 European Research Council (654148) | Deutsche Forschungsgemeinschaft (SFB 755/B07) | Deutsche Forschungsgemeinschaft (SFB 937/A17) | Deutsche Forschungsgemeinschaft (GGNB Grant No. GSC 226/2)

Authors: Johanna Block | Hannes Witt | Andrea Candelli | Jordi Cabanas Danes | Erwin J. G. Peterman | Gijs J. L. Wuite | Andreas Janshoff | Sarah Köster

Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo

JOURNAL ARTICLE published 23 November 2022 in Science Advances

Authors: Fubo Cheng | Wenxu Zheng | Chang Liu | Peter Antony Barbuti | Libo Yu-Taeger | Nicolas Casadei | Jeannette Huebener-Schmid | Jakob Admard | Karsten Boldt | Katrin Junger | Marius Ueffing | Henry Houlden | Manu Sharma | Rejko Kruger | Kathrin Grundmann-Hauser | Thomas Ott | Olaf Riess

Fully 3D-printed soft robots with integrated fluidic circuitry

JOURNAL ARTICLE published 16 July 2021 in Science Advances

Research funded by National Science Foundation (1943356)

Authors: Joshua D. Hubbard | Ruben Acevedo | Kristen M. Edwards | Abdullah T. Alsharhan | Ziteng Wen | Jennifer Landry | Kejin Wang | Saul Schaffer | Ryan D. Sochol

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs

JOURNAL ARTICLE published 16 February 2024 in Science Advances

Authors: Tobias Hochstoeger | Panagiotis Papasaikas | Ewa Piskadlo | Jeffrey A. Chao

Climate warming promotes species diversity, but with greater taxonomic redundancy, in complex environments

JOURNAL ARTICLE published 7 July 2017 in Science Advances

Research funded by Deutsche Forschungsgemeinschaft (award321993,862/2)

Authors: Madhav P. Thakur | David Tilman | Oliver Purschke | Marcel Ciobanu | Jane Cowles | Forest Isbell | Peter D. Wragg | Nico Eisenhauer

A “Global Safety Net” to reverse biodiversity loss and stabilize Earth’s climate

JOURNAL ARTICLE published 4 September 2020 in Science Advances

Research funded by Rockefeller Philanthropies / One Earth (Nov2019)

Authors: E. Dinerstein | A. R. Joshi | C. Vynne | A. T. L. Lee | F. Pharand-Deschênes | M. França | S. Fernando | T. Birch | K. Burkart | G. P. Asner | D. Olson

Mandated Bacillus Calmette-Guérin (BCG) vaccination predicts flattened curves for the spread of COVID-19

JOURNAL ARTICLE published 7 August 2020 in Science Advances

Authors: Martha K. Berg | Qinggang Yu | Cristina E. Salvador | Irene Melani | Shinobu Kitayama

Autocatalytic effect boosts the production of medium-chain hydrocarbons by fatty acid photodecarboxylase

JOURNAL ARTICLE published 31 March 2023 in Science Advances

Authors: Poutoum P. Samire | Bo Zhuang | Bertrand Légeret | Ángel Baca-Porcel | Gilles Peltier | Damien Sorigué | Alexey Aleksandrov | Frédéric Beisson | Pavel Müller

Salt-induced ductilization and strain-insensitive resistance of an intrinsically conducting polymer

JOURNAL ARTICLE published 23 November 2022 in Science Advances

Authors: Hao He | Rui Chen | Shizhong Yue | Suzhu Yu | Jun Wei | Jianyong Ouyang

Structure of the mycobacterial ESX-5 type VII secretion system pore complex

JOURNAL ARTICLE published 25 June 2021 in Science Advances

Research funded by Federal Ministry of Education and Research of Germany (FKZ 031L0100)

Authors: Katherine S. H. Beckham | Christina Ritter | Grzegorz Chojnowski | Daniel S. Ziemianowicz | Edukondalu Mullapudi | Mandy Rettel | Mikhail M. Savitski | Simon A. Mortensen | Jan Kosinski | Matthias Wilmanns

Scaffolding bacterial genomes and probing host-virus interactions in gut microbiome by proximity ligation (chromosome capture) assay

JOURNAL ARTICLE published 3 February 2017 in Science Advances

Research funded by European Research Council (ID0EC2BG14750,260822)

Authors: Martial Marbouty | Lyam Baudry | Axel Cournac | Romain Koszul

A nanosecond time-resolved XFEL analysis of structural changes associated with CO release from cytochrome c oxidase

JOURNAL ARTICLE published 7 July 2017 in Science Advances

Authors: Atsuhiro Shimada | Minoru Kubo | Seiki Baba | Keitaro Yamashita | Kunio Hirata | Go Ueno | Takashi Nomura | Tetsunari Kimura | Kyoko Shinzawa-Itoh | Junpei Baba | Keita Hatano | Yuki Eto | Akari Miyamoto | Hironori Murakami | Takashi Kumasaka | Shigeki Owada | Kensuke Tono | Makina Yabashi | Yoshihiro Yamaguchi | Sachiko Yanagisawa | Miyuki Sakaguchi | Takashi Ogura | Ryo Komiya | Jiwang Yan | Eiki Yamashita | Masaki Yamamoto | Hideo Ago | Shinya Yoshikawa | Tomitake Tsukihara

Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 Å resolution

JOURNAL ARTICLE published 2 September 2016 in Science Advances

Research funded by National Institute of General Medical Sciences (ID0EUHAK,R01 GM30598) | National Institute of Arthritis and Musculoskeletal and Skin Diseases (ID0EGPAK,R01 AR014317) | National Center for Research Resources (ID0EPUAK,S10 RR025080) | NIH Office of the Director (ID0EB3AK,S10 OD018142) | American Heart Association (ID0ETDBK,15PRE25090150)

Authors: Zhongjun Hu | Dianne W. Taylor | Michael K. Reedy | Robert J. Edwards | Kenneth A. Taylor

High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

JOURNAL ARTICLE published 6 December 2019 in Science Advances

Research funded by Deutsche Forschungsgemeinschaft (ZI552/4-2) | Deutsche Forschungsgemeinschaft (SFB 815/Z1) | Academy of Finland (294652) | Austrian Federal Ministry of Education (BMWFW-10.420/0005-WF/V/3c/2017)

Authors: Kristian Parey | Outi Haapanen | Vivek Sharma | Harald Köfeler | Thomas Züllig | Simone Prinz | Karin Siegmund | Ilka Wittig | Deryck J. Mills | Janet Vonck | Werner Kühlbrandt | Volker Zickermann