Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality

JOURNAL ARTICLE published October 2018 in Life Science Alliance

Research funded by KAKENHI (17082005,22122006)

Authors: Daiji Kiyozumi | Yukimasa Taniguchi | Itsuko Nakano | Junko Toga | Emiko Yagi | Hidetoshi Hasuwa | Masahito Ikawa | Kiyotoshi Sekiguchi

Structural insights into CED-3 activation

JOURNAL ARTICLE published September 2023 in Life Science Alliance

Authors: Yini Li | Lu Tian | Ying Zhang | Yigong Shi

Performance and robustness analysis reveals phenotypic trade-offs in yeast

JOURNAL ARTICLE published January 2024 in Life Science Alliance

Research funded by Novo Nordisk Fonden (Distinguished Investigator 2019 #0055044)

Authors: Cecilia Trivellin | Peter Rugbjerg | Lisbeth Olsson

Subunit interactions and arrangements in the fission yeast Mis16–Mis18–Mis19 complex

JOURNAL ARTICLE published August 2019 in Life Science Alliance

Research funded by Cancer Research UK (FC001155) | Medical Research Council (FC001155) | Welcome Trust (FC001155)

Authors: Melanie Korntner-Vetter | Stéphane Lefèvre | Xiao-Wen Hu | Roger George | Martin R Singleton

The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization

JOURNAL ARTICLE published December 2022 in Life Science Alliance

Research funded by NIGMS/NIH (R35 GM127103) | FONDECYT (1190119) | ANID (Fondap 15200002) | Iniciativa Científica Milenio (P09-015F)

Authors: Claudia Molina-Pelayo | Patricio Olguin | Marek Mlodzik | Alvaro Glavic

The ERK activator, BCI, inhibits ciliogenesis and causes defects in motor behavior, ciliary gating, and cytoskeletal rearrangement

JOURNAL ARTICLE published June 2023 in Life Science Alliance

Research funded by HHS | NIH | National Institute of General Medical Sciences (R35GM128702) | NIH | National Institute of General Medical Sciences (P20-GM113132) | NCI Cancer Center (5P30CA023108-37)

Authors: Larissa L Dougherty | Soumita Dutta | Prachee Avasthi

Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity

JOURNAL ARTICLE published June 2019 in Life Science Alliance

Research funded by Francis Crick Institute (FC001142) | UK Medical Research Council (FC001142) | Wellcome Trust (FC001142) | Cancer Research UK (FC001142)

Authors: Rebecca V Stevens | Diego Esposito | Katrin Rittinger

The HDL particle composition determines its antitumor activity in pancreatic cancer

JOURNAL ARTICLE published September 2022 in Life Science Alliance

Research funded by European Research Council (758713) | Austrian Science Fund (P33481-B) | Erwin-Schrödinger Fellowship of the Austrian Science (J3664-B19)

Authors: Raimund Oberle | Kristina Kührer | Tamina Österreicher | Florian Weber | Stefanie Steinbauer | Florian Udonta | Mark Wroblewski | Isabel Ben-Batalla | Ingrid Hassl | Jakob Körbelin | Matthias Unseld | Matti Jauhiainen | Birgit Plochberger | Clemens Röhrl | Markus Hengstschläger | Sonja Loges | Herbert Stangl

Mucosa-associated microbiota drives pathogenic functions in IBD-derived intestinal iNKT cells

JOURNAL ARTICLE published February 2019 in Life Science Alliance

Research funded by Associazione Italiana per la Ricerca sul Cancro (14378) | Italy’s Ministry of Health (GR-2016-02361741) | Fondazione IRCCS Policlinico Maggiore Milano (5X1000 Research Award)

Authors: Claudia Burrello | Gabriella Pellegrino | Maria Rita Giuffrè | Giulia Lovati | Ilaria Magagna | Alice Bertocchi | Fulvia Milena Cribiù | Francesca Boggio | Fiorenzo Botti | Elena Trombetta | Laura Porretti | Antonio Di Sabatino | Maurizio Vecchi | Maria Rescigno | Flavio Caprioli | Federica Facciotti

Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting

JOURNAL ARTICLE published March 2022 in Life Science Alliance

Research funded by National Institutes of Health/National Institute of Allergy and Infectious Diseases (1R01AI121252, 1P01AI125180, U01AI141993, U54CA260563, U19AI110483, R37AI049660, T32AI070081) | Bill & Melinda Gates Foundation (INV-002351)

Authors: Chester J Joyner | Ariel M Ley | Doan C Nguyen | Mohammad Ali | Alessia Corrado | Christopher Tipton | Christopher D Scharer | Tian Mi | Matthew C Woodruff | Jennifer Hom | Jeremy M Boss | Meixue Duan | Greg Gibson | Danielle Roberts | Joel Andrews | Sagar Lonial | Inaki Sanz | F Eun-Hyung Lee

Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function

JOURNAL ARTICLE published April 2020 in Life Science Alliance

Research funded by Wellcome Trust (106239/Z/14/A) | Wellcome Trust (106240/Z/14/Z) | Francis Crick Institute (FC001043) | UK Medical Research Council (FC001043) | Wellcome Trust (FC001043)

Authors: Konstantinos Koussis | Chrislaine Withers-Martinez | David A Baker | Michael J Blackman

Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress

JOURNAL ARTICLE published August 2021 in Life Science Alliance

Research funded by MRC Laboratory for Molecular Cell Biology (MC_UU12018/7) | European Research Council (649101-UbiProPox) | MRC Laboratory for Molecular Cell Biology (MC_U12266B) | Wellcome Trust (WT102871MA) | NIH (R37 AI 51174) | MRC-UCL University Unit (MC_U12266B) | MRC Dementia Platform (MR/M02492X/1) | Wellcome Trust Senior Research Fellowship (217202/Z/19/Z) | Cancer Research UK (FC001076) | UK Medical Research Council (FC001076) | Wellcome Trust (FC001076)

Authors: Moona Huttunen | Jerzy Samolej | Robert J Evans | Artur Yakimovich | Ian J White | Janos Kriston-Vizi | Juan Martin-Serrano | Wesley I Sundquist | Eva-Maria Frickel | Jason Mercer

Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells

JOURNAL ARTICLE published April 2022 in Life Science Alliance

Research funded by Health and Biomedical Sciences (HBMS) Open Fund Shared Infrastructure Support (NRF2017_SISFP09)

Authors: Anthony Torres-Ruesta | Teck-Hui Teo | Yi-Hao Chan | Siti Naqiah Amrun | Nicholas Kim-Wah Yeo | Cheryl Yi-Pin Lee | Samantha Yee-Teng Nguee | Matthew Zirui Tay | Francois Nosten | Siew-Wai Fong | Fok-Moon Lum | Guillaume Carissimo | Laurent Renia | Lisa FP Ng

EngineeringPhotorhabdus luminescenstoxin complex (PTC) into a recombinant injection nanomachine

JOURNAL ARTICLE published October 2019 in Life Science Alliance

Authors: Peter Njenga Ng´ang´a | Julia K Ebner | Matthias Plessner | Klaus Aktories | Gudula Schmidt

Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation

JOURNAL ARTICLE published September 2022 in Life Science Alliance

Research funded by National Institutes of Health (R01 GM122768) | Research Council of Lithuania (S-MIP-22-60)

Authors: Ke-Jun Han | Valeryia Mikalayeva | Scott A Gerber | Arminja N Kettenbach | Vytenis A Skeberdis | Rytis Prekeris

Linking medicinal cannabis to autotaxin–lysophosphatidic acid signaling

JOURNAL ARTICLE published February 2023 in Life Science Alliance

Research funded by Marie Skłodowska-Curie Actions (664726)

Authors: Mathias C Eymery | Andrew A McCarthy | Jens Hausmann

Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19

JOURNAL ARTICLE published October 2021 in Life Science Alliance

Research funded by The Wellcome Trust (107032AIA) | The UK Cystic Fibrosis Trust (001)

Authors: Bridget P Bannerman | Jorge Júlvez | Alexandru Oarga | Tom L Blundell | Pablo Moreno | R Andres Floto

Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models

JOURNAL ARTICLE published November 2022 in Life Science Alliance

Authors: Kristel Kemper | Ellis Gielen | Peter Boross | Mischa Houtkamp | Theo S Plantinga | Stefanie AH de Poot | Saskia M Burm | Maarten L Janmaat | Louise A Koopman | Edward N van den Brink | Rik Rademaker | Dennis Verzijl | Patrick J Engelberts | David Satijn | A Kate Sasser | Esther CW Breij

Nodal andchurchill1position the expression of a notch ligand duringXenopusgerm layer segregation

JOURNAL ARTICLE published December 2022 in Life Science Alliance

Research funded by Agencia Nacional de Promoción Cientı́fica y Tecnológica, Argentina (PICT 2011-1559,PICT 2014-2020,PICT 2019-01439) | Consejo Nacional de Investigaciones Cientı́ficas y Técnicas, Argentina (PIP 2012-0508,PIP 2015-0577,PIP 2021-1818) | Escuela ORT, Argentina (Subsidio a la Investigación. Programa de Prácticas en Investigación Científica 2019.)

Authors: María Belén Favarolo | Diego R Revinski | Matías J Garavaglia | Silvia L López

Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt

JOURNAL ARTICLE published June 2022 in Life Science Alliance

Research funded by National Institute of Health–Heart Lung and Blood Institute (HL135827) | National Institute of Health–Heart Lung and Blood Institute (HL 143905) | National Institute of Health–Heart Lung and Blood Institute (T32-HL-7227) | American Heart Association (16SFRN28620000) | American Heart Association (18CDA34110140) | Deutsche Forschungsgemeinschaft (OE 688/1-1)

Authors: Brittany L Dunkerly-Eyring | Shi Pan | Miguel Pinilla-Vera | Desirae McKoy | Sumita Mishra | Maria I Grajeda Martinez | Christian U Oeing | Mark J Ranek | David A Kass