UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation

JOURNAL ARTICLE published 22 February 2023 in JCI Insight

Research funded by Angelman Syndrome Foundation (ASF: 10-2018) | Netherlands Organisation for Scientific Research (NWO-ZonMw: 91216045)

Authors: Diana C. Rotaru | Ilse Wallaard | Maud de Vries | Julia van der Bie | Ype Elgersma

Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma

JOURNAL ARTICLE published 21 December 2023 in JCI Insight

Research funded by National Institutes of Health (T32 HL007185,F32 HL162422,R01 HL080414,UG1 HL139106,P01 HL107202,U01 HL146002,U10 HL109172,U10 HL109168,U10 HL109152,U10 HL109257,U10 HL109146,U10 HL109250,U10 HL109164,U10 109086) | AstraZeneca (N/A) | Boehringer-Ingelheim (N/A) | Genentech (N/A) | GlaxoSmithKline (N/A) | Sanofi–Genzyme–Regeneron (N/A) | TEVA (N/A)

Authors: Brendan K. Huang | Brett M. Elicker | Travis S. Henry | Kimberly G. Kallianos | Lewis D. Hahn | Monica Tang | Franklin Heng | Charles E. McCulloch | Nirav R. Bhakta | Sharmila Majumdar | Jiwoong Choi | Loren C. Denlinger | Sean B. Fain | Annette T. Hastie | Eric A. Hoffman | Elliot Israel | Nizar N. Jarjour | Bruce D. Levy | David T. Mauger | Kaharu Sumino | Sally E. Wenzel | Mario Castro | Prescott G. Woodruff | John V. Fahy

Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure

JOURNAL ARTICLE published 22 June 2022 in JCI Insight

Research funded by National Institutes of Health (HL61912,HL056882,HL103812,HL132181,HL140034) | DW Reynolds Foundation (1)

Authors: T. Jake Samuel | Shenghan Lai | Michael Schär | Katherine C. Wu | Angela M. Steinberg | An-Chi Wei | Mark E. Anderson | Gordon F. Tomaselli | Gary Gerstenblith | Paul A. Bottomley | Robert G. Weiss

An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus

JOURNAL ARTICLE published 22 April 2021 in JCI Insight

Research funded by Coulter Translational Research Program (none) | Georgia Research Alliance Venture Award (GRA.VL17.C4)

Authors: Janet D. Klein | Ish Khanna | Ram Pillarisetti | Rachael A. Hagan | Lauren M. LaRocque | Eva L. Rodriguez | Jeff M. Sands

Exosomal Tat protein activates latent HIV-1 in primary, resting CD4+ T lymphocytes

JOURNAL ARTICLE published 5 April 2018 in JCI Insight

Research funded by NIH (R01HD072693,P30GM110759,K24HD080539,U54GM115677) | Lifespan/Brown/Tufts CFAR (P01AA019072,P30AI042853) | National Institutes of Health (R01HD072693,P30GM110759,K24HD080539,U54GM115677) | Foundation for the National Institutes of Health (R01HD072693,P30GM110759,K24HD080539,U54GM115677)

Authors: Xiaoli Tang | Huafei Lu | Mark Dooner | Stacey Chapman | Peter J. Quesenberry | Bharat Ramratnam

GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion–positive rhabdomyosarcoma

JOURNAL ARTICLE published 8 December 2022 in JCI Insight

Research funded by National Institutes of Health (R01CA231300,U54CA224081,R01CA204302,R01CA211052,R01CA169338,5K08CA218691) | American Association for Cancer Research (17-20-10-SABN) | National Institutes of Health (P30CA082103)

Authors: Jacqueline Morales | David V. Allegakoen | José A. Garcia | Kristen Kwong | Pushpendra K. Sahu | Drew A. Fajardo | Yue Pan | Max A. Horlbeck | Jonathan S. Weissman | W. Clay Gustafson | Trever G. Bivona | Amit J. Sabnis

Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis

JOURNAL ARTICLE published 8 November 2022 in JCI Insight

Research funded by Wellcome Trust (106809/Z/15/Z) | Medical Research Council (MR/S035842/1) | Medical Research Council (MR/N024907/1) | Versus arthritis (21777) | Wellcome Trust (220268/Z/20/Z) | National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIA AR041199) | National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIA AR041133)

Authors: Nathan Richoz | Zewen K. Tuong | Kevin W. Loudon | Eduardo Patiño-Martínez | John R. Ferdinand | Anaïs Portet | Kathleen R. Bashant | Emeline Thevenon | Francesca Rucci | Thomas Hoyler | Tobias Junt | Mariana J. Kaplan | Richard M. Siegel | Menna R. Clatworthy

IgV somatic mutation of human anti–SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity

JOURNAL ARTICLE published 10 May 2021 in JCI Insight

Authors: Mayara Garcia de Mattos Barbosa | Hui Liu | Daniel Huynh | Greg Shelley | Evan T. Keller | Brian T. Emmer | Emily Sherman | David Ginsburg | Andrew A. Kennedy | Andrew W. Tai | Christiane Wobus | Carmen Mirabeli | Thomas M. Lanigan | Milagros Samaniego | Wenzhao Meng | Aaron M. Rosenfeld | Eline T. Luning Prak | Jeffrey L. Platt | Marilia Cascalho

Cytokine and chemokine signatures associated with hepatitis B surface antigen loss in hepatitis B patients

JOURNAL ARTICLE published 18 October 2018 in JCI Insight

Research funded by the Research Program on Hepatitis from Japan Agency for Medical Research and Development (17fk0310119h0001) | the Research Program on Hepatitis from Japan Agency for Medical Research and Development (17fk0310105h0001) | the Research Program on Hepatitis from Japan Agency for Medical Research and Development (17fk0310106h0001) | National Center for Global Health and Medicine (29-shi-1011) | National Center for Global Health and Medicine (26A201)

Authors: Sachiyo Yoshio | Yohei Mano | Hiroyoshi Doi | Hirotaka Shoji | Tomonari Shimagaki | Yuzuru Sakamoto | Hironari Kawai | Michitaka Matsuda | Taizo Mori | Yosuke Osawa | Masaaki Korenaga | Masaya Sugiyama | Masashi Mizokami | Eiji Mita | Keiko Katayama | Junko Tanaka | Tatsuya Kanto

Cell type–specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes

JOURNAL ARTICLE published 21 February 2019 in JCI Insight

Research funded by JDRF (2-PAR-2015-123-Q-R,3-SRA-2016-209-Q-R)

Authors: Matthew J. Dufort | Carla J. Greenbaum | Cate Speake | Peter S. Linsley

Species-specific differences in NPC1 protein trafficking govern therapeutic response in Niemann-Pick type C disease

JOURNAL ARTICLE published 8 December 2022 in JCI Insight

Research funded by Niemann-Pick Canada (none) | Hope for Marian (none) | University of Pennsylvania Orphan Disease Center (none) | Charles Woodson Collaborative Research Award (none) | Support for Accelerated Research for Niemann-Pick Type C (none) | NICHD (ZIA HD008989) | Ara Parseghian Medical Research Foundation (none) | NIH Clinical Center Bench to Bedside Program (none) | National Institutes of Health (R01 NS063967,R01 NS122746,K01 DK124450,R01NS114413)

Authors: Mark L. Schultz | Kylie J. Schache | Ruth D. Azaria | Esmée Q. Kuiper | Steven Erwood | Evgueni A. Ivakine | Nicole Y. Farhat | Forbes D. Porter | Koralege C. Pathmasiri | Stephanie M. Cologna | Michael D. Uhler | Andrew P. Lieberman

Cell-autonomous retinoic acid receptor signaling has stage-specific effects on mouse enteric nervous system

JOURNAL ARTICLE published 24 May 2021 in JCI Insight

Research funded by Irma and Norman Braman Endowment (None) | Suzi and Scott Lustgarten Center Endowment (None) | The Children’s Hospital of Philadelphia Research Institute (None) | Children’s Discovery Institute of Washington University and St. Louis Children’s Hospital (MD-II2013-269) | National Institutes of Health (R01 DK087715) | March of Dimes (FY15-235) | Burroughs Wellcome Fund (1008525)

Authors: Tao Gao | Elizabeth C. Wright-Jin | Rajarshi Sengupta | Jessica B. Anderson | Robert O. Heuckeroth

Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma

JOURNAL ARTICLE published 3 December 2020 in JCI Insight

Research funded by Cancerfonden (NA) | BioGaia AB (NA) | Knut och Alice Wallenbergs Stiftelse (NA)

Authors: Angelo Limeta | Boyang Ji | Max Levin | Francesco Gatto | Jens Nielsen

TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies

JOURNAL ARTICLE published 22 February 2018 in JCI Insight

Authors: Mahiuddin Ahmed | Andres Lopez-Albaitero | Dmitry Pankov | Brian H. Santich | Hong Liu | Su Yan | Jingyi Xiang | Pei Wang | Aisha N. Hasan | Annamalai Selvakumar | Richard J. O’Reilly | Cheng Liu | Nai-Kong V. Cheung

Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

JOURNAL ARTICLE published 22 September 2021 in JCI Insight

Research funded by National Institutes of Health (DK112232,DK123716,DK123743,DK120447,DK120456,DK104211,DK108120,DK090570,DK106755,DK117147,T32GM007347,F30DK118830,DK20593,P30 CA68485,DK058404,2UC4 DK098085) | The Leona M. and Harry B. Helmsley Charitable Trust (G-2004-03813) | JDRF (n/a) | U.S. Department of Veterans Affairs (BX000666)

Authors: Shristi Shrestha | Diane C. Saunders | John T. Walker | Joan Camunas-Soler | Xiao-Qing Dai | Rachana Haliyur | Radhika Aramandla | Greg Poffenberger | Nripesh Prasad | Rita Bottino | Roland Stein | Jean-Philippe Cartailler | Stephen C.J. Parker | Patrick E. MacDonald | Shawn E. Levy | Alvin C. Powers | Marcela Brissova

Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy

JOURNAL ARTICLE published 21 July 2016 in JCI Insight

Authors: Rachael A. Powis | Evangelia Karyka | Penelope Boyd | Julien Côme | Ross A. Jones | Yinan Zheng | Eva Szunyogova | Ewout J.N. Groen | Gillian Hunter | Derek Thomson | Thomas M. Wishart | Catherina G. Becker | Simon H. Parson | Cécile Martinat | Mimoun Azzouz | Thomas H. Gillingwater

Liver X receptor α mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression

JOURNAL ARTICLE published 23 February 2017 in JCI Insight

Authors: Bradlee L. Heckmann | Xiaodong Zhang | Alicia M. Saarinen | Gabriele Schoiswohl | Erin E. Kershaw | Rudolf Zechner | Jun Liu

Propionibacterium acnes–induced immunopathology correlates with health and disease association

JOURNAL ARTICLE published 7 March 2019 in JCI Insight

Research funded by National Institute of Health (NIH grants R21AI103839 (to GYL),R01GM099530 (to HL).)

Authors: Stacey L. Kolar | Chih-Ming Tsai | Juan Torres | Xuemo Fan | Huiying Li | George Y. Liu

Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling

JOURNAL ARTICLE published 12 March 2020 in JCI Insight

Research funded by NINDS (1F31NS079019) | NIH (T32-MH017168) | NIMH (R01-MH087463)

Authors: Morgan Bridi | Hannah Schoch | Cédrick Florian | Shane G. Poplawski | Anamika Banerjee | Joshua D. Hawk | Giulia S. Porcari | Camille Lejards | Chang-Gyu Hahn | Karl-Peter Giese | Robbert Havekes | Nelson Spruston | Ted Abel

Increased hepatic glucose production with lower oxidative metabolism in the growth-restricted fetus

JOURNAL ARTICLE published 30 April 2024 in JCI Insight

Research funded by NIDDK (DK108910)

Authors: Laura D. Brown | Paul J. Rozance | Dong Wang | Evren C. Eroglu | Randall B. Wilkening | Ashley Solmonson | Stephanie R. Wesolowski