Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation

JOURNAL ARTICLE published 10 April 2023 in JCI Insight

Research funded by Foundation for Barnes-Jewish Hospital (5151) | National Cancer Institute (K12 CA167540) | National Heart, Lung, and Blood Institute (K01HL155231,R25 HL105400) | National Institutes of Health (P01AI116501,R01HL094601,P01 CA101937)

Authors: Laneshia K. Tague | Karolyn A. Oetjen | Anirudh Mahadev | Matthew J. Walter | Hephzibah Anthony | Daniel Kreisel | Daniel C. Link | Andrew E. Gelman

NELL-1 induces Sca-1+ mesenchymal progenitor cell expansion in models of bone maintenance and repair

JOURNAL ARTICLE published 15 June 2017 in JCI Insight

Authors: Aaron W. James | Jia Shen | Rebecca Tsuei | Alan Nguyen | Kevork Khadarian | Carolyn A. Meyers | Hsin Chuan Pan | Weiming Li | Jin H. Kwak | Greg Asatrian | Cymbeline T. Culiat | Min Lee | Kang Ting | Xinli Zhang | Chia Soo

CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking

JOURNAL ARTICLE published 23 August 2021 in JCI Insight

Research funded by Fundação de Amparo a Pesquisa do Estado de Sao Paulo (2017/04187-9,2018/18886-9,2020/01688-0,2020/07069,2016/22158-3) | The Jeffrey Modell Foundation (000/0) | Hyper IgM Foundation (000/0) | Research Grants Committee of the College of Medicine & Health Sciences, UAE University (NP-19-15)

Authors: Tábata Takahashi França | Ashraf Al-Sbiei | Ghada Bashir | Yassir Awad Mohamed | Ranieri Coelho Salgado | Lucila Akune Barreiros | Sarah Maria da Silva Napoleão | Cristina Worm Weber | Janaíra Fernandes Severo Ferreira | Carolina Sanchez Aranda | Carolina Prando | Mayra B. de Barros Dorna | Igor Jurisica | Maria J. Fernandez-Cabezudo | Hans D. Ochs | Antonio Condino-Neto | Basel K. Al-Ramadi | Otavio Cabral-Marques

Spatiotemporal regulation of human IFN-ε and innate immunity in the female reproductive tract

JOURNAL ARTICLE published 22 September 2022 in JCI Insight

Research funded by Bill and Melinda Gates Foundation (OPP1108501) | Australian National Health and Medical Research Council (APP1117527)

Authors: Nollaig M. Bourke | Sharon L. Achilles | Stephanie U-Shane Huang | Helen E. Cumming | San S. Lim | Irene Papageorgiou | Linden J. Gearing | Ross Chapman | Suruchi Thakore | Niamh E. Mangan | Sam Mesiano | Paul J. Hertzog

RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer

JOURNAL ARTICLE published 8 August 2019 in JCI Insight

Research funded by NIH (NIH grant 1P01AI091580-01) | NIH (U10CA180821) | NIH (U24CA196171) | Ministtry of Science and Technology Taiwan (104-2917-I-006-002) | NIH (1R01DK115728) | Alliance NCTN grant (U10CA180821) | The Mark Foundation Cancer Research (Mark Foundation Momentum)

Authors: Oghenekevwe M. Gbenedio | Caroline Bonnans | Delphine Grun | Chih-Yang Wang | Ace J. Hatch | Michelle R. Mahoney | David Barras | Mary Matli | Yi Miao | K. Christopher Garcia | Sabine Tejpar | Mauro Delorenzi | Alan P. Venook | Andrew B. Nixon | Robert S. Warren | Jeroen P. Roose | Philippe Depeille

Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2

JOURNAL ARTICLE published 22 October 2021 in JCI Insight

Research funded by BioIncept unresticted Grant to MJP and MM (N/A) | University Hospital Bern (Forschungsgrant 84800673)

Authors: Marialuigia Spinelli | Celiné Boucard | Sara Ornaghi | Andreina Schoeberlein | Keller Irene | Daniel Coman | Fahmeed Hyder | Longbo Zhang | Valérie Haesler | Angelique Bordey | Eytan Barnea | Michael Paidas | Daniel Surbek | Martin Mueller

Molecular characterization of the calcium release channel deficiency syndrome

JOURNAL ARTICLE published 6 August 2020 in JCI Insight

Research funded by Mayo Clinic (not applicable) | Mayo Clinic (not applicable)

Authors: David J. Tester | CS John Kim | Samantha K. Hamrick | Dan Ye | Bailey J. O’Hare | Hannah M. Bombei | Kristi K. Fitzgerald | Carla M. Haglund-Turnquist | Dianne L. Atkins | Luis A. Ochoa Nunez | Ian Law | Joel Temple | Michael J. Ackerman

Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure

JOURNAL ARTICLE published 27 February 2020 in JCI Insight

Research funded by Canadian Institute of Health Research (377600) | Canadian Institute of Health Research (378100)

Authors: Stephanie Heidemann | Brian Bursic | Sasan Zandi | Hongbing Li | Sagi Abelson | Robert J. Klaassen | Sharon Abish | Meera Rayar | Vicky R. Breakey | Houtan Moshiri | Santhosh Dhanraj | Richard de Borja | Adam Shlien | John E. Dick | Yigal Dror

Deletion of AMPK minimizes graft-versus-host disease through an early impact on effector donor T cells

JOURNAL ARTICLE published 22 July 2021 in JCI Insight

Research funded by NHLBI (K08 HL123631,R01 HL144556,R01 HL11879) | Hyundai Motor America (Hope on Wheels grant) | American Society of Hematology (ASH Scholar Award) | Be-the-match Foundation (Amy Strelzer-Manasevit award) | National Institute of Allergy and Infectious Diseases (P01 AI056299) | National Cancer Institute (P01 CA142106,T32 CA009138)

Authors: Darlene A. Monlish | Kevin J. Beezhold | Pailin Chiaranunt | Katelyn Paz | Nathan J. Moore | Andrea K. Dobbs | Rebecca A. Brown | John A. Ozolek | Bruce R. Blazar | Craig A. Byersdorfer

3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs

JOURNAL ARTICLE published 26 January 2017 in JCI Insight

Authors: Ranu Surolia | Fu Jun Li | Zheng Wang | Huashi Li | Gang Liu | Yong Zhou | Tracy Luckhardt | Sejong Bae | Rui-ming Liu | Sunad Rangarajan | Joao de Andrade | Victor J. Thannickal | Veena B. Antony

T-bet+CD27+CD21– B cells poised for plasma cell differentiation during antibody-mediated rejection of kidney transplants

JOURNAL ARTICLE published 22 June 2021 in JCI Insight

Research funded by National Institutes of Health (R01 AI130010)

Authors: Kevin Louis | Elodie Bailly | Camila Macedo | Louis Lau | Bala Ramaswami | Alexander Chang | Uma Chandran | Douglas Landsittel | Xinyan Gu | Geetha Chalasani | Adriana Zeevi | Parmjeet Randhawa | Harinder Singh | Carmen Lefaucheur | Diana Metes

CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice

JOURNAL ARTICLE published 8 June 2023 in JCI Insight

Research funded by Taysha Gene Therapies Inc. (n/a)

Authors: Hayes Wong | Alexander W.M. Hooper | Hye Ri Kang | Shiron J. Lee | Jiayi Zhao | Chanchal Sadhu | Satinder Rawat | Steven J. Gray | David R. Hampson

Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling

JOURNAL ARTICLE published 2 June 2017 in JCI Insight

Authors: Kari Brown | Alyssa Filuta | Marie-Gabrielle Ludwig | Klaus Seuwen | Julian Jaros | Solange Vidal | Kavisha Arora | Anjaparavanda P. Naren | Kathirvel Kandasamy | Kaushik Parthasarathi | Stefan Offermanns | Robert J. Mason | William E. Miller | Jeffrey A. Whitsett | James P. Bridges

The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age

JOURNAL ARTICLE published 24 May 2021 in JCI Insight

Research funded by São Paulo Research Foundation - FAPESP (2020/09146-1) | São Paulo Research Foundation - FAPESP (2020/07972-1) | São Paulo Research Foundation - FAPESP (2020/07069-0) | São Paulo Research Foundation - FAPESP (2020/01688-0) | São Paulo Research Foundation - FAPESP (2018/18886-9) | São Paulo Research Foundation - FAPESP (2017/05264-7) | Ontario Research Fund (#34876) | Natural Sciences Research Council (NSERC #203475) | Canada Foundation for Innovation (CFI #29272,#225404,#33536) | National Council for Scientific and Technological Development - CNPq (311530/2019<2010>2) | São Paulo Research Foundation - FAPESP (2013/50343-1)

Authors: Paula P. Freire | Alexandre H.C. Marques | Gabriela C. Baiocchi | Lena F. Schimke | Dennyson L.M. Fonseca | Ranieri C. Salgado | Igor S. Filgueiras | Sarah M.S. Napoleao | Desirée R. Plaça | Karen T. Akashi | Thiago Dominguez Crespo Hirata | Nadia El Khawanky | Lasse M. Giil | Gustavo Cabral-Miranda | Robson F. Carvalho | Luis Carlos S. Ferreira | Antonio Condino-Neto | Helder I. Nakaya | Igor Jurisica | Hans D. Ochs | Niels Olsen Saraiva Camara | Vera Lúcia G. Calich | Otavio Cabral-Marques

Frataxin deficiency lowers lean mass and triggers the integrated stress response in skeletal muscle

JOURNAL ARTICLE published 9 May 2022 in JCI Insight

Research funded by Friedreich’s Ataxia Research Alliance (Keith Michael Andrus Cardiology Award) | National Institutes of Health (K23 DK102659) | National Institutes of Health (R01 GM123771) | National Institutes of Health (R01 HL149722) | National Institutes of Health (5UL1TR001878-05)

Authors: César Vásquez-Trincado | Julia Dunn | Ji In Han | Briyanna Hymms | Jaclyn Tamaroff | Monika Patel | Sara Nguyen | Anna Dedio | Kristin Wade | Chinazo Enigwe | Zuzana Nichtova | David R. Lynch | Gyorgy Csordas | Shana E. McCormack | Erin L. Seifert

VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations

JOURNAL ARTICLE published 17 August 2017 in JCI Insight

Authors: René Hägerling | Dominik Drees | Aaron Scherzinger | Cathrin Dierkes | Silvia Martin-Almedina | Stefan Butz | Kristiana Gordon | Michael Schäfers | Klaus Hinrichs | Pia Ostergaard | Dietmar Vestweber | Tobias Goerge | Sahar Mansour | Xiaoyi Jiang | Peter S. Mortimer | Friedemann Kiefer

BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA+ and IGRA– Indian adults

JOURNAL ARTICLE published 19 December 2019 in JCI Insight

Authors: Srabanti Rakshit | Asma Ahmed | Vasista Adiga | Bharath K. Sundararaj | Pravat Nalini Sahoo | John Kenneth | George D’Souza | Wesley Bonam | Christina Johnson | Kees L.M.C. Franken | Tom H.M. Ottenhoff | Greg Finak | Raphael Gottardo | Kenneth D. Stuart | Stephen C. De Rosa | M. Juliana McElrath | Annapurna Vyakarnam

The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP

JOURNAL ARTICLE published 12 March 2020 in JCI Insight

Research funded by National Institutes of Health (NS094151,NS105689)

Authors: Sarrabeth Stone | Shuangchan Wu | Klaus-Armin Nave | Wensheng Lin

Inhibition of stromal cell–derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas

JOURNAL ARTICLE published 6 December 2018 in JCI Insight

Research funded by Grant-in-Aid for JSPS Fellows (10795) | Grant-in-Aid from the Japan Society for the Promotion of Science (17H01509) | Grant-in-Aid from the Japan Society for the Promotion of Science (17H06252) | Ophthalmic Research in Commemoration of Santen Pharmaceutical’s Founder (None) | SENSHIN Medical Research Foundation (None) | Nakatomi Foundation (None) | Cardiovascular Research Fund (None) | Naito Foundation (None)

Authors: Keisuke Omori | Nanae Nagata | Kaori Kurata | Yoko Fukushima | Erika Sekihachi | Nobutaka Fujii | Tomoko Namba-Hamano | Yoshitsugu Takabatake | Marcus Fruttiger | Takashi Nagasawa | Akiyoshi Uemura | Takahisa Murata

MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance

JOURNAL ARTICLE published 24 January 2023 in JCI Insight

Research funded by National Institutes of Health (DK099550,DK126456,DK127497,DK097605,DK107541,DK121747,GM109780,AI007051,DK130551,GM008111)

Authors: Samuel I. Blum | Jared P. Taylor | Jessie M. Barra | Ashley R. Burg | Qiao Shang | Shihong Qiu | Oren Shechter | Aleah R. Hayes | Todd J. Green | Aron M. Geurts | Yi-Guang Chen | Hubert M. Tse